ライフサイエンスコーパス: ligand-gated

1 uCl was solved, the first for any eukaryotic ligand-gated anion channel, revealing a macrocyclic lact

2 luCls) in invertebrates, not affecting human ligand-gated anion channels.

3 ward understanding the roles of voltage- and ligand-gated Ca(2+) channels in triggering specific tran

4 h high spatiotemporal resolution because the ligand-gated Ca(2+)-permeable channel encoded by GLR3.3

5 We fused CaV1.2 to a ligand-gated Ca(2+)-permeable channel, enabling independ

6 are thus inactive but can be converted into ligand-gated catalytically active split-protein kinases.

7 ssed by mutations in acr-23, which encodes a ligand-gated cation channel of the cys-loop family.

8 NX1) opens and forms a pore complex with the ligand-gated cation channel P2X7, allowing the release o

9 ential vanilloid 1 (TRPV1) is a nonselective ligand-gated cation channel responding to noxious heat,

10 TRPV1 is a ligand-gated cation channel that is expressed on a major

11 ic P2X3 and heteromeric P2X2/3 receptors are ligand-gated cation channels activated by ATP.

12 AMPA-type glutamate receptors are ligand-gated cation channels responsible for a majority

13 rs (NMDARs) constitute an important class of ligand-gated cation channels that are involved in the ma

14 N-methyl-D-aspartate receptors (NMDARs) are ligand-gated cation channels that mediate excitatory syn

15 P2X receptors are ligand-gated cation channels that transition from closed

16 ubfamily (TPC1-3) of eukaryotic voltage- and ligand-gated cation channels with two non-equivalent tan

17 e propose that, while P2X receptors are fast ligand-gated cation channels, they are most adept at med

18 N-methyl-d-aspartate (NMDA) receptors are ligand-gated, cation-selective channels that mediate a s

19 TR gating is distinct from that of a typical ligand-gated channel because its ligand (ATP) is usually

20 zation remain unavailable for the pentameric ligand-gated channel family.

21 RPV1 or vanilloid receptor is a nonselective ligand-gated channel highly expressed in primary sensory

22 f ADPR or AMPCPR, identify TRPM2 as a simple ligand-gated channel that obeys an equilibrium gating me

23 TR gating that combines the allosterism of a ligand-gated channel with its unique enzymatic activity.

24 recognition by insect ORs, a novel class of ligand-gated channel.

25 c activation opening voltage gated channels, ligand gated channels, or mobilizing Ca(2+) release from

26 c properties that are common to conventional ligand-gated channels (e.g. unliganded openings and cons

27 allostery that are shared with conventional ligand-gated channels and (ii) the R domain modulates CF

28 fects that have been observed for pentameric ligand-gated channels and may represent a previously unk

29 erpretation of protein allostery for general ligand-gated channels and receptors.

30 For ligand-gated channels each state can represent a differe

31 forms are a family of ubiquitously expressed ligand-gated channels encoded by three individual genes.

32 GABAARs are heteropentameric ligand-gated channels formed by the combination of 19 po

33 Despite their widespread nature, no ligand-gated channels have yet been found within the out

34 Activation of ligand-gated channels is initiated by the binding of sma

35 This increases Ca2+ binding to ligand-gated channels known as ryanodine receptors (RyR2

36 GABAA receptors are pentameric ligand-gated channels mediating inhibitory neurotransmis

37 loop receptors (CLRs) are commonly known as ligand-gated channels that transiently open upon binding

38 tamate receptors are postsynaptic tetrameric ligand-gated channels whose activity mediates fast excit

39 Unlike conventional ligand-gated channels, CFTR is an ATPase for which ligan

40 Ligand-gated channels, in which a substrate transport pa

41 cognized that this small molecule influences ligand-gated channels, including the GABAA receptor and

42 For ligand-gated channels, it is challenging to separate lig

43 Akin to ligand-gated channels, the dilated state of the midplane

44 channels, but not sodium (Na(+)) channels or ligand-gated channels.

45 , a common theme for activating mutations in ligand-gated channels.

46 mechanisms for the superfamily of pentameric ligand-gated channels.

47 data of ethanol action on a wide variety of ligand-gated channels.

48 through the GABA(A) receptor, a postsynaptic ligand-gated chloride channel.

49 in the nematode Caenorhabditis elegans three ligand-gated chloride channels that are receptors for bi

50 Glycine receptors (GlyRs) are ligand-gated chloride channels that mediate inhibitory n

51 cid type A receptors (GABA(A) receptors) are ligand-gated chloride channels that play a central role

52 y mediated by GABA(A) receptors (GABA(A)Rs), ligand-gated chloride channels that play an essential ro

53 ransmission via the allosteric modulation of ligand-gated chloride channels, such as hetero-oligomeri

54 ino acid and neurotransmitter that activates ligand-gated Cl(-) currents, to insulin secretion from i

55 s position within M2 is conserved throughout ligand-gated excitatory cys-loop channel subunits, delet

56 urotoxicity by noncompetitively blocking the ligand-gated GABA(A) receptor ion channel, leading to al

57 We present iTango, a light- and ligand-gated gene expression system based on a light-ind

58 ip, which could be triggered in part through ligand-gated Glu receptors.

59 Ligand-gated heteropentameric GlyRs form chloride ion ch

60 tional and molecular properties of two major ligand-gated inhibitory receptor systems, the GABA(A) re

61 tor (GABA(A)R) is a member of the pentameric ligand gated ion channel (pLGIC) family that mediates io

62 Functional studies of the ligand gated ion channel family (nicotinic acetylcholine

63 al closely related members of the pentameric ligand gated ion channel family.

64 brain involves rapid opening and closing of ligand gated ion channels (LGICs).

65 Pentameric ligand gated ion channels (pLGICs) mediate signal transd

66 acting ionotropic Glu receptors (iGluRs) are ligand gated ion channels and are believed to be involve

67 eptors (adrenoceptors) and P2X1-purinoceptor ligand gated ion channels in male mice, thereby blocking

68 desensitization gate in this novel class of ligand gated ion channels.

69 Members of the cys-loop ligand-gated ion channel (cysLGIC) superfamily mediate c

70 rystal structure of the Erwinia chrysanthemi ligand-gated ion channel (ELIC) in complex with a deriva

71 rom prokaryote homologs-Erwinia chrysanthemi ligand-gated ion channel (ELIC), Gloeobacter violaceus l

72 nts of chlorpromazine binding in the Erwinia ligand-gated ion channel (ELIC).

73 prokaryotic homologs, Gloebacter and Erwinia ligand-gated ion channel (GLIC and ELIC, respectively),

74 membrane domain of the Gloeobacter violaceus ligand-gated ion channel (GLIC) channel, characterize th

75 Gloeobacter violaceus ligand-gated ion channel (GLIC) has served as a valuable

76 etic propofol bound to Gloeobacter violaceus ligand-gated ion channel (GLIC), a bacterial homolog of

77 Crystal structures of Gloeobacter violaceus ligand-gated ion channel (GLIC), a proton-gated prokaryo

78 e bacterial Gloeobacter violaceus pentameric ligand-gated ion channel (GLIC), a structural homolog of

79 /C) receptors, and the Gloeobacter violaceus ligand-gated ion channel (GLIC), are receptors that cont

80 tameric ligand-gated ion channel, Gloebacter ligand-gated ion channel (GLIC), represents an excellent

81 e bacterial Gloeobacter violaceus pentameric ligand-gated ion channel (GLIC), which is sensitive to a

82 ed ion channel (ELIC), Gloeobacter violaceus ligand-gated ion channel (GLIC)-and crystallized eukaryo

83 yotic proton-activated Gloeobacter violaceus ligand-gated ion channel (GLIC).

84 on-gated prokaryotic homologue of pentameric ligand-gated ion channel (LGIC) from G. violaceus, have

85 GLIC, a prokaryotic member of the pentameric ligand-gated ion channel (pLGIC) family, provides a uniq

86 The glycine receptor (GlyR) is a pentameric ligand-gated ion channel (pLGIC) mediating inhibitory tr

87 ion-selective ion channels of the pentameric ligand-gated ion channel (pLGIC) superfamily.

88 The 5-HT(3) receptor, a pentameric ligand-gated ion channel (pLGIC), is an important therap

89 y stimulation of the purinergic receptor P2X ligand-gated ion channel 7 (P2X7) by millimolar concentr

90 As members of the Cys loop ligand-gated ion channel family, neuronal nAChRs are pen

91 eptor (5-HT(3)R) is a member of the Cys-loop ligand-gated ion channel family.

92 The ligand-gated ion channel from Erwinia chrysanthemi (ELIC

93 ELIC, the pentameric ligand-gated ion channel from Erwinia chrysanthemi, is a

94 ing ideas about how activation proceeds in a ligand-gated ion channel from the binding of the agonist

95 rain's major inhibitory neuroreceptor is the ligand-gated ion channel gamma-aminobutyric acid (GABA)

96 ein motions underlying Gloeobacter violaceus ligand-gated ion channel gating in a membrane environmen

97 inhibits the currents of the homopentameric ligand-gated ion channel GLIC, yet the crystal structure

98 e bacterial Gloeobacter violaceus pentameric ligand-gated ion channel homologue (GLIC).

99 icroscopy Torpedo model; the only pentameric ligand-gated ion channel imaged in a native lipid membra

100 ntext of the alpha4beta2 nAChR, a widespread ligand-gated ion channel in the brain and a target for n

101 e receptor (alpha7nAChR) is a homopentameric ligand-gated ion channel mediating fast synaptic transmi

102 ic glutamate receptors (iGluRs), tetrameric, ligand-gated ion channel proteins comprised of three sub

103 t be incorporated into functional pentameric ligand-gated ion channel receptors.

104 GlyRs are members of the pentameric ligand-gated ion channel superfamily (pLGIC) that mediat

105 anniversary of the discovery of the Cys loop ligand-gated ion channel superfamily of neurotransmitter

106 nAChR) is a member of the important Cys loop ligand-gated ion channel superfamily that modulates neur

107 Prokaryotic members of the Cys-loop receptor ligand-gated ion channel superfamily were recently ident

108 tors (GABAARs) are members of the pentameric ligand-gated ion channel superfamily.

109 tion to our knowledge of the entire Cys loop ligand-gated ion channel superfamily.

110 ransient Receptor Potential A 1 (TRPA1) is a ligand-gated ion channel that contributes to inflammator

111 ane conductance regulator (CFTR) is the only ligand-gated ion channel that hydrolyzes its agonist, AT

112 The NMDA-sensitive glutamate receptor is a ligand-gated ion channel that mediates excitatory synapt

113 ents show that G2A activation sensitizes the ligand-gated ion channel TRPV1 in sensory neurons via ac

114 This study provides an example of a ligand-gated ion channel whose deactivation is sensitive

115 the N-methyl-D-aspartate receptor (NMDAR), a ligand-gated ion channel with essential roles in brain d

116 etylcholine receptor is a large, allosteric, ligand-gated ion channel with the subunit composition al

117 ious association of purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7), with asthma exacerb

118 in macrophages via purinergic receptor P2X, ligand-gated ion channel, 7 (P2X(7)), may play a role in

119 d signaling through purinergic receptor P2X, ligand-gated ion channel, 7 (P2X7 receptor; encoded by P

120 The homologous prokaryotic pentameric ligand-gated ion channel, Gloebacter ligand-gated ion ch

121 f function of the ATP-gated P2X(2) receptor (ligand-gated ion channel, purinergic receptor 2) that is

122 receptor, three of the key features of this ligand-gated ion channel.

123 consequences of allosteric ion binding to a ligand-gated ion channel.

124 the gating mechanism in the same pentameric ligand-gated ion channel.

125 ed from presynaptic terminals activates both ligand-gated ion channels (ionotropic receptors) and a v

126 indicate that switches in ion selectivity of ligand-gated ion channels (LGICs) do not affect network

127 Presynaptic ligand-gated ion channels (LGICs) have long been propose

128 Ligand-gated ion channels (LGICs) mediate fast synaptic

129 Pentameric ligand-gated ion channels (LGICs) play an important role

130 e only member of the Cys-loop superfamily of ligand-gated ion channels (LGICs) that is available in h

131 able the systematic creation of a toolbox of ligand-gated ion channels (LGICs) with orthogonal pharma

132 dulation is a general phenomenon of Cys-loop ligand-gated ion channels (LGICs), and whether this modu

133 The presence of two additional ligand-gated ion channels (LGICs), gamma-aminobutyric ac

134 ray cocrystal structure within this class of ligand-gated ion channels (LGICs).

135 Pentameric ligand-gated ion channels (pLGICs) are neurotransmitter-

136 Pentameric ligand-gated ion channels (pLGICs) are targets of genera

137 ructure of full-length eukaryotic pentameric ligand-gated ion channels (pLGICs) is still lacking.

138 ion channels, the superfamily of pentameric ligand-gated ion channels (pLGICs) is unique in that its

139 Pentameric ligand-gated ion channels (pLGICs) mediate fast chemical

140 Pentameric ligand-gated ion channels (pLGICs) mediate fast chemoele

141 Pentameric ligand-gated ion channels (pLGICs) mediate numerous phys

142 Pentameric ligand-gated ion channels (pLGICs) mediate signal transm

143 Pentameric ligand-gated ion channels (pLGICs) play a central role i

144 Rapid opening and closing of pentameric ligand-gated ion channels (pLGICs) regulate information

145 Ketamine inhibits pentameric ligand-gated ion channels (pLGICs), including the bacter

146 Pentameric ligand-gated ion channels (pLGICs), such as nicotinic ac

147 y modulating agonist responses of pentameric ligand-gated ion channels (pLGICs).

148 ucture-based ligand discovery for pentameric ligand-gated ion channels (pLGICs).

149 and modulating membrane-embedded pentameric ligand-gated ion channels (pLGICs).

150 activity of anionic and cationic pentameric ligand-gated ion channels (pLGICs).

151 P2X receptors (P2XRs) are ligand-gated ion channels activated by extracellular ATP

152 NMDA receptors (NMDARs) are Ca(2+)-permeant, ligand-gated ion channels activated by the excitatory ne

153 The activity of many ligand-gated ion channels and cell surface receptors is

154 Glycine receptors are chloride-permeable, ligand-gated ion channels and contribute to the inhibiti

155 into the signalling mechanisms of pentameric ligand-gated ion channels and enhance current understand

156 understanding the mechanisms of operation of ligand-gated ion channels and fast chemical synapses.

157 nactive (R) and active (R*) conformations of ligand-gated ion channels and G protein-coupled receptor

158 (nAChR) belongs to the family of pentameric ligand-gated ion channels and is involved in fast synapt

159 (nAChRs) belong to the family of pentameric ligand-gated ion channels and mediate fast excitatory tr

160 are over-represented in membrane receptors, ligand-gated ion channels and nuclear receptor targets,

161 ave a fold similar to that of other Cys-loop ligand-gated ion channels and that amino acid 256 was un

162 ) is a member of the Cys-loop superfamily of ligand-gated ion channels and the major mediator of inhi

163 , which is vestigial in bacterial pentameric ligand-gated ion channels and was largely removed for cr

164 s: G protein-coupled receptors, voltage- and ligand-gated ion channels and, in a recent update, 49 nu

165 elical receptors are proposed to function as ligand-gated ion channels and/or to act metabotropically

166 Ligand-gated ion channels are activated by agonist bindi

167 Ligand-gated ion channels are allosteric membrane protei

168 Pentameric ligand-gated ion channels are an important family of mem

169 proaches, we show that eukaryotic pentameric ligand-gated ion channels are characterized by loose pac

170 sms by which agonists and other ligands bind ligand-gated ion channels are important determinants of

171 Allosteric modulators of ligand-gated ion channels are of particular interest as

172 Ligand-gated ion channels are prototypic oligomeric memb

173 Pentameric ligand-gated ion channels are targets of general anesthe

174 Allosteric modulators of pentameric ligand-gated ion channels are thought to act on elements

175 N-methyl-d-aspartate (NMDA) receptors are ligand-gated ion channels assembled from GluN1 and GluN2

176 the expression of gephyrin, an organizer of ligand-gated ion channels at inhibitory synapses in hipp

177 and modulate a large number of voltage- and ligand-gated ion channels at the plasma membrane.

178 alpha7 receptors are ligand-gated ion channels composed of five identical sub

179 The OR class insect odorant receptors are ligand-gated ion channels comprised of at least one comm

180 NMDA receptors are tetrameric ligand-gated ion channels comprised of GluN1, GluN2, and

181 Pentameric ligand-gated ion channels control synaptic neurotransmis

182 s), including the NMDA receptor subtype, are ligand-gated ion channels critical to fast signaling in

183 Of the ligand-gated ion channels examined, 20% showed patterned

184 Glycine receptors (GlyRs) are inhibitory ligand-gated ion channels expressed in nerves of the spi

185 Voltage- and ligand-gated ion channels form the molecular basis of ce

186 l excitability, indicating that exclusion of ligand-gated ion channels from the axon is not absolute.

187 Purinergic P2X receptors are a family of ligand-gated ion channels gated by extracellular adenosi

188 l, vanilloid) channels belong to a family of ligand-gated ion channels gated not only by the binding

189 To examine the function of ligand-gated ion channels in a defined membrane environm

190 modulator that activates GPCRs in mammals or ligand-gated ion channels in invertebrates.

191 The ligand-gated ion channels in the Cys-loop receptor super

192 hetics are known to modulate the activity of ligand-gated ion channels in the Cys-loop superfamily, t

193 the mRNA expression patterns of voltage- and ligand-gated ion channels in the DR using the Allen Mous

194 nAChRs are cholinergic receptors forming ligand-gated ion channels in the plasma membranes of cer

195 ng at the extracellular domain of pentameric ligand-gated ion channels initiates a relay of conformat

196 GABA(A) receptors are pentameric ligand-gated ion channels involved in fast inhibitory ne

197 AChR) belongs to a superfamily of pentameric ligand-gated ion channels involved in many physiologic a

198 this review article, an auxiliary subunit of ligand-gated ion channels is defined using four criteria

199 Pentameric ligand-gated ion channels mediate fast chemical transmis

200 cotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels mediating fast cholinergic syn

201 nker but also the M1-M2 linker of pentameric ligand-gated ion channels modulates function in vivo.

202 line receptors (nAChR) are cation-selective, ligand-gated ion channels of the cysteine (Cys)-loop gen

203 imilarity, it is not clear whether these two ligand-gated ion channels operate in a similar manner.

204 Pentameric ligand-gated ion channels or Cys-loop receptors are resp

205 Desensitization in pentameric ligand-gated ion channels plays an important role in reg

206 P2X7 receptors (P2X7Rs) are ligand-gated ion channels sensitive to extracellular ATP

207 Its targets include ligand-gated ion channels such as the GABA(A) receptor,

208 cotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that consist of pentameric com

209 NMDA-type glutamate receptors are ligand-gated ion channels that contribute to excitatory

210 AMPA receptors (AMPARs) are tetrameric ligand-gated ion channels that couple the energy of glut

211 NMDA receptors are ligand-gated ion channels that mediate excitatory neurot

212 NMDA receptors are ligand-gated ion channels that mediate excitatory neurot

213 Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate excitatory signal

214 Ionotropic glutamate receptors are ligand-gated ion channels that mediate excitatory synapt

215 Nicotinic acetylcholine receptors are ligand-gated ion channels that mediate fast chemical neu

216 Glutamate receptors are ligand-gated ion channels that mediate fast excitatory s

217 id type A (GABA(A)) receptors are pentameric ligand-gated ion channels that mediate fast inhibition i

218 Ionotropic glutamate receptors are ligand-gated ion channels that mediate much of the fast

219 oxazolepropionic acid receptors (AMPARs) are ligand-gated ion channels that mediate the majority of f

220 cotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that modulate key physiologica

221 Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that open their ion-conducting

222 MDA) receptors are obligate heterotetrameric ligand-gated ion channels that play critical roles in le

223 oxytryptamine type 3 (5-HT(3)) receptors are ligand-gated ion channels that play important roles in d

224 AMPA receptors are ligand-gated ion channels that show multiple conductance

225 NMDA receptors are ligand-gated ion channels that underlie transmission at

226 M3 to reduce the sensitivities of pentameric ligand-gated ion channels to their surrounding membrane

227 (P2XRs) are ATP-activated calcium-permeable ligand-gated ion channels traditionally viewed as sensor

228 Ligand-gated ion channels undergo conformational changes

229 Inhibitory glycine receptors are pentameric ligand-gated ion channels with a definitive and clinical

230 Ionotropic glutamate receptors (GluRs) are ligand-gated ion channels with a modular structure.

231 NMDA receptors are ligand-gated ion channels with a regulatory intracellula

232 aves the way for engineering light-sensitive ligand-gated ion channels with subtype specificity throu

233 ors, nuclear hormone receptors, voltage- and ligand-gated ion channels) and approximately 3180 bioact

234 members of the Cys-loop family of pentameric ligand-gated ion channels, 5-hydroxytryptamine type 3 re

235 lobular proteins, the opening and closing of ligand-gated ion channels, and ligand binding to hydroph

236 Bacteria have many voltage- and ligand-gated ion channels, and population-level measurem

237 PhTX-433 inhibits several excitatory ligand-gated ion channels, and to improve selectivity tw

238 l shares gating principles with conventional ligand-gated ion channels, but the allosteric network th

239 onnection including ligand-receptor binding, ligand-gated ion channels, chemotaxis, chromatin structu

240 of the effect of agonist and anesthetics on ligand-gated ion channels, developed in earlier work, is

241 cell-surface receptors, and specifically for ligand-gated ion channels, for well over a century.

242 Likewise, mutations in the inhibitory ligand-gated ion channels, GABAA receptors (GABAARs), ca

243 n and function of the prokaryotic pentameric ligand-gated ion channels, GLIC and ELIC, was examined b

244 e receptors, G-protein coupled receptors and ligand-gated ion channels, including the NMDA glutamate

245 rocesses and is considered the prototype for ligand-gated ion channels, motivating a structural deter

246 NMDA receptors (NMDARs), ligand-gated ion channels, play important roles in vario

247 They belong to the family of pentameric ligand-gated ion channels, sharing a highly conserved mo

248 numerous studies have focused on pentameric ligand-gated ion channels, the details of anesthetic bin

249 excitability via the activation of specific ligand-gated ion channels, the P2X3 and P2X2/3 receptors

250 ilies such as G-protein-coupled receptors or ligand-gated ion channels, the sigma1 receptor is an evo

251 Similar to other ligand-gated ion channels, their gating cycle begins wit

252 or interactions of this structural family on ligand-gated ion channels, we employed HEK cells transfe

253 Using the Cys-loop superfamily of ligand-gated ion channels, we show that functional studi

254 (PTX) is a noncompetitive antagonist of many ligand-gated ion channels, with a site of action believe

255 lent cation binding site in other pentameric ligand-gated ion channels.

256 ing selective G-protein-coupled receptors or ligand-gated ion channels.

257 regulation between excitatory and inhibitory ligand-gated ion channels.

258 GABAA) receptors, which are Cl(-)-permeable, ligand-gated ion channels.

259 tylcholine receptors (nAChRs) are pentameric ligand-gated ion channels.

260 xt of current models of anesthetic action on ligand-gated ion channels.

261 similar to synaptic activation of classical ligand-gated ion channels.

262 ng the agonism, coagonism, and modulation of ligand-gated ion channels.

263 ditis elegans glutamate-activated pentameric ligand-gated ion channels.

264 and with their potency in inhibiting certain ligand-gated ion channels.

265 neral pathway to photosensitizing pentameric ligand-gated ion channels.

266 ating candidate agonists and antagonists for ligand-gated ion channels.

267 a complete understanding of drug actions on ligand-gated ion channels.

268 rally and functionally from simple bacterial ligand-gated ion channels.

269 ritical for channel gating in all pentameric ligand-gated ion channels.

270 LIC and possibly other homologous pentameric ligand-gated ion channels.

271 ing of the ion-conducting pore in pentameric ligand-gated ion channels.

272 losteric mechanisms of eukaryotic pentameric ligand-gated ion channels.

273 cal for the normal function of cysteine-loop ligand-gated ion channels.

274 inic AChRs (nAChRs) represent a paradigm for ligand-gated ion channels.

275 lcholine receptor (AChR) is the prototype of ligand-gated ion channels.

276 ing on ion channels, most notably pentameric ligand-gated ion channels.

277 fast synaptic transmission by functioning as ligand-gated ion channels.

278 NMDA receptors are tetrameric ligand-gated ion channels.

279 RPV1 represents an excellent model system of ligand-gated ion channels.

280 nsporters can operate as anion-selective and ligand-gated ion channels.

281 t efficacy in heteromeric nAChRs and related ligand-gated ion channels.

282 ghts on ethanol allosteric interactions with ligand-gated ion channels; and (iii) a first step for de

283 Protein motions in the Cys-loop ligand-gated ion receptors that govern the gating mechan

284 have led to the identification of MPTL-1, a ligand-gated ion-channel subunit of the parasitic nemato

285 onal studies of a dual RCK-containing, multi-ligand gated K(+) channel from Geobacter sulfurreducens,

286 On the other hand, numerous ligand-gated K(+) channels lack such gate, suggesting th

287 , BK channels are homologous to voltage- and ligand-gated K(+) channels, having a voltage sensor and

288 In some eukaryotic and most bacterial ligand-gated K(+) channels, RCK domains regulate ion flu

289 Together, our data identify a unique ligand-gated mechanism to control receptor shedding by A

290 whereas activating an exogenously expressed ligand-gated Na(+) channel, which depolarizes horizontal

291 arly those reactive with ion channels of the ligand-gated nicotinic acetylcholine receptor superfamil

292 Cys-loop ligand-gated nicotinic ACh receptors (nAChRs) and G prot

293 classically been defined as heat-sensitive, ligand-gated, nonselective cation channels that integrat

294 (K(v)) and Ca(2+) channel (L-type) families, ligand-gated P2X receptors (P2X2 and P2X4), tandem P dom

295 r the activity of, the wild-type alpha7nAChR ligand-gated pentameric ion channel, the findings point

296 tic Slo channel families and the majority of ligand-gated prokaryotic K(+) channels and transporters.

297 ng of the transmembrane ion channel of these ligand-gated receptors is driven by conformational trans

298 Glutamate receptors are ligand-gated tetrameric ion channels that mediate synapt

299 ogen receptor alpha (ERalpha) and/or ERbeta, ligand-gated transcriptional regulators.

300 d comprise a structurally distinct family of ligand-gated trimeric ion channels.