ライフサイエンスコーパス: ligand-gated ion channel

1 receptor, three of the key features of this ligand-gated ion channel.

2 consequences of allosteric ion binding to a ligand-gated ion channel.

3 nal changes that take place in a functioning ligand-gated ion channel.

4 ores that occur upon desensitization of this ligand-gated ion channel.

5 the gating mechanism in the same pentameric ligand-gated ion channel.

6 the expression and behaviour of voltage and ligand gated ion channels.

7 desensitization gate in this novel class of ligand gated ion channels.

8 GABAA) receptors, which are Cl(-)-permeable, ligand-gated ion channels.

9 xt of current models of anesthetic action on ligand-gated ion channels.

10 similar to synaptic activation of classical ligand-gated ion channels.

11 ng the agonism, coagonism, and modulation of ligand-gated ion channels.

12 ditis elegans glutamate-activated pentameric ligand-gated ion channels.

13 and with their potency in inhibiting certain ligand-gated ion channels.

14 neral pathway to photosensitizing pentameric ligand-gated ion channels.

15 ating candidate agonists and antagonists for ligand-gated ion channels.

16 a complete understanding of drug actions on ligand-gated ion channels.

17 ritical for channel gating in all pentameric ligand-gated ion channels.

18 rally and functionally from simple bacterial ligand-gated ion channels.

19 LIC and possibly other homologous pentameric ligand-gated ion channels.

20 ing of the ion-conducting pore in pentameric ligand-gated ion channels.

21 losteric mechanisms of eukaryotic pentameric ligand-gated ion channels.

22 cal for the normal function of cysteine-loop ligand-gated ion channels.

23 fast synaptic transmission by functioning as ligand-gated ion channels.

24 inic AChRs (nAChRs) represent a paradigm for ligand-gated ion channels.

25 lcholine receptor (AChR) is the prototype of ligand-gated ion channels.

26 on relationships in GlyRs and possibly other ligand-gated ion channels.

27 r assembles from individual subunits to form ligand-gated ion channels.

28 tion, and has little to no efficacy at other ligand-gated ion channels.

29 s are members of the Cys-loop superfamily of ligand-gated ion channels.

30 properties of native and recombinant single ligand-gated ion channels.

31 NMDA receptors, when tested against various ligand-gated ion channels.

32 ssion and activity of dendritic voltage- and ligand-gated ion channels.

33 ing on ion channels, most notably pentameric ligand-gated ion channels.

34 h nicotinic receptors and related pentameric ligand-gated ion channels.

35 tors, serine proteases, protein kinases, and ligand-gated ion channels.

36 ion and modulation of the Cys loop family of ligand-gated ion channels.

37 ceptor is a member of the Cys-loop family of ligand-gated ion channels.

38 rconnected network in the Cys loop family of ligand-gated ion channels.

39 r in other members of the Cys-loop family of ligand-gated ion channels.

40 ffect the activity of both voltage-gated and ligand-gated ion channels.

41 cal for activation of the Cys-loop family of ligand-gated ion channels.

42 al agonists produce submaximal activation of ligand-gated ion channels.

43 intact, three-dimensional structure of these ligand-gated ion channels.

44 with sites on open than on closed states of ligand-gated ion channels.

45 critical for receptor gating in all Cys loop ligand-gated ion channels.

46 NMDA receptors are tetrameric ligand-gated ion channels.

47 RPV1 represents an excellent model system of ligand-gated ion channels.

48 nsporters can operate as anion-selective and ligand-gated ion channels.

49 t efficacy in heteromeric nAChRs and related ligand-gated ion channels.

50 lent cation binding site in other pentameric ligand-gated ion channels.

51 ing selective G-protein-coupled receptors or ligand-gated ion channels.

52 regulation between excitatory and inhibitory ligand-gated ion channels.

53 tylcholine receptors (nAChRs) are pentameric ligand-gated ion channels.

54 members of the Cys-loop family of pentameric ligand-gated ion channels, 5-hydroxytryptamine type 3 re

55 y stimulation of the purinergic receptor P2X ligand-gated ion channel 7 (P2X7) by millimolar concentr

56 ious association of purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7), with asthma exacerb

57 in macrophages via purinergic receptor P2X, ligand-gated ion channel, 7 (P2X(7)), may play a role in

58 d signaling through purinergic receptor P2X, ligand-gated ion channel, 7 (P2X7 receptor; encoded by P

59 In the Cys loop superfamily of ligand-gated ion channels, a global conformational chang

60 P2X receptors (P2XRs) are ligand-gated ion channels activated by extracellular ATP

61 NMDA receptors (NMDARs) are Ca(2+)-permeant, ligand-gated ion channels activated by the excitatory ne

62 ivity and GLP-1 release from GLUTag cells by ligand-gated ion channel activation, a mechanism that mi

63 in the mammalian brain contain two types of ligand-gated ion channels: AMPA receptors (AMPARs) and N

64 acting ionotropic Glu receptors (iGluRs) are ligand gated ion channels and are believed to be involve

65 taste neurons by expression of an exogenous ligand-gated ion channel and found that cellular activit

66 x-ray structure of a prokaryotic pentameric ligand-gated ion channel and offer insight into the stru

67 The activity of many ligand-gated ion channels and cell surface receptors is

68 Glycine receptors are chloride-permeable, ligand-gated ion channels and contribute to the inhibiti

69 into the signalling mechanisms of pentameric ligand-gated ion channels and enhance current understand

70 understanding the mechanisms of operation of ligand-gated ion channels and fast chemical synapses.

71 nactive (R) and active (R*) conformations of ligand-gated ion channels and G protein-coupled receptor

72 (nAChR) belongs to the family of pentameric ligand-gated ion channels and is involved in fast synapt

73 (nAChRs) belong to the family of pentameric ligand-gated ion channels and mediate fast excitatory tr

74 are over-represented in membrane receptors, ligand-gated ion channels and nuclear receptor targets,

75 ave a fold similar to that of other Cys-loop ligand-gated ion channels and that amino acid 256 was un

76 ) is a member of the Cys-loop superfamily of ligand-gated ion channels and the major mediator of inhi

77 , which is vestigial in bacterial pentameric ligand-gated ion channels and was largely removed for cr

78 s: G protein-coupled receptors, voltage- and ligand-gated ion channels and, in a recent update, 49 nu

79 elical receptors are proposed to function as ligand-gated ion channels and/or to act metabotropically

80 ors, nuclear hormone receptors, voltage- and ligand-gated ion channels) and approximately 3180 bioact

81 role of increasing synaptic strength via its ligand-gated ion channel, and a novel role through the s

82 (nAChRs) are in the superfamily of Cys-loop ligand-gated ion channels, and are pentameric assemblies

83 lobular proteins, the opening and closing of ligand-gated ion channels, and ligand binding to hydroph

84 nical conformational states occupied by most ligand-gated ion channels, and many cell-surface recepto

85 Bacteria have many voltage- and ligand-gated ion channels, and population-level measurem

86 PhTX-433 inhibits several excitatory ligand-gated ion channels, and to improve selectivity tw

87 ghts on ethanol allosteric interactions with ligand-gated ion channels; and (iii) a first step for de

88 Ligand-gated ion channels are activated by agonist bindi

89 Ligand-gated ion channels are allosteric membrane protei

90 Pentameric ligand-gated ion channels are an important family of mem

91 proaches, we show that eukaryotic pentameric ligand-gated ion channels are characterized by loose pac

92 sms by which agonists and other ligands bind ligand-gated ion channels are important determinants of

93 Allosteric modulators of ligand-gated ion channels are of particular interest as

94 Ligand-gated ion channels are prototypic oligomeric memb

95 Pentameric ligand-gated ion channels are targets of general anesthe

96 Allosteric modulators of pentameric ligand-gated ion channels are thought to act on elements

97 Ligand-gated ion channels are transmembrane proteins tha

98 ic glutamate receptors (iGluRs), a family of ligand-gated ion channels, are responsible for the major

99 Cys-loop ligand-gated ion channels assemble as pentameric protein

100 N-methyl-d-aspartate (NMDA) receptors are ligand-gated ion channels assembled from GluN1 and GluN2

101 the expression of gephyrin, an organizer of ligand-gated ion channels at inhibitory synapses in hipp

102 The accumulation of these ligand-gated ion channels at synaptic sites is a prerequ

103 and modulate a large number of voltage- and ligand-gated ion channels at the plasma membrane.

104 nesthetics modulate the function of cys-loop ligand-gated ion channels, binding to a putative site be

105 l shares gating principles with conventional ligand-gated ion channels, but the allosteric network th

106 onnection including ligand-receptor binding, ligand-gated ion channels, chemotaxis, chromatin structu

107 Much of our understanding of ligand-gated ion channels comes from heterologous expres

108 alpha7 receptors are ligand-gated ion channels composed of five identical sub

109 The OR class insect odorant receptors are ligand-gated ion channels comprised of at least one comm

110 NMDA receptors are tetrameric ligand-gated ion channels comprised of GluN1, GluN2, and

111 Pentameric ligand-gated ion channels control synaptic neurotransmis

112 s), including the NMDA receptor subtype, are ligand-gated ion channels critical to fast signaling in

113 Members of the cys-loop ligand-gated ion channel (cysLGIC) superfamily mediate c

114 of the effect of agonist and anesthetics on ligand-gated ion channels, developed in earlier work, is

115 rystal structure of the Erwinia chrysanthemi ligand-gated ion channel (ELIC) in complex with a deriva

116 rom prokaryote homologs-Erwinia chrysanthemi ligand-gated ion channel (ELIC), Gloeobacter violaceus l

117 nts of chlorpromazine binding in the Erwinia ligand-gated ion channel (ELIC).

118 Of the ligand-gated ion channels examined, 20% showed patterned

119 tions of voltage-gated ion channels and fast ligand-gated ion channels expressed at the surface membr

120 Glycine receptors (GlyRs) are inhibitory ligand-gated ion channels expressed in nerves of the spi

121 Functional studies of the ligand gated ion channel family (nicotinic acetylcholine

122 al closely related members of the pentameric ligand gated ion channel family.

123 As members of the Cys loop ligand-gated ion channel family, neuronal nAChRs are pen

124 eptor (5-HT(3)R) is a member of the Cys-loop ligand-gated ion channel family.

125 eptor (5-HT(3)R) is a member of the cys-loop ligand-gated ion channel family.

126 tracellular binding domain of the pentameric ligand-gated ion channel family.

127 They are the only ligand-gated ion channels for which multiple high-resolu

128 cell-surface receptors, and specifically for ligand-gated ion channels, for well over a century.

129 Voltage- and ligand-gated ion channels form the molecular basis of ce

130 Ligand-gated ion channels form transmembrane ionic pores

131 Nicotinic acetylcholine receptors are ligand-gated ion channels formed by five homologous subu

132 cotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels found throughout the central a

133 The ligand-gated ion channel from Erwinia chrysanthemi (ELIC

134 ELIC, the pentameric ligand-gated ion channel from Erwinia chrysanthemi, is a

135 ing ideas about how activation proceeds in a ligand-gated ion channel from the binding of the agonist

136 l excitability, indicating that exclusion of ligand-gated ion channels from the axon is not absolute.

137 Likewise, mutations in the inhibitory ligand-gated ion channels, GABAA receptors (GABAARs), ca

138 rain's major inhibitory neuroreceptor is the ligand-gated ion channel gamma-aminobutyric acid (GABA)

139 Purinergic P2X receptors are a family of ligand-gated ion channels gated by extracellular adenosi

140 l, vanilloid) channels belong to a family of ligand-gated ion channels gated not only by the binding

141 ein motions underlying Gloeobacter violaceus ligand-gated ion channel gating in a membrane environmen

142 inhibits the currents of the homopentameric ligand-gated ion channel GLIC, yet the crystal structure

143 prokaryotic homologs, Gloebacter and Erwinia ligand-gated ion channel (GLIC and ELIC, respectively),

144 membrane domain of the Gloeobacter violaceus ligand-gated ion channel (GLIC) channel, characterize th

145 Gloeobacter violaceus ligand-gated ion channel (GLIC) has served as a valuable

146 etic propofol bound to Gloeobacter violaceus ligand-gated ion channel (GLIC), a bacterial homolog of

147 Crystal structures of Gloeobacter violaceus ligand-gated ion channel (GLIC), a proton-gated prokaryo

148 e bacterial Gloeobacter violaceus pentameric ligand-gated ion channel (GLIC), a structural homolog of

149 /C) receptors, and the Gloeobacter violaceus ligand-gated ion channel (GLIC), are receptors that cont

150 tameric ligand-gated ion channel, Gloebacter ligand-gated ion channel (GLIC), represents an excellent

151 e bacterial Gloeobacter violaceus pentameric ligand-gated ion channel (GLIC), which is sensitive to a

152 ed ion channel (ELIC), Gloeobacter violaceus ligand-gated ion channel (GLIC)-and crystallized eukaryo

153 yotic proton-activated Gloeobacter violaceus ligand-gated ion channel (GLIC).

154 n and function of the prokaryotic pentameric ligand-gated ion channels, GLIC and ELIC, was examined b

155 The homologous prokaryotic pentameric ligand-gated ion channel, Gloebacter ligand-gated ion ch

156 e bacterial Gloeobacter violaceus pentameric ligand-gated ion channel homologue (GLIC).

157 Many clinically important drugs target ligand-gated ion channels; however, the mechanisms by wh

158 icroscopy Torpedo model; the only pentameric ligand-gated ion channel imaged in a native lipid membra

159 eptors (adrenoceptors) and P2X1-purinoceptor ligand gated ion channels in male mice, thereby blocking

160 ntext of the alpha4beta2 nAChR, a widespread ligand-gated ion channel in the brain and a target for n

161 To examine the function of ligand-gated ion channels in a defined membrane environm

162 modulator that activates GPCRs in mammals or ligand-gated ion channels in invertebrates.

163 The ligand-gated ion channels in the Cys-loop receptor super

164 hetics are known to modulate the activity of ligand-gated ion channels in the Cys-loop superfamily, t

165 the mRNA expression patterns of voltage- and ligand-gated ion channels in the DR using the Allen Mous

166 nAChRs are cholinergic receptors forming ligand-gated ion channels in the plasma membranes of cer

167 e receptors, G-protein coupled receptors and ligand-gated ion channels, including the NMDA glutamate

168 ng at the extracellular domain of pentameric ligand-gated ion channels initiates a relay of conformat

169 GABA(A) receptors are pentameric ligand-gated ion channels involved in fast inhibitory ne

170 AChR) belongs to a superfamily of pentameric ligand-gated ion channels involved in many physiologic a

171 Ligand-gated ion channels involved in the modulation of

172 ed from presynaptic terminals activates both ligand-gated ion channels (ionotropic receptors) and a v

173 this review article, an auxiliary subunit of ligand-gated ion channels is defined using four criteria

174 c modulators exert their distinct actions on ligand-gated ion channels is poorly understood.

175 a member of the nicotinicoid superfamily of ligand-gated ion channels, is an inhibitory Cl(-) channe

176 on-gated prokaryotic homologue of pentameric ligand-gated ion channel (LGIC) from G. violaceus, have

177 Regulation of ligand-gated ion channel (LGIC) function and trafficking

178 The members of the Cys-loop ligand-gated ion channel (LGIC) gene family play a major

179 eptor (5-HT(3)R) is a member of the cys-loop ligand-gated ion channel (LGIC) superfamily.

180 For Cys-loop ligand-gated ion channels (LGIC), the protein movements

181 brain involves rapid opening and closing of ligand gated ion channels (LGICs).

182 alter the conformational states of Cys-loop ligand-gated ion channels (LGICs) by binding within disc

183 indicate that switches in ion selectivity of ligand-gated ion channels (LGICs) do not affect network

184 Presynaptic ligand-gated ion channels (LGICs) have long been propose

185 Ligand-gated ion channels (LGICs) mediate fast synaptic

186 Pentameric ligand-gated ion channels (LGICs) play an important role

187 e only member of the Cys-loop superfamily of ligand-gated ion channels (LGICs) that is available in h

188 able the systematic creation of a toolbox of ligand-gated ion channels (LGICs) with orthogonal pharma

189 dulation is a general phenomenon of Cys-loop ligand-gated ion channels (LGICs), and whether this modu

190 The presence of two additional ligand-gated ion channels (LGICs), gamma-aminobutyric ac

191 ray cocrystal structure within this class of ligand-gated ion channels (LGICs).

192 can directly interact with certain types of ligand-gated ion channels (LGICs).

193 Pentameric ligand-gated ion channels mediate fast chemical transmis

194 The Cys loop family of ligand-gated ion channels mediate fast synaptic transmis

195 e receptor (alpha7nAChR) is a homopentameric ligand-gated ion channel mediating fast synaptic transmi

196 cotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels mediating fast cholinergic syn

197 nker but also the M1-M2 linker of pentameric ligand-gated ion channels modulates function in vivo.

198 rocesses and is considered the prototype for ligand-gated ion channels, motivating a structural deter

199 f the conformational changes of an important ligand-gated ion channel of the brain.

200 line receptors (nAChR) are cation-selective, ligand-gated ion channels of the cysteine (Cys)-loop gen

201 imilarity, it is not clear whether these two ligand-gated ion channels operate in a similar manner.

202 Pentameric ligand-gated ion channels or Cys-loop receptors are resp

203 drugs that provide allosteric modulation of ligand-gated ion channels or G-protein-coupled receptors

204 P2X receptors are a family of seven ligand-gated ion channels (P2X1-P2X7) that open in the p

205 NMDA receptors (NMDARs), ligand-gated ion channels, play important roles in vario

206 Desensitization in pentameric ligand-gated ion channels plays an important role in reg

207 tor (GABA(A)R) is a member of the pentameric ligand gated ion channel (pLGIC) family that mediates io

208 GLIC, a prokaryotic member of the pentameric ligand-gated ion channel (pLGIC) family, provides a uniq

209 The glycine receptor (GlyR) is a pentameric ligand-gated ion channel (pLGIC) mediating inhibitory tr

210 ion-selective ion channels of the pentameric ligand-gated ion channel (pLGIC) superfamily.

211 The 5-HT(3) receptor, a pentameric ligand-gated ion channel (pLGIC), is an important therap

212 Pentameric ligand gated ion channels (pLGICs) mediate signal transd

213 Pentameric ligand-gated ion channels (pLGICs) are neurotransmitter-

214 Pentameric ligand-gated ion channels (pLGICs) are targets of genera

215 ructure of full-length eukaryotic pentameric ligand-gated ion channels (pLGICs) is still lacking.

216 ion channels, the superfamily of pentameric ligand-gated ion channels (pLGICs) is unique in that its

217 Pentameric ligand-gated ion channels (pLGICs) mediate fast chemical

218 Pentameric ligand-gated ion channels (pLGICs) mediate fast chemoele

219 Pentameric ligand-gated ion channels (pLGICs) mediate numerous phys

220 Pentameric ligand-gated ion channels (pLGICs) mediate signal transm

221 Pentameric ligand-gated ion channels (pLGICs) play a central role i

222 Rapid opening and closing of pentameric ligand-gated ion channels (pLGICs) regulate information

223 Ketamine inhibits pentameric ligand-gated ion channels (pLGICs), including the bacter

224 Pentameric ligand-gated ion channels (pLGICs), such as nicotinic ac

225 ucture-based ligand discovery for pentameric ligand-gated ion channels (pLGICs).

226 and modulating membrane-embedded pentameric ligand-gated ion channels (pLGICs).

227 activity of anionic and cationic pentameric ligand-gated ion channels (pLGICs).

228 y modulating agonist responses of pentameric ligand-gated ion channels (pLGICs).

229 ic glutamate receptors (iGluRs), tetrameric, ligand-gated ion channel proteins comprised of three sub

230 f function of the ATP-gated P2X(2) receptor (ligand-gated ion channel, purinergic receptor 2) that is

231 tween members of the Cys loop superfamily of ligand-gated ion channel receptors and the acetylcholine

232 t be incorporated into functional pentameric ligand-gated ion channel receptors.

233 A) receptors (GABARs) are chloride-permeable ligand-gated ion channels responsible for fast inhibitor

234 P2X7 receptors (P2X7Rs) are ligand-gated ion channels sensitive to extracellular ATP

235 They belong to the family of pentameric ligand-gated ion channels, sharing a highly conserved mo

236 have led to the identification of MPTL-1, a ligand-gated ion-channel subunit of the parasitic nemato

237 sory G protein-coupled receptors (GPCRs), 71 ligand-gated ion channel subunits and 141 voltage-gated-

238 inding/channel coupling that is unique among ligand-gated ion channel subunits.

239 Its targets include ligand-gated ion channels such as the GABA(A) receptor,

240 subunits composing extracellularly activated ligand-gated ion channels, such as nicotinic, ATP, GABA

241 GlyRs are members of the pentameric ligand-gated ion channel superfamily (pLGIC) that mediat

242 anniversary of the discovery of the Cys loop ligand-gated ion channel superfamily of neurotransmitter

243 e 5-HT3 receptor is a member of the Cys-loop ligand-gated ion channel superfamily participating in sy

244 nAChR) is a member of the important Cys loop ligand-gated ion channel superfamily that modulates neur

245 Prokaryotic members of the Cys-loop receptor ligand-gated ion channel superfamily were recently ident

246 tors (GABAARs) are members of the pentameric ligand-gated ion channel superfamily.

247 tion to our knowledge of the entire Cys loop ligand-gated ion channel superfamily.

248 ransient Receptor Potential A 1 (TRPA1) is a ligand-gated ion channel that contributes to inflammator

249 ane conductance regulator (CFTR) is the only ligand-gated ion channel that hydrolyzes its agonist, AT

250 The NMDA-sensitive glutamate receptor is a ligand-gated ion channel that mediates excitatory synapt

251 otinic acetylcholine receptor is a prototype ligand-gated ion channel that mediates signal transducti

252 cotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that consist of pentameric com

253 NMDA-type glutamate receptors are ligand-gated ion channels that contribute to excitatory

254 AMPA receptors (AMPARs) are tetrameric ligand-gated ion channels that couple the energy of glut

255 NMDA receptors are ligand-gated ion channels that mediate excitatory neurot

256 NMDA receptors are ligand-gated ion channels that mediate excitatory neurot

257 Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate excitatory signal

258 Ionotropic glutamate receptors are ligand-gated ion channels that mediate excitatory synapt

259 Nicotinic acetylcholine receptors are ligand-gated ion channels that mediate fast chemical neu

260 Glutamate receptors are ligand-gated ion channels that mediate fast excitatory s

261 id type A (GABA(A)) receptors are pentameric ligand-gated ion channels that mediate fast inhibition i

262 receptor and related Cys-loop receptors are ligand-gated ion channels that mediate fast synaptic tra

263 Ionotropic glutamate receptors are ligand-gated ion channels that mediate much of the fast

264 oxazolepropionic acid receptors (AMPARs) are ligand-gated ion channels that mediate the majority of f

265 cotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that modulate key physiologica

266 Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that open their ion-conducting

267 MDA) receptors are obligate heterotetrameric ligand-gated ion channels that play critical roles in le

268 ine receptors (nAChRs) belong to a family of ligand-gated ion channels that play important roles in c

269 oxytryptamine type 3 (5-HT(3)) receptors are ligand-gated ion channels that play important roles in d

270 Mutations of several voltage-gated and ligand-gated ion channels that regulate neuronal excitab

271 AMPA receptors are ligand-gated ion channels that show multiple conductance

272 NMDA receptors are ligand-gated ion channels that underlie transmission at

273 numerous studies have focused on pentameric ligand-gated ion channels, the details of anesthetic bin

274 er in the human brain, activates a family of ligand-gated ion channels, the major subtypes of which a

275 excitability via the activation of specific ligand-gated ion channels, the P2X3 and P2X2/3 receptors

276 ilies such as G-protein-coupled receptors or ligand-gated ion channels, the sigma1 receptor is an evo

277 Similar to other ligand-gated ion channels, their gating cycle begins wit

278 M3 to reduce the sensitivities of pentameric ligand-gated ion channels to their surrounding membrane

279 (P2XRs) are ATP-activated calcium-permeable ligand-gated ion channels traditionally viewed as sensor

280 potential (TRP) ion channel superfamily, the ligand-gated ion channel TRPA1 has been implicated in no

281 ents show that G2A activation sensitizes the ligand-gated ion channel TRPV1 in sensory neurons via ac

282 the binding sites of general anesthetics on ligand-gated ion channels, two derivatives of the intrav

283 Ligand-gated ion channels undergo conformational changes

284 or interactions of this structural family on ligand-gated ion channels, we employed HEK cells transfe

285 nt changes in the ionic permeability of some ligand-gated ion channels, we now show for the first tim

286 Using the Cys-loop superfamily of ligand-gated ion channels, we show that functional studi

287 (nAChRs) are in the superfamily of Cys-loop ligand-gated ion channels, which are widely expressed in

288 Members of the Cys-loop superfamily of ligand-gated ion channels, which mediate fast synaptic t

289 This study provides an example of a ligand-gated ion channel whose deactivation is sensitive

290 acetylcholine receptors (nAChRs), pentameric ligand-gated ion channels widely expressed in the nervou

291 e alpha7 nicotinic cholinergic receptor is a ligand-gated ion channel with calcium permeability simil

292 the N-methyl-D-aspartate receptor (NMDAR), a ligand-gated ion channel with essential roles in brain d

293 etylcholine receptor is a large, allosteric, ligand-gated ion channel with the subunit composition al

294 Inhibitory glycine receptors are pentameric ligand-gated ion channels with a definitive and clinical

295 Ionotropic glutamate receptors (GluRs) are ligand-gated ion channels with a modular structure.

296 NMDA receptors are ligand-gated ion channels with a regulatory intracellula

297 aves the way for engineering light-sensitive ligand-gated ion channels with subtype specificity throu

298 (PTX) is a noncompetitive antagonist of many ligand-gated ion channels, with a site of action believe

299 tes, encodes a protein that is homologous to ligand-gated ion channels, with the highest degree of si

300 etylcholine receptor is a well characterized ligand-gated ion channel, yet a proper description of th