ライフサイエンスコーパス: ligand-specific

1 ephrine on the transport of (131)I-P-GUS was ligand specific.

2 The dose response of chimeric receptors was ligand specific.

3 es) or the desensitization rate constant was ligand-specific.

4 of the MAP kinase pathway is cell type- and ligand-specific.

5 combinations of TLR ligands is cytokine- and ligand-specific.

6 teins, but not the 46-kDa protein, exhibited ligand-specific 125I-syringolide binding activity.

7 Ligand-specific activation and cell-cell contact were re

8 Functional selectivity is the ligand-specific activation of certain signal transductio

9 eads to reproductive anomalies; differential ligand-specific activation of HOX genes may be a molecul

10 olymorphic residues in eSRK are required for ligand-specific activation of self-incompatibility in vi

11 Ligand-specific activation of TLR2 and TLR9 are dependen

12 Furthermore, we found ligand-specific active displacement of PR from the MMTV

13 eosinophils and CD4+ T cells are capable of ligand-specific adhesion that is mediated predominantly

14 The results indicate significant, ligand-specific allosteric coupling between thrombin exo

15 or that is composed of two chains: a unique, ligand-specific alpha chain and a beta common chain (bet

16 kin-9 receptor (IL-9R) complex consists of a ligand-specific alpha chain and IL-2R gamma chain.

17 Their receptors are composed of a ligand-specific alpha subunit and a shared common signal

18 ence of tumor phenotype may be attributed to ligand-specific alterations in Notch receptor responses

19 e to the active receptor conformation and 2) ligand-specific alterations in signaling, which probably

20 5d-PGJ2 regulated IL-8 gene expression via a ligand-specific and PPARgamma-dependent pathway.

21 ere, we have analyzed a complementary set of ligand-specific and tissue-specific mouse mutants to sho

22 Ucn 1, opening new avenues for the design of ligand-specific antagonists based on CRF-BP.

23 eno-associated viral vectors (AAVs) encoding ligand-specific antagonists into the tibialis anterior (

24 mologous synthetic oligopeptides function as ligand-specific antagonists of macromolecular traffickin

25 receptor alpha in cells, they functioned as ligand-specific antagonists, indicating that estradiol-a

26 In addition, by using a ligand-specific antibody, we have shown that the peptide

27 om a filamentous virus, M13, combined with a ligand-specific antibody.

28 We proposed a new ligand-specific approach devoted to the binding site pre

29 likely to permit both receptor-specific and ligand-specific assembly of a coactivator complex, and t

30 s and biochemical experiments to unravel the ligand-specific association of membrane proteins GPR124

31 odimers consisting of an alpha-subunit and a ligand-specific beta-subunit that confers their unique b

32 rmational change which allosterically alters ligand specific binding sites and changes ligand selecti

33 gand binding sites suggest that species- and ligand-specific binding may be determined by as few as t

34 nds for the same VEGF receptors can generate ligand-specific biological responses.

35 Interference with the Dll4 signal by ligand-specific blocking antibodies is sufficient to inh

36 Nevertheless, we observed ligand-specific changes in FRET.

37 ies of the enzyme-ligand complexes is due to ligand-specific changes in the spatial relationship betw

38 Ligand-specific co-receptor recruitment provides a mecha

39 These experiments identify Gpr124 as a ligand-specific coactivator of canonical Wnt signaling.

40 tern of gene expression via cooperation with ligand-specific cofactors such as MEK1-ERK1/2 or JNK1/2.

41 eveals that surface expression of WSX-1, the ligand-specific component of the IL-27R, is low on these

42 he first to show a possible mechanism of the ligand-specific conformation-dependent agonist activatio

43 Here we use NMR spectroscopy to investigate ligand-specific conformational changes around a central

44 n the transmembrane (TM) domain is occupied, ligand-specific conformational changes occur in the ECL2

45 ing modes for different ligands resulting in ligand-specific conformational dynamics of the binding s

46 eing used to characterize state-specific and ligand-specific conformational states.

47 binding and provides functional evidence for ligand-specific conformational states.

48 In summary, our study correlates ACKR3 ligand-specific conformational transitions with chemokin

49 pled receptors is believed to originate from ligand-specific conformations that activate only subsets

50 her, these data indicate that DORs may adopt ligand-specific conformations whose distinct recycling p

51 , G(i)-, and G(q)-proteins, 2) that there is ligand-specific coupling of the beta(2)AR to G-proteins,

52 f agonists for binding domain accounts for a ligand-specific desensitization pattern.

53 t not by low-efficacy agonists, suggesting a ligand-specific desensitization pattern.

54 omalies" that may simply arise from receptor/ligand-specific differences between half-lives in soluti

55 ific transmembrane conformational changes or ligand-specific differences in the kinetics of transmemb

56 NA ORN versus imidazoquinoline translates to ligand-specific differential phosphorylation and transcr

57 ressed in a variegated manner, which creates ligand-specific diversity within the NK cell pool.

58 of two major TLRs, TLR2 and TLR4, and their ligand-specific dynamic regulation in the model human in

59 IL-5 had no ligand-specific effect on mIL-5Ralpha or sIL-5Ralpha mRN

60 This inference is supported by observed ligand-specific effects of mutations in this region and

61 MADs are sufficient for inducing most of the ligand-specific effects, and are the primary targets of

62 two residues where mutations had significant ligand-specific effects.

63 e cannabinoid receptor 1 (CB1R), we identify ligand-specific endocytic dwell times, that is, the time

64 rs, cell-type-specific endocytic regulation, ligand-specific endocytic regulation, and endosomal regu

65 m diffusion-limited binding indicates that a ligand-specific energy barrier between the unbound and b

66 n to exist in a GTP-bound state and act as a ligand specific ERalpha co-activator of E2-induced trans

67 elucidate the molecular mechanism underlying ligand-specific estrogen regulation of HOXA10 expression

68 human HOXA10 gene that mediated differential ligand-specific estrogen-responsive transcriptional acti

69 interaction with a target promoter revealed ligand-specific exchange rates.

70 ption of alpha-synuclein and risk of PD in a ligand-specific fashion and constitutes a potential targ

71 T(reg) and T(H)17 cell differentiation in a ligand-specific fashion, constituting a unique target fo

72 ere deficient in adhesion and migration in a ligand-specific fashion, with impaired responses to lami

73 nist U-75302, but not by chemerin peptide, a ligand specific for another RvE1 receptor ChemR23.

74 epitope previously described for Lewis X, a ligand specific for DC-SIGN among the C-type lectin fami

75 Combinations of troglitazone and a ligand specific for either retinoid X receptor or retino

76 ytes was desensitized by MMK-1, an agonistic ligand specific for formyl peptide receptor-like-1 (FPRL

77 scarinic receptor (M3), we used carbachol, a ligand specific for muscarinic receptor, as the secretag

78 Here we show that a ligand specific for NOD1, a peptide derived from peptido

79 n, we generated transgenic mice expressing a ligand specific for the CD28 receptor, which normally sh

80 l)-3-isoquinoline-carboxamide (PK11195) is a ligand specific for the peripheral benzodiazepine recept

81 e in rate was produced only with serine (the ligand specific for the substrate receptor trTsr); no si

82 hange in rate was produced by aspartate (the ligand specific for the tethering receptor Tar).

83 A ligand specific for the WW domain of Pin1 was covalently

84 ligand for both VEGFR-1 and -2) or VEGF-B (a ligand specific for VEGFR-1) led to activation of Erk-1/

85 ty is insensitive to the presence of various ligands specific for 5-HT receptor subtypes.

86 Simultaneous treatment with ligands specific for both PPARgamma and RXR has a synerg

87 The selectivity of ligands specific for certain cells can be used to prefer

88 Radiolabeled ligands specific for cholinesterases have potential for

89 ein-conducting channels of the ER, formed by ligands specific for co- and posttranslational transport

90 (RXR), and PPARgamma-RXR can be activated by ligands specific for either receptor; the presence of bo

91 s) can activate transcription in response to ligands specific for either subunit of the dimer.

92 of RXR-PPARgamma heterodimers to respond to ligands specific for either subunit.

93 ntegrin signaling, we examined the effect of ligands specific for integrin alpha IIb beta 3 on the fu

94 Small-molecule ligands specific for prostate-specific membrane antigen

95 or-posterior axis, whereas in zebrafish only ligands specific for RAR caused embryonic malformations.

96 dine binding to rat brain membranes, whereas ligands specific for serotonin type 3 receptors (5-HT(3)

97 lygalacturonic acid were functionalized with ligands specific for targeting expressed EphA2 receptors

98 and deep active site gorge and indicate that ligands specific for the acylation site at the base of t

99 muli including costimulation of T cells with ligands specific for the T-cell receptor (TCR)-CD3 compl

100 consequences of activating these receptors, ligands specific for TLR2 or dectin-1 were microinjected

101 e received a single intravenous injection of ligands specific for TLR2, TLR3, TLR4, TLR5, TLR7, and T

102 fibroblasts (HIF) were exposed to bacterial ligands specific for Toll-like receptor (TLR)2/6 and 4,

103 work has shown that antigens adjuvanted with ligands specific for Toll-like receptor 4 (TLR4) and TLR

104 This ligand-specific force history effect resembled the effec

105 nthesis and provide preliminary evidence for ligand-specific gene activation by a nuclear receptor.

106 importance, these differences are linked to ligand-specific GHS-R1a conformations, as assessed by in

107 ucidate the dynamic features associated with ligand-specific GPCR conformations.

108 al consequences and a predicted mechanism of ligand-specific GPCR oligomerization.

109 transmembrane protein tyrosine kinase and a ligand-specific GPI-linked protein.

110 timulation is receptor-specific (ErbB-2) and ligand-specific (heregulin).

111 studies have permitted the determination of ligand-specific high-spin states which reveal similariti

112 The aspartate receptor is one of the ligand-specific, homodimeric chemoreceptors that detects

113 sed IL-27 receptor (IL-27R), composed of the ligand-specific IL-27Ralpha chain and gp130.

114 r cells, indicating the formation of KIR2DS2 ligand-specific immunological synapses.

115 oad mechanistic foundation for understanding ligand-specific induction of gene expression profiles.

116 Yet how it relays ligand-specific information across the cell membrane for

117 construct into rat embryo cells demonstrated ligand specific inhibition of AP-1 transactivation.

118 One peptide, C3dp1 (APQHLSSQYSRT) exhibited ligand-specific inhibition at midmicromolar IC(50).

119 To develop ligand-specific inhibitors that would also assist in ide

120 t Ser2.60, plays a crucial role in mediating ligand specific interactions for CP55,940, HU210, and AM

121 or-ligand "anchor points" interspersed among ligand-specific interactions that "tune" the relative IF

122 tant component of receptor mobility and that ligand-specific interactions with remodeling complexes c

123 This suggests that ligand-specific intracellular receptor transport is requ

124 teract with diffusing ligands and to adopt a ligand-specific lid conformation, thus, slowing down dis

125 steines, and the pattern was consistent with ligand-specific "lid" conformations of ECL2.

126 The transmission of ligand-specific local and long range conformational even

127 A) knockdown of STING and MAVS resulted in a ligand-specific loss of IRF3 responsiveness.

128 ometry using either NKG2D tetramers or NKG2D ligand-specific mAb, H60 was identified as the NKG2D lig

129 pecially when these agents are conjugated to ligand-specific mAbs or peptides, which make the dynamic

130 receptor activation of the JNK cascade in a ligand-specific manner explaining several behavioral phe

131 extracellular nucleotides in a receptor- and ligand-specific manner, but the structural bases of thei

132 icate that a prokaryote, P. aeruginosa, in a ligand-specific manner, mobilizes eukaryotic NEU1 to enh

133 a cells and inhibit tumor cell adhesion in a ligand-specific manner.

134 on and intracellular signaling pathways in a ligand-specific manner.

135 xpression was regulated by LRP1 ligands in a ligand-specific manner.

136 mmodation of a non-native metal complex in a ligand-specific manner.

137 nment of the high-spin ferriheme in a highly ligand-specific manner.

138 nment of the high-spin ferriheme in a highly ligand-specific manner.

139 nment of the high-spin ferriheme in a highly ligand-specific manner.

140 ct ligands varies in a voltage-dependent and ligand-specific manner.

141 nd differentiate into memory-like cells in a ligand-specific manner.

142 mbrane affects their binding affinities in a ligand-specific manner.

143 epithelium and olfactory bulb in an odorant ligand-specific manner.

144 nucleic acid-sensing TLRs in a receptor- and ligand-specific manner.

145 itin-dependent control of pAKT dynamics in a ligand-specific manner.

146 ulate diverse signaling pathways, often in a ligand-specific manner.

147 gh both G protein and arrestin pathways in a ligand-specific manner.

148 cells by the PRRs TLR3, MDA5, or RIG-I in a ligand-specific manner.

149 and BB affect expression of several miRs in ligand-specific manner; the most robust changes consisti

150 uman milk and helminth parasites may share a ligand-specific mechanism involved in the generation of

151 w chamber, and microkinetic studies reveal a ligand-specific modulation of L-selectin affinity by DRE

152 Ligand-specific molecular switches composed of RNA were

153 mbination of nonspecific surface effects and ligand-specific near-surface effects.

154 peptide ligands and is useful for analyzing ligand-specific negative selection of CD4 single positiv

155 ich NK cells use to create a diverse pool of ligand-specific NK cells.

156 erative signaling, is here shown to regulate ligand-specific Notch signaling.

157 Inhibition of DLL1/4 with ligand-specific Notch1 decoys increased sprouting of sin

158 A new ligand specific parameter alpha that allows for quantify

159 EFG, denoted W, were expressed by assigning ligand-specific parameters: W(X) to ligands X and W(N) t

160 stem could have been refined toward distinct ligand-specific pathways channeled through MAX2, the mos

161 Our findings support the concept of multiple ligand-specific receptor conformations and demonstrate t

162 This offers a model to specifically study ligand-specific receptor conformations leading to G prot

163 Promoter deletion analysis suggests that ligand-specific receptor transactivation and utilization

164 Smad2 and Smad3 by heteromeric complexes of ligand-specific receptors.

165 Ligand-specific recruitment of arrestins facilitates fun

166 Thus, ligand-specific regulation is defined by interchangeable

167 The mechanism of ligand-specific regulation of HOX gene expression by est

168 ceptor, and they support the hypothesis that ligand-specific regulation of opioid receptors occurs in

169 earlier described with 5-HT and DA, there is ligand-specific requirement for protein kinase C (PKC) i

170 dulated by different ligands, thus eliciting ligand-specific responses ("biased agonism").

171 nal studies, our structures suggest a unique ligand-specific role of residue H142 on the alpha4 subun

172 pressing human CXCR5 (CD8(hCXCR5)) exhibited ligand-specific signaling and chemotaxis in vitro Six in

173 of microRNA-dependent targets in response to ligand-specific signaling in ECs.

174 -evolution has given rise to highly adapted, ligand-specific signaling pathways that control gene exp

175 ion and trigger the immune responses through ligand-specific signaling pathways.

176 les into a non-immune cell and reconstituted ligand-specific signalling when these cells are conjugat

177 Thus, regulation of miRNA biogenesis by ligand-specific SMAD proteins is critical for control of

178 h forms heteromeric complexes with different ligand-specific SMADs after activation.

179 lationships within this novel class of VMAT2 ligands, specific stereochemical forms of MTD, lobelane,

180 utions between 1.65 and 1.80 A reveal unique ligand-specific structural changes in the binding site t

181 only modulates the proportions of responding ligand-specific T cells or also alters responses at the

182 architecture of the evolving inflammation is ligand-specific; TLR4 ligands cause transmural panarteri

183 electing drugs with affinity for a molecular ligand specific to the disease state.

184 exchange activity was inhibited by a peptide ligand specific to the SH3 domain of the Src family tyro

185 We examined the effects of ligands specific to alpha-helix F (alphaHF) of plasminog

186 PAI-1 mechanism, and could be stabilized by ligands specific to alphaHF, controls bifurcation betwee

187 values generated in the multiplex assay for ligands specific to each receptor were comparable to tho

188 e enhanced by administration of high-avidity ligands specific to receptors expressed on T cells.

189 top of the channel and coated with adhesive ligands specific to target cell receptors.

190 The method is suitable for finding ligands specific toward proteins of unknown function and

191 The CD28 ligand-specific transgenic mice will facilitate evaluati

192 We propose that either ligand-specific transmembrane conformational changes or

193 overall trends in naming conventions, though ligand-specific trends were prominent.

194 of Smad proteins by heteromeric complexes of ligand-specific type I and II receptors.

195 of SMAD proteins by heteromeric complexes of ligand-specific type I and type II receptors with serine

196 regulated Smads, by heteromeric complexes of ligand-specific type I and type II serine/threonine kina

197 These conformational changes imparted a ligand-specific volume to the binding pocket, from 490 A

198 on of canonical signaling in NIH3T3 cells is ligand-specific; Wnt11 could effectively repress canonic