ライフサイエンスコーパス: ligase

1 yme], E2 (Ub-conjugating enzyme), and E3 (Ub ligase).

2 a ligand for the von Hippel-Lindau (VHL) E3 ligase.

3 preventing WHSC1 degradation by CRL4Cdt2 E3 ligase.

4 DCAF1 in complex with the CRL4 E3 ubiquitin ligase.

5 nt for the assembly of the HIV-1 Vpr-CRL4 E3 ligase.

6 RING-in-between-RING (RBR) ubiquitin (Ub) E3 ligase.

7 ress-modifying function of this E3-ubiquitin ligase.

8 romoting Complex/Cyclosome (APC/C) ubiquitin ligase.

9 E ubiquitylation by the SCF(Fbw7) ubiquitin ligase.

10 and degradation by the APC/C(Cdh1) ubiquitin ligase.

11 dent manner by redirecting the CRL4-DCAF1 E3 ligase.

12 inding subunit of SCF(cyclin F) E3 ubiquitin ligase.

13 mbers of the C2-WWW-HECT domain E3 family of ligases.

14 recruitment of RNF8/RNF168 histone ubiquitin ligases.

15 strated to work together with Cullin RING E3 ligases.

16 ction within host cells as E3 ubiquitin (Ub) ligases.

17 senger RNA expressions of muscle-specific E3 ligases.

18 n 1, Hemo-oxidized iron regulatory protein 2 ligase 1 (HOIL-1), HOIL-1-interacting protein, and SHANK

19 the ATP-dependent RNA ligase family (T4 RNA ligase 1; Rnl1) and the NAD(+)-dependent DNA ligase fami

20 LISH utilizes the T4 RNA Ligase 2 to efficiently join adjacent chimeric RNA-DNA p

21 WD repeat 4-containing cullin-RING ubiquitin ligase 4 (CRL4WDR4).

22 with CC-220, a modulator of the cullin ring ligase 4-cereblon E3 ubiquitin ligase complex, reduces A

23 ociation with the Cullin-4-RING ubiquitin E3 ligase-4 (CRL4) complex, nucleosomes, and chromatin remo

24 n with and inhibition of acyl CoA-synthetase ligase (ACSL) activity.

25 ants unable to bind RPA or lacking ubiquitin ligase activity also fail to support RPA ubiquitylation

26 ecessarily leads to a trade-off between high ligase activity and fast receptor exchange.

27 Here, we report that TRAF6 E3 ligase activity contributes to but is not essential for

28 nd that Src attenuates the SCF(beta-TrCP) E3-ligase activity in blunting Taz proteasomal degradation.

29 tight control of neddylation and cullin-RING-ligase activity in vivo.

30 from mouse and human, we show that cullin E3-ligase activity is necessary for each step of the muscle

31 LOG2 ubiquitin ligase activity is necessary for GDU1-dependent toleranc

32 e absence of Rqc1; however, its E3 ubiquitin ligase activity is not required.

33 ding Act1, an adaptor protein with ubiquitin ligase activity that couples the IL-17 receptor to downs

34 ferent domains of BRCA1 and its E3 ubiquitin ligase activity to HDR and drug resistance.

35 s) containing a VHL ligand can hijack the E3 ligase activity to induce degradation of target proteins

36 f is shown to be necessary for its ubiquitin ligase activity towards the substrate and also the self-

37 previously reported role in supporting Dnl4 ligase activity, and has implications for repair pathway

38 le host proteins for degradation with its E3 ligase activity, and it disrupts repressor complexes via

39 hPINK1 activates Parkin E3 ligase activity, involving phosphorylation of ubiquitin

40 TRAF6, a TLR effector with ubiquitin (Ub) ligase activity, is overexpressed in MDS hematopoietic s

41 abilized Siah2 and enhanced its E3 ubiquitin-ligase activity, resulting in AR activation.

42 s regulators of ubiquitination by modulating ligase activity, substrate specification, and subcellula

43 vitro unexpectedly revealed robust SMURF2 E3 ligase activity, with biochemical properties previously

44 easome in a manner dependent on AvrPtoB's E3 ligase activity.

45 s to the E6-AP Cterminus (HECT) E3 ubiquitin ligase activity.

46 ine 65 of ubiquitin fully activate ubiquitin ligase activity; however, a structural rationale for the

47 The E3 ubiquitin ligase adaptor speckle-type POZ protein (SPOP) is freque

48 ubstrate-recognition domain of the ubiquitin ligase adaptor SPOP in endometrial and prostate cancers.

49 ation of the abundance and activity of these ligase-adaptor complexes is critical for main-tenance of

50 ent tissues is accompanied by a ubiquitin E3-ligase, AMFR, mediating loss of 11beta-hydroxysteroid de

51 trate-recruiting subunit of an SCF ubiquitin ligase and a major tumor-suppressor protein that is alte

52 B-lineage lymphoma (CBL) is an E3 ubiquitin ligase and a molecule of adaptor that we have shown is i

53 genetic alterations of FBW7, an E3 ubiquitin ligase and a tumor suppressor frequently mutated in CRCs

54 s activity was dependent on both its RING E3 ligase and ADP-ribosylation factor (ARF) GTPase activity

55 nction of Smurf1 requires both its ubiquitin-ligase and C2 phospholipid-binding domains, and involves

56 ation via tighter binding to the cereblon E3 ligase and provides an example of the effect of E3 ligas

57 es demonstrate that UBE3B is an E3 ubiquitin ligase and reveal that the enzyme is regulated by calmod

58 identified a novel E. chaffeensis ubiquitin ligase and revealed an important role for the ubiquitin

59 CH2 into ARMMs is facilitated by the ITCH E3 ligase and the metalloprotease ADAM10, both of which are

60 rategy which expliots the specificity of DNA ligase and the speed of isothermal amplification to simu

61 ubiquitylation of histone H2A by the RNF168 ligase and the subsequent recruitment of RIF1, which sup

62 hesized and processed by essential ubiquitin ligases and effectors that are mutated across neurodegen

63 ell-understood pathways, involving ubiquitin ligases and GTPase exchange factors/GTPase-activating pr

64 ar chaperones, the Pib1 E3 ubiquitin-protein ligase, and the deubiquitylating enzyme Ubp3.

65 of apoptosis protein (XIAP), an E3 ubiquitin ligase, and the E2 conjugating enzyme Bendless.

66 n ubiquitination by SIAH and Nedd4 ubiquitin ligases, and causing its accumulation and aggregation in

67 member of the cullin family of E3 ubiquitin ligases, and it localizes predominantly in the cytoplasm

68 Finally, the Siah2 E3 ubiquitin ligase antagonizes drebrin function, suggesting a model

69 E3 ligases are gaining importance as targets to small molec

70 s that are abundantly available, fast-acting ligases are rare.

71 ding Ube2S E2-conjugating enzyme and RNF8 E3 ligase, are responsible for the assembly of Lys11-linkag

72 activated STAT (PIAS) RING family of SUMO E3 ligases, as essential for mitotic chromosomal SUMOylatio

73 nalosome), are required to control ubiquitin ligase assembly, function, and ultimately substrate degr

74 e identify SIAH2, a RING finger E3 ubiquitin ligase associated with the cellular hypoxic response, to

75 e and apply empirical correction factors for ligase bias.

76 na The peptidase is activated by two RING E3 ligases, Big Brother (BB) and DA2, which are subsequentl

77 ing a target protein binder and an ubiquitin ligase binder connected by a linker.

78 and provides an example of the effect of E3 ligase binding affinity with relevance to other drug dis

79 highlights a two-metal mechanism, whereby: a ligase-bound "catalytic" Mg(2+)(H2O)5 coordination compl

80 An orthologous Ligase C (LigC) complex also co-exists in many bacterial

81 Here we show that the mammalian ubiquitin ligase C-terminal Hsp70-interacting protein (CHIP), if f

82 otein 20 (IFT20) interacts with E3 ubiquitin ligases c-Cbl and Cbl-b and is required for Cbl-mediated

83 WWE domain-containing 1 (HUWE1) E3 ubiquitin ligase cause neurodevelopmental disorder X-linked intell

84 (Arabidopsis thaliana) COP1/SPA E3 ubiquitin ligase causes the degradation of multiple regulators of

85 The ubiquitin ligases CBL and CBL-B are negative regulators of tyrosin

86 y approaches, we found that the E3 ubiquitin ligase CHIP is highly expressed throughout the collectin

87 Our findings suggest that various ubiquitin ligases collaborate to keep the Cse4 level in check, pro

88 Until now, a single E3 ligase complex (LUBAC), one specific deubiquitinase (OTU

89 otoreceptors, such as SPA1/COP1 E3 ubiquitin ligase complex and bHLH transcription factors PIFs, woul

90 itylated by the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex and is targeted to the proteasome for deg

91 tion between the RanBP2-RanGAP1-UBC9 SUMO E3 ligase complex and NUSAP1.

92 omics to identify the SCF(Slmb) ubiquitin E3 ligase complex as a novel SMN binding partner.

93 Of note, this ligase complex is not able to stimulate Artemis activity

94 Polycomb repressive complex 1 (PRC1), the E3 ligase complex responsible for histone H2A ubiquitinatio

95 Mms1 is part of the E3 ubiquitin ligase complex that is linked to replication fork progre

96 iated restriction by forming an E3-ubiquitin ligase complex to polyubiquitinate A3G and trigger its d

97 he Gene Ontology term 'cullin-RING ubiquitin ligase complex' in the TQ-r module.

98 h in mammals, interacts with an E3 ubiquitin ligase complex) is not essential for the inhibition of c

99 SPOP, a key subunit of the CUL3 ubiquitin E3 ligase complex, as a SETD2-interacting protein.

100 eens uncovered genes that encode a ubiquitin ligase complex, components of the PtdIns 3-kinase comple

101 ction point mutations in a component of this ligase complex, Fbxl3, delay CRY1/2 degradation, reduce

102 e cullin ring ligase 4-cereblon E3 ubiquitin ligase complex, reduces Aiolos and Ikaros protein levels

103 ate recognition component of an E3 ubiquitin ligase complex, targets DMRT1 for degradation and thereb

104 on the cell surface by recruiting the VCP/E3 ligase complex, thereby limiting excessive TGF-beta resp

105 proteosomal degradation by the ubiquitin E3 ligase complex.

106 h is part of a multiprotein UV-DDB ubiquitin ligase complex.

107 D9 bromodomain and the cereblon E3 ubiquitin ligase complex.

108 SCF (Skp1-Cullin-F-box) ubiquitin ligases comprise several dozen modular enzymes that have

109 gh inactivation of the cullin-RING ubiquitin ligase CRL4(COP1/DET1) that targets Etv5 for proteasomal

110 impact on G1 progression, and the ubiquitin ligases CRL4(Cdt2) and SCF(Skp2) couple to degrade p21 p

111 The cullin-RING E3 ligases (CRLs) regulate diverse cellular processes in al

112 The Cullin-RING E3 ubiquitin ligases (CRLs) regulate homeostasis of 20% of cellular

113 Ligase-dead UBE3A did not stimulate Wnt pathway activati

114 and Ubc13-Uev1a, in conjunction with the E3 ligase Diap2.

115 core complex of NHEJ factors that includes a ligase (DNA Ligase IV; L4) that relies on juxtaposition

116 The phage encodes its own primase, DNA ligase, DNA polymerase, and enzymes necessary to synthes

117 Deinococcus radiodurans RNA ligase (DraRnl) seals 3-OH/5-PO4 nicks in duplex nucleic

118 se NEIL1 polyubiquitylation, Mcl-1 ubiquitin ligase E3 (Mule) and tripartite motif 26 (TRIM26).

119 conjugating enzyme E2), PIAS (a SUMO-protein ligase E3), and Smt3 (the SUMO isoform in Drosophila) by

120 biquitin conjugating enzyme E2 and ubiquitin ligase E3.

121 SUMO E3 ligases enhance transfer of SUMO from the charged E2 enz

122 Knockdown of each of these E3 ligases enhances LT stability and promotes MCV genome re

123 random deletion mutants of an artificial RNA ligase enzyme representing 32% of all possible deletions

124 ubiquitinating (protease) or ubiquitinating (ligase) enzymes have appeared.

125 ediated suppression of Atg5, an E3 ubiquitin ligase essential for autophagosome elongation, in macrop

126 was found to interact with Atg5, an E3-like ligase essential for autophagy, and to inhibit the induc

127 Importantly, the caspase and the E3 ligase execute this function in a non-additive manner.

128 ligase 1; Rnl1) and the NAD(+)-dependent DNA ligase family (Escherichia coli LigA), captured as their

129 he founding members of the ATP-dependent RNA ligase family (T4 RNA ligase 1; Rnl1) and the NAD(+)-dep

130 The "FA core complex" contains the RING-E3 ligase FANCL and seven other essential proteins that are

131 iron-mediated degradation of IRP1 by the E3 ligase FBXL5 that also targets IRP2.

132 its binding and degradation by the ubiquitin ligase Fbxo45, resulting in loss of Par-4 proapoptotic f

133 eports suggest that SPOP acts as a ubiquitin ligase for ERG and propose that ERG stabilization is the

134 acts as the small ubiquitin-like modifier E3 ligase for FOXP2 sumoylation.

135 Here we show that Parkin is an E3 ubiquitin ligase for hypoxia-inducible factor 1alpha (HIF-1alpha).

136 actor 6 (TRAF6) is identified as a direct E3 ligase for PSD-95, which, together with the E2 complex U

137 -box, is a substrate of beta-TrCP1 and an E3 ligase for SKP2.

138 ins from cells identifies HUWE1 as a main E3 ligase for this chain type, and we show that mitofusin-2

139 ion DNA repair proteins to the CRL4-DCAF1 E3 ligase for ubiquitin-dependent proteasomal degradation.

140 Screening the putative E3 ligases for interaction with LYK5 identified PLANT U-BOX

141 The role of cullin E3-ubiquitin ligases for muscle homeostasis is best known during musc

142 pertoire leading to preferential assembly of ligases for which substrates are available and (ii) diff

143 ere, we have purified the major E3 ubiquitin ligases from human cells responsible for regulation of N

144 Selective disruption of Vpx- or Vpr-CRL4 E3 ligase function was achieved by zinc sequestration using

145 ated AhR but did not affect its E3 ubiquitin ligase function.

146 RING-in-between-RING (RBR) ubiquitin (Ub) E3 ligases function with Ub E2s through a RING/HECT hybrid

147 nt evidence that the DDB1-CUL4A ubiquitin E3 ligase functions as a novel metabolic regulator that pro

148 We show that SUMO E3 ligase GEI-17/PIAS is required for KLP-19 recruitment to

149 found that the Gid4 subunit of the ubiquitin ligase GID in the yeast Saccharomyces cerevisiae targete

150 we show that expression of the E3 ubiquitin ligase Grail is upregulated in CD8(+) T cells that have

151 previously demonstrated that the E6AP/UBE3A ligase harbors two functionally distinct E2 approximatel

152 Although ubiquitin ligases have been implicated in autism, their roles and

153 S ribosomal protein uS10 by the E3 ubiquitin ligase Hel2 (or RQT1) is required for RQC.

154 on of ribosomal proteins by the E3 ubiquitin ligase Hel2/RQT1.

155 e observed need for a general base in the E3 ligase HOIP, which synthesizes linear ubiquitin chains.

156 n is attached to apocarboxylases by a biotin ligase: holocarboxylase synthetase (HCS) in mammalian ce

157 tic protease caspase-8 and the IAP ubiquitin ligases, how and when necroptosis is triggered in physio

158 evisiae, both pathways require the ubiquitin ligase Hrd1, a multi-spanning membrane protein with a cy

159 through an interaction with the E3 ubiquitin ligase HRD1, as immunoprecipitation of Tomo-1 from neuro

160 The human ubiquitin ligase HUWE1 has key roles in tumorigenesis, yet it is u

161 We previously identified ubiquitin ligase Huwe1 in the testis and showed that it can ubiqui

162 Here, we demonstrate that four ubiquitin ligases (i.e., Ubr1, Slx5, Psh1, and Rcy1) work in paral

163 d DNA nicks, our evidence indicates that the ligase IIIalpha-XRCC1 complex binds to DNA nicks in nucl

164 at the ligation occurs within a complex that ligase IIIalpha-XRCC1 forms with the host nucleosome; an

165 forms with the host nucleosome; and that the ligase IIIalpha-XRCC1-nucleosome complex decays when lig

166 (TRAF2), a scaffold protein and E3 ubiquitin ligase important for inflammatory signaling.

167 , we show that Rnf12, an X-encoded ubiquitin ligase important for initiation of X-chromosome inactiva

168 romoting complex/cyclosome (APC/C) ubiquitin ligase in neurons [Cdh1 conditional knockout (cKO)], dis

169 The reexpression of E3 ligase-inactive TRAF6 mutants partially restored IL-1 si

170 equired for signaling in cells expressing E3 ligase-inactive TRAF6 mutants.

171 rophages from knockin mice expressing the E3 ligase-inactive TRAF6[L74H] mutant, but the late-phase p

172 oduct, FPC, also contain the NEDD4 ubiquitin ligase interacting protein, NDFIP2, which interacts with

173 ing prediction of the proteome-wide human E3 ligase interaction network.

174 heterodimerization with Dtx3L, a histone E3 ligase involved in DNA damage repair.

175 is (Arabidopsis thaliana) COP1/SPA ubiquitin ligase is a central repressor that suppresses light sign

176 Protein stability modulation by E3 ubiquitin ligases is an important layer of functional regulation,

177 oteolytic pathway (e.g. a specific ubiquitin ligase) is itself short-lived.

178 MDM2, an E3 ubiquitin ligase, is a potent inhibitor of the p53 tumor suppresso

179 , a coactivator of Nedd4-family E3 ubiquitin ligases, is required for Treg cell stability and functio

180 ate immunity, the itchy E3 ubiquitin protein ligase (ITCH)-A20 ubiquitin-editing complex inhibits rec

181 of NHEJ factors that includes a ligase (DNA Ligase IV; L4) that relies on juxtaposition of 3 hydroxy

182 ential substrate for the RING-type ubiquitin ligase Keep on Going (KEG).

183 the action of the multi-subunit E3 ubiquitin ligase known as the anaphase-promoting complex or cyclos

184 protein 39) to the CUL4-DCAF15 E3 ubiquitin ligase, leading to RBM39 polyubiquitination and proteaso

185 onjugate a target warhead to an E3 ubiquitin ligase ligand via a linker.

186 at are critical for ligation by the NHEJ DNA ligase, LigIV.

187 E DUMPER 1 (GDU1)) that requires a ubiquitin ligase (LOSS OF GDU 2 (LOG2).

188 Salmonella Typhimurium, we show that the E3 ligase LUBAC generates linear (M1-linked) polyubiquitin

189 ort an unexpected phenomenon by which the E3 ligase mahogunin ring finger-1 (MGRN1) translocates to t

190 hese findings suggest that ATP-dependent RNA ligase may act on a specific set of 3'-adenylated RNAs t

191 s shown that dysregulation of p53 and its E3 ligase MDM2 by the ubiquitin-proteasome system (UPS) pro

192 sults in the degradation of the oncogenic E3 ligase MDM2, and leads to re-activation of the tumour su

193 he ubiquitin protease Ubp2 and the ubiquitin ligases Mdm30 and Rsp5 that modulates mitochondrial fusi

194 ed TRIM21 as an IFNgamma-driven E3 ubiquitin ligase mediating the deposition of ubiquitin around path

195 Here, we identify SIAH1/2 (SIAH) as the E3 ligase mediating Wnt-induced Axin degradation.

196 at STUB1, a chaperone-dependent E3 ubiquitin ligase, modulates TFEB activity by preferentially target

197 E3 RING ubiquitin ligases to form MAGE-RING ligases (MRLs) and act as regulators of ubiquitination b

198 Methanothermobacter thermoautotrophicus RNA ligase (MthRnl) catalyzes formation of phosphodiester bo

199 ctivity, we demonstrated that a ubiquitin E3 ligase, murine double minute-2 (Mdm2), is required for G

200 amework for understanding how HECT ubiquitin ligases must be finely tuned to ensure normal cellular b

201 ctly regulates the 3'UTR of the E3 ubiquitin ligase Nedd4 Analysis of embryonic and adult fly heart r

202 tion of Kv1.3, catalyzed by the E3 ubiquitin-ligase Nedd4-2.

203 The ubiquitin ligase Nedd4-like (Nedd4L, or Nedd4-2) binds to and regu

204 er, we determined that the HECT E3 ubiquitin ligase, Nedd4L, interacts with TRP120 during infection a

205 Therefore, ubiquitin ligases need to be tightly controlled.

206 activity is imparted by a conserved novel E3 ligase (NEL) domain that is unique to Gram-negative path

207 ardust (Sdt) as a target of the E3 ubiquitin ligase Neuralized (Neur) in Drosophila melanogaster Neur

208 f Sdt isoforms are targeted by the ubiquitin ligase Neuralized, thus fine tuning the endocytosis and

209 ducin repeat containing E3 ubiquitin protein ligase nuclear accumulation, and iii) Fyn phosphorylatio

210 which is known to either act as E3 ubiquitin ligase or affect chromatin organization, inhibits the tr

211 , Vila et al. report that UBE2O, a ubiquitin ligase overexpressed in some human cancers, specifically

212 These genes encode the E3 ubiquitin ligase parkin and the protein kinase PTEN-induced kinase

213 titatively assess the activity of the RBR E3 ligase PARKIN in a simple experimental setup and in real

214 iously uncharacterized ER membrane ubiquitin ligase, participates in crosstalk between these critical

215 Mechanistically, the TRAF2 E3 ubiquitin ligase promotes K63-linked polyubiquitination of GbetaL,

216 We propose propionate-CoA ligase (PrpE) and acryloyl-CoA reductase (AcuI) as the k

217 f DNA-Pt that colocalized with the ubiquitin ligase RAD18 and the replication protein PCNA.

218 ribe here that the MAGE-F1-NSE1 E3 ubiquitin ligase regulates the CIA pathway through ubiquitination

219 ction of the C2-WWW-HECT domain E3 family of ligases regulating these processes.

220 NEDD8-dependent processes such as cullin E3 ligase regulation.

221 that the assembly of the Vpx- or Vpr-CRL4 E3 ligase requires a highly conserved zinc-binding motif.

222 under stress due to downregulation of the E3 ligase RNF144A.

223 ribe a mouse strain lacking the E3 ubiquitin ligase RNF146 that shows phenotypic similarities to CCD.

224 resses the transcription of the E3 ubiquitin ligase RNF146 through an NF-kappaB-related inhibitory el

225 have identified the RING finger E3 ubiquitin ligase RNF157 as a target at the intersection of PI3K an

226 ascade of events controlled by the ubiquitin ligase RNF168, which promotes the accumulation of repair

227 53BP1 relocation is terminated by ubiquitin ligases RNF169 and RAD18 via unknown mechanisms.

228 a recruitment of the SUMO-targeted ubiquitin ligase, RNF4.

229 ate S/G2 phase, the DNA damage-responsive E3 ligase RNF8 conjugates K63-linked ubiquitin chains to ta

230 e show that MIWI binds the histone ubiquitin ligase RNF8 in a Piwi-interacting RNA (piRNA)-independen

231 onal knockout of the autism-linked ubiquitin ligase RNF8 or associated ubiquitin-conjugating enzyme U

232 By counteracting the E3 ubiquitin ligase Rsp5, Ubp2 and Ubp15 prevent hyperubiquitination

233 hodegron that is recognized by the ubiquitin ligase SCF(Cdc4).

234 hrome itself) and four families of ubiquitin ligases (SCF(EBF1/2), CUL3(LRB), CUL3(BOP), and CUL4(COP

235 ntagonized by IpaH9.8, a bacterial ubiquitin ligase secreted into the host cytosol.

236 oly-ubiquitination, but not the E3 ubiquitin ligase Siah1.

237 n Cdc13 localization at DSBs and on the SUMO ligase Siz1, which is required for de novo telomere addi

238 Here, we identify the E3 ubiquitin ligase Smurf2 as a physiologic regulator of Topo IIalpha

239 tion, which is not shared by the HECT domain ligase Smurf2, leads to the unanticipated depletion of E

240 The activity of the E3 ligase, SMURF2, is antagonized by an intramolecular, aut

241 Here we show that Bre1, an ubiquitin ligase specific for histone H2B, is recruited to chromat

242 or ubiquitination by SUMO targeted ubiquitin ligases (STUbLs).

243 ical stress-sensor cysteine (C151) of the E3 ligase substrate adaptor protein Kelch-like ECH-associat

244 d highlight the functional repurposing of E3 ligase substrate receptors independent of the ubiquitin

245 ly, member A (RhoA), a KCTD13/CUL3 ubiquitin ligase substrate, and is reversed by RhoA inhibition, su

246 functional regulation, but screening for E3 ligase-substrate interactions is time-consuming and cost

247 Here, we show that the E3 ubiquitin ligase subunit Not4/Mot2 of the evolutionarily conserved

248 from binding to Fbx4, an Skp1-Cul1-F box E3 ligase subunit, thereby alleviating proteasomal degradat

249 t functions specifically with Cullin-RING E3 ligases, such as SCF (Skp1-Cullin-F-box).

250 ad to uninfected cells.IMPORTANCE The Cbl E3 ligase suppresses surface signaling responses by inducin

251 closome (APC/C), a multisubunit E3 ubiquitin ligase targeting cell-cycle factors for destruction.

252 diated viral latency through cellular SCF E3 ligase targeting of viral replication proteins is a uniq

253 new modality of chemical intervention on E3 ligases.Targeting the ubiquitin proteasome system to mod

254 TRIM25 is an E3 ubiquitin ligase that activates RIG-I to promote the antiviral int

255 lls with mutations in RFWD3, an E3 ubiquitin ligase that interacts with and ubiquitylates replication

256 The PARK2 gene encodes an ubiquitin E3 ligase that is involved in mitochondrial homeostasis and

257 LUBAC, is the only known mammalian ubiquitin ligase that makes methionine 1 (Met1)-linked polyubiquit

258 s, and identify a putative HECT E3 ubiquitin ligase that may explain the variance.

259 lar hypoxic response, to be the ubiquitin E3 ligase that mediates the degradation of Plk3.

260 another p53 target gene, encodes a ubiquitin ligase that negatively regulates p53 levels by ubiquitin

261 re we identify KIB1 as an F-box E3 ubiquitin ligase that promotes the degradation of BIN2 while block

262 mediated largely by RNF212 and HEI10, two E3 ligases that are also essential for crossover recombinat

263 ullin 1/F-box protein) class of E3 ubiquitin ligases that are important for eukaryotic protein degrad

264 distributed Rnl5 family of nick-sealing RNA ligases, the physiological functions of which are unchar

265 rmation of micronuclei by targeting cellular ligases through a sT domain that also inhibits MCV large

266 re bifunctional molecules that recruit an E3 ligase to a target protein to facilitate ubiquitination

267 By recruiting an ubiquitin ligase to a target protein, PROTACs promote ubiquitinati

268 n can disrupt the binding of an E3 ubiquitin ligase to an E2-conjugating enzyme, leading to prolonged

269 d during apoptosis that inhibits a ubiquitin ligase to overcome therapy resistance in tumors.

270 omo-PROTACs as an approach to dimerize an E3 ligase to trigger its suicide-type chemical knockdown in

271 e that MAGEs assemble with E3 RING ubiquitin ligases to form MAGE-RING ligases (MRLs) and act as regu

272 DNA polymerase, an RNA polymerase and a DNA ligase, to use Fe2+ in place of Mg2+ as a cofactor durin

273 the mRNA export protein Yra1 and the HECT E3 ligase Tom1.

274 version of the RQC complex, the E3 ubiquitin ligase Tom1.

275 protein cereblon, directing the CRL4-CRBN E3 ligase toward the transcription factors Ikaros and Aiolo

276 Here, we report that the host E3-ubiquitin ligase TRIM6 promotes VP35 ubiquitination and is importa

277 graded after ubiquitination by the ubiquitin ligase tripartite motif-containing protein 32 (Trim32).

278 Fungal tRNA ligase (Trl1) is an essential enzyme that repairs RNA br

279 x, regulates the activity of the cullin-RING-ligase type of ubiquitination E3s by promoting neddylati

280 Loss of the E3 ubiquitin-protein ligase UBE3A causes Angelman syndrome.

281 overexpression of the ubiquitin-protein E3A ligase (UBE3A) gene is thought to be the predominant mol

282 The HECT E3 ligases ubiquitinate numerous transcription factors and

283 of the functional interplay between host E3 ligases, ubiquitination, and regulation of EBOV VP40-med

284 show that CED-3 caspase and the E3 ubiquitin ligase UBR-1 form a complex that couples their in vivo a

285 h promoting the activity of the E3 ubiquitin ligase UBR2 towards L1-ORF1p.

286 ed by cyclin D-CDK4 and the cullin 3-SPOP E3 ligase via proteasome-mediated degradation.

287 rotein inhibitor of activated STAT (PIAS) E3-ligases were initially described as transcriptional core

288 e cullins, scaffold subunits of E3 ubiquitin ligases, where neddylation as well as deneddylation, fac

289 mplex (LUBAC) is the only known E3 ubiquitin ligase which catalyses the generation of linear ubiquiti

290 ulated by CHIP through its function as an E3 ligase, which mediates the degradation of PKM2 during tu

291 Vpx and Vpr to recruit host CRL4 (DCAF1) E3 ligase, which represents a target for novel anti-human i

292 and Skp2 Skp-F-box-cullin (SCF) E3 ubiquitin ligases, which degrade and suppress steady-state LT prot

293 F (Skp1/Cullin-1/F-box protein) E3 ubiquitin ligases, which modify protein substrates with polyubiqui

294 on of Nrdp1, a RING finger type E3 ubiquitin ligase whose suppression in GBM also correlates with poo

295 Together, these data identify VHL as an E3 ligase with important cellular functions under both norm

296 Here, we demonstrated that CUL4B forms an E3 ligase with RBX1 (RING-box 1), DDB1 (DNA damage binding

297 dosages of UBE3A, which encodes a ubiquitin ligase with transcriptional co-regulatory functions.

298 We identified the HECT family E3 ubiquitin ligase WWP1 and all four of its WW domains as strong int

299 clease (the Artemis.DNA-PKcs complex), and a ligase (XLF.XRCC4.Lig4 complex).

300 e show in mammalian cells that the ubiquitin ligase ZNF598 is required for ribosomes to terminally st