ライフサイエンスコーパス: limb

1 one on straining the muscles of the affected limb.

2 ntrol of muscle contraction in his paralyzed limb.

3 roll-over anticline with a bend on only one limb.

4 in muscle of the contralateral non-massaged limb.

5 n the performance of the opposite, untrained limb.

6 ber of regulatory T cells in the ipsilateral limb.

7 th the organization of muscle targets in the limb.

8 omotion can be adapted independently to each limb.

9 aken the neural representation of the absent limb.

10 activity is modulated independently in each limb.

11 ependency in vestibular control of the upper limb.

12 teral limb or midstance of the contralateral limb.

13 create a sense of ownership of an artificial limb.

14 t postnatal day 8 to cause paralysis to that limb.

15 e sensations were restricted to the affected limb.

16 role in salt handling by the thick ascending limb.

17 induced collateral vessel growth in rat hind limbs.

18 tion, and homeostatic regeneration of intact limbs.

19 gone previous revascularization of the lower limbs.

20 that generate 3D shapes, such as flowers or limbs.

21 embryonic development, mainly of the CNS and limbs.

22 r truncate (RARbeta antagonist) regenerating limbs.

23 ionary changes in the size and proportion of limbs.

24 oice regulation within developing vertebrate limbs.

25 new prostheses that move and feel like real limbs.

26 luntary control of a patients' own paralyzed limbs.

27 te to severely dampened in 54 of 119 (45.4%) limbs.

28 ly recording muscle activity of the affected limbs.

29 minimum length of 10 cm in 1 of their lower limbs.

30 eleton (spine and iliac crests) and proximal limbs.

31 ma were more likely to have melanomas on the limbs (57% vs 42%, P < .001), and those with a personal

32 ify how sensorimotor adaptation of the upper limb, a cerebellar-dependent process restoring movement

33 th a compensatory response to maintain upper-limb accuracy in the face of body movement.

34 Human limb allografts appeared viable after 24 hours of near-n

35 TATEMENT Strength or skill training with one limb also brings about improvements in the performance o

36 sm of injury, prehospital shock, severity of limb amputation, head injury, and torso hemorrhage.

37 worldwide and is associated with significant limb and cardiovascular morbidity and mortality.

38 eral chloride channel in the thick ascending limb and in the aldosterone-sensitive distal nephron.

39 Shh signaling-dependent tissues such as the limb and neural tube.

40 The mass had vertebral organization, limb and pelvic bones.

41 nd topographical organization of the missing limb and several control body regions in M1 and S1 at ul

42 b was 83.6% of that observed for the trained limb and significantly greater than that of a control gr

43 touch and nociception were delivered to the limb and the electroneurogram signals were recorded simu

44 ins are subdermal veins located in the lower limbs and are mainly associated with aesthetic complaint

45 sensorimotor circuits activated by twitching limbs, and the developmental context in which activation

46 ry localized development of the bent-on-both-limbs anticline is controlled by the geometry of the und

47 ndrome report that movements of the affected limb are slow, more effortful, and lack automaticity.

48 Because salamander limbs are anatomically similar to human limbs, knowing h

49 Our comparisons reveal that regenerated limbs are high fidelity replicas of the originals even a

50 LT uptake in the axial skeleton and proximal limbs assessed by SUVmax correlated with the grade of fi

51 ies female movement, and the ability to move limbs asymmetrically (i.e. independently of the other) m

52 frequency cell lineages to the regenerating limb at once.

53 n immunoprecipitation against Lmx1b in mouse limbs at embryonic day 12.5 followed by next-generation

54 e predictions of enhancers in the developing limb, available through a user-friendly online interface

55 e multisensory perception that an artificial limb belongs to one's own body.

56 peripheral mechanosensation has evolved with limb biomechanics, evolutionarily tuning the neuromechan

57 fluorescent protein (n=5), improved ischemic limb blood flow and limb muscle histology and restored m

58 e uptake in the tumor and muscle and on hind limb blood flow.

59 cubation temperature influences motility and limb bone growth in West African Dwarf crocodiles, produ

60 e hammerstones and anvils processed mastodon limb bones for marrow extraction and/or raw material for

61 Their slender distal limb bones resemble those of Asiatic asses, such as the

62 f concussion and control diagnoses of broken limb bones were identified using the Patient Register fr

63 Complex traits like limbs, brains, or eyes form through coordinated integrat

64 hylome in RA FLS, we recently identified the limb bud and heart development (LBH) gene as a key dysre

65 raction profiles between proximal and distal limb bud cells isolated from mutant stocks where various

66 tive enhancer responsible for patterning the limb bud during development.

67 rough disruption of Tsc2 in craniofacial and limb bud mesenchymal progenitors.

68 Sonic hedgehog (Shh) expression in the limb bud organizing centre called the zone of polarizing

69 odermal ridge (AER) at the distal tip of the limb bud to direct outgrowth along the proximal to dista

70 In the early limb bud, for instance, Sonic hedgehog (Shh) is expresse

71 s widespread cell death within the embryonic limb bud.

72 ion, of tetrads and rosettes in Fgfr2 mutant limb-bud ectoderm.

73 more natural fine motor control of paralyzed limbs by BCI-FES neuroprosthetics.

74 anders are capable of regenerating amputated limbs by generating a mass of lineage-restricted cells c

75 Alx4, all of which are upregulated in Hand2 limb conditional knockouts.

76 cise with or without botulinum toxin-induced limb constraint.

77 lti-limb representation that participates in limb coordination.

78 Here, we examine in mouse and in a mouse limb-derived cell line the dynamic events that activate

79 During limb development, the telomeric TAD controls the early t

80 d to CRMs that are known to be active during limb development.

81 ations that may participate in regulation of limb development.

82 autopod (i.e. wrist/digits) segments during limb development.

83 repeating patterns, such as hair follicles, limb digits, and intestinal villi, during development.

84 odomain transcription factor responsible for limb dorsalization.

85 id (RA), which results in proximodistal (PD) limb duplications.

86 nts is to maintain the accuracy of the upper limb during unpredictable body movement, but only when r

87 The short-limbed dwarfism metaphyseal chondrodysplasia type Schmid

88 s born without hands (individuals with upper limb dysplasia), who use tools with their feet.

89 nalysed how the dimensions of the major hind limb elements in subfossil and modern species scaled wit

90 MATERIAL/We included 155 patients with limb endoprostheses, aged 7-26 years.

91 Here we present the Limb-Enhancer Genie (LEG), a collection of highly accura

92 n this unified TAD, both proximal and distal limb enhancers nevertheless continued to work independen

93 We predict limb enhancers using a combination of >50 published limb

94 enerative and can spontaneously replace lost limbs even as adults.

95 with asprin alone, but reduced major adverse limb events and increased major bleeding.

96 tional outcome of interest was major adverse limb events defined as acute limb ischemia, major amputa

97 Evolocumab reduced the risk of major adverse limb events in all patients (HR, 0.58; 95% CI, 0.38-0.88

98 % CI 0.57-0.90, p=0.0047), and major adverse limb events including major amputation (32 [1%] vs 60 [2

99 .69-1.08, p=0.19), but reduced major adverse limb events including major amputation (40 [2%] vs 60 [2

100 rel for reduction of cardiovascular or acute limb events.

101 s with associated adverse cardiovascular and limb events.

102 Surprisingly, the contralateral non-massaged limb exhibited a comparable 17% higher muscle fibre size

103 rmore, they demonstrate that upper and lower-limb forces are co-ordinated to produce an appropriate w

104 ways were widespread, involving the anterior limb, genu and posterior limb with the M3 projection loc

105 nerate a wide range of pathologies from mild limb girdle muscular dystrophy 2I (LGMD2I), severe conge

106 patients with sarcoglycanopathies, which are limb-girdle muscular dystrophies (LGMD2C-2F) caused by m

107 s in POMT2 have also been linked to a milder limb-girdle muscular dystrophy (LGMD) phenotype, named L

108 ges in prenatal movement influence embryonic limb growth to alter proportions.

109 At 6 and 12 wk postsurgery, the hind limb had significantly less bone mineral density than co

110 The biomechanics of animal limbs has evolved to meet the functional demands for mov

111 mb phenotypes, no direct gene targets in the limb have been confirmed.

112 alysis demonstrated differences in QRS axis, limb (I, aVr), and precordial (V1, V2, V6) ECG leads.

113 to examine the ability to voluntarily reduce limb impedance during force regulation, and the neural m

114 splacements, a behavior characterized by low limb impedance.

115 ided via TMSR affected the maps of the upper limb in primary motor (M1) and primary somatosensory (S1

116 We found that M1 maps of the amputated limb in TMSR patients were similar in terms of extent, s

117 e tissue perfusion causing ischemia to lower limbs in patients with peripheral arterial disease (PAD)

118 Critical steps in forming the vertebrate limb include the positioning of digits and the positioni

119 multifaceted roles of RARs in the salamander limb including regulation of skeletal patterning during

120 ell-developed motor control, so long as this limb independence does not verge into uncontrolled patho

121 RARbeta antagonism in uninjured limbs induced a loss of skeletal integrity leading to lo

122 At day 5, hind limbs injected with ECFC + MPC showed greater blood flow

123 ic device that acts and feels like one's own limb is a major goal in applied neuroscience.

124 suggest that the emergence of digits in the limb is matched by distinct mechanisms for specifying mo

125 e assessed at rest, during 30 min of induced limb ischaemia and during 20 min of recovery after ischa

126 KEY POINTS: Chronic limb ischaemia, characterized by inflammatory mediator r

127 hospitalized for the management of critical limb ischemia (CLI), but limited data are available on t

128 MSC) are promising therapeutics for critical limb ischemia (CLI).

129 jected stem cells in PIRI including critical limb ischemia (CLI).

130 R 1.29, 95% CI 1.08-1.55, P=0.005) and acute limb ischemia (HR 4.23, 95% CI 2.86-6.25, P<0.001) when

131 access despite several risk factors of upper limb ischemia - diabetes, end-stage renal failure, hyper

132 ty-five limbs (of 89 patients) with critical limb ischemia and ankle brachial index >/=1.4 who underw

133 ted in patients with myocardial and critical limb ischemia and in animal models.

134 One of them is upper limb ischemia caused by radial artery thrombosis.

135 ng ankle brachial index testing for critical limb ischemia have noncompressible vessels because of ti

136 In each group, acute limb ischemia occurred in 1.7% of the patients (hazard r

137 s major adverse limb events defined as acute limb ischemia, major amputation, or urgent peripheral re

138 m/y), aneurysm formation (>/=6 cm), organ or limb ischemia, or new uncontrollable hypertension or pai

139 For patients with critical limb ischemia, the goals of revascularization are to rel

140 her rates of myocardial infarction and acute limb ischemia, with similar composite rates of cardiovas

141 llowing the surgical induction of mouse hind-limb ischemia.

142 eovascularization in an animal model of hind limb ischemia.

143 the natural history of intractable critical limb ischemia.

144 segregates with tissue protection from hind-limb ischemia.

145 actable peripheral arterial disease/critical limb ischemia.

146 rathyroidism, or even symptoms of left upper limb ischemia.

147 t81 or Ile81, and subjected the mice to hind-limb ischemia.

148 ditioning (RIPC) by repeated brief cycles of limb ischemia/reperfusion may reduce myocardial ischemia

149 ditioning (RIPC) by repeated brief cycles of limb ischemia/reperfusion reduces myocardial ischemia/re

150 ng economy, stride characteristics and lower limb joint angles were measured.

151 al traits related to endurance (e.g., larger limb joints, spring-like plantar arch) in Homo was somew

152 autotomy, characterized by more flexed hind limb joints.

153 sisted when we controlled for differences in limb kinematics between the two tasks.

154 nder limbs are anatomically similar to human limbs, knowing how they regenerate should provide import

155 tion, interventricular septal diameter, mean limb lead QRS voltage, and grade 3 diastolic dysfunction

156 The FGF4 retrogene segregated with limb length and had an odds ratio of 51.23 (95% CI = 46.

157 cal determinants of locomotor economy (e.g., limb length and posture) and endurance (e.g., muscle vol

158 owth for proper growth plate development and limb length.

159 ed antagonist leg muscle coactivation during limb loading in early stance, and (2) changes in the mag

160 g process and traumatic events such as lower-limb loss can alter the human ability to control stabili

161 However, whilst limb loss is unlikely to be adaptive, females with missi

162 ve cortical plasticity typically found after limb loss, in M1, partially in S1, and in their mutual c

163 elieve pain, help wound healing, and prevent limb loss.

164 into five body regions: cervical, laryngeal, limb, lower cranial and upper cranial.

165 iral warts (7; 24%), short stature (4; 14%), limb lymphoedema (3; 10%), and bronchiectasis (2; 7%).

166 This is a short report of 5 human limbs maintained for 24 hours with ex situ perfusion.

167 nstrate that vestibular control of the upper limb maintains reaching accuracy during unpredictable bo

168 ath through 30 days, and freedom from target limb major amputation and clinically driven target lesio

169 after the procedure and freedom from target limb major amputation and clinically driven target lesio

170 an autosomal-dominant severe frontonasal and limb malformation syndrome, associated with neurocogniti

171 evolution, acquired regeneration capacity or limb malformations in diverse species, including humans.

172 em symptoms but an absence of frontonasal or limb malformations.

173 connectivity in TMSR patients between upper limb maps in M1 and S1 was comparable with healthy contr

174 nlikely to be adaptive, females with missing limbs may play a role in the propagation of both their s

175 Effective movement relies not only on limb mechanics but also on appropriate mechanosensory fe

176 h factors are required to activate Hoxd13 in limb mesenchymal cells.

177 Here we use cultured limb mesenchyme cells to assess the response of the targ

178 but inactive state broadly across the distal limb mesenchyme.

179 bility milestones by 2.1-4.4 years and upper limb milestones by 2.8-8.0 years compared with treatment

180 and clinically meaningful mobility and upper limb milestones.

181 tance of the Twist-family bHLH dimer pool in limb morphogenesis.

182 tivity in growing bones and ultimately gross limb morphology, to generate phenotypic variation during

183 To assess variation in hind limb morphology, we analysed how the dimensions of the m

184 igits represents a specialized adaptation of limb morphology, yet it remains unclear how the specific

185 t most patients with E90K and N98S had upper limb motor conduction velocities <38 m/s.

186 TERPRETATION: Our results suggest that upper limb motor execution, and particularly dexterous coordin

187 ics and phase dependent differences in lower limb movement pattern between the two conditions which i

188 high-cervical spinal cord injury, can regain limb movements through coordinated electrical stimulatio

189 (a composite measure of walking speed, upper-limb movements, and cognition; for this z score, negativ

190 acral networks can activate and modulate the limb-moving lumbar circuitry, it is important to clarify

191 Lower limb MRI scans of patients with LGMD2C-2F, ranging from

192 U)- and mechanical ventilation (MV)-acquired limb muscle and diaphragm dysfunction may both be associ

193 (n=5), improved ischemic limb blood flow and limb muscle histology and restored muscle function (forc

194 Corticospinal drive to upper and lower limb muscle shows developmental changes with an increase

195 herited neuropathies characterized by distal limb muscle weakness and atrophy.

196 iaphragm dysfunction is twice as frequent as limb muscle weakness and has a direct negative impact on

197 with higher ICU and hospital mortality, and limb muscle weakness was associated with longer duration

198 Limb muscle weakness was defined as a Medical Research C

199 actile force with repetitive stimuli of hind-limb muscle, both in vivo and in vitro, this was absent

200 ld age, statin use was associated with lower limb muscle-related outcomes, and some were only apparen

201 asured electromyogram (EMG) activity in hind limb muscles of SOD1G93A mice.

202 t the corticospinal drive to lower and upper limb muscles shows significant developmental changes wit

203 f activation is more severe and sustained in limb muscles than it is in the diaphragm.

204 severe and sustained muscle fiber atrophy in limb muscles when compared with respiratory muscle.

205 tressed diaphragm is higher compared to hind limb muscles, which is probably attributable to constant

206 ntercostal and levator auris muscles but not limb muscles.

207 macrophages in the proximal and distal hind-limb muscles.

208 tely these drive contraction of the tail and limb muscles.

209 While the importance of limb musculature in performing these tasks is well estab

210 hitherto unknown aspects of the onychophoran limb musculature, enabling the 3D reconstruction of indi

211 versely, amputees who wish to replace a lost limb must assimilate a neuroprosthetic with the existing

212 tees who wish to rid themselves of a phantom limb must weaken the neural representation of the absent

213 ysis of the axonal components of human upper limb nerves based on highly specific molecular features

214 and Neuropathy Impairment Score in the Lower Limbs (NIS-LL) were evaluated.

215 t of choice for reticular veins in the lower limbs, no consensus has been reached regarding to the op

216 ular modulation of muscle activity from each limb occurs rapidly at the onset of split-belt walking,

217 ki Patera obtained on 8 March 2015 ut as the limb of Europa occulted Io.

218 ted deletion of PTH1R in the thick ascending limb of Henle (TAL) and in distal convoluted tubules (DC

219 as present in differentiated thick ascending limb of Henle, collecting duct, and stroma; however, it

220 nium of corpus callosum (SPCC) and posterior limb of internal capsule (PLIC).

221 DBS targeting the ventral striatum/anterior limb of the internal capsule (VS/ALIC) in 10 patients wi

222 sions in the ventral portion of the anterior limb of the internal capsule over a 20-year period using

223 ssociated with abnormalities in the anterior limb of the internal capsule, the white matter (WM) bund

224 d as the rat homolog of the primate anterior limb of the internal capsule.

225 nipulations of the striatum and the anterior limb of the internal capsule.

226 region of increased atrophy in the anterior limb of the left internal capsule adjacent to the head o

227 ein produced by cells of the thick ascending limb of the loop of Henle.

228 siologic readings of the parameters in all 4 limbs of all lambs were obtained.

229 ation, neutrophil infiltration into ischemic limbs of AMPKalpha2(DeltaMC) mice was lower than that in

230 dial septal nucleus, vertical and horizontal limbs of the diagonal band of Broca, and the nucleus bas

231 Recent studies have shown that specific limbs of the immune system can be regulated by microbiot

232 METHODS AND One hundred twenty-five limbs (of 89 patients) with critical limb ischemia and a

233 the spinal cord to innervate the human upper limb, of which 10% are motor neurons.

234 Whether we wish to remove a phantom limb or assimilate a synthetic one, we will benefit from

235 ransition and swing phase of the ipsilateral limb or midstance of the contralateral limb.

236 ped to restore function to people with upper-limb paralysis.

237 o forearm enhancers, thereby allowing proper limb patterning.

238 nction) and double-dorsal (gain-of-function) limb phenotypes, no direct gene targets in the limb have

239 level of grip is necessary before the upper limb plays an active role in vestibular-evoked balance r

240 urbations, the gain associated to changes in limb position decayed at a faster rate than the velocity

241 rbed by force patterns dependent upon either limb position or velocity.

242 escribed history-dependence in perception of limb position.

243 growth factor (FGF) signalling in the distal limb primes the ZRS at early embryonic stages maintainin

244 Animals have evolved limb proportions adapted to different environments, but

245 This disclosed that movement alters limb proportions and regulates chondrocyte proliferation

246 African Dwarf crocodiles, producing altered limb proportions which may, influence post-hatching perf

247 hymal tissues may potentially be utilized in limb regeneration.

248 main obstacle to therapeutic approaches for limb regeneration.

249 inning the astonishing biological process of limb regeneration.

250 The baseline risk of cardiovascular and limb-related events demonstrated among patients with sta

251 ric anticlines, which have bends on both the limbs, remains under debate.

252 observed evidence for re-routing to a multi-limb representation that participates in limb coordinati

253 vestibular stimulation (GVS) can evoke upper limb responses to maintain balance.

254 tions for antithrombotic therapy after lower limb revascularization are inconsistent and not always e

255 peripheral artery disease with a history of limb revascularization, the optimal antithrombotic regim

256 LIMB reveals extensive vascular plasticity during bone h

257 ardation, disproportionate shortening of the limbs, round head, mid-face hypoplasia at birth, and kyp

258 pain model, LC(:SC) activation reduced hind-limb sensitisation and induced conditioned place prefere

259 mechanical therapy attenuates stroke-induced limb skeletal muscle injury.

260 enerating appropriate tissue architecture of limb skeleton.

261 elapse, the addition of radiotherapy (RT) to limb-sparing surgery may result in higher local control

262 le reviews all these aspects, in addition to limb-sparing surgery.

263 recessive neurodegenerative subtype of lower limb spastic paraparesis with additional diffuse skin an

264 Progressive limb spasticity and cerebellar ataxia are frequently fou

265 linically characterised by progressive lower limb spasticity.

266 hancers using a combination of >50 published limb-specific datasets and clusters of evolutionarily co

267 ne dosage improves the integrity of anterior limb structures, validating the importance of the Twist-

268 d sodium permeability in the thick ascending limb (TAL), leading to a urine concentrating defect.

269 tis and had a greater percentage of affected limbs than the wild-type mice.

270 el, ribs and skeletal elements in developing limbs), the transverse integration of clonal columns det

271 natomy of nerves innervating the human upper limbs, the definite quantity of sensory and motor axons

272 and is devastating due to the potential for limb-threatening sequelae and mortality.

273 d reduced limb-tissue necrosis and increased limb tissue perfusion compared with Met81- (n=25) or gre

274 BAG3 variant (Ile81; n=25) displayed reduced limb-tissue necrosis and increased limb tissue perfusion

275 it-belt walking and was similar, within each limb, to velocity-matched tied-belt walking.

276 absorptiometry-derived fat mass included the limb-to-trunk fat mass ratio (FMR), fat mass index, and

277 enation challenges, including transient hind-limb tourniquet occlusion.

278 e hyperoxia occurs following release of hind-limb tourniquet occlusions.

279 g motor and sensory nerves from the residual limb towards intact muscles and skin regions.

280 ponding rapidly to perturbations, correcting limb trajectory, and strengthening support.

281 ion give rise that ischemic muscle damage in limb transplantation might be reversible to a certain ex

282 is the spontaneous activity - in the form of limb twitches - that occurs exclusively and abundantly d

283 olotls showed divergent reporter activity in limbs undergoing PD duplication versus truncation, sugge

284 However, at a group level, affected limb (upper or lower) did not predict bias magnitude; no

285 face the daunting task of controlling their limbs using a small set of highly constrained actuators.

286 ch by rescuing necrotizing tissues and whole limbs using two murine models of injury-induced ischaemi

287 The increase in performance of the untrained limb was 83.6% of that observed for the trained limb and

288 a portion of the sciatic nerve from one hind limb was transected at postnatal day 8 to cause paralysi

289 by ptosis, swallowing difficulties, proximal limb weakness and nuclear aggregates in skeletal muscles

290 Limbs were flushed and stored in HTK-N, TiProtec, HTK, o

291 an introduce an anticline with bends on both limbs, while a smooth fault plane will develop a roll-ov

292 nds to electro-mechanical stimulation of the limb, will help to inform the design of prostheses that

293 acing the function of a missing or paralyzed limb with a prosthetic device that acts and feels like o

294 CT can depict the external morphology of the limb with an image quality similar to scanning electron

295 olving the anterior limb, genu and posterior limb with the M3 projection located anteriorly, followed

296 is phase-dependent and modulated across both limbs with changes in locomotor velocity and cadence.

297 ity is phase-dependent and modulated in both limbs with changes in velocity.

298 Of 125 limbs with noncompressible ankle brachial index, 72 (57.

299 could be maintained beyond embryogenesis in limbs with regenerative capacity.

300 Mild atrophy in the left upper and lower limbs without pain, swelling, or skin lesions was noted