ライフサイエンスコーパス: limiting

1 stemic reactogenicity was transient and self-limiting.

2 urgor under conditions in which potassium is limiting.

3 uilding blocks carbon or nitrogen are growth-limiting.

4 marily in deeper beds where light is already limiting.

5 r which product dissociation may become rate limiting.

6 e vast majority of these infections are self-limiting.

7 applications where delivery vector space is limiting.

8 variation can affect which step is turnover-limiting.

9 in that leads to fibrosis, which can be life-limiting.

10 cessive feeding-related behaviors induced by limiting access to a highly palatable diet in rats.

11 these domains are immobilized and clustered, limiting access to aggregation-modulating antibodies.

12 mproving sensitivity during fast flight, but limiting acuity loss when the fly is still.

13 th large extents of intensively managed land limiting 'adaptive' community reorganization in response

14 ications were mild, transient, and not sight limiting after treatment.

15 l TCR expression can promote autoimmunity by limiting agonist selection of self-reactive thymocytes i

16 ption in the affected areas, for example, by limiting air-conditioning (AC) use.

17 ed that these docking interactions sequester limiting amounts of DDK, delaying Eco1 phosphorylation b

18 completed the full MenB vaccination series, limiting analytic power, these data suggest that MenB-FH

19 urred in 3 patients (11%); 2 cases were self-limiting and 1 case was fatal.

20 ymes (GS-GOGAT system) was similar in growth-limiting and non-limiting nitrogen concentrations in P.

21 ory for deciphering various structural, rate limiting and regulatory genes of CPT biosynthetic pathwa

22 ination of nitrogen to Pd(II), which is rate limiting, and directly delivers the intermediate for red

23 e whether unfolding or translocation is rate limiting, and establish that one or a few power strokes

24 As they developed limiting angina, sublingual nitroglycerin was administer

25 cal species reaching the sample, potentially limiting application efficacy.

26 tavalent peroxide ate complex, prior to rate-limiting aryl migration, has evolved.

27 rturbations reduce fluctuations toward their limiting behavior, [Formula: see text], a uniformity sim

28 Bacteria can interpolate between these limiting behaviors by actively tuning their overall acqu

29 demands and hardware requirements increase, limiting biomechanics research potential, as reflected b

30 ding sites interact competitively when TF is limiting but otherwise act additively.

31 Rate-limiting C-O bond cleavage occurs to generate a three-co

32 at this first-order sensory synapse and that limiting Ca(2+) accumulation in the terminal may protect

33 es for flow over the permeable layer for the limiting cases of alpha --> 0 and alpha --> infinity.

34 mber of spins at zero temperature in various limiting cases.

35 that CD79B and surface IgM constitute a rate-limiting checkpoint against B cell dysregulation by MYD8

36 tion needed may be state dependent, however, limiting clinical feasibility.

37 tion of dexamethasone prevented further dose-limiting CLS.

38 acteria to tune the immune response, thereby limiting collateral damage to the host and the risk for

39 We excluded other interventions aimed at limiting community access to pesticides.

40 sion and amalgam saturation, we also present limiting conditions for obtaining and fitting CV-PAC dat

41 ment have led to more young adults with life-limiting conditions living beyond childhood, which means

42 Under nitrogen-limiting conditions, a fraction of the vegetative cells

43 41% in nitrate-, phosphorus-, and potassium-limiting conditions, respectively.

44 ous species to prevent branching under light-limiting conditions.

45 domonas aeruginosa, under different nutrient-limiting conditions.

46 in cleavage rates results from a slow, rate-limiting conformational change prior to HJ cleavage: for

47 winding RNA duplexes without undergoing rate-limiting conformational changes that precede activation.

48 ear readout of a population with information-limiting correlations.

49 s potential improvements in efficiency while limiting damage and simplifying the delivery of editing

50 f repopulating cells, as assessed by extreme limiting dilution assay.

51 We performed limiting dilution, transwell, and cell viability assays

52 R-1 in PAR-1-deficient cells combined with a limiting-dilution transplantation assay demonstrated the

53 obus virus 1 (KRCV-1) causes a mild and self-limiting disease in experimentally infected crab-eating

54 peroxidatic cysteine, and finally, the rate-limiting disulfide bond is formed.

55 revent reactive oxygen species accumulation, limiting downstream oxidative damage and preserving mito

56 sion collapsing blood and lymphatic vessels, limiting drug delivery.

57 NAD availability is limiting during liver regeneration, and supplementation

58 electronic coupling, are suggested to be the limiting dynamics.

59 active lysyl oxidase-like 2 (LOXL2), thereby limiting effects to fibroblasts or cancer cells, the maj

60 ctions, fully abrogated metoprolol's infarct-limiting effects.

61 We defined new pathways limiting EGFR-inhibitor response, including WNT/beta-cat

62 Limiting endothelial HGF reduced Hnf4a, abolished interf

63 isition of Ag may be one of the main factors limiting entry of new B cell clones into ongoing immuniz

64 Glucosylceramide synthase (GCS) is a rate-limiting enzyme catalyzing ceramide glycosylation, there

65 cotinamide phosphoribosyltransferase, a rate-limiting enzyme for NAD synthesis, specifically in the l

66 ithine decarboxylase appeared to be the rate-limiting enzyme for polyamine production.

67 athway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase.

68 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme in the kynurenine pathway of tryptophan

69 reticulum-associated degradation of the rate-limiting enzyme in the pathway, HMG-CoA reductase (HMGCR

70 LDH, which is a non-limiting enzyme of glycolysis in differentiated cells, w

71 ol by inhibiting HMG-CoA reductase, the rate-limiting enzyme of the metabolic pathway that produces c

72 ic expression of the genes encoding the rate-limiting enzymes for glycogenolysis and gluconeogenesis,

73 seizures before remission, absence of a self-limiting epilepsy syndrome, developmental delay, and epi

74 B (TcdB), reducing recurrence presumably by limiting epithelial damage and facilitating microbiome r

75 m a proximal promoter paused state is a rate-limiting event in human gene control.

76 ecruiting the VCP/E3 ligase complex, thereby limiting excessive TGF-beta response.

77 ncing batch reactor by maintaining sustained limiting extant nitrite and dissolved oxygen concentrati

78 anced the recovery of the active principles, limiting extraction time and solvent waste.

79 Light-regime variability is an important limiting factor constraining tree growth in tropical for

80 ults suggest that activated STAT3 is not the limiting factor for collagen enhancer activation in huma

81 wild-type mice, suggesting that Hjv is not a limiting factor for hepcidin expression.

82 We likewise found a limiting factor for the volume of nuclei, which averages

83 rotease cathepsin B in macrophages as a rate-limiting factor in degrading asparaginase both in vitro

84 m temperature.Dissipation of the sensor is a limiting factor in metrology.

85 systems, nitrogen availability is often the limiting factor in the growth of autotrophic organisms,

86 the compactness of heterochromatin was not a limiting factor in the minimal volume of the nuclei.

87 euraminic acid (CMP-Neu5Ac) are considered a limiting factor in the sialylation of glycoproteins.

88 ting that outgrowth of PD-1(-) cells was the limiting factor in the tumor specificity of cells derive

89 ictive allograft syndrome (RAS) is the major limiting factor of long-term survival in lung transplant

90 sistent with the hypothesis that oxygen is a limiting factor shaping the temperature-size rule in fis

91 ht, suggesting that ion pairing density is a limiting factor.

92 We conclude that Aurora A and Plk4 are rate-limiting factors contributing to microtubule growth as t

93 miRNA target proteins are the dominant rate-limiting factors for miRNA-mediated gene silencing.

94 utically exploit their weaknesses, have been limiting factors in realizing the goal of targeting leuk

95 The identification and analysis of the limiting factors of the IQE are accomplished through the

96 ; however, technical and logistic issues are limiting factors.

97 e and performance of the transmitter are key limiting factors.

98 toms of RVFV infection mainly include a self-limiting febrile illness.

99 Given the critical role of BCRP in limiting fetal exposure to drugs and xenobiotics, long-t

100 This switch is rate-limiting for deubiquitination and strongly accelerated b

101 This thermal-mechanical trade-off is limiting for wearable computing, soft robotics, and othe

102 stension of the MPA may play a major role in limiting full aortic expansion during systole, which mod

103 nterventions was lower in quality or absent, limiting further conclusions.

104 The early-night peak in p20, limiting G1/S transition, and its phase angle with the e

105 ylated tRNAPhe during amino acid starvation, limiting Gcn2p kinase activity and suppressing Gcn4p-dep

106 arker (DsRed2) for identification and a self-limiting genetic trait that is repressed by tetracycline

107 Ntcp is the key host factor limiting HBV infection in cynomolgus and rhesus macaques

108 However, the factors crucial for Mvarphi in limiting hepatic inflammation or resolving liver damage

109 within HSCs to promote Tet activity in vivo, limiting HSC frequency and suppressing leukaemogenesis.

110 molecular understanding of its function and limiting immunogen design.

111 tion of defective ribosomal products is rate limiting in generating class I peptide complexes.

112 We also show that active Toll receptors are limiting in wild-type embryos, which is a key factor in

113 epatitis E virus (HEV) is regarded as a self-limiting infection and anti-HEV antibodies seem to prote

114 is is great enough, for acute, normally self-limiting infections, then (i) antibiotics with different

115 omodulatory cytokine with a critical role in limiting inflammation in immune-mediated pathologies.

116 tion, by improving bacterial clearance while limiting inflammation.

117 s is hampered by their complex architecture, limiting insights into the interplay between their organ

118 As part of a healthy diet, limiting intakes of excess sodium, added sugars, saturat

119 ns, we predicted the composition of the self-limiting interfacial oxide.

120 reveals that FBXL5 plays a critical role in limiting IRP1 and IRP2 overaccumulation when cytosolic F

121 activity of distinct viral proteins, thereby limiting its antiviral capacity.

122 Thereby, B12 likely modulates growth, and by limiting its availability to auxotrophs, B12-producing o

123 However, high caffeine content is limiting its direct application.

124 en causes myelosuppression in patients, thus limiting its effectiveness.

125 and exhibits moderate temperature tolerance, limiting its usefulness in hot and low-income countries

126 t cancer resistance protein (ABCG2), thereby limiting its utility in the treatment of non-small cell

127 ses and punctal plugs were more effective in limiting keratopathy, and their use, particularly of ban

128 s, cardiovascular hemodynamics recovery, and limiting kidney dysfunction in a vasopressinergic-depend

129 on level helps to save cellular resources by limiting Lac enzyme expression at high inducer concentra

130 for MOB interneurons remain largely unknown, limiting mechanistic understanding of olfaction.

131 lity by altering microglia transcriptome and limiting Mef2C, a microglia 'off' signal.

132 cysts, and extent of disruption of external limiting membrane (ELM) and ellipsoid zone (EZ) were det

133 observed in the OCT, correspond to the outer limiting membrane and the cone ellipsoids, respectively,

134 ttached and detached state) and the internal limiting membrane of the retina is essential to understa

135 fluorescence of the residual intact internal limiting membrane on the retinal surface also showed pos

136 lana vitrectomy with epiretinal and internal limiting membrane peel was ineffective in the treatment

137 plana vitrectomy and epiretinal and internal limiting membrane peel.

138 ntraluminal vesicles (ILVs) to the endosomal limiting membrane, with a subsequent decrease in APP C-t

139 The reported severity ranges from a self-limiting meningitis to a rapidly fatal meningoencephalit

140 MMR gene mutS in stationary phase, possibly limiting MMR to allow increased mutagenesis.

141 Notably, limiting monocyte infiltration via genetic Ccl2 reductio

142 n A4 (15-epi LXA4), plays a critical role in limiting neutrophil activation and tissue inflammation,

143 neuron survival and target innervation under limiting NGF (NGF(+/-)) conditions.

144 stem) was similar in growth-limiting and non-limiting nitrogen concentrations in P. ruminicola 23, wh

145 ry molecules PD-1, Lag-3, and TIGIT, thereby limiting NK cell-mediated control of pulmonary metastase

146 by restraining effector T cell expansion and limiting nonspecific damage to the host.

147 Molybdenum has been reported as a limiting nutrient for BNF in many ecosystems, including

148 a, but its effects on the potentially growth-limiting nutrient phosphorus (P) had not to our knowledg

149 root adjustments to increase acquisition of limiting nutrient resources, but they may also result in

150 rier transform optically we can overcome the limiting O(nlogn) complexity of fast Fourier transform a

151 Despite their role in limiting obesity, how ILC2s respond to high fat feeding

152 This prevents condensation by limiting opportunities to bridge to other molecules and

153 Although it is clear that limiting or accelerating autophagic flux can result in p

154 Several genetic mechanisms for limiting or eliminating gene drives have been proposed a

155 d production is rarely elucidated since rate-limiting or inactive domain(s) remain unidentified.

156 timates indicate that the kidney is the dose-limiting organ, with an estimated human absorbed dose of

157 The tumor-to-dose-limiting-organ (bone marrow) absorbed dose ratio, that i

158 ted in animals, but generally not in plants, limiting our ability to assess risks associated with cli

159 vity, or resurgence, remain largely unknown, limiting our ability to understand how supervolcanoes wo

160 e mutations and M/XDR-TB treatment outcomes, limiting our current ability to exploit the full potenti

161 al modes directly in a single nanostructure, limiting our understanding of phonon coupling with photo

162 lesterol transport block steps in lysosomes, limiting our understanding of post-lysosomal transport s

163 rse causation and residual confounding, thus limiting our understanding of the effect (if any) of inf

164 iated, immune system-dependent mechanism for limiting parasite population growth during the early sta

165 ted enterocytes are expelled into the lumen, limiting pathogen replication.

166 eutic role for Gbetagamma-GRK2 inhibition in limiting pathological myofibroblast activation, intersti

167 network structure enables spontaneous, self-limiting patterns of subcellular contractility that can

168 Limiting phosphoinositide production leads to a blockage

169 ) predispose plants to hydraulic constraints limiting photosynthesis and promoting hydraulic failure,

170 ation of the IAV polymerase complex, thereby limiting polymerase activity and subsequent viral replic

171 INTERPRETATION: Limiting population use of 4C antibiotics reduced select

172 ons-are increasing demand for N, the element limiting primary productivity in temperate forests, whic

173 with future increases in temperature further limiting production.

174 O2 release could act as a negative feedback, limiting progress of glaciation, dependent on lithology

175 ture (cardiac remodeling) are key factors to limiting progression of this condition to heart failure.

176 r sequencing to evaluate their efficiencies, limiting quantitative assessment.

177 ogenesis caused by UV exposure, to treatment-limiting radiation dermatitis associated with radiothera

178 ish an atomically thin oxide layer in a self-limiting reaction.

179 nd the overall performance and elucidate the limiting reactions of the photobioelectrochemical cell.

180 give quantitative yields (with Cu(II) as the limiting reagent) and selectivity combined with turnover

181 cted C-H functionalization with arene as the limiting reagent.

182 In this work, we view Ca2+/CaM as a limiting resource in the signal transduction pathway owi

183 acing distance, density) often controlled by limiting resources.

184 idering only major critical interventions as limiting), reverse triage would increase surge capacity

185 ties, and the role treatment options play in limiting risks.

186 actericidal capacity play important roles in limiting S. aureus SSTI in females.

187 e 3-OH kinase alpha (PI3K-C2alpha) acting as limiting scaffold protein organizing clathrin and TACC3

188 We examine the mobility-limiting scattering mechanisms by calculating temperatur

189 s are intrinsic to the broad distribution of limiting scission lengths.

190 We identify rate-limiting SHM positions for VRC-PG04 maturation, as well

191 eripheral neuropathy (CIPN) is a common dose-limiting side effect experienced by patients receiving t

192 neuropathy (CIPN), the most common treatment-limiting side effect of all the most common anticancer t

193 their widespread use is constrained by dose-limiting side effects thought to be due to activation of

194 ent's ability to take tolvaptan without dose-limiting side effects was assessed, 1370 patients with A

195 These blooms are terminated by limiting silicate concentrations in summer.

196 l strategies agree on the nature of the rate-limiting step and provided close results for the reactio

197 e that Jak3 autophosphorylation was the rate-limiting step during Jak3 trans-phosphorylation of beta-

198 ization of proline peptide bonds is the rate-limiting step during triple-helix formation.

199 We found that the overall rate-limiting step for aldol cleavage shifted from C-C bond s

200 elimination is predicted to be the turnover-limiting step for one substrate, and this is facilitated

201 voltage sensor in the first domain is a rate limiting step for release of the inactivation domain, an

202 The turnover-limiting step for the formation of a series of fluorene

203 odoxin reported a major revision of the rate-limiting step from MoFe protein and Fe protein dissociat

204 n, catalyst resting state, and turnover-rate limiting step has been examined.

205 It can also be a rate-limiting step if high false positive or negative rates n

206 CYP27A1, the enzyme responsible for the rate-limiting step in 27-hydroxycholesterol biosynthesis, sig

207 d that proteolysis is the regulated and rate-limiting step in generating soluble EGF bioactivity from

208 lar carboxylesterases is considered the rate-limiting step in polyester biodegradation.

209 ase, an enzyme catalyzing the first and rate-limiting step in sphingolipid biosynthesis: the condensa

210 The turnover-limiting step in the catalytic cycle for hydroboration o

211 suppressing end resection, which is the rate-limiting step in the initiation of HDR.

212 -2.8, respectively, indicating that the rate-limiting step in the oxidations involves hydride abstrac

213 ding to the theoretical discussion, the rate-limiting step is the diffusion through the coating; ther

214 ASS1 catalyzes the rate-limiting step of arginine synthesis in urea cycle and ci

215 eral acid nor a reaction partner in the rate-limiting step of electrochemical CO2 reduction catalysis

216 bition of acetyl CoA carboxylase 1, the rate limiting step of FAS, inhibit generation of early memory

217 gest that PCSK9 self-proteolysis is the rate-limiting step of secretion.

218 ion state supports a model in which the rate-limiting step of the hybridization reaction is the align

219 d the last redox event as being the turnover-limiting step of the overall process.

220 u3N bearing a hindered amine shifts the rate-limiting step to proton transfer.

221 e different substrates, reveal that the rate-limiting step under these conditions is the H2 formation

222 To exert control over this rate-limiting step, we designed sequence-specific synthetic t

223 s linear, consistent with an unchanging rate-limiting step.

224 (II)-mediated C-H activation is the turnover-limiting step.

225 d by differences in the kinetics of the rate-limiting steps in transcription between promoters and in

226 chotomous kinetics implicate additional rate-limiting steps that are essential for DNA-damage-induced

227 ing elegantly precise inhibitors of the rate-limiting steps within the signaling pathways that contro

228 proach also allowed us to identify metabolic limiting steps, which could be fruitfully targeted for o

229 vation occurs by reducing the abundance of a limiting subunit, Ndc80.

230 Whether macrophages have mechanisms for limiting such damage is not well understood.

231 this low deltaR agonist efficacy in vivo by limiting surface deltaR expression.

232 through adsorption of autolysins on TiO2 NP, limiting the activity of released autolysins and prevent

233 and efficient way are lacking, considerably limiting the advancement of research in this field.

234 Similar results were found when limiting the analysis to rituximab chemotherapy (OR = 0.

235 Limiting the debilitating consequences of ageing is a ma

236 S also influenced the mode of degradation by limiting the depth of pit formation during degradation p

237 other plasticity genes, are largely unknown, limiting the development of targeted epigenome therapy.

238 vating Fcgamma receptors (FcgammaR), thereby limiting the efficacy of mAb immunotherapy.

239 can contribute to optimal host protection by limiting the extent of endotoxin-induced inflammation in

240 gnaling network, modulating its activity and limiting the fitness cost of unnecessary immune response

241 tools is identified as a crucial bottleneck, limiting the full development of glycosciences and their

242 HRGPs leads to inconsistent gene ontologies limiting the identification of HRGP classes in existing

243 es, suggesting that other mechanisms must be limiting the immune response.

244 c tool and a possible therapeutic target for limiting the impact of PANR in PDAC pathophysiology and

245 ation than in gross primary production, thus limiting the increase of carbon sequestration.

246 bles the emergence of drug-resistant clones, limiting the long-term effectiveness of these therapies.

247 rates are often low, typically around 0.1%, limiting the number of useful images that can be collect

248 ugh the capillary endothelial membrane while limiting the passage of pathogens or toxins.

249 s remained a critical challenge for decades, limiting the performance of CdTe-based semiconductor dev

250 and we propose that this is a mechanism for limiting the phlogistic activity of newly recruited mono

251 gesting that there may be shared constraints limiting the possible evolutionary trajectories.

252 get genes provides therapeutic potential for limiting the progression of atherosclerosis and aneurysm

253 ach and expedited transfer of the allograft, limiting the recovery to a small geographic area.

254 of subsynaptic actin is an important factor limiting the release of large lytic granules from NK cel

255 dband and have a relatively low output power limiting the scope of their potential applications.

256 d framework illustrates a unique approach to limiting the self-quenching ordinarily exhibited at the

257 e responses triggered by cGAMP contribute to limiting the spread of DENV to adjacent uninfected cells

258 s at the time of surgery can be challenging, limiting the surgeon's ability to best determine resecti

259 ency virus (HIV) load testing are pivotal to limiting the threat of HIV drug resistance (HIVDR) accum

260 ilayer destabilization and pore instability, limiting the total number of recorded pulses.

261 f still loosely defined boundary conditions, limiting the translational value of basic research.

262 opic techniques require elevated investments limiting their applicability especially in developing co

263 pproaches are both CPU and memory-intensive, limiting their application to small, single data sets.

264 sets, which are currently curated manually, limiting their availability and accuracy in many organis

265 significantly with age throughout childhood, limiting their clinical applicability.

266 s for serious adverse events (SAEs), thereby limiting their influence on sedation practice and patien

267 e set of processes that may vary temporally, limiting their potential to predict ecological and evolu

268 g(+) ions released from AgNPs, significantly limiting their toxicity, concomitantly reducing microgli

269 s and prolonged experimental protocols, thus limiting their use as rapid clinical screening tools.

270 emical diversity than protein-based ligands, limiting their versatility.

271 robacteriaceae (CPE) are emerging worldwide, limiting therapeutic options.

272 As energy yields become limiting, these networks favor co-metabolic interactions

273 reater positive effect on the processes most limiting to carbon assimilation, which differ by plant t

274 Dose-limiting toxic effects occurred in two (67%) of three pa

275 he study cutoff date of Feb 1, 2017, no dose-limiting toxic effects, substantial cardiovascular toxic

276 Infusions were well tolerated, with no dose-limiting toxic effects.

277 ncluding the maximum tolerated dose and dose-limiting toxic effects.

278 us romidepsin designed to determine the dose-limiting toxicities (DLTs), maximum tolerated dose, phar

279 ds as well as to the kidney, leading to dose-limiting toxicities and adverse events affecting quality

280 ytotoxin delivery to tumor with reduced dose-limiting toxicities and thus have the potential for bett

281 n to FGF19-driven HCC may be limited by dose-limiting toxicities mediated by FGFR1-3 receptors.

282 t patients, four experienced unexpected dose-limiting toxicities: grade 4 sepsis syndrome, grade 4 hy

283 d every 2 weeks x 4 doses with a 4-week dose-limiting toxicity (DLT) period.

284 One patient (60 mg) had cycle 1 dose-limiting toxicity (pulmonary embolus).

285 18 patients were analysed in the dose-limiting toxicity analysis set: three at dose level 1 (1

286 One dose-limiting toxicity occurred at 200 mg (the patient did no

287 Only one dose-limiting toxicity occurred, at the 20 mg/kg dose, and th

288 can temporally segregate efficacy from dose-limiting toxicity of streptozocin, a chemotherapeutic dr

289 as generally well tolerated with only 1 dose-limiting toxicity reported (grade 3 pneumonia at 20 mg/k

290 Only one patient experienced a dose-limiting toxicity-grade 3 transient asymptomatic hyponat

291 er dose of 1000 mg/m(2), and both had a dose-limiting toxicity.

292 usly, we predicted the structure of the rate-limiting transition state that controlled the time-depen

293 Mosquito control programs aimed at limiting transmission of these viruses are ongoing in mu

294 ortunity for therapeutic approaches aimed at limiting tumour heterogeneity and evolution.

295 , might offer new therapeutic approaches for limiting tumour recurrence.

296 A major bottleneck limiting understanding of mechanisms and consequences of

297 fficult to confidently assign these numbers, limiting understanding of their biological significance.

298 g objects with a resolution well below these limiting values.

299 Limiting wasteful testing is important for patient safet

300 campylobacteriosis cases are acute and self-limiting, with Campylobacter excretion ceasing a few wee