ライフサイエンスコーパス: limpet

1 es to calculate the thermal reaction norm of limpet adductor muscle fatigue.

2 ch as the more obvious outgroup, the keyhole limpet, an observation common to other DNA sequence anal

3 species of the genus Haliotis plus a keyhole limpet and a more distantly related gastropod, the Chile

4 rms of 4 closely related intertidal Nacellid limpets, Antarctic (Nacella concinna), New Zealand (Cell

5 unctatus), trematode parasites for a keyhole limpet (Fissurella latimarginata), and pinnotherid pea c

6 conomically important Cape turban shells and limpets from MSA layers along the south and west coasts

7 Focusing on keyhole limpets, genera Fissurella and Diodora from Cape Verde I

8 150 mug GM-CSF) or control (100 mug keyhole limpet haemocyanin) via monthly intradermal injection un

9 RvIII-specific peptide conjugated to keyhole limpet haemocyanin.

10 nt antigen, 2,4-dinitrophenyl hapten-keyhole limpet hemocyanin (DNP(23)-KLH).

11 njugated to immunocyanin monomers of keyhole limpet hemocyanin (IC(KLH)) to create the MCV ICKLH-SOO9

12 d to the immunogenic carrier protein keyhole limpet hemocyanin (Id-KLH).

13 TCR Id protein conjugated to keyhole limpet hemocyanin (KLH) (TCR Id:KLH) and injected with a

14 Fc stimulated the production of anti-keyhole limpet hemocyanin (KLH) Ab, increasing anti-KLH IgG, IgG

15 ed by five subcutaneous boosts of Id/keyhole limpet hemocyanin (KLH) administered with adjuvant.

16 lin (Ig) idiotype (Id) conjugated to keyhole limpet hemocyanin (KLH) and administered with granulocyt

17 derivative was covalently linked to keyhole limpet hemocyanin (KLH) and monophosphoryl lipid A (MPLA

18 were pulsed with 2 foreign proteins, keyhole limpet hemocyanin (KLH) and tetanus toxoid (TT), as well

19 unization with two conjugates, Tn(c)-keyhole limpet hemocyanin (KLH) and Tn(c)-palmitic acid (PAM) wi

20 -idiotypic mAb MK2-23, conjugated to keyhole limpet hemocyanin (KLH) as a carrier and given with Baci

21 nfluenza matrix peptide (Flu-MP) and keyhole limpet hemocyanin (KLH) as control antigens.

22 Subjects were fed keyhole limpet hemocyanin (KLH) before subcutaneous immunization

23 ogenicity, we bound thiolated MEP to keyhole limpet hemocyanin (KLH) by using succinimidyl-4-(N-malei

24 bodies generated to the glycoprotein keyhole limpet hemocyanin (KLH) can cross-link with reactive car

25 njugation of the glycopeptide to the keyhole limpet hemocyanin (KLH) carrier protein completed the pr

26 and conjugated to maleimide-modified keyhole limpet hemocyanin (KLH) carrier protein through backbone

27 t regions plus GM-CSF, or linkage to keyhole limpet hemocyanin (KLH) carrier protein were increasingl

28 To solve this problem, the keyhole limpet hemocyanin (KLH) conjugates of a series of GM3 de

29 Delta71-82 alphaS, human betaS, and keyhole limpet hemocyanin (KLH) control proteins induced no symp

30 Volunteers were immunized with keyhole limpet hemocyanin (KLH) first orally and then parenteral

31 lysates and the immunogenic protein keyhole limpet hemocyanin (KLH) for 24 h and then combined.

32 cally synthesized, and conjugated to keyhole limpet hemocyanin (KLH) for examining its immunogenicity

33 ition (6OXY(Gly)(4)OH) conjugated to keyhole limpet hemocyanin (KLH) has shown early proof-of-efficac

34 ntitumor immunity induced by s.c. Id-keyhole limpet hemocyanin (KLH) immunization.

35 ,4,6-trinitrophenol (TNP)-conjugated keyhole limpet hemocyanin (KLH) in a specific pathogen-free envi

36 ation with the cocaine immunogen GNC-keyhole limpet hemocyanin (KLH) in preventing cocaine self-admin

37 th influenza matrix peptide (MP) and keyhole limpet hemocyanin (KLH) in two healthy subjects.

38 Mice immunized with the Ag keyhole limpet hemocyanin (KLH) mixed with HKL generated a KLH-s

39 neration cocaine immunoconjugate GND-keyhole limpet hemocyanin (KLH) or with the anti-cocaine mAb GNC

40 comprising Id chemically coupled to keyhole limpet hemocyanin (KLH) plus granulocyte macrophage colo

41 onjugated to the immunogenic protein keyhole limpet hemocyanin (KLH) protects mice from tumor challen

42 e PI3P hapten to maleimide-activated keyhole limpet hemocyanin (KLH) provided a PI3P immunogen, which

43 hallenge of the transgenic mice with keyhole limpet hemocyanin (KLH) resulted in a decrease in anti-K

44 l models of inflammation including a keyhole limpet hemocyanin (KLH) study and a collagen-induced art

45 compounds demonstrated efficacy in a Keyhole Limpet Hemocyanin (KLH) study in rats, where the blockad

46 ufactured and covalently linked with keyhole limpet hemocyanin (KLH) to generate Id/KLH.

47 immunogenic foreign carrier protein keyhole limpet hemocyanin (KLH) using glutaraldehyde has shown p

48 Keyhole limpet hemocyanin (KLH) was beneficial in earlier studie

49 ptides and to peptides conjugated to keyhole limpet hemocyanin (KLH) were characterized by their abil

50 t linker methods, to protein carrier keyhole limpet hemocyanin (KLH) were studied in mice.

51 eptide mimetics of GXM conjugated to keyhole limpet hemocyanin (KLH) with glutaraldehyde developed Ab

52 endent (TNP-LPS) or T-dependent (TNP-keyhole limpet hemocyanin (KLH)) Ag.

53 Following challenge with TNP-keyhole limpet hemocyanin (KLH), Ab production in these mice was

54 y) is conjugated to ovalbumin (OVA), keyhole limpet hemocyanin (KLH), and a bis-maleimide; KLH conjug

55 Rats were immunized with keyhole limpet hemocyanin (KLH), and blood samples were taken.

56 ainst an exogenous, nonself antigen, keyhole limpet hemocyanin (KLH), by releasing IL-4 in the microe

57 ddition of a foreign helper protein, keyhole limpet hemocyanin (KLH), can augment the efficacy of tum

58 vaged with a single dose of 20 mg of keyhole limpet hemocyanin (KLH), followed by s.c. immunization w

59 H antigen conjugated to the protein keyhole limpet hemocyanin (KLH), has been in clinical evaluation

60 d 4-6 weeks later by DCs pulsed with keyhole limpet hemocyanin (KLH), HLA-A*0201-positive restricted

61 primary response to PC conjugated to keyhole limpet hemocyanin (KLH), T15 Id(+) Abs constitute >90% o

62 typic mAb immunization protocol (mAb-keyhole limpet hemocyanin (KLH)-Calmette-Guerin bacillus (BCG),

63 However, keyhole limpet hemocyanin (KLH)-priming of IFN-gko mice readily

64 ere cocultured with HDK-1 T cells (a keyhole limpet hemocyanin (KLH)-specific CD4+ Th1 clone) in the

65 nonprotective clone (N-MoPn), and a keyhole limpet hemocyanin (KLH)-specific cell line (KLH-1).

66 nized with ovalbumin peptide or with keyhole limpet hemocyanin (KLH).

67 onjugate, 2,4,6-trinitrophenyl (TNP)-keyhole limpet hemocyanin (KLH).

68 24 to 48 h before immunization with keyhole limpet hemocyanin (KLH).

69 h ovalbumin and a secondary antigen, keyhole limpet hemocyanin (KLH).

70 oduction following immunization with keyhole limpet hemocyanin (KLH).

71 or vehicle before immunization with keyhole limpet hemocyanin (KLH).

72 recombinant HPV16/18 E7 antigens and keyhole limpet hemocyanin (KLH; an immunological tracer molecule

73 droxy-3-nitrophenyl(5) conjugated to keyhole limpet hemocyanin (NP(5)- KLH) or infected with HSV-1, a

74 se to 4-hydroxy-3-nitrophenyl acetyl-keyhole limpet hemocyanin (NP-KLH) and NP-OVA develops within ec

75 3-nitrophenyl acetyl (NP)-conjugated keyhole limpet hemocyanin (NP-KLH) or ovalbumin(323-337) peptide

76 ce primed with 2,4, 6-trinitrophenyl-keyhole limpet hemocyanin (TNP-KLH).

77 Intratumoral VVHY, VVGMCSF, and keyhole limpet hemocyanin (to produce CD4 help) generated spleni

78 to disease-inducing (TNP-conjugated keyhole limpet hemocyanin [TNP-KLH]) and disease-inhibiting (ant

79 Inhibition of anti-keyhole limpet hemocyanin Ab response was dose-dependent in FR10

80 d with nitrophenol hapten-conjugated keyhole limpet hemocyanin adsorbed to Imject aluminum hydroxide-

81 mounted a substantial Ab response to keyhole limpet hemocyanin after completion of anti-CD40L Ab trea

82 Moreover, mDCs(ICOS) pulsed with the keyhole limpet hemocyanin Ag during the maturation phase were be

83 loantigen and secondary responses to keyhole limpet hemocyanin Ag.

84 s vaccination with GM2 conjugated to keyhole limpet hemocyanin and administered with QS-21 (GMK) for

85 ginata hemocyanin in comparison with keyhole limpet hemocyanin and C. concholepas hemocyanin, which w

86 CD4+ T cell sensitization to keyhole limpet hemocyanin and CD8+ T cell sensitization to MART-

87 -hydroxykynurenine (3OHKYN)-modified keyhole limpet hemocyanin and characterized it using 3OHKYN-modi

88 e responses to two soluble proteins, keyhole limpet hemocyanin and chicken egg albumin.

89 sting of tumor Ig protein coupled to keyhole limpet hemocyanin and emulsified in an immunologic adjuv

90 Th2 immune deviation induced with keyhole limpet hemocyanin and IFA did not affect corneal allogra

91 ith cytokine-matured DCs loaded with keyhole limpet hemocyanin and MHC-I alone or MHC-I/II-restricted

92 two different immunogenic carriers, keyhole limpet hemocyanin and N-alpha-palmitoyl-S-[2,3-bis(palmi

93 ral responses to the T-dependent Ags keyhole limpet hemocyanin and OVA, as well as reduced Ag-specifi

94 its production of antibodies against keyhole limpet hemocyanin and Pneumovax in mice, indicating that

95 In response to trinitrophenol (TNP)-keyhole limpet hemocyanin and tetanus/diphtheria vaccine, CD40Lt

96 mocyanin or trinitrophenylated (TNP) keyhole limpet hemocyanin and the type 2 T-independent Ags TNP-F

97 f VlsE was conjugated to the carrier keyhole limpet hemocyanin and used to immunize mice.

98 assay and immunoblots using anti-AGE-keyhole limpet hemocyanin antibody, aminoguanidine inhibited glu

99 nses of L-selectin-deficient mice to keyhole limpet hemocyanin are indistinguishable from wild-type c

100 e induced after immunization with PC-keyhole limpet hemocyanin but at significantly lower levels than

101 eactive CTL, and development of anti-keyhole limpet hemocyanin CD4+ T cells, rejection of allogeneic

102 ccine, MH6, was then contrasted with keyhole limpet hemocyanin conjugate vaccine in a subsequent expe

103 immunized with the native 38C13 IgM-keyhole limpet hemocyanin conjugate vaccine.

104 (MH2[R], MH6, and MH7) or a control keyhole limpet hemocyanin conjugate vaccine.

105 ice vaccinated with the CD20 peptide keyhole limpet hemocyanin conjugates had a 25% decrease in CD19(

106 ogenicity of three synthetic globo H-keyhole limpet hemocyanin conjugates plus the immunologic adjuva

107 ice immunized with PA1 conjugated to keyhole limpet hemocyanin developed high anti-peptide (1/13,000)

108 ) propeptide [SLS(10-30)] coupled to keyhole limpet hemocyanin evoked antibodies in rabbits that comp

109 naive mice with 3H1 conjugated with keyhole limpet hemocyanin Freund's adjuvant induced humoral and

110 ctions using the standard therapy of keyhole limpet hemocyanin Id + GM-CSF.

111 , antigen-specific IgG1 responses to keyhole limpet hemocyanin immunization, regulated CD4(+) T-cell

112 numbers of Th1 cells in response to keyhole limpet hemocyanin immunization.

113 nd in 4-hydroxy-3-nitrophenyl acetyl-keyhole limpet hemocyanin immunized animals; recall responses we

114 a T helper 2 response (ovalbumin or keyhole limpet hemocyanin in alum) and is only seen with T cell-

115 After immunization with OVA or keyhole limpet hemocyanin in CFA, NK cell-deficient (NK-T+) mice

116 , or 100,000-mug doses of intranasal keyhole limpet hemocyanin in conjunction with adjuvant intranasa

117 Efficacy experiments in a keyhole limpet hemocyanin model in rats demonstrated that admini

118 Antibodies were raised by using keyhole limpet hemocyanin modified in vitro by 4-hydroxynonenal

119 ent with a secondary Th2 response to keyhole limpet hemocyanin or A. fumagatus extract, or by intrana

120 loading immature DCs with the neoAgs keyhole limpet hemocyanin or human immunodeficiency virus-1 p24

121 ent, secondary Th2 lung responses to keyhole limpet hemocyanin or primary responses to Nippostrongylu

122 nt (TD) Ags fluorescein-labeled (FL) keyhole limpet hemocyanin or trinitrophenylated (TNP) keyhole li

123 normal and B cell-deficient mice to keyhole limpet hemocyanin over 6 mo and observed diminished IL-2

124 d Th2 responses by immunization with keyhole limpet hemocyanin plus IFA.

125 ve prepared a conjugate vaccine (GD2-keyhole limpet hemocyanin plus immunological adjuvant QS-21) tha

126 the original tumor, including (1) Id-keyhole limpet hemocyanin protein, (2) Id single-chain variable

127 s with an F(2)Pab peptide coupled to keyhole limpet hemocyanin recognized a p53(1-39) peptide phospho

128 ermore, CLEC12A-mediated delivery of keyhole limpet hemocyanin resulted in enhanced proliferation and

129 with peptide 184- 198 conjugated to keyhole limpet hemocyanin showed significant pulmonary eosinophi

130 of ghrelin as compared with Ghr2 or keyhole limpet hemocyanin vaccinated controls.

131 ed-type hypersensitivity response to keyhole limpet hemocyanin was diminished.

132 city of coupling the glycopeptide to keyhole limpet hemocyanin was examined; although both IgM and Ig

133 Abs following immunization with DNP-keyhole limpet hemocyanin was significantly decreased for all Ig

134 networks, the primary Ab response to keyhole limpet hemocyanin was unaltered over a 20-day period.

135 n of high-affinity antibodies to TNP-keyhole limpet hemocyanin were severely impaired, even after ado

136 o CR3 counterligands (fibrinogen and keyhole limpet hemocyanin) by 50%, but did not affect adhesion t

137 iophage phiX 174 and nuclear protein-keyhole limpet hemocyanin) characterized by a reduction in numbe

138 ferative response to recall antigen (keyhole limpet hemocyanin) were normal.

139 moral immunity to model Ags (OVA and keyhole limpet hemocyanin), affecting all major T-dependent Ig c

140 imarginata, and Megathura crenulata (keyhole limpet hemocyanin), on cultures of peritoneal macrophage

141 Ag (keyhole limpet hemocyanin)-specific Th1/Th2 responses of fetal-d

142 by day 3 after immunization with Ars-keyhole limpet hemocyanin, (KLH) and at day 6, large clusters of

143 has been synthesized, conjugated to keyhole limpet hemocyanin, and administered with the immunologic

144 d with caffeine covalently linked to keyhole limpet hemocyanin, and recombinant antibody techniques w

145 eptides were synthesized, coupled to keyhole limpet hemocyanin, and used to produce rabbit antisera.

146 del Ag 4-hydroxy-3-nitrophenylacetyl-keyhole limpet hemocyanin, but GrB-deficient mice produced norma

147 ted from plasma of mice immunized to keyhole limpet hemocyanin, but not from naive or OVA-immunized m

148 when immunized with nitrophenylated-keyhole limpet hemocyanin, Dbc1(-/-) mice produce significantly

149 When immunized with trinitrophenyl-keyhole limpet hemocyanin, dbh-/- mice produced less Th1 cytokin

150 Immunization with DNP-keyhole limpet hemocyanin, heat-killed Brucella abortus, or infe

151 response to the T cell-dependent Ag, keyhole limpet hemocyanin, in the PDE7A(-/-) mice was found to b

152 Imaging of DNA, keyhole limpet hemocyanin, mouse monoclonal IgG, and glucose oxi

153 sponse to Pneumovax, IgG response to keyhole limpet hemocyanin, or cytokine response to LPS).

154 ent Ag, phosphocholine conjugated to keyhole limpet hemocyanin, ppc1-5 NAA B cells mounted a quick Ig

155 DCs with the foreign helper protein, keyhole limpet hemocyanin, prior to intratumoral delivery and co

156 g vaccination with the TCR linked to keyhole limpet hemocyanin, specific anti-TCR humoral responses w

157 ter immunization with trinitrophenyl-keyhole limpet hemocyanin, specific ASC could be isolated from a

158 y response to the T-dependent Ag DNP-keyhole limpet hemocyanin, the Tg mice exhibited severely impair

159 ergic sensitization to a neoantigen, keyhole limpet hemocyanin, using a unique model of human nasal a

160 oantigens, bacteriophage phiX174 and keyhole limpet hemocyanin, was also evaluated.

161 recombinant filarial protein Ags and keyhole limpet hemocyanin, we sensitized T cells from uninfected

162 xylase (GAD), but not the control Ag keyhole limpet hemocyanin, were eliminated in NODJg mu(null) mic

163 lly administered soluble protein Ag, keyhole limpet hemocyanin, were enhanced when mice were treated

164 -I, with or without conjugation with keyhole limpet hemocyanin, were fused with P3/NS1/1-Ag4-1 myelom

165 Ig fusion protein, however, enhances keyhole limpet hemocyanin- specific T-cell proliferation and 2,4

166 Mac-1 were defective in adherence to keyhole limpet hemocyanin-coated glass, iC3b-mediated phagocytos

167 distinct from those generated by the keyhole limpet hemocyanin-epitope conjugates.

168 liferation and cytokine secretion by keyhole limpet hemocyanin-experienced CD4(+) T cells.

169 cific Th2 cells, lymphoid cells from keyhole limpet hemocyanin-immune mice bearing healthy corneal al

170 various preclinical models, such as keyhole limpet hemocyanin-induced Ab responses, alloantigen-indu

171 a pigs immunized intranasally with a keyhole limpet hemocyanin-linked peptide, corresponding to the p

172 ized mice, were able to suppress the keyhole limpet hemocyanin-specific delayed-type hypersensitivity

173 avalin A-stimulated spleen cells nor keyhole limpet hemocyanin-specific proliferation of spleen cells

174 h LPS or upon 6-h coculture with the keyhole limpet hemocyanin-specific Th1 clone HDK-1 in the presen

175 h of incubation with HDK-1 T cells (keyhole limpet hemocyanin-specific TH1 clone) or with 5S8 T cell

176 t were reconstituted with a clone of keyhole limpet hemocyanin-specific Th2 cells and trinitrophenyl-

177 The sera raised against keyhole limpet hemocyanin-SV1 hapten, showed binding values of 5

178 thymus-dependent Ag, phosphocholine-keyhole limpet hemocyanin.

179 scending dose groups challenged with keyhole limpet hemocyanin.

180 g immunization of male SJL mice with keyhole limpet hemocyanin.

181 was increased by conjugating them to keyhole limpet hemocyanin.

182 using FITC-labeled tetanus, OVA, and keyhole limpet hemocyanin.

183 cluding host-restricted responses to keyhole limpet hemocyanin.

184 sponse against 2,4,6 trinitro-phenyl-keyhole limpet hemocyanin.

185 pe-matched control Ig, conjugated to keyhole limpet hemocyanin.

186 e, or to oligosaccharides present on keyhole limpet hemocyanin.

187 otoxin A, as well as to the model Ag keyhole limpet hemocyanin.

188 ith the T cell-dependent (TD) Ag DNP-keyhole limpet hemocyanin.

189 similar after immunization with DNP-keyhole limpet hemocyanin.

190 to the T cell-dependent antigen TNP-keyhole limpet hemocyanin.

191 zed with UO(2)(2+)-DCP conjugated to keyhole limpet hemocyanin.

192 ymphoma immunoglobulin conjugated to keyhole limpet hemocyanin.

193 alian cell and chemically coupled to keyhole limpet hemocyanin.

194 H2 as a hapten, conjugated to BSA or keyhole limpet hemocyanin.

195 d been immunized with trinitrophenyl-keyhole limpet hemocyanin.

196 - to 81-fold) after conjugation with keyhole limpet hemocyanin.

197 uppression of IgE in response to DNP-keyhole limpet hemocyanin/alum and Nippostrongylus brasiliensis

198 ing MoDC with conjugates of primary (keyhole limpet hemocyanin; KLH) and recall (Bet v 1) Ags (H4B4*K

199 d GH to a carrier protein, including keyhole limpet hemocyanion, diphtheria toxoid cross-reactive mat

200 phase III clinical trial vaccine, GH-keyhole limpet hemocyanion/QS21, the GH-DT/C34 vaccine elicited

201 GNE-KLH (keyhole limpet hemocyannin) was found to elicit persistent high-

202 significantly larger than turban shells and limpets in succeeding Later Stone Age (LSA) layers that

203 ely studied bioluminescent systems (those of limpet Latia, earthworms Diplocardia and Fridericia and

204 the unmineralized teeth of the giant keyhole limpet (Megathura crenulata) are shown to attain a stiff

205 thin the translucent shell of the blue-rayed limpet Patella pellucida.

206 We exposed individuals of the limpet Patella vulgata Linnaeus, 1758, to realistic expe

207 sp.), stalked barnacles, limpets, peltospiroid gastropods, anemones, and a predat

208 The bright colour of the limpet's stripes originates from light interference in a

209 ecific locations within the continuum of the limpet's translucent protective shell ensures the vivid

210 aving molluscs, the chiton Chaetopleura, the limpet Tectura, and the snail Lymnaea, the MAPK pathway