ライフサイエンスコーパス: linchpin

1 available in one step on 10 gram scale, as a linchpin.

2 Thus, we conclude that Mg(2+) ions act as a linchpin and that at least one ion must be removed prior

3 application of a novel bifunctional oxazole linchpin; and Stille coupling of a C(28) trimethyl stann

4 A copper-catalyzed three-component linchpin coupling method for the stereoselective union o

5 tages of a one-flask multicomponent dithiane linchpin coupling protocol, over the more conventional s

6 itching the order of epoxide addition in the linchpin coupling step, two analogous dihydropyranones w

7 tin A and B are reported and were based on a linchpin coupling strategy using a boron/tin hetero-bis-

8 based on the Smith three-component dithiane linchpin coupling strategy.

9 [Chemical reaction: See text] A "linchpin" coupling strategy is described for the constru

10 charge migration, this class of bifunctional linchpins employs initial through-bond ARC by an SN 2' r

11 In a number of proteins, the linchpin features are in regions found experimentally to

12 ng for many proteins is limited by critical "linchpin" features, often the backbone torsion angles of

13 res of active RING/U-Box E3/E2 pairs, as the linchpin for allosteric activation of E2~Ub.

14 recise hydrophobic connection that acts as a linchpin for assembly and trafficking of P-gp.

15 ic disorders, indicating that AP-1 acts as a linchpin for intracellular CCV formation.

16 The linchpin for repacking in the adenosine binding site is

17 findings suggest that Golgin-45 serves as a linchpin for the maintenance of Golgi complex structure,

18 the utility of N-Boc alpha-amino nitriles as linchpins for alkaloid synthesis.

19 thesis, and validation of three vinylepoxide linchpins for through-bond/through-space ARC are now rep

20 idation of new highly effective bifunctional linchpins for type II anion relay chemistry (ARC) has be

21 rom (R)-glycidyl tosylate, which served as a linchpin in a one-flask, sequential three-components cou

22 nscriptional activation pathway represents a linchpin in C. glabrata multidrug resistance.

23 This hypothesis is a conceptual linchpin in helix-coil theories and protein folding.

24 icating that the kleisin subunit acts as the linchpin in holocomplex assembly.

25 It may thus constitute a linchpin in multiple aspects of infections with Lyme dis

26 atidylinositol 3-kinase delta (PI3Kdelta), a linchpin in the pre-B-cell receptor and interleukin 7 re

27 sh causality through post hoc reviews is the linchpin in the recommendation for widespread adoption o

28 The use of alpha-boryl enamine and enamide linchpins in the synthesis of nitrogen heterocycles has

29 The linchpin is assignment of a durable power of attorney in

30 cell lysis, supporting a role for ppGpp as a linchpin linking expansion of cytoplasmic volume to the

31 e AP-2 adaptor complex is widely viewed as a linchpin molecule in clathrin-mediated endocytosis, simu

32 We propose that this "zinc linchpin" motif serves to structurally organize the IDC

33 -bearing carbonyl linchpin reagent (carbonyl linchpin N,O-dimethylhydroxylamine pyrrole; CLAmP) is re

34 We conclude that this hydrogen bond is a linchpin of backbone structure around the triple.

35 Ligand-binding assays are the linchpin of drug discovery and medicinal chemistry.

36 Mechanosensitive sensory hair cells are the linchpin of our senses of hearing and balance.

37 A linchpin of this network is gataE which as we show is a

38 mitochondria and the endoplasmic reticulum (linchpins of current theories about the origins of PD) i

39 As a result, the linchpin preserves the carbonyl functionality in the ARC

40 ed and the trans-trisubstituted vinylepoxide linchpins proceed to deliver three-component adducts wit

41 ketones utilizing a pyrrole-bearing carbonyl linchpin reagent (carbonyl linchpin N,O-dimethylhydroxyl

42 esults indicate that the P4/P6 junction is a linchpin region, where even small nucleotide substitutio

43 chment, mediated by a universally conserved 'linchpin' residue in kinesin (N255), triggers a clamshel

44 A critical role for linchpin residues in nucleocytoplasmic coagulation and o

45 21 using backbone-backbone hydrogen bonds, a linchpin serine residue, and hydrophobic side-chain pack

46 The present report is the first example of a linchpin tetraester construct that utilizes ester linkag

47 t identifies a protein called RGS-PX1 as the linchpin that connects signal transduction activated by

48 d BglII, is a sensor for DNA binding and the linchpin that couples base recognition and DNA cleavage.

49 nting rigid structures, zinc actually is the linchpin that orchestrates dynamic changes in response t

50 he anion thus located forms a 4-fold ligated linchpin that tethers the surface domain to the central

51 The development of new bifunctional linchpins that permit the union of diverse building bloc

52 versatile bifunctional dithiane-vinyl iodide linchpin, the unorthodox use of the Evans-Tishchenko rea

53 s, carbon monoxide functions as a one-carbon linchpin to facilitate building structural complexity an

54 ular design, the acetylene motif served as a linchpin to introduce a broad range of carbonyl-containi

55 gher-order relational reasoning" is one such linchpin trait in the evolution of human tool use, socia

56 es in the solvent controlled three-component linchpin union of silyl dithianes for the stereocontroll

57 validation of a unique class of bifunctional linchpins, uniting benzyne reactivity initiated by type

58 Hence, methionine 46 represents a "linchpin" whereby its oxidation is a primary event permi

59 The trans-disubstituted vinylepoxide linchpin yields a mixture of E/Z isomers, whereas the ci