ライフサイエンスコーパス: lineage

1 llion years (1.67 per million years for each lineage).

2 erative effect of a GATA1 deficiency on this lineage.

3 rate a primary abnormality in the eosinophil lineage.

4 , permitted matured differentiation to a FTE lineage.

5 nidaria [6-8], an earlier-branching metazoan lineage.

6 om a single dominant hematopoietic stem cell lineage.

7 ntiation of the progenitors into endothelial lineage.

8 activated satellite cells into the myogenic lineage.

9 level impact of temporal patterning within a lineage.

10 etric division that segregates the germ cell lineage.

11 different time points from the primary tumor lineage.

12 ch is a typical pH limit for the N. europaea lineage.

13 nally active genes in early-diverging fungal lineages.

14 factor strongly conserved across eukaryotic lineages.

15 d chromatin profiles from distinct stem cell lineages.

16 or EZH2 fail to differentiate into ectoderm lineages.

17 ment and survival of multiple haematopoietic lineages.

18 eurulation, during the establishment of cell lineages.

19 tal functions and significant overlap across lineages.

20 e divergence of these two ancient vertebrate lineages.

21 of mesenchymal stem cells into various cell lineages.

22 etic clades corresponding to the major plant lineages.

23 neage sorting obscure well-defined taxonomic lineages.

24 es affiliated with 46 different phylum-level lineages.

25 estrict gene expression in specific neuronal lineages.

26 rth America representing 46 distinct genetic lineages.

27 ted this expansion to various extents across lineages.

28 albuminous seeds of ancient flowering plant lineages.

29 daptive pseudogenization in select mammalian lineages.

30 additional, well-sampled phylogenies of TRF lineages.

31 our analyses suggest are monophyletic sister lineages.

32 e capable of transferring resistance between lineages.

33 reveals new aspects of MEI biology in these lineages.

34 The lineage Abs bore an anionic heavy chain complementarity-

35 d young adults with relapsed or refractory B-lineage acute lymphoblastic leukemia was conducted using

36 tropism for cells of the monocyte-macrophage lineage, affecting swine species and provoking severe ec

37 f nosocomial and community-associated clonal lineages, aided by mechanisms of genetic plasticity that

38 and Notch signalling has been implicated in lineage allocation, but it remains unclear how these pro

39 tes Notch signalling levels, thus regulating lineage allocation.

40 Air-breathing has evolved in many fish lineages, allowing animals to obtain oxygen in hypoxic a

41 cognized mutational process linking cellular lineage and cancer.

42 riptome provide insight into the green algal lineage and carotenoid production.

43 differentiated cell type of the osteoblastic lineage and have important functions in skeletal homeost

44 l-autonomous requirement for THAP1 in the OL lineage and is recapitulated in developmental assays per

45 the number of putative hidden orthologs in a lineage and its "average" evolutionary rate.

46 nally, differences in infection status, cell lineage and MHC class II expression by antigen-bearing c

47 oroughbred MSY was derived from the Turkoman lineage and that English Thoroughbred sires are largely

48 oncogenic transformation: the hematopoietic lineage and the intestinal epithelium.

49 ess accumulation of one or more myeloid cell lineages and a tendency to transform to acute myeloid le

50 ore, the interrelationships between neuronal lineages and neural networks are complex.

51 a mays) that includes several different cell lineages and present whole-genome replication timing pro

52 he Beijing lineage than to the Euro-American lineage, and known resistance-conferring loci accounted

53 analyses suggest that this major retroviral lineage, and therefore retroviruses as a whole, have an

54 val neuroblasts generate longer 50 division lineages, and currently only one mid-larval molecular tr

55 ession has varying phylogenetic signal among lineages, and that the crown squamate ancestor lacked fo

56 l associations of additional regulators in a lineage- and stage-specific context.

57 spective host species although some of these lineages appear to be shared among heterologous hosts pr

58 and conclude that the currently circulating lineages are the result of evolution in different genomi

59 Neoblast lineages arise as organogenesis begins and are required

60 rately derive lung versus thyroid epithelial lineages, as these two cell types each originate from Nk

61 To visualize TRPV1-lineage axons, a genetically engineered mouse model was

62 (peripheral or mature versus precursor) and lineage (B cell, T cell, and natural killer cell).

63 We show that within-lineage bacterial communities are similar, but are disti

64 In this review, we have selected two such lineage-based design strategies to illustrate how such i

65 We show that aggregation method instructs EB lineage bias, with faster aggregation promoting pluripot

66 t Asian ancestry not from the Tibetan/Sherpa lineage, but from low-altitude ancestors who migrated fr

67 tion of multiple innate and innate-like cell lineages, but how Zbtb16 itself is regulated remains unc

68 s emanate from members of a single bacterial lineage, "Candidatus Epulopiscium" and related giant bac

69 oth global and transgenic hCD39- and myeloid lineage CD39-overexpressing mice (transgenic, n=9; myelo

70 ing to its specific receptor on osteoclastic lineage cells and stimulates osteoclastogenesis in vitro

71 G1(+) thymic medullary niche enriched for DC-lineage cells expressing Notch receptors further validat

72 Hh-mediated transcription is increased in B-lineage cells from Gli3-deficient FL and showed that the

73 muscles at day 2 revealed increased myeloid lineage cells in ECFC + MPC-injected muscles compared to

74 Following cartilage injury, Gdf5-lineage cells underpin synovial hyperplasia through prol

75 rved in dsDNA viruses of the PRD1-adenovirus lineage, characterized by a major capsid protein bearing

76 p neural network that prospectively predicts lineage choice in differentiating primary hematopoietic

77 y of fusion proteins and microenvironment in lineage choice, we transplanted human hematopoietic stem

78 al cytokines play a role in conditioning ETP lineage choice, which would impact T cell development.

79 expression to determine both the sequence of lineage choices made by multipotent cells and to identif

80 The lineage classifications by the tools generally only diff

81 drivers for speciation, with a continuum of lineages coexisting across continental Europe, while dis

82 Some lineages colonized lowlands and adjacent montane areas,

83 semi-invariant TCR, which triggers NKT cell lineage commitment and maturation.

84 pG loci within the promoter regions of Th1/2 lineage commitment genes (GATA3, IL-4, IL-4R, STAT4 and

85 Lymphoid lineage commitment is an important process in haematopoi

86 In addition, the potential for T lineage commitment was radiation sensitive with aging.

87 promote stem cell self-renewal and/or direct lineage commitment.

88 nscription factors from prematurely enacting lineage commitment.

89 Differentiation of lineage-committed cells from multipotent progenitors req

90 To determine the lineage contribution of the Nkx2.5+ cardiomyoblasts, we

91 n sites in the protein NS4B of the Brazilian lineage could interfere with phosphorylation of Akt and

92 e up-regulating genes involved in mesodermal lineage decisions.

93 ontribute to the expression of T helper (TH) lineage-defining factors is unknown.

94 -bound enhancer elements critically modulate lineage-dependent expressions of PLZF.

95 ytotoxic lineage integrity by preventing TFH-lineage deviation.

96 ia, although the actual mutations in the two lineages differ.

97 Moreover, these subsets are not fixed in lineage differentiation but can undergo transcriptional

98 ium is critical for induction of appropriate lineage differentiation in organogenesis.

99 em cells increase proliferation, followed by lineage differentiation to replenish damaged cells.

100 nter of origin, but because of high rates of lineage diversification associated with high rates of ev

101 he central complex, generated by the type II lineages DM1-4, form the posterior EB primordium.

102 dial origin and not derived from bone marrow lineages, endothelial-to-mesenchymal transition, or bloo

103 ssels, both tumor-derived and matched normal Lineage-EpCAM-CD73+CD90+ cells supported the assembly of

104 fore expected to evolve only when the B cell lineage evolving breadth is consistently capturing and p

105 mes) are available from all major land plant lineages except ferns.

106 ng across continental Europe, while distinct lineages exist in isolation throughout the UK.

107 ely 22,000 years ago and that the cultivated lineage experienced a steady decline in population size

108 initiates positive selection, but the CD8(+)-lineage fate is thought to be induced by cytokines after

109 ehavioral convergence, with replicate beetle lineages following a predictable phenotypic trajectory d

110 rization of orthologs along the phylogenetic lineage from cassava to A. thaliana, suggests that alter

111 ell of origin, highlighting oligodendroglial lineage genes, and reveals unexpected mechanisms mediati

112 ting the AOTU, BU, and EB represent discrete lineages, genetically and developmentally specified sets

113 oform heterogeneity in the activation of the lineage germline B cell.

114 factors for their capacity to promote multi-lineage haematopoietic engraftment in mouse hosts.

115 cells, but functional diversity of the ILC2 lineage has yet to be fully explored.

116 dependently across newly evolving land plant lineages has long been a matter of debate.

117 the numbers of early cells of the osteoblast lineage, hastens their differentiation into osteoblasts,

118 representing the global VNI and African VNB lineages, highlighted a deep, nonrecombining split in VN

119 o Candidatus Nitrospira defluvii (Nitrospira lineage I) were successfully enriched from activated slu

120 unclear how heterotypic interactions affect lineage identity.

121 Deer tick virus (DTV), a genetic variant (lineage II) of Powassan virus, is a rare cause of enceph

122 The seven orangutan lineage III KIR genes all locate to the centromeric regi

123 cestor of humans and chimpanzees had diverse lineage III KIR that passed on to chimpanzees but not to

124 herited activating KIR2DS4 and an inhibitory lineage III KIR, likely encoding a C1-specific receptor.

125 elicited by cells of monocyte/macrophage/DC lineages.IMPORTANCE We previously demonstrated that a pa

126 ate that is not closely related to any known lineage in 201-protein phylogenomic trees and has a uniq

127 xcess of radical changes in several of these lineages in comparison to their relatives with larger ge

128 pers the routine application of hPSC-derived lineages in disease modeling and regenerative medicine.

129 l as the spatial distribution of the cardiac lineages in neonates and ion-channels in adults.

130 mes and base-resolution methylomes for early lineages in peri- and postimplantation mouse embryos.

131 Furthermore, the distinction of two lineages in the snapping shrimp Alpheus lottini complex,

132 ibution to both embryonic and extraembryonic lineages in vivo and permits generating single-EPS-cell-

133 specifically deleted in cells of the myeloid lineage, including macrophages.

134 to give rise to anlages of different ocular lineages, including retinal cells, lens cells, and ocula

135 naling pathways in a number of hematopoietic lineages, including T lymphocytes.

136 Targeting gdf3 and ndr2 RNA to specific lineages indicates that exogenous gdf3 is able to fully

137 of 78 times independently from saprotrophic lineages, indicating the potential for functional overla

138 By supplying lineage information for each DA cluster, our analysis pr

139 e-resident cells committed to the adipocytic lineage inhibit hematopoiesis and bone healing, potentia

140 ed pathways are involved in transmitting the lineage-instructive signal in primary bone marrow-derive

141 otoxic functions and protected the cytotoxic lineage integrity by preventing TFH-lineage deviation.

142 The MAST-4 lineage is of particular interest, since it is widesprea

143 ired for differentiation of other blood cell lineages, its function during granulopoiesis has remaine

144 d form of necrosis, is executed by the mixed lineage kinase domain-like (MLKL) protein, which is trig

145 in kinase-3 (RIPK3) phosphorylation of mixed-lineage kinase domain-like protein (MLKL), which results

146 he spectrin-betaV amino acid sequence in the lineage leading to mammals, together with substantial di

147 istone lysine methylation, mediated by mixed-lineage leukemia (MLL) proteins, is now known to be crit

148 hromosome rearrangements involving the mixed-lineage leukemia gene (MLL) create MLL-fusion proteins,

149 Mixed-lineage leukemia-1 (MLL1) has been shown to direct gene

150 of different proteins related to hepatogenic lineage like growth arrest specific protein 6, oncostati

151 und upregulation of markers of non-mast cell lineages, loss of proliferative control, chromatin remod

152 and structure, including skewing to myeloid lineages, lower reconstitution potential and loss of pro

153 are initially devoid of differentiated lung lineage markers.

154 to a novel, as-yet-uncultivated mycoplasma (lineage 'Mnola') in the oral cavity of a premature neona

155 w among geographically disparate groups or a lineage more deeply diverging than that of the San contr

156 gene markers may also find wide use in cell lineage MRI studies.

157 verexpressing mice (transgenic, n=9; myeloid lineage, n=6) demonstrated significantly smaller cerebra

158 ther Rag2(-/-) or Rag2(-/-)gammac(-/-) These lineage-negative CD45(+)/Thy1.2(+) cells are found withi

159 tion proliferated normally in vitro, whereas lineage-negative progenitors displayed impaired NK-cell

160 ferences is unconstrained by residential and lineage norms, and is detectable even where marriage rem

161 Microglia belong to a lineage of adult tissue-resident myeloid cells that deve

162 Reconstructing the lineage of cells is central to understanding how the wid

163 ally validated before it is certain that any lineage of ECM fungi actively expresses extracellular en

164 t, nerve cells, and muscle cells in the stem lineage of eumetazoans (bilaterians + ctenophores + cnid

165 enoptera: Aculeata) are an extremely diverse lineage of hymenopteran insects, encompassing over 70,00

166 USA300 is a pandemic clonal lineage of hypervirulent, community-acquired, methicilli

167 and indicated that treehoppers are a derived lineage of leafhoppers.

168 telomere-binding protein in the common stem lineage of marsupial and placental mammals.

169 Over the past 50 years one such lineage of meningococci, known as serogroup A, clonal co

170 An invasive lineage of Phragmites australis roots deeper than native

171 ead coal formation, was dominated by extinct lineages of early-diverging vascular plants.

172 e provide evidence that not all evolutionary lineages of ECM have retained the genetic potential to p

173 ere is a strong bias for sequencing epidemic lineages of methicillin-resistant Staphylococcus aureus

174 enting more peptides to Tfh cells than other lineages of more specific B cells.

175 to promote the emergence of host generalist lineages of the zoonotic bacterium Campylobacter.

176 sequencing approach to trace the metastatic lineages of two CRC patients with matched liver metastas

177 We find that the majority of Andean orchid lineages only originated in the last 20-15 million yr.

178 ction induces both the mass exodus of neural lineages out of the CNS and drastic perturbations to CNS

179 model with Vps34 deletion in the MK/platelet lineage (Pf4-Cre/Vps34(lox/lox)).

180 ges, one of the most ancient extant metazoan lineages, possess an MBD2/3 capable of recognizing methy

181 ch1 expression in HR(+) ETPs, which regain T lineage potential.

182 ra with data to show the importance of local lineages, presenting an integrated view of cholera that

183 ted that the transition from full potency to lineage priming is prevented by inhibition of the FGF/MA

184 rmative phase of pluripotency preparatory to lineage priming.

185 es and can give rise to myeloid and lymphoid lineage progenitors.

186 mitochondrial complex function to efficient lineage progression of adult NSCs and identify mitochond

187 s, and genetic lineage tracing to define the lineage relations and restrictions of the mesenchymal an

188 Reconstructing the lineage relationships and dynamic event histories of ind

189 ethers peripheral heterochromatin containing lineage-relevant genes to the nuclear lamina.

190 through simple fluorescent imaging for each lineage reporter.

191 oforms along with unique fluorescent protein lineage reporters in the same mouse.

192 MF conditions facilitate an efficient direct lineage reprogramming to induced dopamine neurons in vit

193 associated with East-Asian and Euro-American lineages, respectively.

194 veoli) are separately maintained by distinct lineage-restricted stem cells.

195 hich FGF signaling regulates inner cell mass lineage restriction and cell commitment during preimplan

196 the nuclear lamina during cardiac progenitor lineage restriction.

197 k of Neotropical Catasetinae, the angiosperm lineage richest in taxa with ESD.

198 tor family are pivotal regulators of several lineage-selective differentiation programs.

199 on in the embryonic, but not postnatal, Myf5 lineage share an anatomic location that is frequently ad

200 ncestral polymorphisms because of incomplete lineage sorting (ILS) and/or introgression following sec

201 ation sizes, leading to extensive incomplete lineage sorting (ILS).

202 , introgressive hybridization and incomplete lineage sorting obscure well-defined taxonomic lineages.

203 cell cycle progression on the expression of lineage specific genes in precursor cells, and suggests

204 SD1 to an altered expression pattern of lung-lineage specific transcription factors and genes, which

205 The Vd991 genome harbored several exclusive, lineage-specific (LS) genes within LS regions (LSRs).

206 This identification of region- and lineage-specific crosstalk between epithelium and their

207 Steroid hormones mediate critical lineage-specific developmental and physiologic responses

208 We propose that miRNAs compensate for lineage-specific differences in egl-1 transcriptional ac

209 Efficient lineage-specific differentiation was confirmed by unifor

210 Lineage-specific expression of defense-related genes was

211 ction strategies are linked to radiations of lineage-specific gene families.

212 ding to Rybp upregulation and suppression of lineage-specific genes via RYBP-dependent ubiquitination

213 Lineage-specific hypomethylated regions are enriched nea

214 t on the epigenetics and cellular origins of lineage-specific lung tumours.

215 shown that lncRNAs are expressed in a highly lineage-specific manner and control the differentiation

216 ce of many LORe ohnologues with functions in lineage-specific physiological adaptations that potentia

217 Basal lineage-specific profiling and genetic loss-of-function

218 Loss of sexual-lineage-specific RdDM causes mis-splicing of the MPS1 ge

219 c to certain types of tissues or cells, e.g. lineage-specific regulatory elements.

220 of a 3D contact domain comprising IGF2 and a lineage-specific super-enhancer, resulting in high-level

221 an phylogenetic analyses corroborate several lineage-specific TLR gene expansions in urchins and ceph

222 ole in regulating chromatin accessibility to lineage-specific transcription factors.

223 the establishment of accessible chromatin at lineage-specific transcriptional enhancers and promoters

224 ve variation in the amount of DNA gained via lineage-specific transposition, but that DNA loss counte

225 tical transcription factors directing B cell lineage specification and commitment.

226 x3 and Med26 together ensure the fidelity of lineage specification by enhancing the expression of neu

227 al transcription factors regulating pancreas lineage specification have been identified, and Notch si

228 pathways claimed to regulate their distinct lineage specification in vivo or in vitro have varied in

229 (Fgfr) and ERK pathways reversed the skewed lineage specification of Klf5 KO blastocysts.

230 critical developmental stages of alternative lineage specifications.

231 on of in vivo signaling by all six of these 'lineage-specifying cytokines' during positive selection

232 These findings suggest that recruitment of lineage-specifying TFs occurs soon after replication and

233 ary relationships between two ancient animal lineages - sponges and ctenophores - and the remaining a

234 tiplicity of infection > 0.07) of an African lineage strain (MR766 Uganda: ZIKV(U)) considered to be

235 (E-M81, E-M78, and J-M267) and mitochondrial lineages such as U6b, in addition to common Eurasian hap

236 olluscs are descendants of an early-Cambrian lineage superbly adapted to benthic filter feeding.

237 transcriptional activation of the melanocyte-lineage survival oncogene MITF, highlighting a new role

238 overies in Utah suggest that turiasaurs as a lineage survived the Jurassic-Cretaceous extinction boun

239 Instead, adult Scx-lineage tenocytes are not recruited into the defect but

240 icantly more likely to belong to the Beijing lineage than to the Euro-American lineage, and known res

241 asympathetic nerves in generating the acinar lineage that has broad implications for epithelial morph

242 transposition bursts in a given somatic cell lineage that later contributes to differentiation of gam

243 ire was occupied by a small number of recall lineages that did not decline during vaccine response an

244 and phylogenetic structure of mitochondrial lineages that have survived in contemporary descendants

245 We identified three distinct lineages that likely diverged in the Miocene.

246 Although abundant in most lineages, the distribution of these enzymes is variable

247 extant members of early divergent angiosperm lineages, the embryo to seed ratio (E : S) falls squarel

248 le of the variation in speciation rate among lineages, the positive relationship between differentiat

249 iferation is widespread in diverse bacterial lineages, the underlying mechanisms are still incomplete

250 nscriptome of the clinically important PMEN1 lineage to identify which peptide-encoding genes are hig

251 w molecular tools are recruited in different lineages to control interplays between these tissues is

252 VP7 gene of G9 strains identified different lineages to prevail in the respective host species altho

253 contributions of multiple low frequency cell lineages to the regenerating limb at once.

254 We conclude that cell-to-cell and consequent lineage-to-lineage variability in RNA and protein number

255 By lineage tracing analysis, we also found that collagen-ex

256 is healing, Gli1 expression was examined via lineage tracing approaches and the effect of Smo deletio

257 Lineage tracing confirmed that LDB1-depleted, insulin-ne

258 Genetic lineage tracing confirms the presence of the Tbx6(+) NMP

259 vide the first direct evidence using genetic lineage tracing for two basic assumptions in Schwann cel

260 ion of stem cell-derived clones using sparse lineage tracing in the regenerating mouse olfactory epit

261 Here, we performed clonal multicolor lineage tracing of skeletal muscle stem cells (MuSCs) to

262 Genetic in vivo lineage tracing revealed that the Krt15 promoter marks a

263 Here, we demonstrate by cell lineage tracing that the gills of a cartilaginous fish,

264 and robust statistical analyses with in vivo lineage tracing to define a detailed map of the postnata

265 ysis, cell proliferation assays, and genetic lineage tracing to define the lineage relations and rest

266 Here we use genetic lineage tracing to mark the Nppa(+) or Hey2(+) cardiomyo

267 Lineage-tracing analysis revealed that descendants of Sf

268 However, lineage-tracing experiments demonstrate that cells from

269 Lineage-tracing experiments indicated that the majority

270 Fascicles and lineage tracts also demarcate seven columnar neuropil do

271 ials and branchpoints in olfactory stem cell lineage trajectories.

272 at these cells expressed reduced levels of B-lineage transcription factors and B cell receptor (BCR)/

273 We describe an aberrant gastrointestinal-lineage transcriptome expressed in approximately 5% of p

274 rodela and its basal position in the monocot lineage, understanding its genome architecture could she

275 sustained gene marking in myeloid and B-cell lineages up to 20 months of observation.

276 that cell-to-cell and consequent lineage-to-lineage variability in RNA and protein numbers are both

277 ell entropy and predict cell differentiation lineages via the construction of entropy directed cell t

278 rotein, whereas many isolates of the African lineage virus lack this site.

279 This lineage was introduced at least 11 times since 1970, int

280 a new light, as we cannot exclude that this lineage was responsible for the production of Acheulean

281 Lack of melanization in both lineages was associated with loss-of-function mutations

282 tribute progeny to all major pancreatic cell lineages, we also identify numerous unipotent endocrine

283 cellular differentiation into secretory cell lineages, we show that although goblet cells resist E11

284 e will strongly influence the fate of a cell lineage: we describe a mechanism through which coccal (r

285 prophages and the host pneumococcal genetic lineage were strongly associated and some prophages pers

286 The deepest diversifications of African lineages were complex, involving either repeated gene fl

287 all progenitors was required for the myeloid lineage, whereas the other leukemia-induced lncRNAs were

288 PfKelch13 C580Y haplotype (-50 to +31.5 kb) lineage, which emerged in western Cambodia in 2008, was

289 munities are similar, but are distinct among lineages, which is consistent with our results in a comp

290 lls derived from the monocyte and macrophage lineages, which results in tissue damage.

291 s in global temperatures and which microbial lineages will be most impacted.

292 ith higher diversification rates compared to lineages with alternative systems while considering addi

293 Lgr5+ ISCs that contribute to all intestinal lineages with distinct kinetics.

294 Lineages with ESD have consistently higher diversificati

295 ly higher diversification rates than related lineages with other sexual systems.

296 ntiate into multiple cardiac and mesenchymal lineages, with preferential differentiation into fibrobl

297 Typically, stem cells of independent lineages work coordinately within mature organs to ensur

298 of influenza A subtypes H1N1 and H3N2 and B lineages Yamagata and Victoria.

299 re, it is unknown whether African- and Asian-lineage ZIKV have different phenotypic impacts on host i

300 Specifically, Asian-lineage ZIKV infection of pregnant women's blood led to