ライフサイエンスコーパス: lineage commitment

1 t are required by developing Tregs for their lineage commitment.

2 would indicate potential regulators of mSSC lineage commitment.

3 e-pronged blockage of T3 action during glial lineage commitment.

4 stages but then falls sharply during T-cell lineage commitment.

5 remodelling protein functions to facilitate lineage commitment.

6 n and is used as a biomarker to measure Treg lineage commitment.

7 tity and potency, promoting white adipogenic lineage commitment.

8 for all NK cell subsets or how it induces NK lineage commitment.

9 on and in epigenetic modifiers implicated in lineage commitment.

10 er induction of MEG-specific genes following lineage commitment.

11 nitor cell population at different stages of lineage commitment.

12 etry breaking during cell fate decisions and lineage commitment.

13 2-4%), indicative of early oligodendrocytic lineage commitment.

14 and basic research on pluripotency and early lineage commitment.

15 tein, which by contrast is dispensable for T-lineage commitment.

16 landscape is established during early T cell lineage commitment.

17 quired for primitive or definitive erythroid lineage commitment.

18 er, yet little is known about their roles in lineage commitment.

19 r that promotes HSC quiescence and represses lineage commitment.

20 hair cycle, stem cells of each type activate lineage commitment.

21 define a novel role for human CAR in hepatic lineage commitment.

22 abilizing ground-state pluripotency to allow lineage commitment.

23 including cell growth, differentiation, and lineage commitment.

24 tors YAP and TAZ, which serve to control SSC lineage commitment.

25 pression as a faithful molecular marker of T lineage commitment.

26 ity of MLL-Af4 was interlinked with lymphoid lineage commitment.

27 mesoderm differentiation and cardiovascular lineage commitment.

28 nal component of myeloid differentiation and lineage commitment.

29 nction with positive regulators to stabilize lineage commitment.

30 transcriptional circuit critical for B cell lineage commitment.

31 is best known as the master regulator of Th1 lineage commitment.

32 rmine the functional impact of T-bet on Th17 lineage commitment.

33 ulation and enhancers were at work directing lineage commitment.

34 promote stem cell self-renewal and/or direct lineage commitment.

35 ffect favors Foxp3 expression and T reg cell lineage commitment.

36 consistent with molecular characteristics of lineage commitment.

37 yeast and to be important for mammalian ESC lineage commitment.

38 -scale chromatin folding during early neural lineage commitment.

39 rimitive cells and are formed de novo during lineage commitment.

40 fication and that its inhibition delays HSPC lineage commitment.

41 rentiation potential ultimately resulting in lineage commitment.

42 uripotency marker Nanog before they initiate lineage commitment.

43 key component of cytokine regulation during lineage commitment.

44 y assumed to represent the first stage of NK lineage commitment.

45 ed with the balance between pluripotency and lineage commitment.

46 versus B cell commitment and CD4 versus CD8 lineage commitment.

47 urvival and proliferation without inhibiting lineage commitment.

48 and cutaneous immune systems guide Th17 cell lineage commitment.

49 r CCR7 to function in positive selection and lineage commitment.

50 CD8 genes, and transcriptional regulation of lineage commitment.

51 are rate-limiting for metabolic activity and lineage commitment.

52 lineage-inappropriate genes upon trophoblast lineage commitment.

53 lity to positive selection of thymocytes and lineage commitment.

54 licle differentiation and directing IFE cell lineage commitment.

55 lso known as c-Maf) is central to osteoblast lineage commitment.

56 d inhibited both osteogenic and chondrogenic lineage commitment.

57 expressed in precursors immediately before T lineage commitment.

58 spects of the molecular machinery underlying lineage commitment.

59 ing both myeloid and lymphoid haematopoietic lineage commitment.

60 n essential transcription factor for myeloid lineage commitment.

61 pulations, revealing a role in governing HSC lineage commitment.

62 nscription factors from prematurely enacting lineage commitment.

63 ive feedback mechanisms control human T-cell lineage commitment.

64 the BM combined with reduced potential for T lineage commitment.

65 favorable system to study developmental cell lineage commitment.

66 ssion of ThPOK and Runx3 and correct CD4/CD8 lineage commitment.

67 ams that enforce their identity and regulate lineage commitment.

68 led distinct effects on HSC self-renewal and lineage commitment.

69 orchestration of gene expression during cell lineage commitment.

70 tion factors and other genes associated with lineage commitment.

71 tion of TCR specificity into definite T cell lineage commitment.

72 into a cell cycle-independent pattern after lineage commitment.

73 bling precise coupling of TCR specificity to lineage commitment.

74 tor stage, where it is involved in erythroid lineage commitment; (2) during the global expansion of e

75 th Eos maturation (1199 genes) than with Eos-lineage commitment (490 genes), highlighting the greater

76 Cs exhibited impaired function and defective lineage commitment abilities.

77 dynamic changes in transcription and stalled lineage commitment, allowing cells to explore alternativ

78 More importantly, RANKL-mediated lineage commitment also has an impact on P. gingivalis-i

79 opulations to demonstrate that AH suppresses lineage commitment and acquisition of Th1 and Th17 effec

80 signals within the UGS that trigger prostate lineage commitment and bud formation.

81 nt stem cells may interfere with normal cell lineage commitment and cause the accumulation of undiffe

82 less is known about early events leading to lineage commitment and cell fate choice.

83 rks that control critical processes, such as lineage commitment and cellular differentiation.

84 differences in memory and activation status, lineage commitment and cytokine expression.

85 l knockout mice exhibit preferential T(H)-17 lineage commitment and decreased T(reg)-cell functionali

86 r not Setd1a controls specific hematopoietic lineage commitment and differentiation during animal dev

87 Transcriptional programs control cellular lineage commitment and differentiation during developmen

88 Lineage commitment and differentiation into mature cell

89 ugh Notch signaling plays important roles in lineage commitment and differentiation of multiple cell

90 n other species, suggesting greater neuronal lineage commitment and differentiation of self-renewing

91 tion factors (MRFs) are well known to govern lineage commitment and differentiation, exactly how the

92 xpression of genes controlling hematopoietic lineage commitment and differentiation, including Hox fa

93 ontribution of transcription factors to cell lineage commitment and differentiation.

94 ic controls and that pave the way for proper lineage commitment and differentiation.

95 ee of transcriptional diversification during lineage commitment and differentiation.

96 in mammalian cells and eventually determines lineage commitment and differentiation.

97 s a major regulator of mESC self-renewal and lineage commitment and document a multilayer regulatory

98 Runx2 is indispensable for osteoblast lineage commitment and early differentiation but also bl

99 signal leading to differential hematopoietic lineage commitment and enhanced thrombopoiesis.

100 al NSCs, Pnky knockdown potentiates neuronal lineage commitment and expands the transit-amplifying ce

101 ect of the ocular microenvironment on T cell lineage commitment and function, and the role of RA in t

102 (DCs), the transcriptional regulation of the lineage commitment and functional specialization of DCs

103 anscription factor E2-2 was shown to control lineage commitment and gene expression program of PDC.

104 e chromatin marks between genes induced with lineage commitment and genes induced with cell maturatio

105 ptor signaling, was induced during Th17 cell lineage commitment and governed Th17 cell differentiatio

106 RUNX1a, an isoform of RUNX1, parallels with lineage commitment and hematopoietic emergence from hPSC

107 r hierarchy in human megakaryocyte/erythroid lineage commitment and highlights the importance of usin

108 ematopoiesis that begins expression during T-lineage commitment and is required for this process.

109 cations for the role of ligand in gammadelta lineage commitment and its relationship to the specifica

110 t development, early during mesenchymal cell lineage commitment and later during osteoblast maturatio

111 critical developmental stages, including Eos-lineage commitment and lineage maturation.

112 al roles in stringent gene regulation during lineage commitment and maintenance.

113 lignant cells, yet the cellular stages of NK lineage commitment and maturation are incompletely under

114 semi-invariant TCR, which triggers NKT cell lineage commitment and maturation.

115 n this study, we defined the role of IRF8 in lineage commitment and neutrophil vs monocyte differenti

116 er stem and progenitor cell differentiation, lineage commitment and organogenesis during mammalian de

117 that super-enhancers underlie the identity, lineage commitment and plasticity of adult stem cells in

118 intained after the initial specification and lineage commitment and possibly throughout life.

119 tumor cells, could revert corneal epithelial lineage commitment and reinstate a normal p63-related si

120 ranscription 5) signaling to regulate T cell lineage commitment and SRC family kinase LCK and STAT5 s

121 role for Car enzymes in regulating mast cell lineage commitment and suggest that Car enzyme inhibitor

122 Cell-lineage commitment and terminal differentiation are disr

123 imethyl mark from H3K27, is required for the lineage commitment and terminal differentiation of neura

124 tally regulated chromatin transitions during lineage commitment and the molecular etiology of congeni

125 ness to Hippo signaling, the exact timing of lineage commitment and the overall relationship between

126 So what do terms like 'lineage commitment' and helper T-cell 'specification' me

127 sition from pluripotency through early multi-lineage commitment, and demonstrates that functional coo

128 ling can influence stem cell homeostasis and lineage commitment, and discuss the implications of this

129 as potent regulators of stem cell function, lineage commitment, and epigenetic status.

130 ibed to play a role in vascular development, lineage commitment, and in mesoderm differentiation into

131 sms are linked to transmission of cell fate, lineage commitment, and maintenance of cellular phenotyp

132 opoietic stem and progenitor cell expansion, lineage commitment, and maturation have been investigate

133 7R(+) compartment, show a partial block in B lineage commitment, and produce proB cells with aberrant

134 stage of development by factors involved in lineage commitment, and the architecture and chromatin s

135 Cellular differentiation and lineage commitment are considered to be robust and irrev

136 ontributions to early tissue development and lineage commitment are profound.

137 ence to suggest that molecular signatures of lineage commitment are reflected in apoptotic cascades a

138 , activation of genes marked by H3K27me3 and lineage commitments are delayed in Jmj(-/-) ESCs.

139 imens, our understanding of how the earliest lineage commitments are regulated remains narrow.

140 diate two distinct roles played by GATA-3 in lineage commitment, as revealed by removing wild-type or

141 through distinct pluripotent states, before lineage commitment at gastrulation.

142 ed T(H)17-cell differentiation during T(H)17 lineage commitment at least in part through its physical

143 e analysis of the exit from pluripotency and lineage commitment at the single cell level, a potential

144 we show the ability to discriminate between lineage commitments at early stages of culture different

145 ation of Ccr7 does not occur early during DC lineage commitment because monocytes and pre-DCs both ha

146 ERalpha cell autonomously regulates adipose lineage commitment, brown fat and smooth muscle cell for

147 novel and intriguing role for APP in neural lineage commitment but also identify a straightforward a

148 TCF-1 and LEF-1 were dispensable for T cell lineage commitment but instead were required for early t

149 tive thymocytes determines cell survival and lineage commitment, but the genetic and molecular basis

150 he transcription factor EBF1 promotes B cell lineage commitment by directly repressing expression of

151 asymmetric G-rich loop that controls cardiac lineage commitment by interacting with the transcription

152 at IRF8 regulates granulocyte vs monocyte/DC lineage commitment by oligopotent progenitors.

153 Mechanistically, the IVVY motif controls the lineage commitment by reprogramming osteoclast genes int

154 differentiation is not irreversible and that lineage commitment can be overridden following severe ti

155 ossess enhanced proliferative, survival, and lineage commitment capacity that could account for the e

156 ing development is critical to ensure proper lineage commitment, cell fate determination, and ultimat

157 ne expression can lead to drastic changes in lineage commitment, cellular function, and immunity.

158 hematopoietic stem cells undergo a number of lineage commitment decisions that ultimately lead to the

159 These differences permit lineage commitment decisions to be made in different hie

160 ust and broad gene regulation during crucial lineage commitment decisions.

161 matopoietic stem cell (HSC) self renewal and lineage commitment depend on complex interactions with t

162 tudied proteins, the role of Hb in erythroid lineage commitment, differentiation, and maturation rema

163 in our understanding of the regulation of DC lineage commitment, differentiation, diversification, an

164 ass-restricted binding impacts signaling and lineage commitment, discussing TCR force-driven conforma

165 ocess orchestrated by exquisitely timed cell lineage commitment, divisions, migration, and morphologi

166 grams, which in turn determine cell fate and lineage commitment during development.

167 ally steer the HPSC differentiation to mimic lineage commitment during gastrulation to ectoderm (earl

168 y, Foxa2, and Sox17 directs proper stem-cell lineage commitment during streak formation.

169 Processes that require p63 include epidermal lineage commitment, epidermal differentiation, cell adhe

170 However, the role of lineage commitment factor Bcl11b has been unclear.

171 o block B cell development did not require T lineage commitment factor Bcl11b.

172 show that IDO-competent cells express the B-lineage commitment factor Pax5 and surface immunoglobuli

173 Here we show that Bcl11b, known as a T-lineage commitment factor, is essential for proper expre

174 though dispensable during lymphopoiesis post lineage commitment, FADD plays a critical role in early

175 cur within hours of stimulation forecast the lineage commitment fates of human mesenchymal stem cells

176 sity may have important consequences for MSC lineage commitment, fetal fat accrual, and offspring obe

177 insights into dynamics of HSPC expansion and lineage commitment following autologous transplantation.

178 scription factors specifying osteoclast (OC) lineage commitment from monocyte/macrophage remains uncl

179 wing Ad5 immunization exhibited impaired Th1 lineage commitment, generating significantly decreased T

180 pG loci within the promoter regions of Th1/2 lineage commitment genes (GATA3, IL-4, IL-4R, STAT4 and

181 ent repression of muscle differentiation and lineage commitment genes and observed that the loss of P

182 l17) partially conform to the expectation of lineage commitment, genes encoding transcription factors

183 y, important clues to the molecular basis of lineage commitment have been provided by the recent iden

184 In contrast, exit from pluripotency and lineage commitment have not been studied systematically

185 Because lineage commitment hierarchies differ between embryo and

186 e factors, the inability of CPCeA to undergo lineage commitment hinders their capacity to provide fun

187 ding facilitating mechanistic studies of MEP lineage commitment, improving approaches for in vitro ex

188 cal inhibition of Akt alleviated blockade of lineage commitment in CPCeA.

189 ed with both maintenance of pluripotency and lineage commitment in embryonic stem cells, and TET1 bin

190 the earliest steps between pluripotency and lineage commitment in ESCs and find a critical role for

191 an epigenetic mechanism for maintaining cell lineage commitment in ESCs and iPSCs that can be used to

192 ut its role in self-renewal, pluripotency or lineage commitment in ESCs remains undefined.

193 dulates the balance between self-renewal and lineage commitment in ESCs.

194 tion factor Sp7 (osterix) during mesenchymal lineage commitment in mammalian cells.

195 We found that Bcl11b is necessary for T lineage commitment in mice and is specifically required

196 ramming and their enhancement of granulocyte lineage commitment in response to E. coli bacteremia.

197 F-6) are two genetic factors known to affect lineage commitment in the bipotential hepatoblast progen

198 roteins, the key architects of CD4(+)-CD8(+) lineage commitment in the thymus, is critical for CD4(+)

199 quired for development, differentiation, and lineage commitment in various tissues including the inte

200 n GSCs and is essential for self-renewal and lineage commitment in vitro.

201 However, CPCeA exhibit impaired capacity for lineage commitment in vitro.

202 propose that CHD4 allows cells to undertake lineage commitment in vivo by modulating the frequency w

203 The last stage of T lineage commitment in vivo involves mechanisms to suppre

204 data support a novel paradigm in lymphocyte lineage commitment in which the E2A proteins are necessa

205 repressive chromatin states during mesoderm lineage commitment, in particular the activation of deve

206 ractomes of three mouse cells of progressive lineage commitment, including pluripotent embryonic stem

207 ive dynamics of cis-regulatory contacts upon lineage commitment, including the acquisition and loss o

208 ll population followed by the onset of multi-lineage commitment is a fundamental aspect of developmen

209 In the mouse, lineage commitment is achieved by epigenetic regulation

210 duction system has provided insight into how lineage commitment is achieved.

211 Lymphoid lineage commitment is an important process in haematopoi

212 controlling progenitor cell self-renewal and lineage commitment is critical for harnessing these cell

213 d activity of cis-regulatory elements during lineage commitment is crucial for understanding developm

214 ent in CPCeA-treated hearts demonstrates CPC lineage commitment is essential to the regenerative resp

215 In ZBTB20-null mice, although lactotrope lineage commitment is normally initiated, somatolactotro

216 These findings reveal that Treg cell lineage commitment is not only controlled by genetic and

217 on, in which the chance loss of cells due to lineage commitment is perfectly compensated by the dupli

218 and function, whereas the early T(reg)-cell-lineage commitment is regulated by the Akt kinase and th

219 Lineage commitment is regulated during hematopoiesis, wi

220 The first mammalian cell lineage commitment is the formation of the trophectoderm

221 its role at the different steps of stem cell lineage commitment is unclear.

222 Pou5f3 (homologous to mammalian Oct4) drives lineage commitment is unclear.

223 tenance, but whether telomere length affects lineage commitment is unknown.

224 known as E2A), a regulator of B- and T-cell lineage commitment known to be involved in HL pathogenes

225 matin states are established at the stage of lineage commitment, largely independently of GATA1.

226 on of HSC required for their maintenance and lineage commitment (Liu et al, 2014).

227 plays critical roles in regulating lymphoid lineage commitment, mature B-cell development, and the G

228 er hypothesized that sFRP2 inhibition of MSC lineage commitment may reduce heterotopic osteogenic dif

229 To clarify lineage commitment mechanisms, we followed developing T

230 NA) known to control mouse hematopoiesis and lineage commitment might contribute to the ability of 1,

231 on (NuRD) complex, which is required for ESC lineage commitment, modulates both transcriptional heter

232 tent progenitor states, with the first major lineage commitment occurring in multipotent progenitors,

233 ave been discovered, the mechanisms by which lineage commitment occurs are not fully understood.

234 ome appears to be linked to pluripotency and lineage commitment of a cell.

235 hylation patterns plays an important role in lineage commitment of adult stem cells and that it could

236 ctors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development through

237 Molecules that control the lineage commitment of hematopoietic stem cells (HSCs) ma

238 view of promoter interactome dynamics during lineage commitment of human pluripotent cells.

239 ays a pivotal role in cell fate decision and lineage commitment of lymphocytes.

240 Mechanical cues direct the lineage commitment of mesenchymal stem cells (MSCs).

241 l cues play important roles in directing the lineage commitment of mesenchymal stem cells (MSCs).

242 al regulator of definitive hematopoiesis and lineage commitment of murine hematopoietic stem and prog

243 or the proliferation, self-renewal, and cell lineage commitment of neural stem/progenitor cells.

244 deacetylation complex (NuRD) is required for lineage commitment of pluripotent cells; however, the me

245 ression broadly fall into three domains: the lineage commitment of pluripotent stem cells, the approp

246 ZD-selective fashion, enhance the osteogenic lineage commitment of primary mouse and human mesenchyma

247 understanding the factors that influence the lineage commitment of stem cells.

248 trol of genes involved in the attraction and lineage commitment of T cell precursors, Foxn1 regulates

249 closely integrated and likely encoded during lineage commitment of T effectors.

250 defined RNA motif to regulate cardiovascular lineage commitment, opening the door for exploring broad

251 sociated with significant changes in CD4/CD8 lineage commitment or activation profile.

252 cell differentiation have focused on initial lineage commitment or proximal differentiation events.

253 C-released factors deflect CHIR99021-induced lineage commitment over time.

254 establish an early branch point for separate lineage-commitment pathways from hematopoietic stem cell

255 rtant implications for studies of melanocyte lineage commitment, pigmentation disorders and cell repl

256 re, we show that E4bp4 is required at the NK lineage commitment point when NK progenitors develop fro

257 uired in postselection thymocytes for helper lineage commitment, presumably mediating the maintenance

258 ineage-restriction stage at which the T cell lineage-commitment process transits from the bone marrow

259 Furthermore, the DP lineage commitment program can be exploited for generati

260 rom the pluripotent state or upregulation of lineage commitment programs.

261 a as the key transcriptional regulator of OC lineage commitment, providing a unique therapeutic targe

262 ponents controlling enhancer turnover during lineage commitment remain largely unknown.

263 the connection between marker expression and lineage commitment remains unclear.

264 nderstood, especially since efficient T-cell lineage commitment requires a reduction in Notch signall

265 T lineage commitment requires the coordination of key tran

266 romoter in precursor cells to make Treg cell lineage commitment responsive to a broad range of TCR st

267 aive T cell activation, differentiation, and lineage commitment result in epigenetic changes and a fi

268 influence epigenetic changes associated with lineage commitment, specification, and self-renewal.

269 precise signaling pathways that govern their lineage commitment still remain enigmatic.

270 Lineage commitment studies in mammary glands have focuse

271 sed' enhancers and at genes involved in HSPC lineage commitment suggest that CD34+ cell subtype heter

272 in culture while maintaining their intrinsic lineage commitment suggests their potential in stem cell

273 interconnected: the role of TCR signaling in lineage commitment, the regulation of expression of the

274 , in contrast to TCF1, controls human T-cell lineage commitment through direct regulation of three di

275 and iTreg master regulators prescribe T cell lineage commitment through interactions with each other,

276 e osteoclast lineage and RANKL regulates the lineage commitment through the IVVY motif.

277 Thus Pcid2 controls lymphoid lineage commitment through the regulation of SRCAP remod

278 f kinases that can block the transition from lineage commitment to a differentiating state in myoblas

279 nx proteins and Cbfbeta restrict granulocyte lineage commitment to facilitate multilineage hematopoie

280 Lung stem cells undergo self-renewal or lineage commitment to replenish tissue, depending on cro

281 fate in GMPs, but instead acts downstream of lineage commitment to selectively control neutrophil and

282 el for nucleotide biosynthesis regulates HSC lineage commitment under conditions of metabolic stress.

283 Given the central role of ThPOK in lineage commitment, understanding its upstream regulatio

284 en mESC differentiation from pluripotency to lineage commitment, using an unbiased single-cell transc

285 ogical agents modulate shape-based trends in lineage commitment verifying the critical role of focal

286 study demonstrate that IKKalpha regulates B-lineage commitment via combined canonical and noncanonic

287 we show that T-bet negatively regulates Th17 lineage commitment via direct repression of the transcri

288 f focal adhesion formation and osteochondral lineage commitment was observed as a function of both fe

289 In addition, the potential for T lineage commitment was radiation sensitive with aging.

290 m by which transcription factors regulate OC lineage commitment, we mapped the critical cis-regulator

291 ies have elucidated key elements influencing lineage commitment, we still lack a full understanding o

292 Del-1-induced HSC proliferation and myeloid lineage commitment were mediated by beta3 integrin on he

293 CD161 is a marker informative of the NK cell lineage commitment, whereas CD56, CD117, and CD94/NKG2A

294 , were less quiescent and showed accelerated lineage commitment, which resulted in progressive deplet

295 enitor-Like (iPL)" cells, which can maintain lineage commitment while undergoing controlled expansion

296 pe 0 (Th0), Th1, Th17, and regulatory T-cell lineage commitment, with dampened cytokine production an

297 The cell cycle molecules that specify lineage commitment within the early pancreas are unknown

298 ATA6 levels regulate the timing and speed of lineage commitment within the ICM.

299 data demonstrate the critical importance of lineage commitment within the tumor cell-of-origin in de

300 d in pluripotency, tumor initiation, early B-lineage commitment, Wnt/Ras signaling and the epithelial