ライフサイエンスコーパス: lineage-specific

1 nd neuraminidase combinations being strongly lineage specific.

2 ated regulation of cell expansion seem to be lineage-specific.

3 fic whereas the majority (94.4%) are primate lineage-specific.

4 ross the angiosperms and, in most cases, are lineage-specific.

5 lox/flox);CAG-CreER) or oligodendrocyte (OL)-lineage specific ablation (Lrp1(flox/flox);Pdgfra-CreER)

6 karyotic genomes, which predicts continuous, lineage-specific acquisition of prokaryotic genes in div

7 fates; such repressors, in combination with lineage-specific activators, would be prime candidates f

8 st providing ohnologues available solely for lineage-specific adaptation.

9 scoideum indicate that the TPS genes mediate lineage-specific adaptations.

10 Here, we describe a lineage-specific, adeno-associated virus (AAV)-derived e

11 Lineage-specific analysis of mitochondrial protein evolu

12 Both symbiotic systems are lineage specific and differ in the number of UCYN-A cell

13 led patterns of neuronal diversification are lineage-specific and can differ drastically even among n

14 ecialized metabolic enzymes, which are often lineage-specific and derived from gene duplication follo

15 m plastomes was a mixture of locus-specific, lineage-specific and IR-dependent effects.

16 therefore, shows that metabolic switching is lineage-specific and not a required step for exit of plu

17 trate the ongoing ability of EBOV to develop lineage-specific and potentially phenotypically importan

18 Loci transcribing both lineage-specific annotated and novel lncRNA are adjacent

19 Using myeloid lineage-specific APC depletion in mice, we found that mo

20 lack cellulases but encode a distinctive and lineage-specific array of mostly intracellular carbohydr

21 This expansion shows strong lineage-specific aspects, most notably that hypomethylat

22 overlap between resistant and hypervirulent lineages, specific bacterial and host factors contributi

23 mary normal or SCD human HSCs expressing the lineage-specific BCL11A shRNAmiR gave rise to erythroid

24 es of the Rad51/RecA family and also reveals lineage-specific behaviors reflecting properties that ar

25 The roles of these factors are not always T-lineage-specific, but they balance and modulate each oth

26 Thus, Phf6 is a "lineage-specific" cancer gene that plays opposing roles

27 al targets was determined by a Cre-mediated, lineage-specific, CB1 expression-rescue strategy in a CB

28 Lineage-specific cell ablation leads to diminished conne

29 Lineage-specific cell depletion revealed that Tregs prom

30 L1 and the CAL1 N terminus, as critical for lineage-specific CENP-A incorporation.

31 Instead, it was contingent on a lineage-specific change to an overlapping transcription

32 expansion and controls the proliferation and lineage-specific characteristics of their progeny.

33 incidence and severity, time to engraftment, lineage-specific chimerism, immune reconstitution, and d

34 re are no large studies looking at long-term lineage-specific chimerism.

35 through the establishment and maintenance of lineage-specific chromatin and methylation status.

36 expression regulation, our studies identify lineage-specific chromatin architectures and associated

37 ds directly to promoters and associates with lineage-specific chromatin interactions and gene express

38 served in pluripotent cells, suggesting that lineage-specific chromatin structure is established in t

39 We found lineage-specific clusters that derive from transposition

40 oring genes can also be included in species-/lineage-specific comparisons.

41 , introduced, and Gulf lineages to determine lineage-specific controls on rhizosphere bacteria.

42 y, our phylogenetic analysis revealed rodent lineage-specific CPAMD8 deletion, precluding a developme

43 erimental K14.Cre (+) .Foxo1 (L/L) mice with lineage-specific Cre recombinase deletion of floxed FOXO

44 This identification of region- and lineage-specific crosstalk between epithelium and their

45 ental program and uncover the targeting of a lineage-specific cytokine signaling by miRNAs as a mecha

46 s, the memory cells are capable of producing lineage specific cytokines much more rapidly than the na

47 G-CSF and M-CSF are two lineage-specific cytokines that play a dominant role in

48 In 5 patients, overall and lineage-specific DC were </=10% for >6 months (median, 5

49 Second, we find evidence of lineage-specific de novo evolution for many genes, inclu

50 We found allele-specific and lineage-specific de novo methylation at CG and CH sites

51 notype and revealed cellular, molecular, and lineage specific defects following knockdown of transcri

52 development, we generated mice with a T cell lineage-specific deficiency in N-myristoyl transferase (

53 arrest in hematopoietic progenitors, myeloid lineage specific deletion of C/EBPalpha resulted in sign

54 Pharmacologic antagonism of AhR or its lineage-specific deletion in CD11c(+) cells abrogated th

55 We found here that lineage-specific deletion of components of the Notch pat

56 Lineage-specific deletion of EGFR in Tregs resulted in r

57 nd disease susceptibility, whereas Treg-cell-lineage-specific deletion of Il4 and Il13 was protective

58 We hypothesized that lineage-specific deletion of Ship1 expression in cells k

59 We previously demonstrated that myeloid lineage-specific deletion of SOCS3 resulted in a severe,

60 By lineage-specific deletion of the forkhead box-O 1 (FOXO1

61 Here, we have demonstrated that induced B lineage-specific deletion of the gene encoding RAPTOR, a

62 opment and function, we analyzed mice with B lineage-specific deletion of the HuR gene.

63 -responsive cells by generation of mice with lineage-specific deletion of the receptor for IFN-lambda

64 We also compared the results with mice with lineage-specific deletion of the transcription factor FO

65 We demonstrate using lineage-specific deletions of IL-10Ralpha that IL-10 act

66 Prostate cancer exhibits a lineage-specific dependence on androgen signaling.

67 Steroid hormones mediate critical lineage-specific developmental and physiologic responses

68 We propose that miRNAs compensate for lineage-specific differences in egl-1 transcriptional ac

69 This work defines lineage-specific differences in layer 3 from HIV-1 and S

70 This work defines lineage-specific differences in layer 3 from HIV-1 and t

71 idual progenitors balancing self-renewal and lineage-specific differentiation has never been describe

72 h Runx3 as a key transcription factor in the lineage-specific differentiation of ILC1 and ILC3 cells.

73 We further observe enhanced unbiased lineage-specific differentiation potential of naive hESC

74 The lineage-specific differentiation states of cells from th

75 Efficient lineage-specific differentiation was confirmed by unifor

76 Recent studies indicate that stem cells show lineage-specific differentiation when cultured on substr

77 ulation of Sox21 expression in TSCs affected lineage-specific differentiation, based on both marker a

78 ons in the ability of these cells to undergo lineage-specific differentiation.

79 , we show its utility as a method to control lineage-specific differentiation.

80 To prioritize lineage-specific, disease-associated lncRNA expression,

81 ly over tens of millions of years, promoting lineage-specific diversification regimes under prevailin

82 uring land plant evolution, with evidence of lineage-specific diversification.

83 Here, we identify lineage-specific DNA methylation at an alternate, non-CG

84 We also observed lineage-specific DNA methylation between myeloid and lym

85 Large- and small-scale lineage-specific duplications have contributed to the ex

86 Gene family analyses reveal lineage-specific duplications of genes involved in the t

87 Therefore, lineage-specific effects of IL-10 skew the cytokine depe

88 utilizing HSC gene transfer techniques using lineage-specific endogenous gene promoters to confine tr

89 amily protein that plays pioneering roles in lineage-specific enhancer activation and gene transcript

90 This indicates that distinct lineage-specific enhancer platforms regulate a shared ne

91 d in ETPs to establish and maintain a T-cell-lineage-specific enhancer repertoire, including regulato

92 plexes are preferentially targeted to distal lineage specific enhancers and interact with p300 to mod

93 on by constraining the activation of dormant lineage-specific enhancers and promoters.

94 is revealed that Jmjd2c is re-distributed to lineage-specific enhancers during ESC priming for differ

95 Examination of lineage-specific enhancers identifies transcription fact

96 nd female germline stem cells identifies the lineage-specific enhancers involved in germline stem cel

97 s of single nucleotide polymorphisms in core lineage-specific enhancers revealed disease associations

98 MED12 deletion destabilizes P300 binding at lineage-specific enhancers, resulting in H3K27Ac depleti

99 ut also remodel the epigenetic signatures at lineage-specific enhancers, which is mediated, at least

100 he assembly of mediator-cohesin complexes at lineage-specific enhancers.

101 ns of epigenomes we can detect developmental lineage-specific enhancers.

102 notyping to fine map causal polymorphisms in lineage-specific enhancers.

103 hat EBF2 binds and regulates the activity of lineage-specific enhancers.

104 in which de novo methylation creates a cell-lineage-specific epigenetic signature that controls gene

105 ram, TP53 may tune its response based on the lineage-specific epigenomic landscape.

106 a major branch of innate immunity, and that lineage-specific ERVs have dispersed numerous IFN-induci

107 d G. soja, the evolution of FT2c is a G. max lineage specific event.

108 Although there was a paucity of lineage specific events, we did find one 54 kb deletion

109 an important factor in plant evolution, and lineage-specific expanded (LSE) genes are of particular

110 Gene tree analyses suggest recent, lineage-specific expansion and diversification among hom

111 O. sinensis displays considerable lineage-specific expansion of gene families functionally

112 Lineage-specific expansion of GFP-encoding genes in the

113 TEs exhibit dynamic lineage-specific expansion, and many viper TEs show brai

114 to a recent whole-genome duplication event, lineage-specific expansions of genes associated with fla

115 mics concerns the mechanisms responsible for lineage-specific expansions of genome size in eukaryotes

116 e from ancestral DNA exaptation, rather than lineage-specific expansions of repeat elements.

117 tinct isoHb clades, and provided evidence of lineage specific expression of particular isoHbs.

118 t sequences as templates in association with lineage-specific expression of cytidine deaminases.

119 Lineage-specific expression of defense-related genes was

120 n-1/2-deficient NKT17 cells show exaggerated lineage-specific expression of nearly all NKT17-defining

121 structure and regulatory features directing lineage-specific expression of Runx genes, the models of

122 ype identity by establishing and maintaining lineage-specific expression profiles, yet reconstruction

123 Thus, lineage specific factors largely mediate enhancer-promot

124 ption of ribosomal genes and upregulation of lineage-specific factors coordinately controls lineage d

125 ability of genomic regions for activation by lineage-specific factors is regulated in part through dy

126 Second, lineage-specific factors might prevent asexuals from rea

127 Collectively, we identify the lineage-specific function of CDC42 in lung tumorigenesis

128 Together, our data reveal novel, lineage-specific functions for E2F-2 and suggest that so

129 Coupled with lineage-specific G1 lengthening, a divergent ciliation p

130 l lineages in the ventral nervous system via lineage-specific GAL4 lines and molecular markers.

131 ng and repressing components that determines lineage-specific gene expression and cellular differenti

132 dy we examined the role of BRD4 in promoting lineage-specific gene expression and show that BRD4 is e

133 te differentiation and broad deregulation of lineage-specific gene expression during mesoderm inducti

134 on machinery, are essential for establishing lineage-specific gene expression programs during cell di

135 ific DNA within promoter regions to regulate lineage-specific gene expression, either as activators o

136 factor 2 (EBF2) selectively activates brown lineage-specific gene expression.

137 ction strategies are linked to radiations of lineage-specific gene families.

138 bottle gourd and other cucurbits, as well as lineage-specific gene family expansions in bottle gourd.

139 iptome analysis of heart development reveals lineage-specific gene programs underlying normal cardiac

140 hromatin organization in normal and aberrant lineage-specific gene transcription.

141 ntrinsic factor that controlled an iNKT-cell lineage-specific gene-expression program and epigenetic

142 gene expression that involves activation of lineage specific genes and repression of pluripotency ge

143 cell cycle progression on the expression of lineage specific genes in precursor cells, and suggests

144 The discovery of salamander lineage-specific genes (LSGs) expressed during limb rege

145 cell types through coordinated expression of lineage-specific genes and modification of complex chrom

146 ression and are intragenic or adjacent to TH lineage-specific genes encoding proteins with immunologi

147 ylation of histone 3 lysine 27 (H3K27me3) at lineage-specific genes has been linked to the repression

148 While many of the EIEC lineage-specific genes have unknown functions, those wit

149 Epigenetic regulation of lineage-specific genes is important for the differentiat

150 organelle functions, as well as a number of lineage-specific genes of unknown function, in response

151 suggest that a unique subset of enhancers in lineage-specific genes that are accessible for regulator

152 ding to Rybp upregulation and suppression of lineage-specific genes via RYBP-dependent ubiquitination

153 Lineage-specific genes were differently expressed betwee

154 sed on their functions and the expression of lineage-specific genes, including those encoding effecto

155 supports the Polycomb-mediated repression of lineage-specific genes, independent of p53.

156 luding changes in the spatial arrangement of lineage-specific genes, nuclear bodies, and heterochroma

157 es showed that activated lncRNAs can repress lineage-specific genes, while lncRNAs activated in multi

158 racts with p300 to activate oligodendroglial lineage-specific genes, while suppressing astroglial dif

159 omote transforming lesions at cell type- and lineage-specific genes.

160 ng preference for stage-specific rather than lineage-specific genes.

161 velopmental process by activating a group of lineage-specific genes.

162 ons in regions of low gene density and maize lineage-specific genes.

163 stages of murine brain development by using lineage-specific genetic ablation of TRF2, an essential

164 t ultimately demonstrates the maintenance of lineage-specific genetic variation among local populatio

165 e by RNA polymerase (RNAP), the functions of lineage-specific Gfh proteins remain unknown.

166 Osteoclast-lineage-specific Gna13 conditional knockout mice have a

167 helial cells and induced erythroblasts using lineage-specific growth factors.

168 00 murine haematopoietic cells, to infer the lineage-specific haematopoietic activity present in huma

169 Burn/tenotomy performed in lineage-specific Hif1alpha knockout mice (Prx-Cre/Hif1al

170 ght into how developing thymocytes translate lineage-specific high-affinity TCR signals to adopt the

171 We identify a few human lineage-specific hub genes that have evolved brain devel

172 Lineage-specific hypomethylated regions are enriched nea

173 ferences that were subsequently amplified by lineage-specific innovations after divergence.

174 Plasmodium falciparum utilizes a battery of lineage-specific innovations to invade and multiply in h

175 ing function of E proteins is facilitated by lineage-specific isoform expression and by BET-dependent

176 In contrast, NRF2 activation through cell lineage-specific Keap1 disruption (i.e., in T cells, mye

177 Experiments with cell-lineage-specific knockouts revealed that stabilin-1 expr

178 differential loss; and (3) that continuous, lineage-specific lateral gene transfer, although it some

179 functional role and molecular mechanism of a lineage-specific Linc-RAM as a regulatory lncRNA require

180 The Vd991 genome harbored several exclusive, lineage-specific (LS) genes within LS regions (LSRs).

181 t on the epigenetics and cellular origins of lineage-specific lung tumours.

182 demonstrate that lncRNAs are expressed in a lineage-specific manner and control the development of s

183 shown that lncRNAs are expressed in a highly lineage-specific manner and control the differentiation

184 opean Americans do not vary in an allele- or lineage-specific manner, unlike the differential express

185 y elements that repress gene expression in a lineage-specific manner.

186 commissioning' phase that is controlled in a lineage-specific manner.

187 PAL is currently defined by a limited set of lineage-specific markers proposed in the 2008 World Heal

188 ell-derived cardiomyocytes and characterized lineage-specific maturation defects in hearts of mice wi

189 cally distinct from the established model of lineage-specific maturation.

190 cates that sex is often stabilized by highly lineage-specific mechanisms.

191 in lymphoid and myeloid disease, suggesting lineage-specific methylation aberrations promoted by Dnm

192 Only a few lineage-specific miRNAs have been studied for evolutiona

193 Here, we explore the use of species and lineage specific models for the prediction of DNA-bindin

194 SIN-vector: one controlled by an endothelial lineage-specific, murine vascular endothelial cadherin (

195 ulate neural temporal fate by RNA-sequencing lineage-specific neuroblasts at various developmental ti

196 neuroblast lineages, we marked and isolated lineage-specific neuroblasts for RNA sequencing.

197 different neuroblasts may govern the diverse lineage-specific neuron fates.

198 ype-specific transcription factors can drive lineage-specific neuronal reprogramming, providing a gen

199 Alu elements are major contributors to lineage-specific new exons in primate and human genomes.

200 F-kappaB p65 binding analyses demonstrated a lineage specific, NF-kappaB-dependent transcriptional pr

201 Lineage-specific novel lncRNA loci are transcribed from

202 ariability, identifying a potential role for lineage-specific nuclear topology.

203 Here we propose a model, 'lineage-specific ohnologue resolution' (LORe), to addres

204 master transcription factor p63 to maintain lineage-specific open chromatin regions.

205 ts megakaryocyte development by modulating a lineage-specific P-TEFb activation mechanism, revealing

206 T-cell cultures and those that display a TH lineage-specific pattern of expression and are intrageni

207 ce of many LORe ohnologues with functions in lineage-specific physiological adaptations that potentia

208 Thus, histamine couples lineage-specific physiological demands to intrinsically

209 subject to regulated cell type-specific and lineage-specific positioning and correlates with the acc

210 We also found evidence for lineage-specific positive selection on a subset of genes

211 N system and that interferomes are shaped by lineage-specific pressures.

212 Basal lineage-specific profiling and genetic loss-of-function

213 iptomes of human embryonic stem cell-derived lineage-specific progenitors by single-cell RNA-sequenci

214 tages of B-cell development largely prevents lineage-specific programmed demethylation events.

215 Lineage-specific programming of oligodendrocytes results

216 st recent genetic fate-mapping studies using lineage-specific promoters have provided valuable insigh

217 c annotated and novel lncRNA are adjacent to lineage-specific protein-coding genes in the genome.

218 oded proteome had a much higher incidence of lineage-specific proteins than the cytosolic fraction (5

219 Lineage-specific proteome differences indicate that vert

220 ely early, massively independently, and with lineage-specific rates.

221 Loss of sexual-lineage-specific RdDM causes mis-splicing of the MPS1 ge

222 oxins relevant for both species, whereas the lineage-specific receptors enable the detection of subst

223 OSTN is a crucial factor for proper exocrine lineage-specific regeneration after severe acute pancrea

224 c to certain types of tissues or cells, e.g. lineage-specific regulatory elements.

225 Lineage-specific relaxation of functional constraints on

226 Groucho (also known as TLE), are considered lineage-specific repressors, it remains unclear how iden

227 This pharmacological approach to lineage-specific reprogramming may have many important t

228 Tissue-specific networks predict lineage-specific responses to perturbation, identify the

229 on of genetics, retroviral fate mapping, and lineage-specific retroviral barcode labeling, we find th

230 in phosphoinositol metabolism critical for a lineage-specific Rickettsia entry mechanism.

231 e eight-cell stage to postimplantation using lineage-specific RNA sequencing.

232 erg and van den Heuvel identify an important lineage-specific role for a SWI/SNF chromatin-remodeling

233 Moreover, cell lineage-specific scUMCs are associated with essential de

234 at cis-regulation can evolve under polygenic lineage-specific selection in prokaryotes.

235 that genes encoding kinases show evidence of lineage-specific selection on their cis-regulation.

236 However, applying the sign test for lineage-specific selection revealed the polygenic up-reg

237 in and among orders, possibly resulting from lineage-specific selective pressures inherent to each ta

238 sideration when selecting common, apparently lineage-specific self-antigens as targets for TCR-based

239 Harnessing an osteogenic lineage-specific Shox2 inactivation approach we show tha

240 Lineage-specific, shRNAmiR-mediated suppression of BCL11

241 directed into various cell types via soluble lineage-specific signals, without establishing a pluripo

242 he subset of their target loci that requires lineage-specific silencing.

243 In conclusion, an endothelial lineage-specific single inducible SIN lentiviral vector

244 The HPV11 (sub)lineage-specific SNPs and the representative region iden

245 HPV11 (sub)lineage-specific SNPs within the CG were identified, as

246 To characterize lineage-specific, spatiotemporal developmental programs,

247 tion, yet the functions of most species- and lineage-specific splicing events are not known.

248 ever, small-molecule approaches for inducing lineage-specific stem cells from somatic cells across li

249 nerve-derived Shh is a critical regulator of lineage-specific stem cells that maintain specialized se

250 Thus, lineage-specific stiffness and cyclic stretch can be app

251 We hypothesized that combining lineage-specific stiffness with cyclic stretch would res

252 tracellular bacteria with both conserved and lineage-specific strategies for invading and surviving w

253 We predict Th17 lineage specific subnetworks that are activated sequenti

254 toolkit', with reduced numbers of PCWDEs and lineage-specific suites of mycorrhiza-induced genes.

255 of a 3D contact domain comprising IGF2 and a lineage-specific super-enhancer, resulting in high-level

256 ed by all subtypes, such as SPRY1, and other lineage-specific super-enhancers, such as SOX2 in brain-

257 The structure reveals details of Vpx lineage-specific targeting of SAMHD1 N-terminal "degron"

258 a macrophage differentiation system that the lineage-specific TF PU.1 keeps macrophage-specific genes

259 Most lineage specific TFs were stochastically expressed in th

260 l "window of opportunity" for recruitment of lineage-specific TFs to DNA.

261 hat were highly stage specific and were more lineage specific than those of protein-coding genes.

262 an phylogenetic analyses corroborate several lineage-specific TLR gene expansions in urchins and ceph

263 the origin of new genes and the emergence of lineage-specific traits in both prokaryotes and eukaryot

264 These lineage-specific trajectories reveal the expression of n

265 SD1 to an altered expression pattern of lung-lineage specific transcription factors and genes, which

266 opoietic system depends on the expression of lineage specific transcription factors.

267 cell identity, enabling us to identify a new lineage-specific transcription factor that instructs PN

268 FOXP3 is a lineage-specific transcription factor that is required f

269 The CD4(+) lineage-specific transcription factor Thpok is required

270 demonstrates that minimal reduction of a key lineage-specific transcription factor, which commonly oc

271 Lineage-specific transcription factors (TFs) are importa

272 These three lineage-specific transcription factors are consistently

273 l enhancers that are co-occupied by multiple lineage-specific transcription factors driving expressio

274 cell polarity proteins, HIPPO signaling and lineage-specific transcription factors such as CDX2.

275 egulating these genes, but instead regulates lineage-specific transcription factors that control spat

276 dulate cell growth by facilitating access of lineage-specific transcription factors to enhancer reper

277 Expression of lineage-specific transcription factors, including the er

278 ole in regulating chromatin accessibility to lineage-specific transcription factors.

279 such identity can be imparted by additional lineage-specific transcription factors.

280 ession of Cebpa and Gata1, myeloid/erythroid lineage-specific transcription factors.

281 rogram that is tightly controlled by myeloid lineage-specific transcription factors.

282 lly uses overexpression of the corresponding lineage-specific transcription factors.

283 rs from de novo methylation to ensure robust lineage-specific transcription upon differentiation.

284 ietic TF, thereby interfering with essential lineage-specific transcriptional circuits in this diseas

285 ssed Stat5a/b locus is subject to additional lineage-specific transcriptional control in mammary epit

286 the establishment of accessible chromatin at lineage-specific transcriptional enhancers and promoters

287 work due to changes in the global targets of lineage-specific transcriptional master regulators such

288 ions through an EMT-mediated disruption of a lineage-specific transcriptional network.

289 s signaling cascades that ultimately dictate lineage-specific transcriptional outputs.

290 ts the dynamics of proliferation and loss of lineage-specific transposable elements; and (3) that var

291 ve variation in the amount of DNA gained via lineage-specific transposition, but that DNA loss counte

292 ECFCs) have received widespread attention as lineage-specific 'true' vascular progenitors.

293 important functions fully explains the cell lineage-specific tumorigenesis.

294 A-485 selectively inhibited proliferation in lineage-specific tumour types, including several haemato

295 cific novel lncRNA loci are transcribed from lineage-specific typical- and supertranscriptional enhan

296 was designed to assess high-risk HPV variant lineage-specific vaccine efficacy (VE).

297 These data demonstrate HLA-A allelic lineage-specific variation in expression levels, and DNA

298 A Myrtales lineage-specific whole-genome duplication event was dete

299 show that conditional deletion of the ST/PE lineage-specific Wilms' tumor suppressor gene (Wt1) in t

300 n governed the subsequent diversification of lineage-specific wing forms.