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1 drug actions on ion channel function are not linear.
2 en alkynes to generate a structurally rigid, linear 1,3-diyne linkage has been known for over a centu
6 rfold higher following administration of the linear agents gadodiamide and gadobenate dimeglumine com
8 e sigmoid on a log-log plot is very close to linear, allowing the unknown endogenous concentration to
9 ers a regioselectivity switch, allowing both linear and branched isomers to be prepared with high sel
11 We provide examples of learning linear, non-linear and chaotic dynamics, as well as the dynamics of
12 The method can be applied to synthesize both linear and cyclic peptides, as well as peptides composed
14 Postoperative findings were compared with linear and generalized linear mixed-effects regression m
19 e as a function of the input pump power, the linear and nonlinear losses, and the coupling factors.
20 brain metabolism were modeled using multiple linear and nonlinear mathematic equations, and the signi
21 plaque score, and periodontal severity with linear and ordinal logistic regression models before and
24 different RNA hybridization networks with a linear architecture, and we implemented them in Escheric
25 fc = 1,1'-ferrocenediyl), composed of a near linear arrangement of donor atoms, exhibits a large ener
30 treatment as covariates, revealed a positive linear association between PCSK9 levels and the risk of
32 The mass-transport regime is altered from "linear" at very short time, where the amperometric respo
33 romatic stabilization energy, while extended linear benzannelation results in increased retro-Bergman
34 w a network of spiking neurons can learn non-linear body dynamics using local, online and stable lear
36 n disease severity and dopamine loss appears linear, but the majority of longitudinal studies point t
37 d method is simple, fast (<12.0min), present linear calibration curves (r(2)=0.995), and relative sta
42 his method to be used for fingerprinting and linear combination analysis of known XANES reference com
45 ementary to the physical potentials, where a linear combination of the profile score with the FoldX p
48 es and employed a curve fitting approach for linear comparison of cell types and introduced a novel s
49 -FET was tested for NADH detection showing a linear concentration range 1aM to 1nM and a low detectio
51 es are observed when going from isomers with linear connectivity of the fused benzene rings to those
53 For samples heated with hot air, the best linear correlation achieved was R(2)=0.90 and by microwa
54 ide linear range 0.03-600 ng/mL) with a good linear correlation coefficient (0.9999), a high detectio
56 rocedure was applied to the abdomen phantom, linear correlation of phantom and patient Hounsfield uni
60 procedure consisting of fissure opening with linear cutting staplers buttressed with paired alginate
61 nd recent computational work suggests that a linear decoder can approximate marginalization by taking
62 a challenging task because of noncompatible linear detection ranges or strong signal overlap that su
63 er the analytical parameters optimization, a linear detection response from 0.01pg/mL to 2pg/mL, a li
64 with a height 10 mm or greater or a longest linear diameter greater than 16 mm or a height greater t
66 ysis, and computational approaches including linear discriminant analysis (LDA) and sparse canonical
68 measurements have shown an unusually robust linear dispersion (up to [Formula: see text]2 eV) with m
69 two-dimensional electronic bands, each with linear dispersion and the additional Berry phase predict
71 m its two-dimensional (2D) structure, with a linear dispersion of the electronic states at the corner
73 chloroplast genome that is composed only of linear DNA molecules is unprecedented among eukaryotes,
75 onensis Each strain encodes a 9.8- to 9.9-kb linear double-stranded DNA (dsDNA) genome with large inv
77 oup developed higher IgG responses against a linear epitope in the gp120 C1 region of the HIV-1 envel
81 hat VWF is first converted from a compact to linear form by flow, and is subsequently activated to bi
82 tail peptide via cation-pi interactions, but linear free energy trends suggest they do not contribute
84 O2 response of the fabricated electrodes was linear from 2.5 x 10(-3) to 6.5 mM with a sensitivity of
85 regions where the dynamics are approximately linear from those that are strongly nonlinear.The huge a
87 samples with 13 and 25 mol% cholesterol is a linear function of the heat capacity measured by differe
89 at chromosomal looping, bypassing 1524 kb of linear genome, connects Auts2 to the Caln1 gene locus un
91 LYP, CASPT2, and CCSD(T) methods all predict linear geometries for both the anions and the neutral ra
92 e in rural Gambia had a very small effect on linear growth and did not reduce morbidity compared to u
97 the suppression of the Knight shift and the linear-in-T spin echo decay that increases with doping.
99 the testes were significantly elevated and a linear increasing trend of 15-HETE concentrations was de
101 rimotor noise from multiple sources, and non-linear input transformations, for example thresholds or
104 reas are extremely sensitive to changing non-linear interactions between individual components caused
107 ent discrete model and use the method of non-linear least squares to estimate the age-specific annual
109 ed-coil 1 domain that impedes the binding of linear (M1-linked) di-ubiquitin to its coiled-coil 2-leu
110 te exhibit the abrupt appearance of positive linear magnetostriction, leading to a trigonal distortio
111 h 12 (mean of months 6 and 12), which used a linear mixed effects model for repeated measures and rep
114 t), and the variance stabilizing transformed linear mixed model (VST) outperform the voom-transformed
116 ses the correlation between residuals of the linear mixed model to estimate the null distribution of
120 stressors and their interactions, we fitted linear mixed models controlling for relatedness for the
126 and executive functioning test scores using linear mixed models, adjusted for sex and education, and
129 alyzed by linear mixed models or generalized linear mixed models, which controlled for fiber intake,
133 and e' velocity using multivariable-adjusted linear mixed-effects models (to account for relatedness
134 Disease Risk Score-associated proteins using linear mixed-effects models in 2 population-based cohort
142 cific means were compared by using a general linear model with false discovery rate control for multi
146 Comparison of teeth and implants via general linear models based on orthogonal polynomials showed sim
147 ssociations were estimated using Poisson log-linear models controlling for continuous air temperature
155 rate that the frequency of a small number of linear motifs three amino acids in length can accurately
156 realization of the importance of angular and linear movement-integration in generating spatial maps.
160 s treated with DTT, and did not occur with a linear (non-disulfide-bonded) peptide, or when the doubl
163 d breath of the complete series of saturated linear omega-hydroxyalkanoic acids, omega-oxoalkanoic ac
164 ne of these approaches have yet demonstrated linear optical isolation with ideal characteristics over
166 e are multiple, degenerate, interchangeable, linear or 3D hydrophobic stretches that become available
168 -, partially- and per-fluorinated aliphatic (linear or branched at the alpha-carbon) and aromatic est
169 ltrathin FeRh/MgO bilayers exhibits distinct linear or nonlinear behavior across the AFM to FM metama
172 the sequence of RAM is poorly conserved, the linear patterning of oppositely charged residues shows m
173 u)2-COOtBu, the longest to be solved for any linear peptoid, revealed a PPI helix of great regularity
175 ntrast to previous work, coherence-based non-linear phase inversion processing was used to reject tis
176 for confounding factors using a generalized linear Poisson model, in high-risk cluster the prevalenc
177 our most conservative simulation), variable linear polarization of a prompt optical flash that accom
182 od can efficiently implement data-driven non-linear projection and incorporate prior biological knowl
183 on-based radiation-sensitivity index and the linear quadratic model to derive the genomic-adjusted ra
184 alysis of variance was performed to evaluate linear, quadratic and interaction effects between fermen
185 ns as well as neutral loss scans in a single linear quadrupole ion trap have recently been described.
186 t of single analyzer neutral loss scans in a linear quadrupole ion trap using orthogonal double reson
187 on single analyzer precursor ion scans in a linear quadrupole ion trap, we now report the developmen
188 The proposed CLIA assay demonstrated a wide linear range 0.03-600 ng/mL) with a good linear correlat
189 ows the lowest detection of 1ngml(-1) with a linear range 100ng to 1microg due to the increased react
190 changes in absorption from 540 to 580nm; the linear range and the limit of detection are 30-1000micro
191 sensitivity of 26.2nm/microM in addition to linear range from 0 to 3microM with an invincible LOD va
192 used for the determination of NO2(-) with a linear range from 0.1-1600microm and a detection limit o
193 TCNE photoelectrochemical sensor presented a linear range from 0.6 to 250mumolL(-1), sensitivity of 0
194 ucleotides specifically and sensitively in a linear range from 50.0fM to 1.0nM with a detection limit
195 ts non-sandwich counterpart, which yielded a linear range of 0.05-0.40microgmL(-1), with a detection
196 proposed method could detect the CEA with a linear range of 0.05-0.50microgmL(-1) and a detection li
197 l performances in cancer cell detection with linear range of 1x10(2) to 1x10(6)cellsml(-1), detection
200 n outstanding analytical performance, with a linear range that spans from 1microM to 10mM and limit o
201 -glucose microbiosensor revealed an extended linear range, high sensitivity and selectivity, fast res
202 k, deviated from the predictions for optimal linear readout of a population with information-limiting
203 rrelated with the quercetin concentration by linear regression (molar extinction coefficient 23.2 (+/
204 ve binominal regression (plaque number), and linear regression (plaque size), and compared between ra
206 esults from age- and race/ethnicity-adjusted linear regression analyses indicated modest, but statist
209 -media thickness (cCIMT) using multivariable linear regression analysis among 1554 African Americans
214 lity and gait difficulty motor PD subtype in linear regression analysis, but staging of alpha-synucle
217 the eQTLs identified by QRank but missed by linear regression are associated with greater enrichment
227 ational diabetes mellitus (GDM), and we used linear regression models to estimate associations with f
228 , cell types, and covariates, we used robust linear regression models to examine associations of pren
240 atic PDFF accuracy were assessed by means of linear regression with the respective reference standard
241 -phenotypes were analyzed using logistic and linear regression, and Cox proportional hazards models.
242 ifying mean effects on gene expression using linear regression, evidence suggests that genetic variat
244 tants (k values), which were obtained by non-linear regression, showed that the degradation rate of d
245 ect to a sum-to-zero constraint in penalized linear regression, where the correspondence between nonz
246 after TAVR were examined using multivariable linear regression, with adjustment for baseline health s
251 n positions but rather are caused by the non-linear relationship between binding affinity and binding
252 ous asymmetric configurations, we revealed a linear relationship between the magnitude of cooperative
258 vity and sensitivity towards NSE, produced a linear response in the concentration range from 0.01 to
260 rease and/or amplification highlight the non-linear response to sea-level variations, with the potent
262 ed by the excitonic state, and then a second linear-response TDDFT calculation is used to determine t
263 s based on a two-step calculation in which a linear-response TDDFT calculation is used to generate or
265 was synthesized in 23 steps for the longest linear route, with a 1.7% overall yield from d-cellobios
268 s prepared from simple building blocks via a linear sequence of six chemical reactions in five flow r
269 st current non-PCR detection methods rely on linear signal amplification, which hinders the detection
270 We propose that these contigs correspond to linear single-stranded DNA molecules that fold onto them
271 stic relaxation model, for example, standard linear solid (SLS) or power-law rheology (PLR), best sui
274 t fly Drosophila melanogaster results in the linear sorting of a set of diverse isogenic female lines
275 account for relatedness among subjects) with linear splines (spline 1: ESI </=3.7 g/day, spline 2: ES
276 isson regression with confounder adjustment; linear splines were used to account for nonlinearity.Mat
277 l) in a microfluidic channel that produced a linear SS gradient over a 20mm field ranging from 0-16 d
278 f macrolide natural products in as few as 15 linear steps (21 total) with an overall yield of 4.6%.
280 mentum-space mapping of the second-order non-linear structure factor is the source of this contrast a
282 lly measured with BOLD imaging in humans, as linear sums of groups of neurons (channels) tuned for vi
283 for 18 h versus the absorbed dose followed a linear survival curve with alpha = 0.51 +/- 0.05 Gy(-1)
284 patially bandpass early filtering means that linear systems techniques, such as deriving channel sens
286 ercise performance and composite outcome was linear; thus, no reliable cutoff point could be identifi
288 Our findings revise prevailing paradigms for linear, time-invariant resonant systems, challenging the
289 rm that the former is caused by a 400 K non-linear-transport-driven instability and the latter is ca
291 s, where we found the surprising effect that linear two filament connections act as transistor-like,
298 tion of one of these V2 Abs revealed how the linear V2 epitope could be engaged, despite the lack of
299 ed two types of latitudinal patterns, either linear, when related to body size, or parabolic in shape
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