ライフサイエンスコーパス: linkage

1 utilizing either a disulfide or a thioether linkage.

2 n (CHD) of Af4 was sufficient to confer this linkage.

3 e acetylation state of GlcNAc did not affect linkage.

4 of model BG505 NFL trimers to allow covalent linkage.

5 al motifs are connected through an acetylene linkage.

6 R demonstrated formation of a Glcalpha1,3Fuc linkage.

7 in a chain possessing more than one type of linkage.

8 ed glucose residues joined by (1 --> 3)-beta-linkages.

9 ished from clinical assessments and registry linkages.

10 e repeat units, connected via 3',5'-backbone linkages.

11 esence of IHD) was assessed through registry linkages.

12 lar aggregates connected by discrete surface linkages.

13 -phase dissociation mechanisms of glycosidic linkages.

14 reactions for the formation of skeletal C-C linkages.

15 selective formation of 3'-5' internucleotide linkages.

16 al dissociation (HCD) to determine disulfide linkages.

17 , which typically occur in PG-polysaccharide linkages.

18 isolate, underscoring the fragility of these linkages.

19 turally and electronically varied artificial linkages.

20 ving all but 1 of its 21 distinct glycosidic linkages.

21 of 2-5-linkages comparing to the native 3-5-linkages.

22 actions or through intermolecular isopeptide linkages.

23 her track by the formation/breakage of ester linkages.

24 suggest the possibility of the hypothesized linkages.

25 e provide the first demonstration that mixed-linkage (1 --> 3), (1 --> 4)-beta-D-glucan (MLG) is comm

26 8, 95% CI 0.97-1.21, p = 0.13), mean time to linkage (2.5 days versus 7.5 days, p = 0.189), retention

27 onal laboratory and hospital admissions data linkage; (2) cohort study to assess patient risk; (3) mi

28 formation of inter- and intramolecular cross-linkages, a process critical for the remodeling of the E

29 In previous linkage analyses, we identified a major locus on chromos

30 Linkage analysis and whole exome sequencing were perform

31 Linkage analysis in MF5L6 identified a chromosome 3 locu

32 xample for the concept that population-based linkage analysis is a useful strategy to identify comple

33 METHODS AND Genome-wide linkage analysis mapped the SND+AVB disease locus to chr

34 Linkage analysis of affected families, including a very

35 Linkage analysis produces two separate complementary mar

36 Genome-wide linkage analysis revealed two small candidate regions on

37 xome sequencing, array-based genotyping, and linkage analysis to identify putative pathogenic variant

38 The genome-wide variant-level linkage analysis using 4,328 independent common variants

39 atients followed by homozygosity mapping and linkage analysis were performed.

40 Here we combine linkage analysis with whole-genome resequencing in patie

41 included incorporation of radiolabeled Glc, linkage analysis, and imaging of cellulose microfibril f

42 In this study, deep sequencing, genetic linkage analysis, and transcriptome data were used to pr

43 omosome 6 were then tested in the gene-level linkage analysis, using the collapsed haplotype pattern

44 were used to select high-quality markers for linkage analysis.

45 ntions about the importance of international linkage and aid.

46 We conducted a genome-wide linkage and association study in three European populati

47 veral pockets, one adjacent to the disulfide linkage and conserved in K5-K14.

48 Using a multistep approach involving linkage and haplotype analyses followed by exome sequenc

49 ndard, HDX could effectively distinguish all linkage and stereoisomers that were examined and present

50 s hindered by the inability to differentiate linkage and stereoisomers.

51 (CIS) targeting prevalent barriers to timely linkage and sustained retention in HIV care in Mozambiqu

52 n characterized by the formation of mixed Ub linkages and branched structures.

53 nce of selected noncellulosic polysaccharide linkages and primary structures.

54 , closely separates the confounding between 'linkage' and 'QTL effect', makes a fine genome division,

55 ed for CPRD and Hospital Episodes Statistics linkage, and were registered with their general practice

56 ar types, chemical modifications, glycosidic linkages, and anomeric states.

57 s that contain a mixture of 2',5'- and 3',5'-linkages, and overcoming this backbone heterogeneity has

58 mers to an octamer) with 5-5 and/or beta-O-4 linkages, and three synthesized S-lignin model compounds

59 ith (alpha1-->3) and (alpha1-->6) glycosidic linkages, and was similar in structure to a previously r

60 and Cometin, it is likely that the disulfide linkages are also conserved.

61 We report that Sp-configured PS linkages are stabilized relative to Rp, providing stereo

62 These new linkages are stable at a wide range of pH values (pH 2.8

63 The covalent linkages are visualized by scanning probe techniques wit

64 stronger interactions, possibly by covalent linkages, are involved, providing new insights on WPM/po

65 Here we introduce silyl ether linkage as a novel dynamic covalent motif for dynamic ma

66 mponent of the primary outcome, mean time to linkage, assessment for ART eligibility, ART initiation

67 gellin proteins (FlaBs) of T. denticola by O-linkage at multiple sites near the D1 domain, a highly c

68 ame RNA duplex containing four and eight 2-5-linkages at different positions, providing new insights

69 and 129S1.B6-Cdh23(ahl) congenic mice, and a linkage backcross involving these strains localized a Ch

70 ry thyroid cancer (PTC), applying a combined linkage-based and whole-genome sequencing strategy and i

71 diversity was identified to be the critical linkage between above- and belowground communities, cont

72 two species, as expected from the documented linkage between destabilization of the folded state and

73 The linkage between elevated Kdm8 expression, hypomethylatio

74 , but also improves the understanding of the linkage between EMs and MCSs.

75 ion, whereas the association and mechanistic linkage between folate status and insulin resistance rem

76 In this study, we report a novel linkage between genomic instability and phagocytosis eva

77 ative example for these points describes the linkage between inhibition of cytochrome P450 19A aromat

78 The trophic linkage between marine bacteria and phytoplankton in the

79 Such loose linkage between the alphaI and betaI is attributed to th

80 in cells especially in the light of a strong linkage between the DDR impairment and the occurrence of

81 The linkage between the familiar macroscopic shape of hexago

82 nanohybrid materials with a direct covalent linkage between the graphene carbon network and the func

83 This result suggests that the covalent linkage between the growing polyketide chain and the enz

84 ided by signal gradients and the mechanistic linkage between tip growth and guidance.

85 ation and fine-scale synteny suggest genetic linkage between traits within species and a conserved ge

86 A less understood linkage between weather and air quality is the temperatu

87 Sparse lens materials form via low-valence linkages between disordered loops protruding from the pr

88 In an effort to better understand the linkages between iron metabolism and breast cancer, a pr

89 carbon cycles that is characterized by tight linkages between methane-utilizing (methanotrophic) and

90 This work demonstrates linkages between terrestrial and marine ecosystems, and

91 the creation of stronger and more functional linkages between the primary levels (ie, local or commun

92 bserved trends for each region, but possible linkages between the regional trends have not been studi

93 We explored linkages between the relative abundance of AM and ECM tr

94 nucleotide polymorphisms (SNPs) representing linkage blocks of the SLC2A14 gene.Both GLUT14 isoforms

95 ematic modulation of the length of aryl-aryl linkage, but also the ability to arylate neutral and ele

96 lity of replication through these artificial linkages by primer extension, PCR, and deep sequencing r

97 We find that single linkage clustering has high performance, with specificit

98 lation counts and performs a modified single-linkage clustering of methylation sites into genomic reg

99 e less favorable solvent interactions of 2-5-linkages comparing to the native 3-5-linkages.

100 he synthesis of alpha-glucans with different linkage compositions, size and physico-chemical properti

101 survey (response rate 83%), 836 of which had linkage data (96%).

102 h Centers for Medicare and Medicaid Services linkage data, the mortality at 30 days and at 1 year was

103 catalyses the generation of linear ubiquitin linkages de novo LUBAC is a crucial component of various

104 ishment and maintenance of cohesin-dependent linkages depend on two distinct proteins, sororin and sh

105 hallenge with methods based on the admixture linkage disequilibrium (ALD) is to remove the effect of

106 ], are the true biological representation of linkage disequilibrium (LD) among multiple loci.

107 ty varies with minor allele frequency (MAF), linkage disequilibrium (LD) and genotype certainty.

108 al variant effect sizes while accounting for linkage disequilibrium (LD) and overlapping GWAS samples

109 We demonstrate that heterogeneity in linkage disequilibrium (LD) between causal variants and

110 ome-wide association studies, are usually in linkage disequilibrium (LD) with each other within a sma

111 A total of 2255 variants in linkage disequilibrium (LD) with GWAS identified SU/gout

112 RES based on SNP prior information including linkage disequilibrium (LD)-weighted genic annotation sc

113 tion based on hierarchical representation of linkage disequilibrium (LinDen).

114 r, we identified 44 of these Alu elements in linkage disequilibrium (r(2) > 0.7) with the trait-assoc

115 56, a single-nucleotide polymorphism in high linkage disequilibrium (r(2)=0.7) with rs10995, which bo

116 In particular, the differences in linkage disequilibrium and allele frequency patterns acr

117 ecular genetic estimates of Ne computed from linkage disequilibrium and approximate Bayesian computat

118 A linkage disequilibrium block of polymorphisms located in

119 (plasticity) a priori candidate genes within linkage disequilibrium blocks for these loci.

120 28 dogs from 3 breeds to compare the SNP and linkage disequilibrium characteristics together with the

121 various functional annotations and allow for linkage disequilibrium estimated from reference genotype

122 favored because it prevents the breakdown of linkage disequilibrium generated by migration; the selec

123 Given the small blocks of linkage disequilibrium in Drosophila, we obtain near bas

124 l mechanisms of selection that maintain high linkage disequilibrium in MHC haplotype blocks.

125 Linkage disequilibrium is positive (Dij'>0) among freque

126 This method is referred as multi-marker linkage disequilibrium mapping (mmLD).

127 estry inference in adMixed Populations using Linkage Disequilibrium method (LAMP-LD) and evaluated th

128 d that 51 traits could be linked through the linkage disequilibrium of 115 associated loci and these

129 Comparison of linkage disequilibrium patterns between the 13 lead SNPs

130 Linkage disequilibrium rapidly decayed around LanFTc1, s

131 Linkage disequilibrium score regression and polygenic pr

132 Linkage disequilibrium score regression of 220 cell type

133 Using linkage disequilibrium score regression, we estimate the

134 d genetic correlations were calculated using linkage disequilibrium score regression.

135 effect allele frequency, effect size and the linkage disequilibrium structure of credible set variant

136 me-wide analyses identified multiple SNPs in linkage disequilibrium with each other that were signifi

137 say to sequence a small number of regions in linkage disequilibrium with heading date QTL in thousand

138 SNP rs2227473, in linkage disequilibrium with rs2227476, was also associat

139 mating their effect sizes in the presence of linkage disequilibrium.

140 epistatic loci do not systematically exploit linkage disequilibrium.

141 ain HLA allele combinations co-occur in high linkage disequilibrium.

142 algorithms to construct or merge a complete linkage dominant marker maps.

143 gold current collector via short conducting linkages eliminates the need for fillers, resulting in a

144 different functional moieties and reducible linkages exploited in these systems, and outline their d

145 An additional linkage for alpha5 and alphaIIb is the synergy site loca

146 neuraminidase selective for 2-3 sialic acid linkages generated a KM value of 3 +/- 2 mM (Vmax, 900 +

147 e three important routes to antigen-scaffold linkage: genetic fusion, chemical cross-linking and plug

148 oglucan (XyG), beta(1-->3)/beta(1-->4) mixed-linkage glucan (MLG) and beta(1-->3) glucan components o

149 exploration of genetic diversity along each linkage group, and clarification of macrosynteny between

150 These markers were mapped to 29 linkage groups (LGs) with 30,591 unique marker positions

151 omic and disomic regions in the right arm of linkage groups 2 and 5.

152 wever, many exceptional cases of incongruent linkage groups and increased marker distances were also

153 ) detection of linkage, i.e. construction of linkage groups in case of segregation distortion; (iv) d

154 34 SNPs for linkage mapping, resulting in 27 linkage groups with a minimum logarithm of odds (LOD) of

155 erate a structurally rigid, linear 1,3-diyne linkage has been known for over a century.

156 ultimately provides a means to quantify the linkage (i.e., 2-3 versus 2-6) of sialic acids.

157 Call Format (VCF) files; (iii) detection of linkage, i.e. construction of linkage groups in case of

158 ated that the relative contents of beta-O-4' linkages in SRELs were higher than that in CEL.

159 ucture changes with increased numbers of 2-5-linkages in the same duplex.

160 c IL-1beta signaling, and that the disulfide linkage indirectly affects signaling by blocking conform

161 Furthermore, the covalent linkage induced by DOPA oxidation allows covalent captur

162 -PCCDas micelles, incorporation of disulfide linkage into POEG-b-PSSDas micelles facilitated efficien

163 Identification of the linkage is a first step toward identifying the linking e

164 A disulfide linkage is present in IL1RN, but is not in IL-1beta beca

165 in proteins, and their pairing in disulfide linkages is a common post-translational modification in

166 Differentiation between the sialyl linkages is often critical to understanding biological c

167 importance of genomic draft, in which strong linkage limits the ability of selection to purge deleter

168 chains containing Lys-63, Lys-48, and Lys-11 linkages (Lys-63 > Lys-48 > Lys-11).

169 This linkage map anchored 1,602 scaffolds of the reference ge

170 to (i) develop a new high-density consensus linkage map based on new, transcriptome-anchored markers

171 sequencing technology over the past decade, linkage map densities have been increasing dramatically,

172 hile there is software available to generate linkage map graphics, none are freely available, produce

173 The constructed linkage map revealed strong collinearity in marker order

174 A framework genetic linkage map was constructed and combined with locus orde

175 (GBS) was used to construct the high-density linkage map.

176 PSEQ-v2.0, which was based on a high-density linkage map.

177 We use quantitative behavioral assays and linkage mapping to identify a genetic locus (nict-1) tha

178 Through linkage mapping we assign these variants to a particular

179 By integrating linkage mapping, polyploid phylogeny and sex-determining

180 We selected 7,734 SNPs for linkage mapping, resulting in 27 linkage groups with a m

181 ns between dominant loci and recovering true linkage maps of 6 dominant loci in coupling and unknown

182 We also construct de novo linkage maps on 7-12x whole-genome data on the Red postm

183 s produces two separate complementary marker linkage maps that have little use in disease association

184 by-sequencing approach and generated genetic linkage maps with 6,291 and 3,297 single nucleotide poly

185 ndians), and their inclusion in the original linkage model reduced the linkage signal to virtually nu

186 Here, we constructed a T2D phenotypic-linkage network (T2D-PLN), by integrating diverse gene f

187 y every 10 cM and a model-free nonparametric linkage (NPL-all) analysis was carried out.

188 the widespread Wzy mechanism, we found that linkage occurs via the reducing end glucose of CPS and t

189 ion-based cohort study used individual-level linkage of administrative and public health registers in

190 This linkage of amygdalar and LC output to primary sensory si

191 itro potential was developed by the covalent linkage of an oxime nucleophile and a peripheral site li

192 t-translational modification involving the O-linkage of beta-N-acetylglucosamine to serine/threonine

193 ICD2 and are therefore expected to result in linkage of cargos to dynein-dynactin complexes that have

194 Despite the important linkage of cell extrusion to developmental, homeostatic

195 e, the co-alignment to reference genomes and linkage of contigs provided by paired-end reads, as well

196 Using linkage of Danish national registers, we constructed a c

197 iency to iron replete to iron excess, 3) the linkage of iron status with health outcomes beyond hemat

198 roanatomical features, especially the strong linkage of left perisylvian language areas (frontal and

199 andscapes will probably require the explicit linkage of livestock yield increases with habitat protec

200 Furthermore, the linkage of LSD1 to an altered expression pattern of lung

201 epidemiologic approach, which relies on the linkage of nutrient intakes to chronic disease with subs

202 At transition state (TS), a linkage of O-H-O involving O 2p and H 1 s orbitals is fo

203 This reveals a duality in the functional linkage of organic soils to aquatic ecosystems whereby t

204 udies have enhanced our understanding of the linkage of oxygenation and metazoan evolution in Early C

205 es for outpatients (patient episode) through linkage of population-based registers.

206 process comprising genotyping and mutant HTT-linkage of SNPs, followed by personalised allele-selecti

207 f cell-to-cell junctions, HGF attenuates the linkage of stress fibers to cell-to-cell junctions with

208 ell-to-substrate junctions, HGF augments the linkage of stress fibers to cell-to-substrate junctions

209 r of variables by determining the biological linkage of the 68 previously unconsidered genes.

210 we tested both cobalt coupling and covalent linkage of the trimers to the liposomes by reengineering

211 an intuitive stability profile based on the linkage of two triple helical repeats connected by a hel

212 -type macrodomains also hydrolyze derivative linkages on the distal ribose ring.

213 lities are particularly vulnerable to missed linkage opportunities.

214 ing a 2'-O-photocaged 5'-S-phosphorothiolate linkage or 5'-thiol-labeled RNAs is also further investi

215 Deprotonated compounds with only beta-O-4 linkages, or both 5-5 and beta-O-4 linkages, showed majo

216 Moreover, glycans with unique glycosidic linkages, particularly from prokaryotes, which are resis

217 ccharide components, but also their specific linkage patterns and the change associated with differen

218 s of 6 dominant loci in coupling and unknown linkage phases.

219 tructures to accommodate these non-canonical linkages (Proc.

220 4K(+) borate hydrogels by using borate ester linkages (Pt-G4K(+)B hydrogel).

221 g or canonical splicing mutations within the linkage region but identified several nonconserved nonco

222 number variations, 99 genes overlapping with linkage regions, 240 differentially expressed genes, 465

223 n applied in the construction of alpha-FucN3 linkages relevant to bacterial saccharides.

224 ive predictive value all >99%, whereas other linkages result in a significant loss of sensitivity.

225 ss ratios for (1) Current Pace of detection, linkage, retention, and virologic suppression and (2) NH

226 n in care at 12 months regardless of time to linkage (RR 1.48, 95% CI 1.18-1.86, p = 0.002), assessme

227 h the tri(ethyleneoxy) arm para to the ester linkages, "short-armed" cryptand 3, did display a higher

228 beta-O-4 linkages, or both 5-5 and beta-O-4 linkages, showed major 1,2-eliminations of neutral compo

229 ecamer RNA duplex containing two and six 2-5-linkages, showing how RNA duplexes adjust the structures

230 on in the original linkage model reduced the linkage signal to virtually null.

231 Linkage specific distribution of these sialic acids was

232 We used sialic acid linkage-specific derivatization methods to improve separ

233 eptors and do not provide information on the linkage specificity.

234 Candidate gene and genome-wide linkage studies have not significantly contributed to ou

235 ne disruption in animal models or by genetic linkage studies.

236 This is a population-based linkage study of 979,912 term singleton pregnancies in S

237 ster Epidemiology Project, which is a record-linkage system of medical records for all patient-physic

238 tion-based study that uses a medical records linkage system to enumerate all individuals aged 50-89 y

239 oselectivity as well as result in non-native linkages that may suffer from instability in vivo and ad

240 ecular cues or force on specific kinetochore linkages that other attachment geometries cannot provide

241 appearance at least 3 billion years ago, and linkage through an electron transfer chain to photosyste

242 lacement of a single phosphate with an amide linkage throughout the guide strand of siRNAs.

243 ug through a hydrolytically degradable ester linkage to a common hydrophilic polymer, polyvinyl alcoh

244 Combining naloxone distribution with linkage to addiction treatment or pre-exposure prophylax

245 bination of naloxone distribution, PrEP, and linkage to addiction treatment was the optimal strategy

246 the combination of naloxone distribution and linkage to addiction treatment was the optimal strategy

247 ervices increase HIV testing, diagnoses, and linkage to care among sex partners of people with HIV in

248 We examined differences in prevalence of linkage to care and antiretroviral (ARV) treatment among

249 nting to the intervention was high, although linkage to care and ART initiation took longer than expe

250 We analysed linkage to care at 6 months (defined as 1-LTFU) as the p

251 Prevalence of linkage to care increased from 79% in 2008 to 87% in 201

252 OC arm had the following secondary outcomes: linkage to care regardless of retention at 12 months (RR

253 gramme failure; timely HIV testing and rapid linkage to care remain an urgent priority.

254 n WL are anticipated with increased testing, linkage to care, and access to DAA therapy.

255 Linkage to care, mortality and survival rates were calcu

256 for hepatitis B vaccination, screening, and linkage to care.

257 y interventions in screening, detection, and linkage to care.

258 s that the wall stiffening arises from cross-linkage to cell wall polymers.

259 do not include the population stages before linkage to clinical care.

260 d higher rates of adequate syringe coverage, linkage to HIV care and OST.

261 approaches to confidential HIV testing with linkage to HIV services.

262 ficate underlying or contributing causes, by linkage to National Death Index records through 2011.

263 nts were followed-up for CVD mortality after linkage to national mortality registries for a median of

264 ovision of injection equipment, HIV testing, linkage to opioid substitution treatment (OST) programs

265 A direct glycosidic linkage to PG was also demonstrated for serotypes 8 and

266 es often rely on exposure estimates based on linkage to residential addresses.

267 acted from Hospital Episode Statistics, with linkage to the Office for National Statistics to create

268 tbreak if they attended or had epidemiologic linkage to the university.

269 Linkage to these two registers and to the National Crime

270 By linkage to vaccination records we ascertained prevalence

271 Ufd2p functions by switching ubiquitin chain linkages to allow the degradation of proteins modified w

272 f high-quality clinical care for obesity and linkages to community resources resulted in improved fam

273 cryosphere, as evidenced by fast and strong linkages to global ice volume and Arctic paleoclimate in

274 e then sequentially added via alpha-carboxyl-linkages to the growing glutamate side chain.

275 e aspirin prescriptions were identified from linkages to the United Kingdom Clinical Research Practic

276 The C=C linkages topologically connect pyrene knots at regular i

277 27-crown-9 with tri- and tetra-(ethyleneoxy) linkages transposed were synthesized regiospecifically i

278 We show that RNF8- and Ube2S-dependent Lys11-linkage ubiquitin conjugation plays an important role in

279 l silencing, distinct from the role of Lys63-linkage ubiquitin in the recruitment of DNA damage repai

280 Western Australian Department of Health Data Linkage Unit records, all patients undergoing bariatric

281 study to the synthesis of various glycosidic linkages using different sugar series.

282 The linkage was acetolysis susceptible, indicative of a 1,6

283 wering pathway genes VRN2 and FT, whereas no linkage was observed at VRN1 Characterization of these c

284 h its shared biology, homology, and physical linkage was pivotal to later studies that investigated t

285 In a register linkage we linked women born 1925-1954 having survived t

286 a dimer, trimer, and tetramer) with beta-O-4 linkages, were evaporated and deprotonated using negativ

287 dation of proteins modified with a ubiquitin linkage, which is normally not targeted to the proteasom

288 sialic acid monomers with an alpha2-3,6,8,9 linkage, which is similar to values reported in the lite

289 ncident lung cancers were identified through linkage with cancer registries from enrollment (2005-200

290 agnoses of cancer in this population through linkage with corresponding cancer registries and calcula

291 enes of the folate pathway to understand its linkage with folate levels.

292 Our results indicate that linkage with multiple cancer registries can be a sensiti

293 h medical records, 338 were also detected by linkage with the 23 state cancer registries (sensitivity

294 Variants in linkage with the CKD-associated single-nucleotide polymo

295 beta-blockers and other medications through linkage with the national Prescribed Drug Register.

296 lotype sharing analysis in 1 family excluded linkage with the North Carolina macular dystrophy (MCDR1

297 Linkage with these registries may be a cost-effective me

298 th respect to incident LC identified through linkage with U.S. state cancer registries.

299 Resolution of the anomeric alpha/beta glycan linkage within oligosaccharides remains a particular cha

300 to a strategy to distinguish alpha- and beta-linkages within natural underivatized carbohydrates.