ライフサイエンスコーパス: linkage analyses

1 age was assessed by multipoint nonparametric linkage analyses.

2 e considered for genome-wide, non-parametric linkage analyses.

3 o either 17q23.1-23.2 or 17q11.1-12 based on linkage analyses.

4 metry techniques, along with composition and linkage analyses.

5 , and 3) how association analyses complement linkage analyses.

6 en developed explicitly for meta-analysis of linkage analyses.

7 le of men and women by using association and linkage analyses.

8 re characterized by glycosyl composition and linkage analyses.

9 ith various glycosidase digestions and GC-MS linkage analyses.

10 iabetes diagnosis, and BMI and nonparametric linkage analyses.

11 n the peak LOD score after adjustment in the linkage analyses.

12 se of these markers for whole-genome genetic linkage analyses.

13 By using parametric and nonparametric linkage analyses and allowing for genetic heterogeneity

14 ed heightened interest after a succession of linkage analyses and association studies identified mult

15 , genotype error detection and affected pair linkage analyses and can handle more markers than other

16 rome, and the collection of new families for linkage analyses and clinical assessments.

17 Recent evidence from linkage analyses and follow-up candidate gene studies su

18 Candidate genes identified by linkage analyses and genome-wide association scans in ad

19 h a dense set of 31 markers using multipoint linkage analyses and monitoring for shared marker allele

20 Subsets linkage analyses and recurrence risk ratios in a combine

21 had previously been suggested based on gene linkage analyses and shared clinical features.

22 was established by glycosyl composition and linkage analyses, and by one- and two-dimensional NMR sp

23 mericans, including studies of heritability, linkage analyses, and candidate genes.

24 ia, Europe, and South America, haplotype and linkage analyses, and case-control analyses, and determi

25 Although animal models, linkage analyses, and genome-wide association studies ha

26 Linkage analyses are often limited by both sample size a

27 the available marker information, multilocus linkage analyses are performed.

28 e pursued both allele-sharing and parametric linkage analyses as implemented in Genehunter, version 2

29 We applied model-based and model-free linkage analyses, as well as the pedigree disequilibrium

30 performed Haseman-Elston and DeFries-Fulker linkage analyses, as well as transmission/disequilibrium

31 Nonparametric linkage analyses at microsatellites surrounding D12S83 w

32 s and of genotype data can cause problems in linkage analyses based on genome-scan data.

33 Genome-wide linkage analyses, based on 1142 participants from the 31

34 We have performed linkage analyses between the disorder and markers close

35 which involved non-parametric and parametric linkage analyses, both yielded significant linkage peaks

36 Stratification of genome-wide linkage analyses by disease associated variants is now p

37 Sibpair linkage analyses, by contrast, provided only marginal su

38 QTL mapping and/or linkage analyses can establish a large genomic region (

39 Here, genetic linkage analyses combined with exome sequencing identifi

40 Linkage analyses conditioning on pedigrees in which one

41 Although linkage analyses confirmed the presence of a genetic sus

42 Multipoint linkage analyses confirmed this interval and generated a

43 Linkage analyses for COL2A1 locus markers were performed

44 hese findings support the utility of genetic linkage analyses for identification of novel risk factor

45 Multipoint linkage analyses for insulin sensitivity phenotypes were

46 e-components technique to conduct multipoint linkage analyses for localizing susceptibility genes tha

47 oint lod score and nonparametric (Zlr score) linkage analyses for social phobia were completed with A

48 e-components technique to conduct multipoint linkage analyses for two phenotypes: type 2 diabetes (a

49 bserved at marker D22S685, and nonparametric linkage analyses gave consistent results, with a P value

50 four major categories: association studies, linkage analyses, gene expression and literature search.

51 Recent genome-wide linkage analyses have identified a locus encoding suscep

52 Human linkage analyses have implicated the MS4A2-containing ge

53 such as genome-wide association studies and linkage analyses, have been confounded by the genetic an

54 Because previous linkage analyses identified chromosome 1q25-32, which ha

55 Linkage analyses identified QTLs associated with dietary

56 Genomewide linkage analyses identified the recessive IBM locus on c

57 Quantitative trait linkage analyses in 1044 pairs of siblings, by using bot

58 We performed linkage analyses in 146 multiplex families ascertained t

59 We carried out the linkage analyses in 22 Finnish multiplex MS families ori

60 Genetic linkage analyses in a family with autosomal dominant age

61 We undertook platelet function studies and linkage analyses in a pedigree of CSS-affected German sh

62 6 to maximize the informativeness of genetic linkage analyses in a region where they previously repor

63 In addition, two-point linkage analyses in an enlarged family sample (n = 670)

64 omputationally practical option for accurate linkage analyses in genome scans with both large numbers

65 nic analysis and greater refinement of viral linkage analyses in HIV prevention studies.

66 Here, we conducted linkage analyses in order to (1) create a platform for Q

67 This leads to specific strategies for linkage analyses in schizophrenia.

68 Prior linkage analyses in the Boston Early-Onset COPD Study ha

69 conducted age at diagnosis (AAD) stratified linkage analyses in the Diabetes UK Warren 2 sibpairs.

70 Linkage analyses in this subset of 65 pedigrees generate

71 We have performed linkage analyses in two inter-related inbred kindreds, c

72 We performed nonparametric multipoint linkage analyses, in 152 families from the Autism Geneti

73 xamine this latter possibility, we performed linkage analyses, in 159 pedigrees affected by hereditar

74 Cumulative multipoint linkage analyses indicate that an FHF gene is likely to

75 Linkage analyses indicate that FHL is genetically hetero

76 Singlepoint and multipoint linkage analyses indicate that marker D10S1654 on chromo

77 Glycosyl linkage analyses indicated that N-acetylglucosamine (Glc

78 identification of genes under selection, and linkage analyses involving association studies in natura

79 A common problem encountered in linkage analyses is that execution of the computer progr

80 apped to mouse chromosome 11 by conventional linkage analyses, its candidate region was broad and und

81 Linkage analyses mapped the defect to this type II kerat

82 as characterized by glycosyl composition and linkage analyses, mass spectrometry, and one- and two-di

83 S was determined by glycosyl composition and linkage analyses, matrix-assisted laser desorption-time

84 Previous linkage analyses of 19 cutaneous malignant melanoma/dysp

85 DESIGN, SETTING, AND PATIENTS: Model-free linkage analyses of 21 concordant-affected sibling pairs

86 Association and sib-pair linkage analyses of a polymorphism in intron 7 of the TP

87 using segregation and joint segregation and linkage analyses of a quantitative trait.

88 statistic [Z] 2.98; P=.001), and subsequent linkage analyses of additional markers and association a

89 gram to provide parametric and nonparametric linkage analyses of affected individuals.

90 After genome-wide linkage analyses of blood pressure levels, we resequence

91 sought to incorporate AAO as a covariate in linkage analyses of BP using two different methods, LODP

92 Valid linkage analyses of censored data require the developmen

93 pertension-related traits employs genomewide linkage analyses of families and association studies of

94 he findings from three successful genomewide linkage analyses of families segregating autosomal reces

95 Previous linkage analyses of families with multiple cases of schi

96 t chronic obstructive pulmonary disease, and linkage analyses of FEF(25-75%) and FEF(25-75%)/FVC were

97 Linkage analyses of genetic diseases and quantitative tr

98 add an important dimension of complexity for linkage analyses of human autoimmune disease.

99 In black individuals, bivariate linkage analyses of log serum creatinine and pulse press

100 Linkage analyses of melanoma pedigrees from many countri

101 een missed and deserves wider application in linkage analyses of quantitative traits.

102 Nonparametric, sibling-pair, genome-wide linkage analyses of refraction (spherical equivalent adj

103 Genome-wide linkage analyses of schizophrenia have identified severa

104 We performed parametric and nonparametric linkage analyses of seven genetic markers on chromosome

105 Linkage analyses of the 12 endophenotypes collectively i

106 Linkage analyses of the 6,055 single-nucleotide polymorp

107 sample of 126 ASPs to 270 ASPs and provides linkage analyses of the entire sample, using polymorphic

108 However, additional linkage analyses of these crosses showed that loci contr

109 We conducted genomewide linkage analyses on 1,152 individuals from 250 families

110 We therefore performed multipoint linkage analyses on both GFR measures using models that

111 To overcome these issues, we have performed linkage analyses on members of 301 HPC families genotype

112 basis for this strain-dependent sensitivity, linkage analyses on the progeny of a B6CBAF1 intercross

113 We conducted multipoint variance components linkage analyses on these factors with the program SOLAR

114 ined geographical regions could be useful in linkage analyses or quantitative trait locus studies.

115 vidence for linkage was observed by sib-pair linkage analyses (P values ranged from .24 to .81).

116 ozygosity rates in individuals, and powerful linkage analyses, particularly in coding regions.

117 Genome-wide linkage analyses performed in a Finnish study sample hav

118 overing the entire X chromosome were used in linkage analyses performed on 42 genomic DNA samples (13

119 6 novel baboon microsatellites were used in linkage analyses performed with the MultiMap expert syst

120 opportunity to identify the disease gene by linkage analyses, positional cloning, and analysis of ca

121 Both pedigree-based and population-based linkage analyses rely on estimating recent IBD, and evid

122 Stratified linkage analyses resulted in a marked increase in eviden

123 Linkage analyses revealed 8 QTLs linked to number of DNs

124 Multipoint variance components linkage analyses revealed suggestive linkage on chromoso

125 Linkage analyses revealed that genes influencing risk fo

126 Pedigree and linkage analyses revealed that the Class III phenotype (

127 Genetic linkage analyses show a TBC1D1 R125W missense variant co

128 Two-point linkage analyses showed linkage to markers on 16q22 with

129 Linkage analyses showed suggestive linkage to the COL2A1

130 Model-free, multipoint linkage analyses (SIBPAL2, SAGE version 4.0) and exclusi

131 Bivariate linkage analyses strongly rejected both the null hypothe

132 These linkage analyses suggest that a genetic element on chrom

133 Parametric linkage analyses suggested a low-penetrance, dominant mo

134 In genome-wide linkage analyses, suggestive linkage (logarithm of odds

135 Applying linkage analyses that assume linkage equilibrium to dens

136 e now present the results of our genome-wide linkage analyses that provide evidence that regions on c

137 By genetic linkage analyses, the gene responsible for this disease,

138 After over a decade of linkage analyses, the identification of non-major histoc

139 From linkage analyses, the location of elg on chromosome 4, b

140 In SIBPAL linkage analyses, the maximum number of sibpairs availab

141 the application of traditional nonparametric linkage analyses to complex human traits and diseases.

142 nn, we carried out variance components-based linkage analyses to evaluate the contribution of variati

143 mosome 6q, we conducted bivariate multipoint linkage analyses to map the correlated IRS phenotypes.

144 linked by numerous genome-screen studies and linkage analyses to markers on human chromosome 5q31-q34

145 ci, we performed genomewide parent-of-origin linkage analyses under an allele-sharing model for discr

146 the data, using parametric and nonparametric linkage analyses under both a narrow phenotype model (DS

147 Ophthalmic examinations and linkage analyses using a variety of polymorphisms were p

148 Nonparametric linkage analyses using GENEHUNTER and ASPEX were perform

149 The multipoint linkage analyses using Genehunter and SIMWALK 2.40 provi

150 Two-point and multipoint linkage analyses using informative markers excluded most

151 ilies (599 sibpairs) identified through tree-linkage analyses using interacting covariates of age, se

152 merging difficulties by simply carrying out linkage analyses using laboratory-specific allele labels

153 rmed oligogenic simultaneous segregation and linkage analyses using Markov Chain Monte Carlo methods

154 r three diagnostic models, we have conducted linkage analyses using parametric (heterogeneity LOD [HL

155 We performed linkage analyses using parametric and allele-sharing mod

156 Linkage analyses using scores from the Social Responsive

157 Linkage analyses using the resultant component scores id

158 After performing linkage analyses using various methods implemented in th

159 Model-free linkage analyses, using a dichotomous definition for dia

160 Using linkage analyses, we discovered a quantitative trait loc

161 In previous linkage analyses, we identified a major locus on chromos

162 rming standard parametric and non-parametric linkage analyses, we observed a 'highly significant' lin

163 Using both nonparametric and parametric linkage analyses, we obtained evidence for a small numbe

164 cluding 1,249 sib pairs) that are useful for linkage analyses, we performed a whole-genome linkage sc

165 ere genotyped, and multipoint allele-sharing linkage analyses were carried out.

166 Multipoint, nonparametric linkage analyses were conducted in affected relative pai

167 Genomewide linkage analyses were conducted of serum creatinine, est

168 Linkage analyses were conducted to quantify the evidence

169 Two- and three-point linkage analyses were conducted using a previously repor

170 Linkage analyses were conducted using data from a genome

171 Linkage analyses were conducted using model-free methods

172 Homozygosity mapping and linkage analyses were conducted using two pedigrees deri

173 Parametric and nonparametric genome-wide linkage analyses were conducted with Morgan and Merlin i

174 Linkage analyses were conducted with parametric and nonp

175 Nonparametric multipoint linkage analyses were conducted, and the strongest evide

176 ped for 335 markers, and multipoint sib pair linkage analyses were conducted.

177 Genomewide linkage analyses were first performed separately in each

178 , and a recessive model with 85% penetrance, linkage analyses were performed assuming a narrow (BP an

179 Segregation and linkage analyses were performed for adult height in a po

180 Two-point and multipoint linkage analyses were performed for all 218 families and

181 Linkage analyses were performed on 1201 samples from 10

182 Affected sib-pair linkage analyses were performed on 98 diabetic sibling p

183 Genomewide, model-free, multipoint linkage analyses were performed separately for each popu

184 to localize susceptibility genes, stratified linkage analyses were performed using clinical criteria

185 Multipoint linkage analyses were performed using data from a 10-cM-

186 Standard linkage analyses were performed using GENEHUNTER and Has

187 c and nonparametric two-point and multipoint linkage analyses were performed using the FASTLINK, HOMO

188 Linkage analyses were performed using three methods (sin

189 Linkage analyses were performed with 11 candidate genes,

190 Parametric and nonparametric linkage analyses were performed with a denser map of mar

191 Linkage analyses were performed with an "affecteds-only"

192 Multipoint nonparametric linkage analyses were performed with diabetes, and diabe

193 Genome-wide sibling-pair linkage analyses were performed with the phenotypes como

194 Genetic linkage analyses were performed with the use of microsat

195 Two-point and multipoint nonparametric linkage analyses were performed, and 1-parameter allele-

196 Both two-point and multipoint linkage analyses were performed, by use of affected/unaf

197 Multipoint non-parametric linkage analyses were performed, with further stratifica

198 Nonparametric multipoint and two-point linkage analyses were performed.

199 Two-point and multipoint linkage analyses were performed.

200 ellite markers in 12 families, and two-point linkage analyses were performed.

201 Nonparametric multipoint linkage analyses were the primary approach, although par

202 Multipoint linkage analyses were undertaken using both non-parametr

203 Multipoint linkage analyses were undertaken using both nonparametri

204 ed from 46 U.S. families in which multipoint linkage analyses were undertaken using nonparametric (mo

205 ith bipolar disorder and (2) association and linkage analyses with a common silent exonic polymorphis

206 The authors conducted lod score linkage analyses with both phenotypes using both a domin

207 Clinical examinations and linkage analyses with polymerase chain reaction (PCR) po

208 Linkage analyses yielded a total of 95 linkage groups, s