ライフサイエンスコーパス: linkage analysis

1 ased model to perform variant and gene-based linkage analysis.

2 SCA-affected Italian family by whole-genome linkage analysis.

3 us on chromosome 2p11.1-q12.2 by genome-wide linkage analysis.

4 memory performance were used for genome-wide linkage analysis.

5 ty in this family using exome sequencing and linkage analysis.

6 pG ODN defect, we have performed genome-wide linkage analysis.

7 a causal RBM20 mutation without the need for linkage analysis.

8 on a 0.3-Mb region of mouse chromosome 4 by linkage analysis.

9 ly inherited traits otherwise intractable by linkage analysis.

10 portant data sources for mapping QTL through linkage analysis.

11 the rgt mutants were elucidated by glycosyl linkage analysis.

12 implicated in essential hypertension by gene linkage analysis.

13 onstrating its potential for oligosaccharide linkage analysis.

14 lized along with disease status in bivariate linkage analysis.

15 design, the authors conducted nonparametric linkage analysis.

16 pported as the causal mutation by parametric linkage analysis.

17 nd reduced digests that facilitate disulfide linkage analysis.

18 BD) probabilities is the key in family-based linkage analysis.

19 s can be used for non-parametric genome-wide linkage analysis.

20 orical information compared with traditional linkage analysis.

21 A founder effect was excluded by linkage analysis.

22 f common CD-associated risk variants and for linkage analysis.

23 cleft lip and/or palate through genome-wide linkage analysis.

24 were used to select high-quality markers for linkage analysis.

25 e 2H on chromosome 8q13-21.1 was excluded by linkage analysis.

26 from the same family and was integrated with linkage analysis.

27 We genotyped the mice and performed linkage analysis.

28 e glycotope were based on mass spectrometry, linkage analysis, (1)H nuclear magnetic resonance spectr

29 whereby QTL were detected using a sire-based linkage analysis, a sparse SNP marker map and exploiting

30 riants were found at both loci identified by linkage analysis: a homozygous stop codon in PI3-kinase

31 onal statistical genetics approaches such as linkage analysis and association studies have limited po

32 We performed genetic linkage analysis and candidate gene sequencing on 13 pat

33 candidate mutations, which were narrowed by linkage analysis and confirmed by Sanger sequencing and

34 e gene mutation was determined by genomewide linkage analysis and DNA sequencing.

35 with calf weakness, we identified by genetic linkage analysis and exome sequencing a heterozygous mis

36 The combined linkage analysis and exome sequencing in the index famil

37 We used linkage analysis and exome sequencing of a multiplex fam

38 Whole-genome linkage analysis and exome sequencing of distant relativ

39 We used linkage analysis and exome sequencing to identify the ca

40 Genome-wide linkage analysis and exome sequencing were performed in

41 By linkage analysis and exome sequencing, we identified a p

42 By linkage analysis and exome sequencing, we unexpectedly i

43 albumin-to-creatinine ratio, we performed a linkage analysis and explored gene-by-diabetes, -hyperte

44 Pakistani families, we performed genome-wide linkage analysis and fine mapping and identified linkage

45 Using linkage analysis and fine mapping, we identified the dis

46 Linkage analysis and genetic-complementation testing ind

47 soriasis, for which application of classical linkage analysis and genome-wide association investigati

48 guineous family with five affected siblings, linkage analysis and genomic sequencing revealed the gen

49 Linkage analysis and homozygosity mapping combined with

50 relevant genes and complementing traditional linkage analysis and homozygosity mapping.

51 We applied genetic linkage analysis and next-generation sequencing and func

52 mined the individual genotypes by SNPlex for linkage analysis and parental transmission disequilibriu

53 esis-independent genetic studies of CRS (ie, linkage analysis and pooling-based genome-wide associati

54 Here, we review the principles of linkage analysis and provide practical guidelines for ca

55 ich is not used by current methodologies for linkage analysis and QTL mapping.

56 We performed genome-wide linkage analysis and refined the linkage area with micro

57 Here we used linkage analysis and targeted deep sequencing to detect

58 Further evaluation of one group by linkage analysis and targeted sequencing identified rece

59 ci associated with 49 DCPs were confirmed by linkage analysis and tests of genetically modified paras

60 an unbiased genome-wide approach using both linkage analysis and variant filtering across the exome

61 We have demonstrated that a combination of linkage analysis and whole exome sequencing can be used

62 Linkage analysis and whole exome sequencing revealed a h

63 Linkage analysis and whole exome sequencing were perform

64 Using combined genome-wide linkage analysis and whole-exome sequencing (WES), we id

65 TE-affected families by performing SNP-array linkage analysis and whole-exome sequencing and identifi

66 Linkage analysis and whole-exome sequencing identified a

67 Linkage analysis and whole-exome sequencing identified a

68 We performed genomewide linkage analysis and whole-exome sequencing in a family

69 ions, we identified through a combination of linkage analysis and whole-exome sequencing KCTD17 c.434

70 Using linkage analysis and whole-exome sequencing of DNA sampl

71 Using linkage analysis and whole-exome sequencing on samples f

72 We performed sequential genome-wide linkage analysis and whole-exome sequencing to evaluate

73 We used linkage analysis and whole-exome sequencing to identify

74 Using linkage analysis and whole-exome sequencing, we identifi

75 We used linkage analysis and whole-genome sequencing of a consan

76 We used linkage analysis and whole-genome sequencing of a multip

77 sted to be involved in schizophrenia through linkage analysis, and duplications at 1p36.33 and CGNL1.

78 Genome-wide SNP-typing, linkage analysis, and exome sequencing revealed a homozy

79 By genomic sequencing, linkage analysis, and functional validation, we identifi

80 included incorporation of radiolabeled Glc, linkage analysis, and imaging of cellulose microfibril f

81 AR families are generally too small for linkage analysis, and length of homozygous regions is un

82 cluding monosaccharide analysis, methylation linkage analysis, and mass spectrometry of native LM spe

83 In this study, deep sequencing, genetic linkage analysis, and transcriptome data were used to pr

84 The Utah linkage analysis approach of using singly informative ex

85 Here we describe a global linkage analysis approach, GLINT, for rapid discovery of

86 ative to dystonia, large families suited for linkage analysis are exceptional.

87 We performed linkage analysis, association analysis and haplotype ana

88 Additionally, linkage analysis based on sibling structure within the c

89 We used linkage analysis, based on arrays with single-nucleotide

90 LINK, a novel application that performs MCMC linkage analysis by spreading the computational burden b

91 240 mutation was determined by a genome-wide linkage analysis by use of simple sequence length polymo

92 ton/deuterium exchanges, the composition and linkage analysis can be determined in a single step.

93 traditional gene mapping techniques, such as linkage analysis, can help identify the genetic basis of

94 The primary linkage analysis coded persons with either ASD or specif

95 We utilised a genome-wide marker set for linkage analysis combined with cytological mapping of cr

96 Parametric linkage analysis combined with exome sequencing in a FH4

97 Linkage analysis combined with whole-exome sequencing in

98 A population-based record-linkage analysis compared psychiatric patients with the

99 Here we report a genetic segregation and linkage analysis conducted on F2 progeny of a reciprocal

100 Combining the four families in linkage analysis confirmed a significant genome-wide lin

101 t Xyl levels decreased in uxs3 uxs5 uxs6 and linkage analysis confirmed that the xylan content in uxs

102 Linkage analysis confirmed the region with a logarithm o

103 uage impairment as "affected." The secondary linkage analysis consisted of quantitative metrics of au

104 Linkage analysis defined Quantitative Trait Loci (QTLs)

105 Using whole-exome sequencing, SNPchip-based linkage analysis, DNA microarray, and Sanger sequencing,

106 Genome-wide linkage analysis, DNA sequencing, and an allelic test we

107 enzyme degradation, permethylation glycosyl linkage analysis, electron microscopy, and mutagenesis s

108 d not have been identified using traditional linkage analysis, emphasizing the need for exome sequenc

109 Linkage analysis excluded all variants except a Phe93Leu

110 In a large Dutch FEVR family, we performed linkage analysis, exome sequencing, and segregation anal

111 Genetic linkage analysis, exome sequencing, tumor studies, and f

112 ion of an excised corneal button, genomewide linkage analysis, fine mapping linkage and haplotype ana

113 tic abnormality in this family, we performed linkage analysis followed by whole-exome capture and nex

114 Linkage analysis for BMI was performed on 657 subjects i

115 This report confirms that linkage analysis for common disorders can be successful

116 We consider the problem of multiple locus linkage analysis for expression traits of genes in a pat

117 AF4, carbohydrate composition and glycosidic linkage analysis for the dominating population was perfo

118 Genomewide linkage analysis generated one significant LOD score of

119 When used in concert with linkage analysis, haplotyping can help delineate a locus

120 Family-based linkage analysis has been a powerful tool for identifica

121 eal model organisms for such approaches, but linkage analysis has been only modestly successful due t

122 s has been extensively studied, conventional linkage analysis has failed to locate the factors that c

123 Genetic linkage analysis has identified loss-of-function mutatio

124 By a combination of linkage analysis, homozygosity mapping, and exome sequen

125 Genetic linkage analysis identified 14 loci that were associated

126 Linkage analysis identified 2 disease-associated loci.

127 Joint-linkage analysis identified 32 quantitative trait loci (

128 Homozygosity mapping and linkage analysis identified a candidate region on chromo

129 Linkage analysis identified a peak (LOD = 4.29) on chrom

130 Whole-genome sequencing and linkage analysis identified a variant in a gene that exp

131 Genome wide linkage analysis identified an approximately 18 Mb disea

132 Linkage analysis identified five regions of the genome t

133 Linkage analysis identified potential modifier-gene loci

134 Linkage analysis identified the multi-allelic locus Sen1

135 Genetic linkage analysis identified three loci with an LOD score

136 Comparative genomics and linkage analysis identify candidate genes associated wit

137 We have combined polysaccharide linkage analysis, immuno-labeling, and transcriptome pro

138 s of the remaining cases of DC, we undertook linkage analysis in 20 families and identified a common

139 We thus perform an unbiased linkage analysis in 3A9 TCR F2 (NOD.H2(k) x B10.BR) mice

140 Here we combine whole genome sequencing with linkage analysis in a 3-generation family affected by ca

141 A whole-genome linkage analysis in a Finnish pedigree of eight cases wi

142 Here we use genome-wide linkage analysis in a large ALS/FTD kindred to identify

143 rformed genome-wide expression profiling and linkage analysis in a large F2(DA x PVG) intercross, whi

144 erformed a genome-wide association study and linkage analysis in a sample of 3456 young healthy indiv

145 We conducted a preliminary linkage analysis in a subset of 487 participants with av

146 Using exome sequencing and linkage analysis in a three-generation family with a uni

147 Linkage analysis in a three-generation family with affec

148 We performed genetic linkage analysis in consanguineous families affected by

149 Using genome-wide linkage analysis in consanguineous families, we mapped t

150 Linkage analysis in F2 intercross (B6 x MSM) progeny ide

151 Whole-genome linkage analysis in five informative families identified

152 Linkage analysis in MF5L6 identified a chromosome 3 locu

153 We performed a genome-wide linkage analysis in patients with cardiac laterality def

154 We performed whole-genome SNP-based linkage analysis in seven consanguineous families with P

155 We carried out a genetic linkage analysis in the extended DYT4 family that spanne

156 Genome-wide linkage analysis in this family revealed a new locus for

157 Genome-wide linkage analysis in two families identified a 7.5-Mb loc

158 utosomal sex-determining gene was mapped via linkage analysis in two families with 46,XY DSD to the l

159 Linkage analysis, including an enantiomeric specific pro

160 Linkage analysis indicated that IDF was composed of homo

161 Linkage analysis indicates that SecA dimerization is cou

162 Nonlinear linkage analysis indicates that this unusual behavior ca

163 Thermodynamic linkage analysis indicates that TRAPP weakens nucleotide

164 xample for the concept that population-based linkage analysis is a useful strategy to identify comple

165 reased use of whole-genome sequencing (WGS), linkage analysis is again emerging as an important and p

166 Linkage analysis is useful in investigating disease tran

167 udies in dogs have primarily employed either linkage analysis, leveraging the typically large family

168 Non-parametric-linkage analysis, linkage-disequilibrium-model analysis,

169 locus, was identified on chromosome 16 using linkage analysis (logarithm of the odds, 9.1).

170 Genetic linkage analysis mapped loci with lod scores of 5 to 7 o

171 METHODS AND Genome-wide linkage analysis mapped the SND+AVB disease locus to chr

172 Genome-wide linkage analysis mapped two equally plausible loci to ch

173 as performed by the Markov chain Monte Carlo linkage analysis method, MCLINK, and a set of SNPs was f

174 sociation methods including mixed models and linkage analysis methods.

175 Genetic analysis included linkage analysis (n = 17) with exome sequencing (n = 7).

176 Using a combination of linkage analysis, next-generation sequencing, and modeli

177 Linkage analysis of >13,500 single-nucleotide polymorphi

178 y new CAD genetic loci through a large-scale linkage analysis of 24 large and multigenerational famil

179 oma in some but not all cases in the family, linkage analysis of 31 families subsequently identified

180 also successfully replicated in our previous linkage analysis of 428 nuclear families.

181 any compelling associations, but parametric linkage analysis of 460 families (1062 affected individu

182 Linkage analysis of 486 sibling pairs from the family ba

183 We further carried out combined linkage analysis of 53 multiplex families with AP and 36

184 Through linkage analysis of a cross-intercross of these two pare

185 Linkage analysis of AD identified the strongest linkage

186 Linkage analysis of affected families, including a very

187 A genome-wide linkage analysis of backcrossed animals with EAG reveale

188 and asthma and that has been identified via linkage analysis of BMI in a population ascertained on a

189 Through linkage analysis of crosses between the C57BL/6J (B6), B

190 Study and performed a model-free genome-wide linkage analysis of fibromyalgia with 341 microsatellite

191 We conducted a genome-wide linkage analysis of IGRA phenotypes in families from a t

192 n Leishmania, opening the way toward genetic linkage analysis of important traits and providing stron

193 A multipoint posterior probability of linkage analysis of multiplex families from the Philippi

194 ral phenotyping of the families also enabled linkage analysis of quantitative measures, including nor

195 However, linkage analysis of seed carotenoids in Arabidopsis thal

196 e controlled by a large number of genes, and linkage analysis of several traits implicates a 'common

197 antitative refraction and refractive errors, linkage analysis of spherical equivalent, myopia, and hy

198 is, to our knowledge, the first genome-wide linkage analysis of the extended Utah high-risk CMM pedi

199 Combined linkage analysis of the two families confirmed that RTTN

200 Through the parallel linkage analysis of the two NAM panels, both common and

201 Comparative linkage analysis of these differences is currently under

202 assical univariate and bivariate genome-wide linkage analysis of TNF production using the data from b

203 We identified the disease locus through linkage analysis on 15q21.2, and exome sequencing reveal

204 Here, by exome sequencing and linkage analysis on a Chinese family with autosomal domi

205 ld dataset, performing parametric multipoint linkage analysis on a highly consanguineous pedigree wit

206 K cell functional maturation, we performed a linkage analysis on F2 (B6.Rag1(-/-) x NOD.Rag1(-/-) int

207 a variant-level and a gene-level parametric linkage analysis on nine PNTM families (16 affected and

208 ple members affected with focal epilepsy and linkage analysis on one of these.

209 three different inbred strains and performed linkage analysis on the DPOAE data obtained from the sec

210 ring cleavage ions are potentially useful in linkage analysis, one of the most critical steps of glyc

211 me a widely used epidemiological method like linkage analysis or genome-wide association analysis.

212 Compared with traditional approaches for linkage analysis, our new model can efficiently infer IB

213 ool capable of modeling genetic association, linkage analysis, polygenic effects, shared environment,

214 Linkage analysis produces two separate complementary mar

215 version and a 109x speed-up over the popular linkage analysis program SIMWALK.

216 Linkage analysis ranked the TTN region as falling under

217 Linkage analysis remains an important tool in elucidatin

218 The observed heterogeneity in linkage analysis results may just be a reflection of the

219 Here, in the four-generation family UW-AP, linkage analysis revealed four regions that provided the

220 Initial genome-wide linkage analysis revealed suggestive linkage to chromoso

221 Genome-wide linkage analysis revealed that EEM was linked to the 6q2

222 Genome-wide linkage analysis revealed two small candidate regions on

223 Linkage analysis, reverse genetic approaches, and molecu

224 Model) and SOLAR-MGA (Sequential Oligogenic Linkage Analysis Routines -Major Gene Analysis) have sim

225 ODS AND We used SOLAR (Sequential Oligogenic Linkage Analysis Routines) to evaluate heritability of A

226 as implemented in the Sequential Oligogenic Linkage Analysis Routines, was used to estimate heritabi

227 Unfortunately, methods to perform multipoint linkage analysis scale poorly with either the number of

228 Linkage analysis showed a 7-Mb candidate interval on chr

229 Two-point linkage analysis showed positive linkage between cold so

230 Results from linkage analysis showed strong evidence that a region of

231 s of the TbGnTII null mutants by methylation linkage analysis suggests that, in wild-type parasites,

232 Genetic studies included linkage analysis, targeted Sanger sequencing, and next-g

233 The steps of the linkage analysis (testing for distorted segregation, clu

234 Here, we describe an alternative approach to linkage analysis that makes use of a nonreversible deute

235 In this study, we perform an unbiased linkage analysis to determine the genetic loci that may

236 and assess a statistical design that deploys linkage analysis to estimate and test the pattern and ex

237 As a proof of concept, we have used linkage analysis to identify 36 high-confidence novel ed

238 We previously used linkage analysis to identify a major HIVAN susceptibilit

239 xome sequencing, array-based genotyping, and linkage analysis to identify putative pathogenic variant

240 n 221 C57BL/6xBALB/c F2 progeny, followed by linkage analysis to identify quantitative trait loci (QT

241 Here, we use linkage analysis to map the chromosomal location of the

242 ode of discovery has been the application of linkage analysis to mouse crosses.

243 ker panel, a subset of which may be used for linkage analysis to reduce computational burden and to l

244 Here, we have used linkage analysis to show that both mRNA editing and alte

245 We used whole-genome sequencing with linkage analysis to study a consanguineous family with e

246 We have employed cysteine labelling and linkage analysis to the full length of Bak in mitochondr

247 Quantitative trait linkage analysis using 261 microsatellite markers identi

248 The genome-wide variant-level linkage analysis using 4,328 independent common variants

249 To identify candidate loci, we performed linkage analysis using 5 p.G206A carrier families (n = 5

250 Genome-wide linkage analysis using Affymetrix GeneChip Mapping 10K d

251 We did genome-wide linkage analysis using data from multi-incident Arab-Ber

252 Linkage analysis using inbred mouse strains identified a

253 Linkage analysis using this growth inhibition phenotype

254 omosome 6 were then tested in the gene-level linkage analysis, using the collapsed haplotype pattern

255 Genome-wide linkage analysis was carried out in 14 family members fo

256 Joint family linkage analysis was conducted with 7,386 markers in the

257 Linkage analysis was largely supplanted by the wide adop

258 Linkage analysis was performed and the disease locus nar

259 Linkage analysis was performed by testing for associatio

260 Genetic linkage analysis was performed in a family with a PCD su

261 A genome-wide STR and SNP based linkage analysis was performed in one large family that

262 Parametric genomewide linkage analysis was performed on 10 affected family mem

263 Single-nucleotide polymorphism-based linkage analysis was performed on DNA samples from the 4

264 Genome-wide linkage analysis was performed to map the locus.

265 Data linkage analysis was performed with the Office for Natio

266 For many years, linkage analysis was the primary tool used for the genet

267 Linkage analysis was then broadened to comprise 25 addit

268 iants shared in all affected individuals and linkage analysis was used to further filter shared varia

269 us on chromosome 3, originally identified by linkage analysis, was in fact due to three closely linke

270 Through a genome-wide linkage analysis, we detected a locus for autosomal-domi

271 Using linkage analysis, we have mapped the position of this mu

272 Using linkage analysis, we identified a 13-Mb locus on mouse c

273 Using family linkage analysis, we identified a keratoconus susceptibi

274 by analyzing families with recurrent SPTB in linkage analysis, we identified a linkage peak close to

275 Using quantitative trait linkage analysis, we identified Id2, a homolog of Id3, t

276 Using a combination of exome sequencing and linkage analysis, we investigated an English family with

277 By linkage analysis, we mapped a locus at 1p36.22 containin

278 Using genetic linkage analysis, we mapped a new locus for the disease

279 Using genome-wide linkage analysis, we mapped the AR-GPS gene to a 9.4-Mb

280 Using linkage analysis, we mapped the rd11 locus to mouse chro

281 By linkage analysis, we mapped the Tsk2 gene mutation to <3

282 In combination with linkage analysis, we performed whole-genome sequencing o

283 tural amino acid substitution and a standard linkage analysis, we show that a His97' NH(epsilon2)...O

284 iously, using quantitative trait locus (QTL) linkage analysis, we showed that D3Tx-AOD is controlled

285 atients followed by homozygosity mapping and linkage analysis were performed.

286 We performed linkage analysis, whole-exome and whole-genome sequencin

287 sease-associated mutations were sought using linkage analysis, whole-exome sequencing, and copy numbe

288 Exclusion of known ADTKD genes coupled with linkage analysis, whole-exome sequencing, and targeted r

289 Multipoint parametric linkage analysis with 13 members of this family identifi

290 We combined genome-wide linkage analysis with exome sequencing and identified 14

291 Parametric linkage analysis with general dominant and recessive mod

292 h PauR were also suggested by chemical cross-linkage analysis with glutaraldehyde.

293 ither through follow-up interviews or record linkage analysis with hospital discharge and PD outpatie

294 rhosis in the cohort was ascertained through linkage analysis with nationwide death registry.

295 n of the pedigree was performed, followed by linkage analysis with the redefined disease statuses, an

296 In this study, we combined linkage analysis with whole-exome sequencing of two indi

297 Here we combine linkage analysis with whole-genome resequencing in patie

298 ed all 49 heritable phenotypes using genetic linkage analysis, with special emphasis on phenotypes ju

299 disease gene to be on chromosome 19p13, and linkage analysis yielded a combined multipoint log(10) o

300 Genome-wide linkage analysis yielded a maximum two-point logarithm o