ライフサイエンスコーパス: linkage study

1 f Pima subjects who had been analyzed in the linkage study.

2 ed to obtain useful prior information from a linkage study.

3 haplotypes in the context of a family-based linkage study.

4 atically affect the overall conclusions of a linkage study.

5 ues concerning the genetic markers used in a linkage study.

6 level, which is useful in the planning of a linkage study.

7 chromosome (Xq25-q27) through a genome-wide linkage study.

8 s the maximum peak we observed in a previous linkage study.

9 is for the BP-IR relationship from a genetic linkage study.

10 ividuals) were used to perform a genome-wide linkage study.

11 arge family presented here is suitable for a linkage study.

12 story can increase the analytical power of a linkage study.

13 2q11 deletion syndrome (22q11DS) and genetic linkage studies.

14 n chromosome 8p21-22 found by several family linkage studies.

15 iously unattainable level of performance for linkage studies.

16 d data completeness with high throughput for linkage studies.

17 iew of the disparate findings from different linkage studies.

18 gions have been detected through genome-wide linkage studies.

19 cently collected or previously collected for linkage studies.

20 ry and genotyping of polymorphisms in family linkage studies.

21 locus of interest to pairs of relatives for linkage studies.

22 ci previously implicated in schizophrenia by linkage studies.

23 ne disruption in animal models or by genetic linkage studies.

24 some 22q11 has been suggested by genome-wide linkage studies.

25 obands that is sufficient for use in genetic linkage studies.

26 on the usual allele-sharing methods used in linkage studies.

27 with HIV and AIDS as determined by registry linkage studies.

28 bility genes in both rodent models and human linkage studies.

29 f candidate genes among families sampled for linkage studies.

30 ore than sufficient for typical whole-genome linkage studies.

31 rotein in Northwestern, gel-shift, and cross-linkage studies.

32 ere will be useful in future association and linkage studies.

33 cer-susceptibility genes identified in other linkage studies.

34 on research that moves away from traditional linkage studies.

35 d and will serve as useful markers in future linkage studies.

36 of risk genes is awaited by means of family linkage studies.

37 r 10-20% of XLRP patients, as predicted from linkage studies.

38 nterest in the use of quantitative traits in linkage studies.

39 n the 70-75% of XLRP patients predicted from linkage studies.

40 hich may have utility as a marker for future linkage studies.

41 ng were considered "definitely affected" for linkage studies.

42 d on chromosome 12q21-23 by four independent linkage studies.

43 much higher resolution than previous genomic linkage studies.

44 loci have been replicated across independent linkage studies.

45 bolic syndrome (MetS) in several genome-wide linkage studies.

46 by many somatic deletion studies and genetic linkage studies.

47 on than older ones, for example, genome-wide linkage study?

48 In the linkage study, 1,210 women met criteria (23% with postpa

49 obtained from our collaborative whole-genome linkage study (254 families).

50 In 71 families ascertained for a genetic linkage study, 337 subjects with major affective disorde

51 Several linkage studies across multiple population groups provid

52 In this large, population-based record-linkage study, advancing parental age, especially advanc

53 The pooling of results across primary linkage studies allows greater statistical power to dete

54 Region-specific or chromosome-specific linkage studies also benefit from the availability of as

55 ings from several new independent genomewide linkage studies and also have completed ordered subset a

56 Recent linkage studies and association analyses indicate the pr

57 e approaches: pedigree and affected sib-pair linkage studies and association studies of population sa

58 Genetic linkage studies and candidate gene association studies h

59 Genetic linkage studies and exome sequencing have identified fou

60 bility 1 (Pas1) locus identified in previous linkage studies and further narrowed this quantitative t

61 tant findings of candidate gene, genome-wide linkage studies and genome-wide association studies.

62 In both pedigree linkage studies and in population-based association stud

63 ellites as the markers of choice for genetic linkage studies and many other studies of human pedigree

64 Inheritance studies are reviewed, including linkage studies and molecular mapping, and the positions

65 Genetic analysis was performed using linkage studies and PCR gene identification.

66 To expedite linkage studies and positional cloning efforts in the do

67 Previous genetic linkage studies and sequencing of plausible gene candida

68 implicated in hyper-/hypocholesterolemia by linkage studies and single nucleotide polymorphisms by g

69 ly discovered in independent association and linkage studies and uncovered many promising new candida

70 Using a combination of genome-wide linkage studies and whole-exome sequencing in a kindred

71 A mutation was identified via a genome-wide linkage study and candidate gene analysis.

72 her, the combination of our unbiased genetic linkage study and the in silico analysis positions genes

73 We performed a sequential genome-wide linkage study and whole-exome sequencing in a family wit

74 esults compared favorably with other Populus linkage studies, and addition of SSR loci from the popla

75 n, genotype imputation from sequence data in linkage studies, and additional tools.

76 ued by low mapping resolution in traditional linkage studies, and an inability to identify variants t

77 chromosomal region 6p21 in three independent linkage studies, and association was reported between JM

78 Sperm typing technologies, linkage studies, and computational inferences from popul

79 Copy number analyses, linkage studies, and exome sequencing were used to ident

80 ies, family studies, candidate gene studies, linkage studies, and genome-wide association studies (GW

81 lity loci through candidate gene approaches, linkage studies, and GWASs is still in its infancy.

82 There have been relatively few genome-wide linkage studies, and no chromosomal region has yet been

83 e genes in both parametric and nonparametric linkage studies, and now more and more studies combining

84 ia candidate gene association and genomewide linkage studies, and to set the stage for the numerous g

85 de polymorphisms (SNPs), because traditional linkage studies are not as powerful in identifying genes

86 Genomewide linkage studies are tending toward the use of single-nuc

87 commonly arises when families sampled for a linkage study are included in an association study.

88 yses, including genome-wide and fine-mapping linkage studies, based on insulin levels measured during

89 isease has been established through multiple linkage studies, but the specific gene(s) has not been i

90 n studies identified genes not found in this linkage study, but these human transcription factors are

91 Linkage studies can point to a genomic region containing

92 Genetic association and linkage studies can provide insights into complex diseas

93 Recent genetic linkage studies complement the existing evidence that im

94 nd from 1989 onwards), and the Oxford record linkage study (data for Oxfordshire and surrounding area

95 Linkage studies demonstrate that nm1054 maps to a geneti

96 ugh some positive results were observed, our linkage study does not provide statistically significant

97 on human recombination as well as for future linkage studies, especially those involving populations

98 5-step protocol, consisting of a genome-wide linkage study followed by association analysis, to ident

99 The first 2 independent linkage studies for obsessive-compulsive disorder (OCD)

100 To date, nine linkage studies for quantitative lipid traits have been

101 We previously reported a genomewide linkage study for human longevity using 308 long-lived i

102 Genome-wide linkage studies from Sudan and Brazil identified a putat

103 The pilot linkage study further confirms the heterogeneity of IOP

104 ce from animal studies, Mendelian syndromes, linkage studies, genetic association studies and express

105 Two linkage studies give strong evidence of a locus at almos

106 utations in BRCA1 and BRCA2 as compared to a linkage study group.

107 Evidence from a genetic linkage study had suggested a possible syndrome in some

108 n order of magnitude greater than individual linkage studies, has increased power to detect novel loc

109 Four major RA genome-wide linkage studies have been carried out, but apart from th

110 Linkage studies have been conducted in high-risk CLL fam

111 Although several linkage studies have been conducted, all samples to date

112 influence common human diseases, but to date linkage studies have been constrained to searching for s

113 Results of autism linkage studies have been difficult to interpret across

114 Previous methods for the meta-analysis of linkage studies have been proposed, and, although some m

115 Linkage studies have clearly identified a primary diseas

116 win, adoption, segregation, association, and linkage studies have confirmed that genetics plays a maj

117 Genome-wide linkage studies have defined a broad susceptibility regi

118 Recent genetic linkage studies have defined confirmed susceptibility lo

119 ross experiments in combination with genetic linkage studies have firmly established that the phenoty

120 A number of type 2 diabetes linkage studies have found evidence of linkage to 20q12-

121 Multiple linkage studies have found evidence suggestive of anothe

122 Linkage studies have identified a major locus at the chr

123 Several genome-wide linkage studies have identified a number of putative sus

124 Recent linkage studies have identified a significant associatio

125 Candidate gene studies and genomewide linkage studies have identified genes in the bone morpho

126 To date, linkage studies have identified more than a dozen genomi

127 Genetic linkage studies have identified mutations in the gene en

128 ome-wide association studies and traditional linkage studies have identified several genetic loci inv

129 In contrast to Mendelian diseases, however, linkage studies have identified very few reproducibly li

130 Linkage studies have implicated 10q22-q23 as a schizophr

131 Linkage studies have implicated chromosome 17q21-22 as a

132 Linkage studies have implicated several genomic regions

133 Linkage studies have mapped a susceptibility gene for ty

134 Candidate gene and genome-wide linkage studies have not significantly contributed to ou

135 with the syndrome have been identified, and linkage studies have placed the gene locus in Xq13.2.

136 Recent linkage studies have provided evidence in favor of sever

137 More recently, family and linkage studies have provided some evidence for overlapp

138 Several type 2 diabetes linkage studies have reported linkage to chromosome 6q22

139 Disease linkage studies have revealed many susceptibility loci f

140 in the recombination interval defined in the linkage study, identified mutations in SMC and DMC patie

141 Genetic linkage studies implicated deficiency of CD36, a membran

142 Because of linkage studies implicating 7q31 in autism, where langua

143 In most genome-wide linkage studies, implication of a causative disease gene

144 We report here on linkage studies in 100 families of European descent asce

145 h autism spectrum disorder (ASD) and several linkage studies in ASD have nominally implicated the reg

146 The relatively short history of linkage studies in bipolar disorders (BPs) has produced

147 rating both gene association and genome-wide linkage studies in both mice and humans to understand th

148 pressor genes (TSGs) have been found through linkage studies in cancer predisposed families where the

149 Genome-wide linkage studies in combination with whole-exome and conv

150 Previous genome-wide linkage studies in crosses of these strains identified t

151 omosome 8p22-23 in prostate cancer cells and linkage studies in families affected with hereditary pro

152 ve resulted in a call for the abandonment of linkage studies in favor of genome scans for association

153 Association and linkage studies in human and rodent species have been su

154 Linkage studies in humans and experimental animals have

155 is (PCA), homozygosity rate estimations, and linkage studies in humans are classically conducted thro

156 Linkage studies in humans suggest that at least some sus

157 knockout models, as well as association and linkage studies in humans.

158 tag SNP maps that will be useful for genetic linkage studies in humans.

159 Genetic linkage studies in informative [C57BL/6JxSM/J]F2 mice id

160 y of overcoming this problem is to carry out linkage studies in large complex pedigrees.

161 Previous linkage studies in Mexican-Americans localized a major s

162 To identify the disease locus, we performed linkage studies in one of these families using the Affym

163 Linkage studies in rare Mendelian bone diseases have ide

164 One such approach uses linkage studies in rodent models to identify homologous

165 Previous linkage studies in schizophrenia have been discouraging

166 bined magnetoencephalography and genome-wide linkage study in 212 healthy siblings demonstrates that

167 We performed a genetic linkage study in 37 multigenerational human pedigrees of

168 Here we report the results of a genome-wide linkage study in a large ALS and FTD kindred using Affym

169 We performed a whole-genome linkage study in an expanded data set of 102 multiplex f

170 The lack of consensus amongst linkage studies, including this study, is probably an in

171 Genetic linkage studies indicate that germline variations in a g

172 Genome-wide linkage studies indicate that more than three genes cont

173 We apply CFA to published linkage studies investigating age-of-onset of Alzheimer'

174 Linkage studies involving the four-generation family of

175 ata from combined genome-wide expression and linkage studies is essential for the development of test

176 rvative, evaluation of the results from such linkage studies is possible.

177 mmonly used to increase statistical power in linkage studies is the study of extremely discordant sib

178 Our investigations reveal that if the linkage study is informative, the procedure improves pow

179 y, the loss in power is small, even when the linkage study is uninformative.

180 Linkage studies localized the SMC and DMC disease genes

181 Recent linkage studies mapped a susceptibility locus for stutte

182 Results of initial linkage studies mapped the Comel-Netherton syndrome in 1

183 Our previous linkage studies mapped the gene responsible for FEO to a

184 Linkage studies mapped the locus for the autosomal domin

185 The results of sib-pair linkage studies may be compromised if a substantial numb

186 on of age at onset as a covariate in genetic-linkage studies may reduce genetic heterogeneity and inc

187 st that the bladder problems observed in the linkage study may be IC.

188 sample sizes commonly used in human genetics linkage studies, minor QTL effects often go undetected a

189 of Pima Indians who had participated in the linkage study (n = 1,228).

190 New linkage studies now provide strong evidence for Alzheime

191 gs from previous independent GWAS of ALS and linkage studies of ALS-frontotemporal dementia.

192 ion glaucoma (NTG) on chromosome 12q14 using linkage studies of an African-American pedigree (maximum

193 Linkage studies of bipolar disorder and schizophrenia ha

194 ociated with ascertainment of families, most linkage studies of Bipolar I disorder (BPI) have used re

195 replication; however, it does indicate that linkage studies of BMI are robust with respect to measur

196 Because many linkage studies of complex diseases sampled affected sib

197 Linkage studies of complex traits frequently yield multi

198 cently, the following question has arisen in linkage studies of complex traits: at what distance do w

199 On the basis of genomewide linkage studies of families affected with age-related ma

200 ecular causes of MFM will probably come from linkage studies of informative kinships or from systemat

201 Later, genome-wide linkage studies of multiplex GV families identified NLRP

202 ycystin proteins (PC and PKD), identified in linkage studies of polycystic kidney disease, are candid

203 Early genome-wide linkage studies of psoriasis focused on segregation of m

204 Until recently, linkage studies of rare Mendelian disorders of hypertens

205 We report on our initial genetic linkage studies of schizophrenia in the genetically isol

206 chromosome 5 has been implicated in previous linkage studies of schizophrenia, the identification of

207 To understand its genomic basis, eight linkage studies of sibling pairs have been performed.

208 Our objective was to conduct genetic linkage studies of the type of OCD thought to have the s

209 rlaps with a region previously implicated by linkage studies of unipolar and bipolar disorders and co

210 We report here a genomewide linkage study of 21 multiplex pedigrees with gout from a

211 Population-based data-linkage study of 321,287 term singleton first-born offsp

212 A record linkage study of 386,485 singleton-born men from 331,089

213 This is a population-based linkage study of 979,912 term singleton pregnancies in S

214 In a recent genome-wide linkage study of a large Asian Indian kindred, a genetic

215 e screened the families of the Collaborative Linkage Study of Autism for several markers spanning a c

216 g psychiatrists on 524 subjects in a genetic linkage study of BPI disorder.

217 We performed a linkage study of chromosome 22 in 200 families with AS a

218 sibships who had participated in a previous linkage study of diabetes and related traits; they compr

219 ) has been mapped to chromosome 3q13-21 in a linkage study of early-onset CAD.

220 The authors conducted a genetic linkage study of families that have both autism spectrum

221 The first family linkage study of lung cancer has identified linkage of l

222 otaling 14.3 Mb, initially identified in our linkage study of obesity and the metabolic syndrome.

223 We now report a high-density genome-wide linkage study of opioid dependence.

224 study; N=1346), 2) an affected sibling pair linkage study of recurrent depression (probands from the

225 result has been confirmed in an independent linkage study of severe obesity in Utah pedigrees.

226 , we performed the following analyses: (1) a linkage study of six markers in and around the HPC2/ELAC

227 A linkage study of the X-chromosome using 234 affected sib

228 it to serve as an endophenotype in a genetic linkage study of these families.

229 A record linkage study of two large databases of hospital admissi

230 for prostate cancer susceptibility genes by linkage studies offered early hope that finding genes wo

231 te the unverifiability of these assumptions, linkage studies often invoke them to estimate p, using t

232 orted linkage to these regions, we conducted linkage studies on 144 PRCA families by using microsatel

233 genetic variants, we performed a genome-wide linkage study on 73 multiplex AP families by genotyping

234 vered by genome-wide association studies and linkage studies only partially explain the influence of

235 psy is frequently unhelpful, whereas genetic linkage studies or mutations in the UMOD gene may identi

236 y to have participated in a previous genetic linkage study (OR, 4.30; 95% CI, 1.84-10.10).

237 es of hospital admissions, the Oxford Record Linkage Study (ORLS) and an English national record link

238 As shown in the genome-wide linkage studies, our association depends mainly on apoli

239 ied that contribute to BRV and no systematic linkage studies performed.

240 A genome-wide linkage study prompted a search of the genes encoding be

241 A previous linkage study provided evidence for a prostate cancer-su

242 lysis, together with data from several other linkage studies, provides compelling evidence for the ex

243 olds for statistical significance in genetic linkage studies, real data are often complicated by many

244 ationships can have serious consequences for linkage studies, resulting in either reduced power or fa

245 Genome-wide linkage studies reveal that each model is regulated by m

246 3 nuclear families who had participated in a linkage study revealed that type I error rates for these

247 ility locus for lung cancer and suggest that linkage studies should preferentially recruit young lung

248 Genetic linkage studies showed that there was a high level of co

249 These results are consistent with genetic linkage studies showing protective associations for alco

250 These findings and recent genetic linkage studies strongly implicate NMDA receptor deficie

251 Case reports and linkage studies suggest additional loci at 1p36, 1q43 an

252 Previous linkage studies suggest that different genetic component

253 Recent linkage studies suggest that multiple genes are importan

254 Linkage studies suggest that the related LMS and ADULT s

255 Although genetic linkage studies support a critical underlying role for g

256 Multiple genetic linkage studies support the hypothesis that the 15q13-14

257 dies, functional candidate gene studies, and linkage studies that can adopt a hypothesis-free approac

258 These results strongly suggest that previous linkage studies that employed sparse microsatellite maps

259 findings are consistent with those of other linkage studies that have reported linkage to chromosome

260 acid, are associated with CaP risk and from linkage studies that the AMACR gene region at 5p13 is li

261 As in classic linkage studies, the most efficient strategy is to use m

262 ascertained for two bipolar disorder genetic linkage studies: the University of Chicago, Johns Hopkin

263 deficiency and indicate the value of genetic linkage studies, thereby improving the genetic diagnosis

264 cus, designated RP1, has been mapped through linkage studies to a 4-cM interval at 8q11-13.

265 analysis of prevalent cases may be useful in linkage studies to detect nephropathy susceptibility loc

266 etic maps are used routinely in family-based linkage studies to identify the rough location of genes

267 ches described in this review and perform F2 linkage studies to positionally locate QTL in a fixed ge

268 ne responsible for HGF1, we extended genetic linkage studies to refine the chromosome 2p21-p22 candid

269 We undertook an X-chromosome linkage study to determine any contribution of the X-chr

270 Subsequently, a gene for LD was mapped, by linkage studies, to a 16-cM region at 16q24.3.

271 has also been suggested, by association and linkage studies, to be a susceptibility gene for schizop

272 ation studies, complemented by selection and linkage studies, to identify and understand mechanisms o

273 ostic data from a multisite bipolar disorder linkage study, to explore clinical and demographic facto

274 Linkage studies using DNA from the family and an intrage

275 Here we review classical linkage studies using laboratory crosses and population

276 hrenia, we conducted genetic association and linkage studies using samples ascertained independently

277 and cognitive impairment) in which previous linkage studies using short tandem repeat polymorphisms

278 In previous linkage studies using the uniquely susceptible Wistar Ky

279 n to breast cancer can now be sought through linkage studies using this quantitative trait.

280 rovide practical guidelines for carrying out linkage studies using WGS data.

281 A comprehensive, population-based record linkage study using the Danish Psychiatric Central Resea

282 In this data linkage study, vaccination data for children in the Heal

283 A series of linkage studies was previously conducted to identify qua

284 A genome-wide linkage study was performed to identify the locus respon

285 A combined genome-wide association and linkage study was used to identify loci causing variatio

286 To facilitate association-based linkage studies we have studied the linkage disequilibri

287 In linkage studies, we may have information about different

288 expression quantitative trait loci (eQTL) in linkage studies, we observe extensive allelic heterogene

289 (DR) families (N=1312) used in the original linkage study, we fine mapped the QTLs with 2031 tagging

290 Genetic-linkage studies were performed in 5 familial pancreatiti

291 Linkage studies were performed in a large family with an

292 To identify the causal gene defect, linkage studies were performed.

293 ng with microsatellite analysis, and genetic linkage studies were performed.

294 t cancer cases are being used in traditional linkage studies, which are expected to yield only modera

295 ese methods are applied to a prostate cancer-linkage study, which emphasizes their potential advantag

296 A genome-wide affected sib-pair linkage study with 221 Japanese families with coronary a

297 We did a registry-linkage study with data from population-based HIV and ca

298 t that this family is suitable for a genetic linkage study with the aim of identifying the location o

299 n the first generation of candidate gene and linkage studies, with a substantial increase in complexi

300 s chromosome 22q, for which five independent linkage studies yielded strong evidence for a susceptibi