ライフサイエンスコーパス: linker

1 well-defined domains separated by a flexible linker.

2 e end of the relatively immobile interdomain linker.

3 nd an ubiquitin ligase binder connected by a linker.

4 d coiled coil regions by a flexible Gly-rich linker.

5 basic groups to insulin via a light cleaved linker.

6 associating more closely with the CTD-distal linker.

7 transient helices connected by a hydrophobic linker.

8 rhead to an E3 ubiquitin ligase ligand via a linker.

9 sured for aeg-PNA duplexes with a base stack linker.

10 riple helical repeats connected by a helical linker.

11 is controlled by the sequence of the peptide linker.

12 he weave feature pi-stacking of the bridging linker.

13 d GLP-1R agonist through a linear 7 A diynyl linker.

14 suggesting the absence of an oligosaccharide linker.

15 e but injectable polymer via a light cleaved linker.

16 ffinity compared to a cyclohexane and phenyl linker.

17 with probes that contain the helices in the linker.

18 electrode via a short, flexible polypeptide linker.

19 ) due to restrictions imposed by the shorter linker.

20 g 4-fluoro-3-nitro-azidobenzene (FNAB) cross-linker.

21 no acid sequence, called here the N-terminal linker.

22 stabilize the complex through the N-terminal linker.

23 ains tethered by an intrinsically disordered linker.

24 arated by a short, structurally well-defined linker.

25 ding C-terminal DHHA1 domain via an extended linker.

26 circularly permuted GFP placed in the S3-S4 linker.

27 ein regions, unreachable with a single cross-linker.

28 her cysteine cathepsins can cleave the VC(S) linker.

29 ellulose interaction for the nonglycosylated linker.

30 (SBD), which are tethered by an interdomain linker.

31 se of two related cages with longer flexible linkers.

32 atial organization and the presence of cross-linkers.

33 epeat protein scaffold and avoiding flexible linkers.

34 n over-abundance of motor and nonmotor cross-linkers.

35 ing the functional groups on the imidazolate linkers.

36 DNA and the lengths of the interspersed DNA linkers.

37 fferent functional groups to the surrounding linkers.

38 , were coupled to AMPARs via different-sized linkers.

39 zaldehyde when increasing amounts of bdc-NH2 linkers (0%, 20%, 46%, 70%, and 100%) are incorporated i

40 Sodium channel and clathrin linker 1 (SCLT1) mutations were associated with the oral

41 like fold but lacks an elongated beta1-beta2 linker, a region that typically acts as a gate to direct

42 ow the abundance of motor and nonmotor cross-linkers affects the speed of cytokinetic furrowing.

43 Additional removal of the linker allowed caspase-6 to gain more flexibility in the

44 Additionally, a shortened beta1-beta2 linker allows for the formation of a deep, solvent-acces

45 oring titin in the Z-disk is the actin cross-linker alpha-actinin.

46 an ortho position relative to one acetylene linker and a para position relative to the other, destru

47 all three CaM domains including the central linker and both lobes.

48 itro-azidobenzene (FNAB), which act as cross-linker and further covalently binds to anti-TNF-alpha an

49 o interact directly with the FAK FERM-kinase linker and induce FAK kinase activity and Y397 phosphory

50 amide, and ammonium persulphate as the cross linker and initiator.

51 r histidine kinases (SHK) consist of sensor, linker and kinase modules and different models for SHK s

52 ential diffusion distance of unreacted cross-linker and monomer into a prepolymerized hydrogel sink r

53 s that calmodulin can act as a protein cross-linker and Spc29 is an extended, flexible protein.

54 We find that the coiled coil linker and the attached histidine kinase domains undergo

55 the urea binding site on the indicator cross-linker and the carboxylate group of the analyte was stil

56 ding to MdmX in the presence of the flexible linker and the intramolecular binding motif by assuming

57 mains of SUR2: D207E in the intracellular L0-linker and Y985S, G989E, M1060I, and R1154Q/R1154W in TM

58 due to the presence of the cationic viologen linker and, in the cases of HT and HS, permanent porosit

59 ibody against HER2, a novel enzyme-cleavable linker, and a topoisomerase I inhibitor payload.

60 a mechanism that is influenced by the S4-S5 linker, and by a separable voltage-sensor intrinsic rela

61 They usually contain sensor, linker, and kinase modules and the structure of many of

62 nucleotide binding domain, the inter-domain linker, and the beta-basket of the substrate binding dom

63 r concentrations of protein, exogenous cross-linkers, and blending synthetic polymers has all been ap

64 ents, of linkers, targeting groups and cross-linkers, and of the actual properties and in vivo fate o

65 Aminated linkers are known to enhance the absorption of light and

66 hese results suggest that protease-cleavable linkers are unlikely to increase the therapeutic index o

67 ssembly of metal ions and functional organic linkers, are an emerging class of porous materials with

68 cross-linking by myosins and nonmotor cross-linkers, are thought to promote contractility.

69 ferential binding implicates the interdomain linker as a dynamic allosteric switch.

70 ith doxorubicin via an acid-labile hydrazone linker as a function of local pH and time within live ce

71 peptide motif (RXWV) in the TlyA interdomain linker as indispensable for co-substrate binding.

72 domain contacts the nucleosome dyad and both linkers, associating more closely with the CTD-distal li

73 By using a series of haptens with a linker at alternative tethering sites of the boscalid fr

74 and ethylene glycol dimethacrylate as cross-linker at different ratios.

75 is problem have incorporated auto-immolative linkers at the cost of atom economy and synthetic advers

76 112a, MFM-115a, and MFM-132a, with different linker backbone functionalization.

77 ement dynamics when the length between cross-linkers becomes smaller than the length between entangle

78 cular binding motif by assuming the flexible linker behaves as a wormlike chain.

79 proach was the utilization of an appropriate linker between 1,2,4-triazole and benzimidazolone moieti

80 d native Env trimers but includes a covalent linker between gp120 and gp41, an engineered 201-433 dis

81 proper kAE1 membrane residency, as a crucial linker between kAE1 and actin cytoskeleton-associated pr

82 Removing the beta-propeller, or inserting a linker between NLS and beta-propeller, disrupts specific

83 d triazoles are described, which vary in the linker between the biaryl pyrazole and imidazole/triazol

84 nhibited scaffold that serves as a molecular linker between the synapsin-dependent reserve pool and t

85 s was synthesized in which the length of the linker between the two iron-binding catecholamide units

86 The linker between the VH and VL domains exhibits the domina

87 inal NADH, and FAD domains, and the flexible linker between them is essential for optimal intra-domai

88 The linker-binding site on the SBD is a potential target for

89 We demonstrate that the amine-specific cross-linker Bis(sulfosuccinimidyl)suberate (BS3), which is us

90 ted anti-bacteria antibodies as bifunctional linkers (BLs) to mediate the aggregation of streptavidin

91 from laser irradiation of the HNPs promoted linker breakdown resulting in prodrug liberation.

92 spases cleave gasdermin-D in the interdomain linker but not GSDMB.

93 rate levels of both motor and nonmotor cross-linkers but attenuated by an over-abundance of motor and

94 rk shows how the specific arrangement of the linkers can play a key role in the photophysical propert

95 cortical tension increases faster than cross-linkers can unbind, the marginal band will coil, whereas

96 While the linker causes an order-of-magnitude increase in the over

97 d its receptor IL2Rbeta joined via a peptide linker (CIRB).

98 l over the release rate of the drug from the linker, combined with prolonged circulation of the dendr

99 e also reveals two equally distributed S4-S5 linker conformations in the closed channel, suggesting a

100 e made advances in engineering the antibody, linker, conjugation site, small-molecule payload, and dr

101 ng for the p59 N-terminal domain and for the linker connecting it to the phosphodiesterase domain.

102 A carboxy-terminal linker connecting S6 and the cyclic-nucleotide-binding d

103 uorination yields dependent on the length of linker connecting the metal chelating unit to the hydrox

104 A flexible linker connecting the N-terminal domain (NTD) and C-term

105 We identify the linker connecting transmembrane repeats II and III in tw

106 A short S4-S5 linker connects nearby voltage-sensing and pore domains

107 cs simulations on several GalNAc-T2 flexible linker constructs show altered remote prior glycosylatio

108 In the absence of linker contacts, H-NS binding is significantly reduced,

109 was achieved using long-chained alkanethiol linkers coupled with oligoethylene glycol (LCAT-OEG).

110 main, an intrinsically disordered C-terminal linker (CTL), and a C-terminal conserved peptide (CTC).

111 In this work, we introduced missing linker defects into a homochiral metal-organic framework

112 This study revealed drug-linker design as a critical parameter in ADC development

113 matic study investigating the impact of drug-linker design on the in vivo properties of a series of h

114 The best performing drug-linker design was further used to prepare ADCs with diff

115 The linker design we identified should ultimately support ex

116 ion of the relative orientation of the TBAPy linkers determined by their respective framework topolog

117 on preferences, confirming that the flexible linker dictates the rotation of the lectin domain, thus

118 nzimidazolone moieties, whereby a cyclobutyl linker displayed superior affinity compared to a cyclohe

119 n structural properties-most importantly the linker distributions-and synthesis mechanisms of these t

120 a 197 bp nucleosome bearing symmetric 25 bp linker DNA arms in complex with vertebrate linker histon

121 effective in neutralizing negatively charged linker DNA because it has a reduced net charge, and in D

122 biases methylation toward inter-nucleosomal linker DNA in Arabidopsis thaliana and mouse.

123 More strikingly, these linker DNA regions with 6mA are usually flanked by well-

124 hat 6mA occurs mostly in the AT motif of the linker DNA regions.

125 ucleosomes into positions with more flanking linker DNA than CHD7.

126 d CHD7 both bind with high affinity to short linker DNA, whereas CHD8 requires longer DNA for binding

127 (AT-IN) and outward (AT-OUT) bending of the linker DNA.

128 r the asymmetry created by the presence of a linker DNA.

129 t enable the enzyme to stably associate with linker DNA.

130 teractions with the SBD, and the predominant linker-docking site is available in only one allosteric

131 report a child with a novel mutation in the linker domain of STAT1 who had life-threatening autoimmu

132 lly, suggesting a ruler-like function of the linker domain.

133 Likewise, substitutions in the linker domains of GluA2 completely removed any effect of

134 fully assembled SNARE motifs but uncomplexed linker domains.

135 -2 family motors with different length neck-linker domains.

136 Solvent assisted linker exchange (SALE) and de novo synthesis of mixed-li

137 controlled single-crystal to single-crystal linker exchange of 2-methylimidazole in ZIF-8 membrane g

138 The linker-exchange effect depends on the membrane synthesis

139 surements on porphyrin oligomers with alkyne linkers exhibiting different preferred conformations.

140 s in the presence of the physiological cross-linker, filamin.

141 of a GPCR and G protein tethered by an ER/K linker flanked by FRET probes.

142 on and reduction of TTF moieties changes the linker flexibility, which in turn switches the breathing

143 Linker for activation of T cells (LAT) is a transmembran

144 the most critical residue of the N-terminal linker for inhibiting binding of the VWF A1 domain to Gp

145 mercaptoethoxyglycinamide (MEGA) solid-phase linker for the facile synthesis of latent peptide alpha-

146 The proteins demonstrate an evolved set of linkers for self-assembly of nanoparticles into volumetr

147 ture of truncated HjLPMO9A revealed that the linker forms an integral part of the catalytic domain st

148 Additionally, the C-terminal region of the linker forms previously unreported, transient interactio

149 Here, we report on a linker-free strategy that employs adventitious electroni

150 promise of a synthetic surfactant- and cross-linker-free technique to prepare highly stable pectin-co

151 Our new linker-guided strategy can be used to enrich the discove

152 Our findings reveal that the VC(S) linker has multiple paths to produce active catabolites

153 ly designed pyrrolobenzodiazepine (PBD) drug-linkers have been synthesized via intermediate 19 for us

154 The addition of amine and thiol linkers have shown a significant effect on cytotoxicity,

155 we propose in situ Hi-C method named Bridge Linker-Hi-C (BL-Hi-C) for capturing structural and regul

156 We find that HMGNs counteract linker histone (H1)-dependent stabilization of higher or

157 Adding linker histone H1 further increased compaction of the A-

158 Remarkably, we discovered that linker histone H1 phosphorylated at S/T18 decorated the

159 p linker DNA arms in complex with vertebrate linker histone H1.

160 ns of the decades-old observation of mitotic linker histone phosphorylation, serving as a paradigm to

161 Thus, chaperone-assisted eviction of linker histones and Shugoshins is a fundamental step in

162 serving as a paradigm to explore the role of linker histones in bio-signaling processes.

163 ino acid intrinsically disordered C-terminal linker (IDL) that connects the DNA binding domain with t

164 We capture the role of the linker in a heuristic scaling model, and we find that co

165 -symmetry bicyclo[2.2.2]octane dicarboxylate linker in a Zn4O cubic lattice.

166 conformational landscape of the interdomain linker in ADP-bound DnaK and supported our simulations b

167 and the rest of A1 that lock the N-terminal linker in place such that it reduces binding to GpIbalph

168 to esterases due to an embedded ester cross-linker in the particle's core.

169 s elucidate the crucial role of the chemical linkers in determining the level alignment when molecule

170 individual atomic columns of Zn and organic linkers in the framework.

171 The linkers in this MOF are pyrenes linked to the nodes via

172 Static cross-linkers increase the likelihood of a stalled "tug-of-war

173 w sequence-encoded information in disordered linkers influences phase transitions of multivalent prot

174 metathesis, guest incorporation, and capping linker installation, we were able to achieve the highest

175 The interdomain linker is a well-structured participant in the interdoma

176 s and the chemical function of the imidazole linker is essential for directing the swing effect in ZI

177 Escherichia coli Hsp70 DnaK, the interdomain linker is flexible.

178 the slower phase, suggesting that the S4-S5 linker is important for communications between the pore

179 We found that hydrolysis of the acid-labile linker is incomplete because the pH range of 4-7 in the

180 Our results suggest that the RAM linker is more than a passive tether, contributing local

181 This linker is removed in a NEK2A kinase-dependent manner as

182 When the linker is shortened, the diffusion distance is reduced p

183 al molecular imprinting approaches, no cross-linker is used.

184 The controlled cleavage of the peptide linkers is not only a useful strategy for intracellular

185 formances are impacted by the amount of such linkers is poorly understood.

186 We demonstrate that linker labilization method can create controllable hiera

187 ion assays (trans-activity), irrespective of linker length between lectin domains.

188 onomer incorporations depend strongly on the linker length between the diene moiety and functional gr

189 The optimum linker length of five matches that present in natural si

190 d ensuing tumor growth inhibition reveal the linker length to be a bidirectional switch for cis-activ

191 Marked dependency on linker length was observed for BET-degrading and cMyc-dr

192 he majority of constructs contained variable linker length while one was rationally designed for opti

193 hS-x-BD, x = 3-7), in particular for certain linker lengths high comonomer reactivity ratios stand ou

194 nts (scFvs) derived from HJ8.5 with variable linker lengths, all specific to human tau.

195 ustering algorithm is used to refine the DCD-linker locations.

196 The linker makes DNA contacts that are required for gene sil

197 This linker may prove useful in expanding the repertoire of s

198 ary preferred positioning of A-tracts in DNA linkers may control chromatin higher-order folding and t

199 s in the closed channel, suggesting an S4-S5 linker-mediated PtdInsP2 gating mechanism among TRPML ch

200 functionality of ZIFs is provided, including linker modifications, functional hybridization of ZIFs v

201 ength of the intrinsically disordered C-tail linker modifies the interfilament spacing.

202 ide evidence that the disordered interdomain linker modulates the histone-binding affinity by interac

203 neous localization of bdc-NH2 in these mixed-linker MOFs.

204 , beyond its role as a recombinosome-axis/SC linker molecule, Mer2 has important functions in relatio

205 The S4-S5 linker mutation, G546L, impeded the faster phase of volt

206 Owing to the vast diversity of linkers, nodes, and topologies, metal-organic frameworks

207 However, linker O-glycans greatly impact cellulose conversion via

208 r simulations predict an additional role for linker O-glycans, namely that they are responsible for m

209 of this velocity reduction is that the neck linker of a kinesin only detaches from the motor head wh

210 be associated with immunodeficiency, such as linker of activation of T cells (LAT); B-cell CLL/lympho

211 nalysis confirmed that JZTx-27 bound to S3-4 linker of NsVBa, with F98 being the critical residue in

212 ty, and migration and is usually mediated by linker of nucleoskeleton and cytoskeleton (LINC) complex

213 components SUN1 and SUN2, two members of the linker of nucleoskeleton and cytoskeleton (LINC) complex

214 n containing proteins and lamin A/C form the LInker of Nucleoskeleton-and-Cytoskeleton (LINC) bridgin

215 ds on particular residues in the interdomain linker of SpoIVFB.

216 e functionalities covalently tethered to the linkers of IRMOF-74-III results in a material that can u

217 ters used demonstrates that amination of all linkers of the MOF is not required to obtain the maximum

218 8, 9], to form the so-called LINC complexes (linkers of the nucleoskeleton and cytoskeleton) that spa

219 ne (DHA) photoswitching subunits, bridged by linkers of varying chain length.

220 is (DOS) is achieved with a versatile oxalyl linker offering rapid access to complex alkaloid mimics

221 protease-cleavable valine-citrulline [VC(S)] linker on ADC efficacy.

222 chemical functionalization of the imidazole linker on the framework dynamics.

223 ected to the electrode through two different linkers, one directly to the backbone and one directly t

224 While the indicator cross-linker outperformed its corresponding monomer twin, esta

225 the length and sequence of the integrase-RDF linker peptide did not affect fusion protein recombinati

226 In the remaining conformations, the linker position was in flux, and the reader adopted both

227 nfluenced by the number density of the TBAPy linkers presented by the topology of a given MOF that ar

228 c index of ADCs and that resistance based on linker processing is improbable.

229 The genetically encoded photo-cross-linkers promise to offer a temporally controlled tool to

230 Identification of PRAS40 as a linker protein paves the way for understanding how stres

231 To identify the linker protein, we took advantage of a unique finding in

232 SLMAP binding to autophosphorylated MST2 linker recruits STRIPAK and promotes PP2A-mediated depho

233 e known (main) binding site, we identified a linker region and a secondary binding site that are cruc

234 rved residues (R151, I155) in the syntaxin-1 linker region as key sites for the MUN domain interactio

235 YopO phosphorylated gelsolin in the linker region between gelsolin homology domains G3 and G

236 the conformational change of the syntaxin-1 linker region induced by Munc13-1 initiates ternary SNAR

237 The linker region of seven residues in NS5, rich in serotype

238 m SH2 domain of S. cerevisiae Spt6 binds the linker region of the RNA polymerase II subunit Rpb1 rath

239 L4 and in the 130s region, the intersubunit linker region, the 26-32 region as well as in the stabil

240 rises from its central domain, with a short "linker" region narrowed to within amino acids 324-348, b

241 The resulting models imply that the linker regions confer great flexibility between domains,

242 (GSH)-induced degradation of self-immolative linkers released BENSpm from the DSS-BEN polymers.

243 -conjugated system via additional ethenylene linker results in a significant reduction of the HOMO-LU

244 We found that while the interdomain linker samples many conformations, it behaves as three r

245 tational analyses, peptide binding analysis, linker-scanning mutagenesis, and nuclear magnetic resona

246 ydrate-binding module (CBM1) connected via a linker sequence.

247 We utilize variant barcodes, invariant linker sequences and modular template-specific primers t

248 s further support the concept of interdomain linkers serving a dual role in substrate binding by appr

249 Phylogenetic reconstruction of the linker set was consistent with these findings.

250 iverse roles for the actin-microtubule cross-linker Shortstop (Shot) in mitotic spindle function in D

251 Linker-specific methylation can evolve simply by breakin

252 rescent reporter system in order to optimize linker stability for mitochondrial release.

253 The hydrophobic cross-linkers stabilize the fold by macrocyclic restraints, an

254 ecules to specific sites of the DNA particle-linker strands, thereby modulating dye-nanoparticle dist

255 s and that of the hydrophobic components, of linkers, targeting groups and cross-linkers, and of the

256 ugating SN-38 to the dendrimer via different linker technologies we sought to vary the release rate o

257 ribe the general applicability of this novel linker technology for the preparation of stable and effi

258 tion, provided they are joined by a flexible linker that allows the two domains to face each other.IM

259 bility, which is facilitated by a 75-residue linker that connects the two halves of P-gp.

260 nding domain of MdmX by a conserved flexible linker that is 85 residues long.

261 ver, these IDRs have only been thought of as linkers that allow flexible spatial arrangement of the s

262 es may be coupled covalently through peptide linkers that are designed to be cleaved by intracellular

263 e scaffold which are appended with aliphatic linkers that enable coupling to bioactive carriers.

264 n a meta position relative to both acetylene linkers, the daughter conductance remains as low as the

265 enclosing 816 uranium nodes and 816 organic linkers-the largest unit cell found to date for any nonb

266 rains with 2-imidazolecarboxaldehyde (ZIF-90 linker), thereby enlarging the effective aperture size o

267 tion, ChIP, proximity ligation with a bridge linker, Tn5 tagmentation, PCR amplification and high-thr

268 Extending the linker to -C(O)NH(CH2)2- resulted in a loss of antimycob

269 t of a pre-miRNA binding unit connected by a linker to a Dicer inhibiting unit.

270 an antibody domains fused through a flexible linker to an engineered one-domain soluble human CD4.

271 two-component strategy, allowing peptide and linker to be separately engineered and then assembled in

272 it functions as a motor or as an actin cross-linker to exert its essential role is disputed [1, 4, 5]

273 ructed a mutant murine P-gp with a shortened linker to facilitate structural determination.

274 docking of the approximately 13-residue neck linker to the leading head (deemed to be the power strok

275 o three rings in length and up to four bonds linkers to give an in silico database of approximately 1

276 acts at specific locations in the nucleosome linkers to induce inward (AT-IN) and outward (AT-OUT) be

277 tent macrocycles as novel multitopic organic linkers to prepare SMDHs.

278 m-, or p-xylylene (o-, m-, or p-Xy) covalent linkers to produce o-ExBox(4+) (3.5 A), m-ExBox(4+) (5.6

279 ndscape of the nucleosome by drawing the two linkers together and reducing their flexibility.

280 linked through a differentially hydrolyzable linker unit, N-4-carboxymethylphenyl-methyloxycarbonyl-l

281 ctural variations in acetal- and ketal-based linkers upon their degradation kinetics is studied throu

282 lene-, tolane-, and diphenylbutadiyene-based linkers using imine formation.

283 tly improved methane storage capacities with linker vacancy defects.

284 p and a six carbon long aliphatic chain as a linker was found to inhibit HDACs.

285 ultiple positions, and in situ, its flexible linker was removed, yielding fully mature heterodimeric

286 eraction among the pi-conjugated macrocyclic linkers was studied within three tetraphenyl-pyrene (1,3

287 transmembrane sequence containing a flexible linker were expressed in a cell line derived from PrP kn

288 Selected peptide linkers were conjugated to cell penetrating peptides and

289 MOFs with robust metal nodes and pro-labile linkers were initially synthesized.

290 sts of two alpha-helical domains joined by a linker, which allows the trimer to adopt either a closed

291 n is resolved by reversible unfolding of the linker, which is a singular mechanism that allows a flex

292 and Co(II)) and the synthetic dihydroxamate linkers, which yielded an expanded library of 15 ferriti

293 domain (CTD) localizes primarily to a single linker, while the H1 globular domain contacts the nucleo

294 that inhibition of the proposed static cross-linker will produce disordered transport of short MTs an

295 In this model, the linker with a plasma release half-life of 21h achieved s

296 lar ditopic cation, suitable to be used as a linker within extended structure.

297 the critical additional interactions of its linker within the TTR central channel.

298 stem from the highly organized chromophoric linkers within their frameworks.

299 Mixed-linker zeolitic imidazolate frameworks (ZIFs) are a subc

300 change (SALE) and de novo synthesis of mixed-linker ZIFs have been demonstrated, but the differences