ライフサイエンスコーパス: linker region

1 nabled by negatively charged residues in the linker region.

2 cted to a C-terminal hook-like segment via a linker region.

3 ansducer, via phosphorylation of the Smad1/5 linker region.

4 o-localizing with rootletin and Cep68 in the linker region.

5 p on the substitution pattern of the C22-C24 linker region.

6 dimerization domain, connected by a flexible linker region.

7 cularly inhibited by the adjacent C-terminal linker region.

8 l domain of approximately 16 kDa by a narrow linker region.

9 hich is connected to the channel pore by a C-linker region.

10 eside in two separate domains connected by a linker region.

11 ne Hsp33 requires the unfolding of a central linker region.

12 omatic moieties as well as the amino alcohol linker region.

13 omologous to prokaryotic IF3, connected by a linker region.

14 consists of two globular domains joined by a linker region.

15 ir C terminus as well as in the proline-rich linker region.

16 the C terminus as well as at an interdomain linker region.

17 ia MAPK-mediated phosphorylation of the Smad linker region.

18 sidual activity depends significantly on the linker region.

19 yltransferase domain, pivoting about a short linker region.

20 embly domain, and portions of an intervening linker region.

21 tional after proteolytic cleavage at the X-Y linker region.

22 lyze inhibitory phosphorylation in the Smad1 linker region.

23 ylation of Smad3 at the C terminus or in the linker region.

24 n to polysialylate O-glycans on the adjacent linker region.

25 s by systematic chemical modification of the linker region.

26 domains (N- and C-terminal lobe) joined by a linker region.

27 ent of SRP domains connected by the flexible linker region.

28 te HCN and CNG channels and that contain a C-linker region.

29 in the amino-terminal domain and downstream linker region.

30 mTORC1 and/or ERK, including new ones in the linker region.

31 me midpoints rather than in internucleosomal linker regions.

32 ilitates GGR, especially in internucleosomal linker regions.

33 xtended conformations of the two interdomain linker regions.

34 not inhibit catalysis as a result of missing linker regions.

35 atalytic core domain-carboxy-terminal domain linker regions.

36 new elements of dynamic structure within IDP linker regions.

37 n the loss of glycosylation of three of four linker regions.

38 ving phosphorylation sites in their tail and linker regions.

39 whereas iASPP predominantly interacts with a linker region adjacent to the core domain.

40 The linker region adopts a unique conformation that contains

41 Mutations to the linker region affect neither catalytic rate nor domain-d

42 Within this linker region all herpesviruses contained a conserved, h

43 fragments corresponding to the PLC-zeta X-Y linker region also bind with higher affinity to polyvale

44 ordered region in domain II and the adjacent linker region also permitted partial cell fusion and vir

45 epeats arranged in series are unique in that linker regions also feature calcium-binding motifs.

46 letion mutagenesis studies identified acidic linker region (amino acids 117-128) on Akt as an Hsp27 b

47 s several regulatory elements, including a C-linker region and a cyclic nucleotide-binding domain (CN

48 e known (main) binding site, we identified a linker region and a secondary binding site that are cruc

49 distinct SMAD3 phosphorylation sites at the linker region and at the C terminus determined the up-re

50 similarities between Hsp33's own metastable linker region and client proteins present a possible mod

51 from interactions between the H1-like basic linker region and DNA around the entry/exit site, which

52 naling response by phosphorylating the Smad2 linker region and enhancing the level of Smad2 activatio

53 Many of these mutations are in the linker region and the RING finger of CBL, leading to a l

54 have extended the SAR studies to include the linker region and the surface recognition group to optim

55 (FNIII9(4G)10) insertion in the interdomain linker region and used surface plasmon resonance to dete

56 epitope is less constrained by the flanking linker regions and is positioned so that the symmetry of

57 is also regulated by phosphorylation in the linker region (and N terminus) by a variety of intracell

58 ture of DsbP reveals an N-terminal domain, a linker region, and a C-terminal catalytic domain.

59 en consecutive N-terminal ankyrin repeats, a linker region, and a C-terminal phospholipase catalytic

60 to the end of the helix C of repeat 14, the linker region, and the B-C loop of repeat 15.

61 ther mutations in the N-terminal domain, the linker region, and the C-terminal domain had little or n

62 encompassing the C-terminal end of RRM1, the linker region, and the N-terminal end of RRM2, whereas t

63 g that conformational changes involving this linker region are critical to the GABA activation pathwa

64 rence and a novel alkoxyurea connecting unit linker region are described.

65 ors with a novel alkoxyamide connecting unit linker region are described.

66 erine/threonine phosphorylation sites in the linker region are followed by the proline residue.

67 nce and possibly structural features of this linker region are indispensable for the kinase activity

68 , it is concluded that stable intact helical linker regions are needed to maintain the soft elasticit

69 The linker region (Arg-394-Pro-411) between the N terminus o

70 identified amino acids 290-300 of the Smad4 linker region as critical for the specific interaction o

71 rved residues (R151, I155) in the syntaxin-1 linker region as key sites for the MUN domain interactio

72 ine mutation was introduced into the TM2-TM3 linker region at position 281 (K281P) of the alpha1 GlyR

73 , increased occupancy of the nucleosome-free linker region at the insulator site, and increased repre

74 g of ECD and TMD and the conformation of the linker region at the interface of ECD and TMD are of par

75 interacting and trafficking domains relieves linker region autoinhibition of the VSE to produce maxim

76 sites to an O-glycan cluster located in the linker region between b2 and c domain.

77 tope located on the lateral ridge of DI, the linker region between DI and DIII, the hinge interface b

78 ate mechanism of autoinhibition in which the linker region between domains and a C-terminal amphipath

79 s of highly conserved serine residues in the linker region between domains I and II of genotype 2a JF

80 YopO phosphorylated gelsolin in the linker region between gelsolin homology domains G3 and G

81 rough cis-trans proline isomerization in the linker region between MLL1's third PHD finger and bromod

82 ts in potency were realized by extending the linker region between the 6-(S) position and the termina

83 OLGs increases the flexibility of the hinge linker region between the D3 and A1 domain, facilitating

84 The linker region between the domains is a dynamic random co

85 us assembly is sensitive to mutations in the linker region between the helicase and protease domains

86 diated partly by a highly negatively charged linker region between the KHC-interacting and cargo-bind

87 phosphorylation of four sites in TAK1, in a linker region between the kinase and TAB2/3 binding doma

88 found developmental delay, is located in the linker region between the ligand-binding and transmembra

89 This activity localizes to the charged linker region between the longin and GTPase domains of S

90 Here, we demonstrate that the linker region between the M3 and S2 domains, which in cu

91 We found that the 40-amino acid linker region between the MIT and the ATPase domain of V

92 ing Pro(396) to Ala (P396A) in the predicted linker region between the MORN and the kinase homology d

93 est that amino acids 487-501, located in the linker region between the N-terminal domains and the cat

94 onal assays identified Cys124 located in the linker region between the N-terminal pleckstrin homology

95 role in dimerization in solution, while the linker region between the predicted N-terminal coiled-co

96 ation and amino acid deletion shows that the linker region between the PX and N-terminal SH3 domain p

97 The deafness mutation D101G, in the linker region between the repeats, causes a slight bend

98 Here, we have examined the role of the linker region between the TRPM8 inner gate and the TRP b

99 on of a tyrosine residue (Y380) found in the linker region between the two catalytic domains of the e

100 hows a unique, well-ordered structure of the linker region between the two dsRBDs that differs from t

101 ithin the CX5C or CX3H regions or within the linker region between the two fingers also perturbed bot

102 al ubiquitin-like (Ubl) domain and the short linker region between the two Ubl domains, explaining wh

103 l domain, the N-terminal zinc finger and the linker region between the two zinc fingers.

104 The linker region between the X and Y catalytic domains of P

105 A flexible linker region between three fragments allows antibodies

106 We find that the short linker regions between LDLR class A repeats contain an e

107 Our studies demonstrate that linker regions between modular domains can contribute to

108 equence indicates certain enriched motifs in linker regions between nucleosomes and reveals a sequenc

109 The linker regions between repeats are thus critical determi

110 y we identified O-glycosylation sites in the linker regions between the characteristic LDLR class A r

111 C-terminal deletions of BBP reveal that the linker regions between the two zinc knuckles and between

112 sites for these b ions happen to be near the linker regions between the variable domains and the cons

113 inding domain, transmembrane domain, and the linker regions between these domains were particularly i

114 cross-link with the PBS are situated in the linker region, between the N- and C-terminal domains and

115 g domains, and a protein containing just the linker region bind to thin filaments with about a 1:1 mo

116 The crystal structure of the Pan2 linker region bound to a Pan3 homodimer shows how the un

117 Chaetomium thermophilum (ctPRC2), a flexible linker region, but not the H3K27M cancer mutant peptide,

118 s, they are phosphorylated at an interdomain linker region by CDK8 and CDK9, which are components of

119 eport that the phosphorylation of Mad in the linker region by the Wg antagonist Zw3 (homolog of verte

120 of Nrf2 was accompanied by concomitant Smad linker region/C-terminus phosphorylation, induction of t

121 connected to the platelet cell membrane by a linker region called the stalk.

122 The mechanistic complexity of the linker region can be described by a spring model with Br

123 ly bound to Munc18-1, whereas the syntaxin-1 linker region changes its conformation, similar to that

124 Ks play a role in IL-1beta activation of the linker region, chondrocytes were preincubated with speci

125 Linker region comparisons suggest that the active CCPs o

126 The resulting models imply that the linker regions confer great flexibility between domains,

127 ed His-rich cluster (His-Gly-His-His) in the linker region connecting its two catalytic domains sense

128 ne/proline consensus motifs localized in the linker region connecting PDZ2 to PDZ3 domains.

129 monstrated that the C-terminal helix and the linker region connecting the N-terminal coiled-coil doma

130 We discovered a role for the unstructured linker region connecting the N-terminal oligomerization

131 The 20-residue linker region connecting the two conserved domains of Co

132 e domain (CYT(CDH)) containing heme b, and a linker region connecting the two domains.

133 man AMPK was abolished when a portion of the linker region containing the alpha-hook domain was delet

134 s, nucleosome phasing shifts to increase the linker region containing the EPO-R transcription start s

135 revealed that conformational changes in the linker region contribute to mobility of the catalytic do

136 -194 contain the Hc alpha-helix and flexible linker region controlling transition of syntaxins betwee

137 s within the first EF-hand domain and the XY linker region dramatically reduces the binding of PLCzet

138 unidentified role for the E protein DI/DIII linker region during the DV2 assembly process.

139 previously unidentified role for the DI-DIII linker region during the low-pH-dependent refolding of E

140 e BRICHOS domain, possibly together with the linker region, during pro-SP-C biosynthesis in the ER.

141 o different protein domains and inter-domain linker regions encoded in the non-LTR retrotransposons,

142 reveal that the partial unfolding of Hsp33's linker region facilitates client binding to an amphipath

143 as uncovered an essential role for the short linker region flanked by the SH2 and kinase domains of I

144 ns, FKBP12, FRB, and GST, presents a peptide linker region for target protein binding only in the abs

145 While the linker regions for the EC1'-EC2' and EC3'-EC4' pairs dis

146 uster of negatively charged residues in this linker region form the Laminin-binding site.

147 extended Mint1 PTB fragment reveals that the linker region forms a short alpha-helix that folds back

148 omain, and achieved via removal of the LNRAB linker region from the HD domain.

149 When overexpressed in MIN6 cells, this Hc-linker region functioned as a competitive inhibitor of e

150 and, indicating that the structure of the DT linker region has a role in cleavage at a fixed distance

151 The N-linker region has high mechanical lability and acts as t

152 r Src homology (SH) 3 domains and SH2 kinase linker regions has a key role in down-regulation of kina

153 phosphorylation at three sites in the Smad3 linker region in addition to the two C-terminal residues

154 sults highlight an active role of the PX-SH3 linker region in maintaining p47 (phox) in its fully aut

155 LSD2 alone and LSD2 in complex with the NPAC linker region in the absence or presence of histone H3 p

156 the binding is mediated through a predicted linker region in the lipid kinase.

157 ed as a single polypeptide with a 31-residue linker region in the middle of the protein.

158 The linker region in the resulting product contains an exocy

159 the conformational change of the syntaxin-1 linker region induced by Munc13-1 initiates ternary SNAR

160 mouse PLCzeta, mimicking cleavage at the X-Y linker region, induced [Ca2+]i oscillations and embryo d

161 by the regulatory domain and how the kinase linker region interacts with the regulatory nucleotide-b

162 d/or provide factor I-cofactor activity, the linker region is highly conserved only in the former.

163 ve been studied extensively, the role of the linker region is less well known, despite the potency of

164 ircular dichroism studies, suggests that the linker region is not extended but folds into a domain st

165 This linker region is part of the subunit interface between m

166 particularly if the intervening polyproline linker region is retained.

167 ted threonine 179-proline motif in the Smad3 linker region is the major binding site for Pin1.

168 This linker region is the site of adaptive mutations.

169 in a manner dependent upon the unstructured linker region joining the amino-terminal microtubule int

170 Here, we identify a "linker region" (KSRKERERLEEK) that connects the TM senso

171 Mutations in the pro-SP-C BRICHOS domain or linker region lead to amyloid formation of the SP-C prot

172 cal connection between the transmembrane and linker regions, leading to an apparently new characteriz

173 not Wnt/GSK3, phosphorylation of the Smad1/5 linker region localizes to a ventral vegetal gastrula re

174 ) and an effector domain (ED) separated by a linker region (LR), is implicated in replication, pathog

175 h domains fold in an independent manner, the linker region makes polar interactions with the catalyti

176 de-modulated channels, suggesting that the C-linker region may be highly dynamic in the KCNH, hyperpo

177 ectrostatic repulsion in the heptad repeat B linker region may contribute to the triggering of HMPV F

178 the sole mammalian sperm factor and that its linker region may have important regulatory functions du

179 ed crystal structures of the wild type and a linker region mutant of the H6N6 NS1 (A/blue-winged teal

180 One such linker region mutant, A257T, is analogous to the A359T m

181 stigated the mechanism by which CBL-Y371H, a linker region mutant, and CBL-C384R, a RING finger mutan

182 rises from its central domain, with a short "linker" region narrowed to within amino acids 324-348, b

183 cision when the lesion is present in the DNA linker region of a nucleosome.

184 Mechanistically, this linker region of caspase 8 acts as a Src homology 2 bind

185 tion of a critical tyrosine (Tyr-341) in the linker region of Cbl-c by Src or a phosphomimetic mutati

186 tained from the binding between LSD1 and the linker region of CoREST are similar to those obtained fr

187 presence of the matrix-exposed, unstructured linker region of Cox15 needed for Cox15 oligomerization,

188 The N-terminal basic region and the basic linker region of HIV-1 NCp7 were found to be important f

189 GFP viruses with mutations in the head-stalk linker region of HN.

190 D2 and D1 domains) is mediated by the D1-D2 linker region of its neighboring protomer.

191 of cysteine thiol groups by inducers in the linker region of Kelch-like ECH-associated protein-1 (Ke

192 In the linker region of Mcd1p, we identified a novel evolutiona

193 ved with Gag constructs containing the basic linker region of NC.

194 ase (MAM) domain and the O-glycan-containing linker region of neuropilin-2 are necessary and sufficie

195 ated across tumor types, as exemplified by a linker region of PIK3CA in which biophysical simulations

196 was due to changes in basic residues in the linker region of PLN.

197 eracts with RSK2 through residue W332 in the linker region of RSK2 and that this association is requi

198 The linker region of seven residues in NS5, rich in serotype

199 oprecipitated and form a complex through the linker region of Smad1.

200 The linker region of Smad3 and the tryptophan-aspartic acid

201 the glycogen-binding domain of Gal83 or the linker region of the alpha subunit were competent for AD

202 contrast, removal of the autoinhibitory X/Y-linker region of the catalytic core of PLC-epsilon marke

203 eptible to proteolysis within the N-terminal linker region of the first calcium-binding epidermal gro

204 main (which lacks the SH3 domain including a linker region of the full length protein), we observe a

205 ENP-B box sequence was located in the distal linker region of the nucleosome.

206 m SH2 domain of S. cerevisiae Spt6 binds the linker region of the RNA polymerase II subunit Rpb1 rath

207 s with high affinity by binding to the M1-M2 linker region of these channels.

208 Truncation of a charged linker region of yeast Hsp90 (Hsp82Deltalinker) was know

209 KBP prolyl isomerase enzymes is recruited to linker regions of chromatin.

210 The glycosites in linker regions of LDLR class A repeats are conserved in

211 oform(s) contributed to glycosylation of the linker regions of the LDLR class A repeats by in vitro e

212 joins the ligand-binding, transmembrane, and linker regions of the NarX sensor kinase to the signalin

213 ultimately fusion, are the transmembrane and linker regions of the vesicle-associated protein, synapt

214 tabilizes the relative positions of the neck linker regions of ZEN-4.

215 nding to GAF-B causes movement, through this linker region, of the catalytic domains, such that the H

216 To quantify the role of disorder in the RAM linker region on the effective concentration enhancement

217 The DNA-binding domain plus a flanking linker region on the HSF (DL) is essential for the RNA b

218 Second, the DT linker region participates in distance determination, as

219 naling in the absence of DLC1 mediated SMAD3 linker region phosphorylation and TGF-beta-induced expre

220 s, Tak1 regulates both R-Smad C-terminal and linker region phosphorylation in TGF-beta signaling.

221 lly, we demonstrate that the agonist-induced linker region phosphorylation of Smad2 at Thr-220, which

222 ays a role in agonist-induced C-terminal and linker region phosphorylation of the receptor-mediated R

223 ent ERK MAP kinase activity leading to Smad3 linker region phosphorylation.

224 er) signal was regulated by sequential Smad1 linker region phosphorylations at conserved MAPK and GSK

225 idence, also generated by SDSL-EPR, that the linker regions play a key role in IF structure and regul

226 the redox-controlled unfolding of the Hsp33 linker region plays the central role in the activation p

227 to the basic cluster (charge=+7) within the linker region, PLC-zeta-(374-385), binds to PC/PS vesicl

228 eas CrkII possesses in addition a C-terminal linker region plus a SH3 domain, which operate as regula

229 (SNAG) and zinc finger motifs separated by a linker region poorly conserved with GFI1B, its closest h

230 our studies reveal the critical role of the linker region (positioned between the CNB domain and the

231 Short intersubunit linker regions provide the molecular basis for flexibili

232 A linker region (residues 62 to 66) between two gH/gL bind

233 domains) and Gaussian Bayes classifiers (for linker regions), respectively.

234 studies suggest that these mutations in the linker region result in a rearrangement within the cr-u-

235 -beta-induced phosphoThr-ProTyr motif in the linker region, resulting in Smad2/3 polyubiquitination a

236 ncluding residues comprising the interdomain linker region, revealed an expanded heterodimer interfac

237 the function of four conserved motifs in the linker region, revealing a key role for a conserved PXXP

238 -terminal domain and are joined by a charged linker region rich in serine and arginine residues (SR l

239 C-terminal domain (CTD), joined by a charged linker region rich in serine and arginine residues (SR-r

240 ous norovirus cleavage sites inserted into a linker region separating cyan fluorescent protein and ye

241 with N-terminal transmembrane and disordered linker regions serving as the anchor and attachment to t

242 the incorporation of ERK/MAPK signals at its linker region, Smad1 physically interacts with androgen-

243 ta signaling caused phosphorylation of Smad3 linker region (Smad3L) at Ser213, resulting in the up-re

244 erminal residue E220 and the residues of the linker region stabilized a compact structure of TIS11d i

245 The presence of conserved Gly residue in the linker region suggests that flexibility between the tran

246 the BRICHOS domain or in its peptide-binding linker region supports the in vivo relevance of the prop

247 rentiation and generates a longer nucleosome linker region surrounding the GATA1 sites by shifting th

248 catalysis: (1) an N-terminal tail and (2) a linker region tethering DHFR to TS, and encoding a cross

249 average, 10-15% lower substitution rates in linker regions than in nucleosomal DNA.

250 ally, a Syntaxin1A mutant lacking a flexible linker region that allows NRD movement abolished stimula

251 single gas-phase cleavable bond within their linker region that can be selectively fragmented within

252 thus identify 10 residues in the interdomain linker region that change their conformations upon subst

253 We also know little about the linker region that connects the inhibitor site to the N-

254 e, Pro-Pro-Ser-Pro, residing in the variable linker region that connects the protease and translocato

255 ey clustered within and flanking the central linker region that connects the two catalytic domains an

256 subunit of the alpha(1)beta(2) GABA(A)R in a linker region that is believed to span the subunit.

257 as a series of insertion mutants in the A-M3 linker region that led to significant shifts in measured

258 olerance of hydrophilic substitutions in the linker region that was exploited to improve the fraction

259 ged in series, with either flexible or rigid linker regions that determine their elasticity.

260 hreonine 179 and other residues in the Smad3 linker region the same as TGF-beta, Pin1 is unable to bi

261 L4 and in the 130s region, the intersubunit linker region, the 26-32 region as well as in the stabil

262 s to the constitutive unfolding of the Hsp33 linker region thereby turning Hsp33 into a constitutivel

263 ntrol the structural integrity of cadherin's linker regions, thereby affecting cadherin's equilibrium

264 its dsRNA-binding motif 2 to bind dsRNA, its linker region to interact with Dicer, and its C-terminus

265 Similarly, the addition of the linker region to the AAV5 Rep endonuclease domain also c

266 ggle that adjusts the thermostability of the linker region to the cell redox status.

267 ssion of phosphorylation signals through the linker region to the other domains of the protein.

268 action between the ligand-binding domain and linker region to the pore that regulated channel desensi

269 ed the contribution of each of the HAMP-like linker regions to the functionality of DhNik1p and found

270 regulated via a conformational change in the linker region, triggering a movement of the N-terminal d

271 A conserved glutamic acid/glutamine in the linker region underlies MBF1 specificity for a subgroup

272 rin on Ser(169) located in the SH2-C1 domain linker region via protein kinase Cdelta, which retained

273 alternative phosphorylation of R-Smad in the linker region via the MAPK pathway (primarily p38 and JN

274 -binding experiments revealed that the basic linker region was essential for the membrane association

275 Flexibility of the linker region was found to be important for the reorient

276 ed that the calmodulin domain binding to the linker region was important for regulating the distance

277 (bp) that accumulate in long internucleosome linker regions was more efficient for identifying transc

278 ethods that map nucleosomes based on cuts in linker regions, we utilize DNase I cuts both outside and

279 smembrane segments S3-S5+S6 and the DIII/DIV linker region were associated with high probability of p

280 tion, and residues 340-356 of the SH2 kinase linker region were identified to be important for suppre

281 ch the lipophilic tail, polar headgroup, and linker region were modified to extend the structure-acti

282 Single residues in the S3-S4 linker region were substituted with cysteine, and the cy

283 Five structural domains and two linker regions were identified in what is probably a pos

284 ly the result of PLCzeta cleavage at the X-Y linker region, were present in fresh sperm as well as in

285 r oxidation occurs for residues of the first linker region, whereas greater oxidative modifications o

286 eotide-gated (CNG) channels, MloK1 lacks a C-linker region, which critically contributes to the molec

287 regulated by phosphorylation of Y221 in the linker region, which forms an intramolecular SH2-pY221 a

288 nsic conformational energy difference of the linker region, which is identical for both dimers.

289 sence of oxidants and an adjacent metastable linker region, which responds to unfolding conditions.

290 causes moderate destabilization of the Hsp33 linker region, which seems sufficient to convert the red

291 Mutations in the TFIIB reader and linker region, which were inactive on duplex DNA, were s

292 ylation of SMAD2 and SMAD3 proteins at their linker regions, which negatively regulated the TGF-beta

293 Thus, the linker regions, which tolerate few point mutations witho

294 residues 293-380, also known as the CoREST "linker" region, which is a central isolated helix that i

295 tructurally important alpha-helix within the linker region, while the mutation in CBL-b was located i

296 proximately 4.4 nm by 5.8 nm) separated by a linker region with a diameter of approximately 3 nm, fol

297 at connect the domain I-domain III (DI-DIII) linker region with the E1 core trimer, including H3.

298 two inhibitors differ only in their central linker regions, with compounds 1 and 2 containing a sing

299 inantly via the destabilization of the Hsp33 linker region without affecting zinc coordination, redox

300 y that recognizes the conserved zinc fingers linker region (ZnFL) in multiple KRAB-ZNF.