ライフサイエンスコーパス: lipid bilayer

1 he membrane, HDL becomes integrated into the lipid bilayer.

2 eins to, and regulates transport across, the lipid bilayer.

3 and Tween 80 as edge activators (EAs) in the lipid bilayer.

4 toxins form a pore that penetrates the cell lipid bilayer.

5 s of hDAT dimerization and its dynamics in a lipid bilayer.

6 alization of this domain with respect to the lipid bilayer.

7 ific binding pockets or penetration into the lipid bilayer.

8 Hofmeister effect outside the context of the lipid bilayer.

9 nanosheets induce physical disruption of the lipid bilayer.

10 e tails to nickel lipids integrated into the lipid bilayer.

11 binding domain near the inner leaflet of the lipid bilayer.

12 o characterize how it differs from that of a lipid bilayer.

13 he pH midpoint of peptide insertion into the lipid bilayer.

14 ng cavity formed by TatB and TatC inside the lipid bilayer.

15 ly charged DMPG, causing strong asymmetry in lipid bilayer.

16 quencies throughout an oscillating supported lipid bilayer.

17 from Oldenlandia affinis when embedded in a lipid bilayer.

18 transmitted directly to the channel from the lipid bilayer.

19 antial increase of the tensile stress in the lipid bilayer.

20 ad group and in the inner core region of the lipid bilayer.

21 at suggest communication between BAM and the lipid bilayer.

22 es a similar challenge in the context of the lipid bilayer.

23 stress, and the mechanical properties of the lipid bilayer.

24 suitable tag and can be reconstituted into a lipid bilayer.

25 eins are energetically coupled to their host lipid bilayer.

26 mation resulting in monomeric protein on the lipid bilayer.

27 als engage the channel to gain access to the lipid bilayer.

28 ects its direct contact with the peroxisomal lipid bilayer.

29 rotein functional states within the membrane lipid bilayer.

30 ired for IL-1beta transport across an intact lipid bilayer.

31 channels' hydrophobic cores and that of the lipid bilayer.

32 sibility of the TMD in bicelles that mimic a lipid bilayer.

33 ely oriented single channels within the same lipid bilayer.

34 l translocation of the transducer across the lipid bilayer.

35 the lateral diffusion of PI(4,5)P2 along the lipid bilayer.

36 sed it to study vesicle fusion to a tethered lipid bilayer.

37 m and is connected to its neighbor through a lipid bilayer.

38 e overall stability of the Env TMD trimer in lipid bilayer.

39 mponent pathway reconstituted on a supported lipid bilayer.

40 ngle RyR1 channels reconstituted into planar lipid bilayers.

41 lic particles smaller than 6 nm can embed in lipid bilayers.

42 rotein conformational dynamics within native lipid bilayers.

43 precursor allylamine hydrochloride (AH) with lipid bilayers.

44 to measure bound-cholesterol orientation in lipid bilayers.

45 P0 is only slightly higher than that of pure lipid bilayers.

46 cell monolayers; and permeabilize synthetic lipid bilayers.

47 dermined by the fluidic and labile nature of lipid bilayers.

48 investigates their interactions on supported lipid bilayers.

49 kDa cytochrome P450-cytochrome b5 complex in lipid bilayers.

50 sting phases and composition fluctuations in lipid bilayers.

51 it B (CTxB) in quasi-one-component-supported lipid bilayers.

52 elf-assembled supramolecular channels within lipid bilayers.

53 the spheroid as the lipids bind to cellular lipid bilayers.

54 ntly assembled in the plane of merged target lipid bilayers.

55 y and mobility for transmembrane proteins in lipid bilayers.

56 incorporating the TRPM3 protein into planar lipid bilayers.

57 llular compartments that are not enclosed by lipid bilayers.

58 channel with subconductant states in planar lipid bilayers.

59 ties in packing order were detected in mixed-lipid bilayers.

60 aggregation of htt and its interaction with lipid bilayers.

61 d to the instability of the proteins outside lipid bilayers.

62 on htt aggregation in solution and on model lipid bilayers.

63 lphaS as it acts as to anchor the protein to lipid bilayers.

64 amics, and hydration of the BM2 TM domain in lipid bilayers.

65 human Fas TM domains in bicelles that mimic lipid bilayers.

66 e SNARE-mediated fusion with solid-supported lipid bilayers.

67 s from fluid-phase proteins to form pores in lipid bilayers.

68 eate compartments, and are usually formed by lipid bilayers.

69 fold involves the burial of side chains into lipid bilayers.

70 ess dynamically propagate through biological lipid bilayers.

71 or OMP assembly into mycolic acid-containing lipid bilayers.

72 vidual bacteriorhodopsin molecules in native lipid bilayers.

73 s show that gA subunits can exchange between lipid bilayers.

74 the generated channels was studied in planar lipid bilayers.

75 A core coated with one or several concentric lipid bilayers.

76 We show here that CPP binding to lipid bilayers, a simple model of the cell membrane, can

77 Thus, ubiquitin and the substrate lipid bilayer act synergistically to induce a conformati

78 ing regions in the helical domain toward the lipid bilayer, allowing membrane interaction.

79 is reduced because of their slippage in the lipid bilayer, an effect that we directly observed using

80 type-I integral membrane proteins within the lipid bilayer, an event preceded by shedding of most of

81 to two 85 A beta-hairpins that traverse the lipid bilayer and assemble into a 168-strand beta-barrel

82 nment' is defined in a flexible manner, from lipid bilayer and crystal contacts, to substrate or liga

83 t-simulating an entire mammal red blood cell lipid bilayer and cytoskeleton as modeled by multiple mi

84 The membrane skeleton strengthens the lipid bilayer and endows the membrane with the durabilit

85 nts under near-physiological conditions in a lipid bilayer and in the presence of transport substrate

86 Using planar lipid bilayer and liposome patch clamp electrophysiology

87 provides membrane proteins with a nativelike lipid bilayer and much-needed solubility and enables in

88 been found to be residing on the surface of lipid bilayer and permeabilizing bacterial membranes at

89 he mechanical forces required to remodel the lipid bilayer and serving as a scaffold to recruit key r

90 can be affected by the physical state of the lipid bilayer and specific lipid-protein interactions.

91 ent knobs elevates the shear response in the lipid bilayer and stiffens the RBC membrane.

92 substrate and co-substrate Na(+) across the lipid bilayer and the transport cycle, respectively.

93 trin-based cytoskeleton to the erythrocyte's lipid bilayer and thereby contributes critically to the

94 to demonstrate that interactions between the lipid bilayer and transmembrane (TM) helices of Escheric

95 The interaction between lipid bilayers and Amyloid beta peptide (Abeta) plays a

96 ns and a structured region that inserts into lipid bilayers and disrupts their integrity.

97 1a strain H77 adopts a conical shape within lipid bilayers and forms a viroporin upon oligomerizatio

98 nalysis revealed that SspA auto-inserts into lipid bilayers and forms IAA-94-sensitive ion channels.

99 the transport of Cl(-) anions through planar lipid bilayers and into vesicles.

100 neous FCS and FRAP measurements on supported lipid bilayers and live cell membranes to test how far t

101 The nuclear envelope, composed of two lipid bilayers and numerous accessory proteins, has evol

102 ical adsorption of the molecular motors onto lipid bilayers and subsequent activation of the motors u

103 Interactions between lipid bilayers and the membrane-proximal regions of memb

104 hore (benzoporphyrin derivative, BPD) in the lipid bilayer, and a nanoparticle containing cabozantini

105 ormation of additional interactions with the lipid bilayer, and especially with PIP molecules, which

106 xpressed, correctly inserted and folded in a lipid bilayer, and trafficked to the proper cellular loc

107 sensitive to membrane undulations, unlike in lipid bilayers, and it strongly affects both lipid-packi

108 the two crystal structures embedded in model lipid bilayers, and steered their transport domain towar

109 lectively pattern domains of phase-separated lipid bilayers, and the patterning is also observed for

110 to binding of autoinhibited Vn to supported lipid bilayers, and to unbinding in freestanding lipid v

111 At ambient temperature and in a lipid bilayer, Aqy1 adopts a closed conformation that is

112 h the properties of the cell plasma membrane lipid bilayer are broadly understood to affect integral

113 tures and properties of membrane proteins in lipid bilayers are expected to closely resemble those in

114 e partitioning of membrane proteins into the lipid bilayer as well as the secretion of proteins to th

115 assembled into oligomers that inserted into lipid bilayers as well-defined pores and adopted a speci

116 and SNAP-25 while simultaneously binding the lipid bilayer at both its N- and C-terminal ends.

117 require membrane protein reconstitution in a lipid bilayer at high concentrations.

118 we present the cryo-EM structure of PKD2 in lipid bilayers at 3.0 A resolution, which establishes PK

119 ons of bitopic membrane proteins embedded in lipid bilayers at atomic-level.

120 f cadherin ectodomains tethered to supported lipid bilayers at varying Ca(2+) concentrations.

121 ps under near-physiological conditions, in a lipid bilayer, at 37 degrees C, and during substrate-sti

122 r envelope, which can be modeled as a double lipid bilayer attached to a viscoelastic gel (lamina) wh

123 y to measure fusion of liposomes to a planar lipid bilayer (BLM).

124 P4 depends on the cholesterol content in the lipid bilayer, but it was not clear whether changes in p

125 sidered mere building blocks of the membrane lipid bilayer, but the subsequent realization that phosp

126 spectrin tetramers that are tethered to the lipid bilayer by ankyrin and by actin-based junctional c

127 t and dynamical behavior of MAG2 in oriented lipid bilayers by using (2)H-NMR on Ala-d3-labeled pepti

128 ld fluctuations at the interfacial region of lipid bilayers by using a combination of ultrafast time-

129 n and, uniquely, physical transformations of lipid bilayers can be monitored on a length scale of mic

130 n that Myo1c bound to PtdIns(4,5)P2 in fluid-lipid bilayers can propel actin filaments in an unloaded

131 can-loaded silicasome carrier that comprises lipid bilayer-coated mesoporous silica nanoparticles (MS

132 The ability to make artificial lipid bilayers compatible with a wide range of environme

133 stigated the action of Aurein 1.2 in charged lipid bilayers composed of DMPC/DMPG.

134 ed composition, to quantify the influence of lipid bilayer composition on protein-glycolipid binding

135 r membrane (OM) of Gram-negative is a unique lipid bilayer containing LPS in its outer leaflet.

136 rized the interaction of zetacyt with planar lipid bilayers containing mixtures of acidic and neutral

137 ations of the isolated TM domain in explicit lipid bilayers coupled to thermodynamic potential of mea

138 to the concentration of the planar-supported lipid bilayers, CTxB was (12 +/- 4)x more concentrated o

139 ately 10-fold greater affinity than C461 for lipid bilayers, despite both solutes having similar hydr

140 Steeper gradients caused lipid bilayer destabilization and pore instability, limi

141 m albumin (DNP-BSA) or mobile in a supported lipid bilayer (DNP-SLB).

142 regimes, which have long been recognized in lipid bilayer dynamics, notably in the lateral diffusion

143 es are extracellular nanosized vesicles with lipid bilayers encapsulating nucleic acids and proteins,

144 ndicated a highly purified population of the lipid bilayer enclosed vesicles that were enriched in ex

145 Microparticles are lipid bilayer-enclosed vesicles produced by cells under

146 provide a relatively monodisperse nanoscale lipid bilayer environment for delivering membrane protei

147 proteins which takes into consideration the lipid bilayer environment for docking as well as for ref

148 s and designed to address docking within the lipid bilayer environment.

149 Artificial lipid bilayers equipped with purified human TRPA1 showed

150 , but an integrated understanding of how the lipid bilayer exerts its effect has remained elusive.

151 In the research, planar lipid bilayer experiments were used to study the channel

152 ect measurement of fluoride transport across lipid bilayers facilitated by a series of strapped calix

153 these systems to be combined with supported lipid bilayers for sensing membrane proteins through loc

154 paramagnetic labeling, and reconstitution in lipid bilayers) for both ssNMR and DEER.

155 A separate lipid bilayer formed at the interface between each dropl

156 e imparted by protein nanopores spanning the lipid bilayer formed at the interface of the encapsulate

157 itis C virus (HCV) p7 protein into supported lipid bilayers formed from physiologically relevant lipi

158 al tendency to partition preferentially into lipid bilayers from aqueous solution.

159 y stalk expansion, a key intermediate of the lipid bilayer fusion reaction.

160 rnalized within the lumen as a fragment upon lipid bilayer fusion.

161 easurements of a multimeric ion channel in a lipid bilayer have allowed us to probe the structural ch

162 Dynamic studies of lipid bilayers have been constrained, however, by the re

163 ffold protein encircles a small portion of a lipid bilayer) have native-like membrane properties.

164 h intracellular compartments surrounded by a lipid bilayer, have been recently shown to target the su

165 ear whether it threads beta-strands into the lipid bilayer in a stepwise fashion or catalyzes the ins

166 coring the important role of the surrounding lipid bilayer in the delicate conformational coupling of

167 erimental evidence ruling out a role for the lipid bilayer in their ion channel effects.

168 ation enabled the formation of two adjoining lipid bilayers in a controlled manner, a requirement for

169 monomer transition, we made use of supported lipid bilayers in conjunction with atomic force microsco

170 ted 1,2-dioleoyl-sn-glycero-3-phosphocholine lipid bilayers in different saline solutions, that ions

171 and communication across leaflets in ternary lipid bilayers, including saturated lipids with between

172 ated by allyl isothiocyanate or heat suggest lipid bilayer-independent conformational changes outside

173 Mechanical properties of the lipid bilayer influence their neighbouring membrane prot

174 The lipid bilayer is a dynamic environment that consists of

175 ontinuum elastic model for gramicidin A in a lipid bilayer is shown to describe the sensitivity to th

176 structure, but its disposition when bound to lipid bilayers is controversial.

177 l reconstitution of membrane proteins within lipid bilayers is crucial for understanding their biolog

178 ng of DNA crossover tiles with blunt ends on lipid bilayers is investigated using atomic force micros

179 vely, ethanol's effect on vesicles fusing to lipid bilayers is not known.

180 Fusion between two lipid bilayers is one of the central processes in cell b

181 Fusion of lipid bilayers is usually prevented by large energy barr

182 motors, that is, motors attached to a fluid lipid bilayer, is poorly understood.

183 enomena were not linked to properties of the lipid bilayer itself.

184 involving unspecified interactions with the lipid bilayer known as the unitary lipid-based hypothesi

185 hat iron was present close to and inside the lipid bilayer magnetosome membrane.

186 mechanical properties may be a signature of lipid bilayer-mediated effects of amphiphilic drugs.

187 synthetic signal transducer embedded in the lipid bilayer membrane acts as a switchable catalyst, ca

188 ation constants of CPR/CYP2C9 complexes in a lipid bilayer membrane for the first time.

189 nt K-Ras interacts with a negatively charged lipid bilayer membrane in multiple orientations.

190 The surfactant permeabilizes the lipid bilayer membrane to facilitate release of an encap

191 etic molecular transducer from one side of a lipid bilayer membrane to the other.

192 of the skeleton attachment to the fluidlike lipid bilayer membrane, including a specific accounting

193 cells, with a size range of 40-150 nm and a lipid bilayer membrane.

194 verse structure and regulated deformation of lipid bilayer membranes are among a cell's most fascinat

195 Multicomponent lipid bilayer membranes display rich phase transition an

196 nd reproducible method to form free-standing lipid bilayer membranes in microdevices made with Norlan

197 naling proteins transduce information across lipid bilayer membranes in response to extra-cellular bi

198 ng the nanoscale dynamic organization within lipid bilayer membranes is central to our understanding

199 and amplification of chemical signals across lipid bilayer membranes is of profound significance in m

200 one of the most potent anion transporters in lipid bilayer membranes reported to date.

201 The self-assembly of lipid bilayer membranes to enclose functional biomolecul

202 alysis reveals the transport of water across lipid bilayer membranes with a relative water permeabili

203 rates that peptide 1a interacts with anionic lipid bilayer membranes, like oligomers of full-length a

204 cells is known to be supplied by both their lipid bilayer membranes, which resist bending and local

205 measure stages of phase separation in model lipid bilayer membranes.

206 pid-exposed His, Lys, and Arg side chains in lipid bilayer membranes.

207 exposed directly to lipid acyl chains within lipid bilayer membranes.

208 he Rab-GTPase Ypt7 needed for SNARE-mediated lipid bilayer merger.

209 GTPases and tethers to drive SNARE-mediated lipid bilayer mixing.

210 ied simplified models, namely four-component lipid bilayer mixtures.

211 membrane in combination with a conventional lipid bilayer model to generate a membrane-bound configu

212 Using vesicles of various sizes as a lipid bilayer model, we show GTP-dependent membrane bind

213 It also indicates that the lipid bilayer modulates channel gating, although it is n

214 membrane mimetic membranes and conventional lipid bilayer molecular dynamics simulations yielded a d

215 also bound lipid membranes and disrupted the lipid bilayer morphology less aggressively compared with

216 Herein, we demonstrate that a combination of lipid bilayer nanodiscs and a multiplexed silicon photon

217 le-molecule measurements of F0F1 embedded in lipid bilayer nanodiscs, we observed that the ability of

218 to purified NPC1 that was incorporated into lipid bilayer nanodiscs.

219 We found that the lipid bilayer of bicelles stabilized the chromophore-fre

220 20 amino acid residues at the center of the lipid bilayer of OmpLA.

221 release of the protein precursor within the lipid bilayer of the inner membrane, followed by cleavag

222 transport of neutral doxorubicin across the lipid bilayer of the liposomes.

223 incorporation of membrane proteins into the lipid bilayer of the vesicles.

224 In this work, homogeneous lipid bilayers of 21 distinct lipid A types from 12 bact

225 ral physical techniques are used to open the lipid bilayers of cellular membranes.

226 rophilic transmembrane cavity exposed to the lipid bilayer on the fungal scramblase nhTMEM16 serves a

227 By preparing supported lipid bilayers on beads of different curvature, we recon

228 the bending modulus and fluidity of vesicle lipid bilayers on the micrometer scale, and distinguish

229 using approaches that include the supported lipid bilayer platform as well as DNA tension sensor tec

230 tions between membrane protein interfaces in lipid bilayers play an important role in membrane protei

231 Bt toxins permeabilize receptor-free planar lipid bilayers (PLBs) by forming pores at doses in the 1

232 Lipid-bilayer presentation of viral antigens in Nanodisc

233 ty to tune the 3D cubic phase nanostructure, lipid bilayer properties and the lipid mesophase is limi

234 al anesthetics and related nonanesthetics on lipid bilayer properties using an established fluorescen

235 tions of certain anesthetic agents did alter lipid bilayer properties.

236 sting that pore flickering was controlled by lipid bilayer properties.

237 chment protein receptor (SNARE) proteins and lipid bilayer properties.

238 ce assay that senses drug-induced changes in lipid bilayer properties.

239 EV are submicron structures composed of lipid bilayers, proteins, and nucleic acids that are rel

240 in MtrC, obtained by a combination of planar lipid bilayer recordings and in silico techniques.

241 howed that the peptide was on the surface of lipid bilayer regardless of the charged lipid ratio.

242 OH radicals whereas the regions spanning the lipid bilayer remain inert to the labeling.

243 ts of the c-ring reconstituted into a planar lipid bilayer revealed a large unitary conductance of ~8

244 In the structural investigations of lipid bilayer's response to Abeta binding, Small Angle N

245 r docking of the templated-SUVs to supported lipid bilayers (SBL), one to two pairs of SNAREs are suf

246 etical analysis of elastic deformations in a lipid bilayer shows that stiffer lipid domains tend to d

247 s that control ionic flow across a supported lipid bilayer (SLB) should therefore be ideal for interf

248 used biotinylated surfaces such as supported lipid bilayers (SLBs) and self-assembled monolayers (SAM

249 tinguishing adsorbed vesicles from supported lipid bilayers (SLBs) as well as profiling the extent of

250 at formation of alphaS clusters on supported lipid bilayers (SLBs) impairs lateral lipid diffusion an

251 , and electrostatic DNA binding to supported lipid bilayers (SLBs) presents an opportunity to build d

252 of lipid domains in raft-mimicking supported lipid bilayers (SLBs).

253 rce to the membrane to deform and reorganize lipid bilayer structure.

254 e diffusion measurements of VSG in supported lipid bilayers substantiate this possibility, as two fre

255 fect the physicochemical interactions in the lipid bilayer such as cholesterol incorporation, tempera

256 urification and reconstitution in artificial lipid bilayers such as liposomes or nanodiscs.

257 ation of MS ion channels in planar supported lipid bilayers, such as the DHB, has not yet been establ

258 rogeneous silicon mesostructures to design a lipid-bilayer-supported bioelectric interface that is re

259 the charges of extramembrane domains and the lipid bilayer surface.

260 Nanodiscs that hold a lipid bilayer surrounded by a boundary of scaffold prote

261 Here, using purified proteins and the lipid bilayer system, we characterize Gbetagamma and Na(

262 les was 25 +/- 5x higher in planar supported lipid bilayers than within nanoscale membrane curvature.

263 ere performed in a solid-supported cushioned lipid bilayer that closely matched the chemical composit

264 ly into nanovesicles or incorporation into a lipid bilayer that encapsulates mesoporous silica nanopa

265 sids, the encapsidation of HCMV capsids by a lipid bilayer that occurs before virions exit the cell.

266 CD4 T cells were applied to supported lipid bilayers that were reconstituted with HIV Env gp12

267 Overcoming the lipid bilayer to deliver RNA into cells has remained the

268 by which the toxin monomers insert into the lipid bilayer to perforate the target membrane.

269 et, forming an interfacial entrance from the lipid bilayer to the catalytic centre for both the lipid

270 The response of lipid bilayers to osmotic stress is an important part of

271 Our Zn10 L15 prism thus inserts into lipid bilayers to turn on anion transport, which can the

272 philic lipid probe from HDL particles to the lipid bilayer upon contact.

273 idylinositol bisphosphate (PIP2) -containing lipid bilayer, using coarse-grained molecular dynamics.

274 re matches the polar/apolar interface of the lipid bilayer very well.

275 a spheroplast, contrary to the response of a lipid-bilayer vesicle, which always showed a membrane ar

276 Here we show that lipid bilayer vesicles (liposomes) can be triggered to r

277 ectly in a parallel position relative to the lipid bilayer via hydrophobic and electrostatic interact

278 specifically targeting phospholipids in the lipid bilayer via the production of singlet oxygen ((1)O

279 the characteristic gap between Drp1 and the lipid bilayer was lost when the mitochondrial specific l

280 a misfolded luminal protein domain across a lipid bilayer, we have reconstituted retrotranslocation

281 holesterol to reduce the permeability of the lipid bilayer, we improved the signal-to-noise ratio of

282 ulations of a dipalmitoylphosphatidylcholine lipid bilayer, we observed nanometer-wide stress pulses,

283 etching vibration in hydrated phosphocholine lipid bilayers, we are able to measure a correlation fun

284 er understand how it interacted with charged lipid bilayers, we employed Small Angle Neutron Scatteri

285 Furthermore, using planar lipid bilayers, we show that although cholesterol did no

286 e formed on the PDMS patterned surface while lipid bilayers were on the bare glass surface.

287 ht, changes in the biophysical properties of lipid bilayers were revealed.

288 that can form nanodiscs containing a planar lipid bilayer which are useful to reconstitute membrane

289 ace with large sidechains is immersed in the lipid bilayer, while the inner barrel surface is highly

290 transmembrane domain (TMD) forms a trimer in lipid bilayer whose structure has several peculiar featu

291 DNA strands, attached to the lipid bilayer with cholesterol anchors, act as an exempl

292 i, the outer membrane is a unique asymmetric lipid bilayer with lipopolysaccharide in the outer leafl

293 y of the device and vertical position of the lipid bilayer with respect to the microscope focal plane

294 order rate constant for transport across the lipid bilayer with values in the range from 1 to 3x10(-1

295 m immunological synapses formed on supported lipid bilayers with laterally mobile ICAM-1 and anti-CD3

296 e that biological membranes are organized as lipid bilayers with some proteins on the surface and oth

297 We simulate model lipid bilayers with the MARTINI coarse-grained force fie

298 1c ensembles can generate forces parallel to lipid bilayers, with larger forces achieved when the myo

299 peptides that spontaneously cross synthetic lipid bilayers without bilayer disruption.

300 adhesion molecule-functionalized, supported lipid bilayers, yielding a 2D Kd of approximately 5,000