ライフサイエンスコーパス: lipid composition

1 rt vesicles according to their size and bulk lipid composition.

2 loid-beta protein, on membrane thickness and lipid composition.

3 mbrane space, only in the vicinity of native lipid composition.

4 s to achieve this can be heavily affected by lipid composition.

5 ponsive to post-assembly changes in membrane lipid composition.

6 artitioning to membrane domains of different lipid composition.

7 ns at membrane interfaces through changes in lipid composition.

8 llowing a threshold change in proteoliposome lipid composition.

9 pids triggered by a change in proteoliposome lipid composition.

10 aried by >100 times depending on the bilayer lipid composition.

11 in a model system with a complex biological lipid composition.

12 ound form in response to changes in membrane lipid composition.

13 ely over time and results in altered ciliary lipid composition.

14 ic cells may be regulated through changes in lipid composition.

15 nto buds and tubules of defined geometry and lipid composition.

16 be locally slowed down due to variations in lipid composition.

17 giant unilamellar vesicles (GUVs) of complex lipid composition.

18 tal observations and is robust to changes in lipid composition.

19 econstituted the TCR in liposomes of defined lipid composition.

20 ies point to P limitation-induced changes in lipid composition.

21 infectivity involves alterations of membrane lipid composition.

22 in granular layers and significantly altered lipid composition.

23 dynamically driven, and the yield depends on lipid composition.

24 is difficult to manipulate cellular membrane lipid composition.

25 limate, can be observed in terms of membrane lipid composition.

26 ry structure of bR in nanodiscs of different lipid compositions.

27 membrane function requires distinct leaflet lipid compositions.

28 ed giant unilamellar vesicles with different lipid compositions.

29 ctivated protein C to seven different binary lipid compositions.

30 influenza virus and vesicles with a range of lipid compositions.

31 cretion [15], organized in part by the local lipid composition [16].

32 The human brain shows the most distinct lipid composition: 76% of 5,713 lipid compounds examined

33 Altered cellular lipid composition activates the endoplasmic reticulum un

34 The mechanisms by which these changes in lipid composition affect cellular function and ultimatel

35 Surprisingly, perturbation of cellular lipid composition also activates the UPR, with important

36 ore, we show that KIFs control mitochondrial lipid composition and activity in a cell-intrinsic manne

37 118 different lipids suggests that membrane lipid composition and adaptation mechanisms in Thaumarch

38 es and their effects on membranes that mimic lipid composition and biophysical properties of the vira

39 rane proteins are thought to be modulated by lipid composition and by the underlying cytoskeleton, wh

40 microscope were used to study the effects of lipid composition and concentrations of myelin basic pro

41 ooperativity, depends distinctly on membrane lipid composition and correlates to the degree of alphaS

42 d spectroscopy (NIR) was applied to estimate lipid composition and degradation of two lean fish speci

43 The LAURDAN spectrum is sensitive to the lipid composition and dipolar relaxation arising from wa

44 lidations of the calibrations indicated that lipid composition and FFA of hoki and saithe can be esti

45 are embedded in cellular membranes of varied lipid composition and geometrical curvature.

46 We quantified the effect of lipid composition and GTP on membrane binding and remode

47 estigated only a single clotting protein and lipid composition and have yielded widely different bind

48 Hepatic lipid composition and histopathology revealed that devel

49 rol was used to investigate the influence of lipid composition and lipid asymmetry upon the conformat

50 t cells actively regulate and modulate their lipid composition and localization during division, with

51 o cytoplasmic myelin membranes with modified lipid composition and low MBP concentration, as in demye

52 innate immune signaling, affecting cellular lipid composition and membrane fluidity.

53 lipid vesicles of various sizes, as well as lipid composition and membrane mechanical properties, we

54 How these protein clusters modify local lipid composition and membrane morphology is largely unk

55 -1 Gag to membranes is sensitive not only to lipid composition and net negative charge, but also to t

56 ver, little is known about the regulation of lipid composition and organization in synaptic membranes

57 by SERINC5 does not depend on alterations in lipid composition and organization of HIV-1 particles an

58 hese results reveal developmental changes in lipid composition and palmitoylation that facilitate the

59 of the dry weight without affecting membrane lipid composition and plant growth.

60 for the first time the effect of changes in lipid composition and regulators of cellular processes.

61 nclusion, dietary lipids can modulate T cell lipid composition and responses in lipoprotein receptor

62 modulus, for lipidic assemblies of arbitrary lipid composition and shape, from molecular dynamics sim

63 g the main experimental conditions: liposome lipid composition and size to be similar to those of Dox

64 ng lipoproteins by approximately 3-fold; the lipid composition and stoichiometry of these particles w

65 rom pS to nS) that are dependent both on the lipid composition and the applied potential.

66 ith a dynamics tightly regulated by membrane lipid composition and the cortical cytoskeleton.

67 fraction (XDMSO) of <0.1, regardless of the lipid composition and the lipid phase.

68 th liposomes in the case of some but not all lipid compositions and ionic strengths.

69 hat the method can be used with a variety of lipid compositions and probe the mechanism of templated

70 the relationship between gas-phase behavior, lipid composition, and instrumental polarity was investi

71 imilarities, despite significantly different lipid composition, and interesting differences.

72 ugh there is strong evidence that in myelin, lipid composition, and lipid membrane morphology are aff

73 lation on morphology, protein incorporation, lipid composition, and membrane fusion.

74 CAV1) deficiency results in altered cellular lipid composition, and plasma membrane (PM) phosphatidyl

75 Here we studied the effects of flow, lipid composition, and salt concentration on Min pattern

76 en the major energy-sensing kinase, membrane lipid composition, and transcription.

77 ane compartments with characteristic shapes, lipid compositions, and dynamics.

78 GlpG, captured within three different native lipid compositions, and identify protein regions sensiti

79 for erythrocytes, as judged by outer leaflet lipid composition; and plasma membrane outer leaflet pho

80 thylakoid membrane ultrastructure, and bulk lipid composition appeared unaltered.

81 react to and/or induce changes in shape and lipid composition are discussed here.

82 Hepatic fat accumulation and changes in lipid composition are hallmarks of nonalcoholic fatty li

83 were found to exhibit a radically different lipid composition as compared to cultures in the exponen

84 rom that in symmetric vesicles with the same lipid composition as the asymmetric vesicles and from th

85 DAN has the advantage to be sensitive to the lipid composition as well as to membrane fluidity.

86 s over similarly high temperatures and broad lipid compositions as in corresponding membranes contain

87 Samples with similar lipid compositions as those of the fingerprints were col

88 om 15 degrees C to 25 degrees C and membrane lipid composition assessed.

89 sults revealed previously unknown changes of lipid composition associated with obesity and steatohepa

90 h extensibility was therefore related to its lipid composition at the start of mixing.

91 ealed, demonstrating significantly different lipid compositions between the various tissue types with

92 e modeled the influence of OmpA on the local lipid composition both at a coarse-grained (CG) resoluti

93 her, our studies indicate that by tuning the lipid composition, both the domain size and morphology c

94 tion, VLDL particle composition, and hepatic lipid composition but selectively enhanced clearance of

95 In vivo remodeling of the mitochondrial lipid composition by lithocholic acid treatment or by ab

96 Manipulation of seed lipid compositions by heterologous over-expression of an

97 These results imply that lipid composition can be a critical factor that affects

98 ctra in heterogeneous Nanodiscs and that the lipid composition can be determined by using a dual Four

99 n an in vitro proteoliposome system in which lipid composition can be systematically controlled befor

100 ur results indicate that the manipulation of lipid composition can indeed control orientation of an a

101 hysical literature demonstrates that varying lipid composition can influence the size, membrane stabi

102 r crowding, rather than changes in monolayer lipid composition, causes proteins to fall off the LD su

103 The lipid bilayers had a lipid composition characteristic of the cytoplasmic leaf

104 n systems with dramatically different sizes, lipid compositions, charge carriers, or protein machiner

105 duced glycerol concentration, and changes to lipid composition compared with the wild type, including

106 The thylakoid membrane has a unique lipid composition, consisting mostly of galactolipids.

107 An enormous complexity in lipid composition could be revealed.

108 embranes, many factors such as cytoskeleton, lipid composition, crowding, and molecular interactions

109 ystems to living cell membranes with complex lipid compositions, cytoskeletal attachment, and membran

110 To study the lipid-composition dependence of photocycle kinetics of b

111 that the P2X7 receptor itself constitutes a lipid-composition dependent dye-permeable pore, whose op

112 ial effects, the insulin:C-peptide ratio and lipid composition differ between EVs from healthy pancre

113 tive abundances of these IPLs and their core lipid compositions differ systematically between the phy

114 These changes in lipid composition due to different enzyme activity are s

115 The determination of the lipid composition during an LCD enables the identificati

116 Here we altered wheat flour lipid composition during bread making using lipases in s

117 We evaluated the changes in lipid composition during weight loss and their associati

118 n orientation can only partially explain the lipid composition effect on transport rate.

119 s, temperature sensitivity, altered membrane lipid composition, elevated envelope-related stress resp

120 over, the simulations also indicate that the lipid composition especially in terms of charged lipids

121 rms of signaling require a distinct membrane lipid composition, found at cilia.

122 ng from water penetration, but disentangling lipid composition from membrane fluidity can be obtained

123 tion to the membrane depends strongly on its lipid composition from virtually nonexistent for membran

124 MAT adipocyte development, regulation, size, lipid composition, gene expression and genetic determina

125 The effects of pH, ionic strength, and lipid composition have also been explored.

126 Changes to the SC lipid composition have been associated with barrier impa

127 Similar changes in lipid composition have been observed in marine photoauto

128 that modulate the permeability in different lipid compositions have remained unclear.

129 mulations have focussed on relatively simple lipid compositions, helping to inform our understanding

130 were closest to mammalian plasma membrane in lipid composition (i.e., with brain SM, POPC, and/or hig

131 DAC6 leads to significant age-dependent EFA, lipid composition imbalance, and reduced animal longevit

132 ens new avenues for metabolic engineering of lipid composition in algae.

133 ary alveolar proteinosis (PAP), we evaluated lipid composition in alveolar macrophages and lung surfa

134 sh that membrane homeostasis is regulated by lipid composition in Arabidopsis and reveal a mechanism

135 fect on activation through the regulation of lipid composition in cell membranes.

136 Because manipulation of the lipid composition in cells is difficult, we investigated

137 beta-Catenin ASO altered hepatic lipid composition in high-fat-fed mice.

138 to delineate the role of FADSs in modulating lipid composition in human liver.

139 altering gene transcription and controlling lipid composition in human livers.

140 this investigation was to better understand lipid composition in human meibum.

141 acterize the spatial and temporal changes in lipid composition in lung tissue.

142 nguishing the putative role(s) of the native lipid composition in modulating membrane protein conform

143 (PS) and DOPE (PE) to understand the role of lipid composition in MP1's anticancer characteristics.

144 IB-ToF-SIMS was used to elucidate changes in lipid composition in nine breast cancer biopsy samples.

145 ovule development and significantly altered lipid composition in ovaries were observed in NbSACPD-C

146 C plays a critical role maintaining membrane lipid composition in ovule development for female fertil

147 t the acyl composition of organelle membrane lipid composition in response to cold stress.

148 The altered lipid composition in the circulation, and of T cells, wa

149 The impact of heat treatments on the lipid composition in the fish tissue seems to be species

150 different lipids and thus retains the native lipid composition in the solubilized particles.

151 his homeostatic circuit maintains a constant lipid composition in the trans-Golgi network and post-Go

152 n relative to the membrane normal and of the lipid composition in the vicinity of the bound peptide.

153 This result indicates that the lipid compositions in one leaflet are strongly coupled t

154 opy, we have characterized phases of ternary lipid compositions in the presence of saturated phosphol

155 55 is relatively insensitive to the membrane lipid composition, in agreement with experimental observ

156 LS is defined by a specific protein and lipid composition, including saturated and unsaturated p

157 y can be changed simply by changing membrane lipid composition independent of other cellular factors.

158 d systems that describe these modulations in lipid composition indicate that the average stored curva

159 rs were not in rapid equilibrium at a static lipid composition indicating that duality of topology is

160 hat different Ras nanoclusters have distinct lipid compositions, indicating that Ras proteins engage

161 Lipid composition-induced phase transitions as specified

162 , a better understanding of how the regional lipid composition influences cholesterol abundance and e

163 lipid vesicles (i.e. with identical membrane lipid composition, ionic strength, and nucleotide and su

164 rane properties, demonstrating that membrane lipid composition is a biochemical control parameter and

165 l variations in the material stiffness do as lipid composition is changed.

166 Their lipid composition is detailed here with special emphasis

167 A regime of lipid composition is found where all properties are favo

168 Our results suggest that proper PM lipid composition is important to stabilize the central

169 r, how they induce and maintain their unique lipid composition is largely unknown.

170 The membrane lipid composition is tightly regulated by the cell, main

171 a number of novel properties even though its lipid composition is very similar to that of growing cel

172 Lipid composition, lipid oxidation and hydrolysis, and s

173 apsulation of high refractive index markers, lipid composition, liposome size, and surface modificati

174 d T cell responses in vivo along with T cell lipid composition, membrane order, and activation ex viv

175 esiding in 60 nm unilamellar vesicles, whose lipid composition mimics the mammalian plasma membrane o

176 Here we report how changes in lipid composition modulate this insertion scheme.

177 r metabolic activity of this depot makes its lipid composition more dependent on LpL-mediated uptake.

178 Plasma membrane lipid composition must be maintained during growth and u

179 PLTP absence drastically altered the lipid composition of apoB:1000 lipoproteins; these parti

180 levated sphingolipid turnover and an altered lipid composition of both MAM and mitochondrial membrane

181 he effect of lactation stage and size on the lipid composition of bovine milk fat globules (MFG) and

182 tics that target pathological changes in the lipid composition of cancerous cells.

183 The lipid composition of cell membranes has increasingly bee

184 es these lymphocytes to sense changes in the lipid composition of cells and tissues as a result of in

185 e mechanisms that have evolved to modify the lipid composition of cellular and viral membranes to inh

186 The lipid composition of cellular organelles is tailored to

187 In this study, we analyzed lipid composition of Chamaecyparis obtusa extract, and w

188 scarcity of comparative data on the membrane lipid composition of cultivated representatives, includi

189 tolerogenic, induce different changes in the lipid composition of cultured CD11c(+) cells, and highli

190 omes, suggesting that the unique protein and lipid composition of exosomes does not appreciably impac

191 biosynthesis of membrane lipids and because lipid composition of HIV particles is a major determinan

192 The envelope lipid composition of influenza virus differs from that o

193 The lipid composition of insulin secretory granules (ISG) ha

194 cs of model bilayers which mimic the in vivo lipid composition of mammalian plasma membranes, reveali

195 he argan seed, the anatomy, ploidy level and lipid composition of mature seed tissues were investigat

196 nd is presumably triggered by changes in the lipid composition of membrane microdomains.

197 results show a direct connection between the lipid composition of membranes and membrane-protein adso

198 ate the structure of actin filaments and the lipid composition of membranes.

199 hanisms responsible for the heterogeneity in lipid composition of nascent HDL particles may provide a

200 MS) to image and chemically characterize the lipid composition of oncocytic thyroid tumors, as compar

201 The lipid composition of plasma membrane (PM) and the corres

202 with significant alterations in steady-state lipid composition of producer cells and HIV particles.

203 The lipid composition of Ras nanoclusters, however, has not

204 usvirus RdRp activation, we propose that the lipid composition of targeted subcellular membranes migh

205 The membrane lipid composition of tgd1-1 sdp1-4 and tgd1-1 pxa1-2 dou

206 at the sphingolipids acyl-chain length links lipid composition of TGN subdomains with polar secretory

207 atidylglycerol/cardiolipin (CL) to mimic the lipid composition of the bacterial inner membrane, were

208 ervations suggest that direct sensing of the lipid composition of the ER membrane contributes to the

209 is demonstrably related to the difference in lipid composition of the external and internal leaflets

210 marily focused on the fatty acid and neutral lipid composition of the host and symbiont.

211 Furthermore, the lipid composition of the inner and outer cotyledons diff

212 hich was previously proposed to modulate the lipid composition of the LCV.

213 Using phase-separated GUVs with known lipid composition of the Ld and Lo phases, we demonstrat

214 The effects of varying the lipid composition of the liposomes indicate that PulD fi

215 Lipid composition of the membrane and rhodopsin packing

216 ciated membrane proteins and possibly by the lipid composition of the membrane itself.

217 Small changes to the lipid composition of the membrane that do not change the

218 y peptides/proteins and thereby modulate the lipid composition of the membranes.

219 n sphingomyelin/cholesterol or mimicking the lipid composition of the mitochondrial outer membrane we

220 The membrane lipid composition of the other planktonic archaeal group

221 transport activity of nhTMEM16 is due to the lipid composition of the reconstitution membranes and to

222 tion and regulation depends crucially on the lipid composition of the surrounding membrane.

223 The lipid composition of the tunica media reflected the alte

224 ospray-mass spectrometry elucidated that the lipid composition of the two fractions contained various

225 Although a role in modulating the lipid composition of the unique mycomembrane has been pr

226 ized the viral membranes, depending on their lipid composition of the viral envelop.

227 cale mass spectrometry-based analysis of the lipid composition of three brain regions as well as kidn

228 Here, we studied the lipid composition of thylakoid membranes and chloroplast

229 The lipid composition of thylakoid membranes inside chloropl

230 and direct infusion to quantitatively assess lipid compositions of cells and subcellular fractions.

231 Using model membranes mimicking the lipid compositions of eukaryotic organelles, we determin

232 Lipid compositions of the membrane and the ionic, protei

233 and time, and in relation to the respective lipid compositions of the MFGM from bovine, goat and she

234 results demonstrate a significant effect of lipid composition on both total protein adsorption as we

235 P cytotoxicity, and therefore the effects of lipid composition on modulating IAPP-membrane interactio

236 nism has the potential to explain effects of lipid composition on the kinetics of any membrane protei

237 distinct decrease in protein and increase in lipid composition on the surface of LPA-treated cells.

238 kcal/mol, revealing a sizeable influence of lipid composition on TM complex stability.

239 metabolism rely on the quantification of the lipid composition or amount.

240 In biological membranes, changes in lipid composition or mechanical deformations produce def

241 membrane binding affinities with changes in lipid composition or salt concentration, can differentia

242 peptide structure as a function of membrane lipid composition or the presence of an anionic lipid en

243 le HA acylation did not influence VLP shape, lipid composition, or HA lateral spacing, acylation sign

244 onstration of pronounced changes in the lens lipid composition over a lifetime, suggests that some li

245 atin was accompanied by selective changes in lipid composition, particularly in the cholesterol conte

246 However, over the long-term at 25 degrees C, lipid composition patterns are not consistent with HVA e

247 Here, we show that plasma membrane lipid composition plays a key role in coordinating plasm

248 ptides were added to liposomes with membrane lipid compositions ranging from pure phosphatidylcholine

249 lipid mixing during fusion of liposomes with lipid compositions reflecting the mitochondrial membrane

250 which contain additional alterations in leaf-lipid composition relative to fab1.

251 at molecular genetic alterations in membrane lipid composition result in many phenotypes, and uncover

252 namics simulations performed using different lipid compositions reveal that the bilayer composition d

253 Analyses of leaf-lipid compositions revealed that mutations at all four o

254 secretory system, producing abnormalities in lipid composition, secretion, and/or extracellular lamel

255 To this end, cells evolved a network of lipid composition sensors and pipelines along which lipi

256 affinity for small unilamellar vesicles with lipid composition similar to synaptic vesicles, in addit

257 of small vesicles (below 300 nm) varying in lipid composition, size and charge; it offers effective

258 ereby the regulation of CNS endothelial cell lipid composition specifically inhibits the caveolae-med

259 tate binding assays indicate that more rigid lipid compositions stabilize Hpr association.

260 Droplet size (0.17 versus 1.20 mum), lipid composition (stearin versus olein) and cooling rat

261 Here, we found that changes in lipid composition strongly increased the KcsA open proba

262 2), gp41 FP induces membrane ordering in all lipid compositions studied, whereas a nonfusion mutant F

263 gs linking aS scavenging activity with brain lipid composition suggest a possible etiological mechani

264 ated PGs from k1 k3 showed a modified prenyl-lipid composition, suggesting reduced activity of PG-loc

265 The influences of solid lipid composition, surfactant blend concentration (2, 4,

266 For most lipid compositions tested, SNARE-mediated and nonspecifi

267 primary cilium require a unique protein and lipid composition that is determined by gating mechanism

268 umerous subpopulations with distinct protein/lipid compositions that are not reflected in the HDL cho

269 les of tens of microns in size, the range of lipid compositions that can be used to grow GUVs by the

270 phospholipids into nanoclusters with defined lipid compositions that determine K-Ras signaling output

271 cisely controlling exposure to vesicles with lipid compositions that mimic both bacterial and mammali

272 phospholipid synthesis and changes membrane lipid compositions that ultimately induce the activation

273 Over a broad range of permissive lipid compositions, the Arg-325 variant consistently exh

274 just lipid metabolism in response to dietary lipid composition through the transcriptional regulation

275 e can be modulated, without major changes in lipid composition, through proteins such as MPP1.

276 ure, leading to the modification of membrane lipid composition to ensure optimal biochemical and phys

277 he TGN but the underlying mechanisms linking lipid composition to functional polar sorting at TGN sub

278 n LTP in conveying information about dietary lipid composition to the brain to regulate Insulin signa

279 s (Ka) were measured for SERMs using varying lipid compositions to examine how lipid phase, packing d

280 s of Drp1 helices on nanotubes with distinct lipid compositions to mimic membrane interactions with t

281 omer and homodimer as a function of membrane lipid composition using a multiscale simulation approach

282 Alteration of the DSM 10140 membrane lipid composition using modified growth medium to more c

283 Membrane lipid composition varies greatly within submembrane comp

284 Fatty acid and polar lipid composition was determined in each size group, at

285 By controlling the lipid composition we are able to direct the aquaporin in

286 nformers is dependent solely on the membrane lipid composition, we determined the topological organiz

287 g MA to model membranes with well-controlled lipid composition, we dissect the multiple interactions

288 rate the impact of AtLtpI-4 on extracellular lipid composition, we expressed the protein in Arabidops

289 IACYLGLYCEROL ACYLTRANSFERASE (PDAT) on seed lipid composition were assessed in several Camelina sati

290 and FA composition, tissue transcriptome and lipid composition were compared during development.

291 Shifts in lipid composition were similar for high-dose simvastatin

292 onstants of one protein interacting with all lipid compositions were simultaneously determined.

293 Four lipid compositions were tested, representative of liposo

294 constituting GltPh into liposomes of defined lipid composition where the primary lipid is phosphatidy

295 ors, but there is no information about their lipid composition, which might reveal candidate theranos

296 id oxidation, and also led to alterations in lipid composition, which were confirmed by gas chromatog

297 es a small amount of energy independently of lipid composition, while direct transition from a stalk

298 reveals a significant change to the cellular lipid composition with drug treatment; furthermore, this

299 ngases, resulted in new overall seed storage lipid compositions with altered patterns of distribution

300 ence and salt concentration, but also by the lipid composition within these superstructures.