ライフサイエンスコーパス: lipidation

1 as the optimal position for neoglycopeptide lipidation.

2 nd that further expansion occurs via post-ER lipidation.

3 action at a level similar to that of protein lipidation.

4 licated in palmitoyl transfer during protein lipidation.

5 preventing or limiting the extent of apoA-I lipidation.

6 nt properties of Ha-Ras activation state and lipidation.

7 ollowed by a slower process of MTP-dependent lipidation.

8 t that apoB may interact with MTP before its lipidation.

9 cations, such as oxidation, nitrosation, and lipidation.

10 ction, and NOX inhibition does not block LC3 lipidation.

11 low levels of apoE4 lipoprotein association/lipidation.

12 e generation of small vesicles active in LC3 lipidation.

13 1/ABCG1-induced apoE lipoprotein association/lipidation.

14 important for E3 interaction as well as LC3 lipidation.

15 diated autophagy in plants by promoting ATG8 lipidation.

16 ree assay, purified PlcA protein blocked LC3 lipidation, a key step in early autophagosome biogenesis

17 artment (ERGIC) as a membrane source for LC3 lipidation, a key step of autophagosome biogenesis.

18 ck a known recognition signal for C-terminal lipidation, a modification that is generally necessary f

19 ed to be the result of the impairment of Ras lipidation, a stable modification (T1/2 approximately 20

20 induction and flux, including synthesis and lipidation/activation of the ubiquitin-like protein LC3

21 recruitment of COPII to the ERGIC to bud LC3 lipidation-active vesicles as one potential membrane sou

22 he donor membrane in the generation of small lipidation-active vesicles.

23 When expressed in cells with endogenous lipidation activity, the substrate is intracellularly li

24 orm in astrocytes, suggesting that increased lipidation acts as a folding chaperone enabling E4 to ad

25 we examined the roles of N-glycosylation and lipidation/acylation in regulating the activities of Win

26 MmcO is membrane associated, probably by lipidation after export across the inner membrane by the

27 Recent studies have shown that the lipidation and assembly state of apolipoprotein E (apoE)

28 induced by sorafenib was validated by LC3B-I lipidation and autophagosome accumulation.

29 omises starvation- and rapamycin-induced LC3 lipidation and autophagosome formation.

30 autophagosomes and by measuring LC3B protein lipidation and autophagy-related protein expressions.

31 esidues is the only known reversible form of lipidation and has been implicated in protein membrane a

32 of ABCA1 in humans and mice causes abnormal lipidation and increased catabolism of HDL, resulting in

33 for morphology, Western blotting for LC3B-I lipidation and mammalian target of rapamycin signaling m

34 Lipidation and processing of NilC occurs by a mechanism

35 gene into PLTP-KO hepatocytes stimulated the lipidation and secretion of apoB:1000-containing lipopro

36 lore the mechanism involved, we examined the lipidation and secretion of nascent very low-density lip

37 before adding OA and the inhibitor, apoB100 lipidation and secretion were no longer impaired.

38 Both ligand lipidation and target field response influence the gradi

39 in the N-terminal mutation, the position of lipidation and the linkage to lipid.

40 through a similar function for TM6SF2 in the lipidation and/or export of both hepatically and intesti

41 creased ABCA1, apoE4 lipoprotein-association/lipidation, and apoE4/Abeta complex, decreased soluble A

42 0 had no detectable effect on the synthesis, lipidation, and secretion of apoB:1000-containing partic

43 ical experimental conditions, the synthesis, lipidation, and secretion of endogenous apoB100-containi

44 anterior muscles, the levels of LC3B protein lipidation, and the expression of autophagy-related gene

45 e membrane as might be allowed by the normal lipidation; and (4) in order to function properly, there

46 ion of markers of autophagy (LC3 punctae and lipidation) around mitochondria in human dopaminergic ce

47 s essential for its subsequent intracellular lipidation as apoB28 synthesized in hepatoma cells under

48 ether chaperone binding is dependent on apoB lipidation as they secrete both unlipidated and lipidate

49 Knockdown of HSF-1 increased the LC3 lipidation associated with formation of autophagosomal o

50 Post-translational lipidation by prenylation of the CaaX-box C-terminal mot

51 We conclude that lipidation can make Abeta more prone to aggregation and

52 reinhardtii based on the protein abundance, lipidation, cellular distribution, and mRNA levels of th

53 ncreased tubule length whereas expression of lipidation-defective LC3 decreased tubule length relativ

54 indings were associated with reversal of the lipidation deficiency of apoE4 and of the cognitive impa

55 suggest that this is due to reversal of the lipidation deficiency of apoE4.

56 (o)G204A, RGS-insensitive alpha(o)G184S, and lipidation-deficient alpha(o)G2A were all defective in t

57 is the E2-like enzyme necessary for ATG8/LC3 lipidation during autophagy.

58 ative analysis of dynamic changes in protein lipidation during vertebrate embryonic development.

59 Lipidation enhanced membrane affinity for most Legionell

60 ide is able to reverse ATG8 accumulation and lipidation, even in wild-type plants when autophagy is i

61 N-myristoylation is a protein lipidation event in which myristate is covalently linked

62 e necessary only for early translocation and lipidation events.

63 nsity lipoproteins depends on lipid binding (lipidation) for its secretion.

64 protein that requires assembly with lipids (lipidation) for its secretion.

65 odified peptides (e.g. amidation, oxidation, lipidation, glycosylation or d-amino acids), and peptide

66 owever, little is known about how N-terminal lipidation governs membrane compartmentalization of prot

67 of both a substrate and a product of protein lipidation in a biologically relevant context.

68 alysis is required to study roles of protein lipidation in cellular regulation.

69 PLTP expression significantly increases VLDL lipidation in hepatocyte microsomal lumina, and also VLD

70 omplex interplay between phosphorylation and lipidation in mediating the localization of GAP43 in neu

71 Our data show a novel role of lipidation in targeting a checkpoint protein to KTs thro

72 asmic reticulum (ER), followed by subsequent lipidation in the ER and Golgi compartment.

73 both necessary and sufficient to trigger LC3 lipidation in vitro.

74 nding cassette transporter A1-mediated apoAI lipidation increases HDL biogenesis, thus stabilizing ci

75 assage B. burgdorferi spirochetes of a novel lipidation-independent activity capable of inducing cyto

76 s B. burgdorferi spirochetes express a novel lipidation-independent activity which induces secretion

77 However, how phosphorylation and lipidation interplay to mediate sorting of GAP43 is uncl

78 LC3B lipidation inversely correlates with thigh cross-section

79 In the vastus lateralis, LC3B protein lipidation is increased by COPD and the expression of au

80 's disease, ABCA1 role as a modifier of APOE lipidation is of significance for this disease.

81 ranslational modification whereby C-terminal lipidation leads to protein localization to membranes.

82 ion strategies, others hijack the eukaryotic lipidation machinery to ensure plasma membrane localizat

83 ked glycosylation site insertion and protein lipidation mapping in conjunction with cellular fraction

84 ivity was shown to be dependent upon protein lipidation, mast cell TNF-alpha release was not induced

85 teins in cellular membranes via differential lipidation may be more subtle than previously thought.

86 studies suggest that both N-methylation and lipidation may contribute to antibiotic activity, wherea

87 substrate for Lpcat1 and reveal that histone lipidation may occur through its O-palmitoylation as a n

88 or mammalian proteins that commonly undergo lipidation might also function as antigens.

89 at the nature and regiochemistry of glycosyl lipidation modulated vancomycin-resistent Enterococci po

90 RrgA, an ancillary pilus subunit devoid of a lipidation motif, particularly when presented as part of

91 Thus, dual lipidation motifs on Gpa1p and Ste18p are required for a

92 Lipidation occurs in the endoplasmic reticulum and is de

93 oteins reside in secretory vesicles, or full lipidation occurs post-ER.

94 n the folding of apoB before any substantial lipidation occurs.

95 GGTase-I catalyzes C-terminal lipidation of >100 proteins, including many GTP- binding

96 f ABCA1, thereby allowing the second step of lipidation of apoA-I and formation of nascent high densi

97 Lipidation of apoA-I by ABCA1 increases its potential fo

98 Initial lipidation of apoA-I by hepatic ABCA1 is critical for pl

99 ways than lipid-free apoA-I in vitro and (2) lipidation of apoA-I prevents it from rapidly associatin

100 est that ABCA1 is necessary for the adequate lipidation of apoAI, which enables the interaction with

101 eride transfer protein (MTP), which mediates lipidation of apoB in HepG2 cells.

102 ational assembly pathway, post-translational lipidation of apoB28 displayed a strict dependence upon

103 tative functional role of MTP in the initial lipidation of apoB:1000 in stable transformants of McA-R

104 trate that Abca1 is essential for the proper lipidation of ApoE and mediates the effects of T0 on Abe

105 found to have markedly decreased levels and lipidation of apoE in the central nervous system.

106 he conclusions that increased ABCA1-mediated lipidation of apoE in the CNS can reduce amyloid burden

107 sing ABCA1 in the brain would have increased lipidation of apoE-containing lipoproteins and decreased

108 Tg primary astrocytes demonstrated increased lipidation of apoE-containing particles.

109 containing lipoproteins, suggesting abnormal lipidation of apoE.

110 If the APOE4 loss-of-function is lipidation of apoE4, then induction of ABCA1/ABCG1 may b

111 This implies that lipidation of apolipoprotein A-I by the ABCA1 pathway is

112 phospholipid transfer activity of MTP in the lipidation of apolipoprotein B and CD1d has been indicat

113 epithelial cells (IECs) and is essential for lipidation of apolipoprotein B, associates with CD1d in

114 use models by inducing the transcription and lipidation of apolipoprotein E (apoE).

115 inhibited under stress conditions to ensure lipidation of ATG8 and thus autophagy progression in C.

116 tidylinositol-3-phosphate, as well as on the lipidation of Atg8/LC3-like proteins, this area of resea

117 However, the lipidation of Atg8p and assembly of the micropexophagic

118 e palmitoylation, a common posttranslational lipidation of cysteine residues.

119 nsporter, which plays a critical role in the lipidation of extracellular apolipoprotein acceptors, tr

120 Mutagenesis of the site of lipidation of FlgP (C18G) prevented [3H]palmitate incorp

121 o complement this defect, demonstrating that lipidation of FlgP is essential for its role in intestin

122 idence that overexpression of Bcl-2 inhibits lipidation of GABARAP, a key step in autophagosome forma

123 -/- mice to ask whether ABCA1 is involved in lipidation of HDL in the central nervous system (CNS).

124 irculation of mature HDL particles by direct lipidation of hepatic lipid-poor apoA-I, slowing its cat

125 However, a role for adipose in cholesterol lipidation of high-density lipoprotein (HDL) in vivo is

126 sferase (FTase) catalyzes post-translational lipidation of key signal transduction proteins and is es

127 h its effect on ATG5, HuD contributed to the lipidation of LC3 and the formation of LC3-positive auto

128 Lipidation of LC3 is required for its coclustering with

129 Autophagy results in the covalent lipidation of LC3, conferring the property of membrane a

130 e proteolytic cleavage of pro-LC3 and the de-lipidation of LC3-PE from autophagosomes, both executed

131 Lipidation of methionine sulfoxide reductase A occurs in

132 elated genes Atg4c and Atg7 (involved in the lipidation of microtubule-associated protein 1 light cha

133 iciently suppressed a key step in autophagy, lipidation of microtubule-associated protein 1 light cha

134 formation of autophagosomes by promoting the lipidation of microtubule-associated protein LC3 (light

135 ansfer protein (MTP) plays a key role in the lipidation of nascent apoB and the secretion of apoB-con

136 of the endoplasmic reticulum and in the net lipidation of nascent apoB, and may be essential for lip

137 Hence, we reasoned that lipidation of peptidomimetic ligands could promote membr

138 rase (FTase) catalyzes the carboxyl-terminal lipidation of Ras and several other cellular signal tran

139 not the glycine-rich motif, is required for lipidation of TbpB and tethering to the outer membrane.

140 alysts that exhibit site-selectivity for the lipidation of the aliphatic hydroxyls on vancomycin, gen

141 ES1 deficiency promotes the accumulation and lipidation of the ATG8 protein, which is associated with

142 ion of WHAMM in healthy cell lines inhibited lipidation of the autophagosomal protein LC3 and clearan

143 to the peripheral cytoplasm, contributing to lipidation of the autophagy protein LC3B and maturation

144 geranyltransferase were both involved in the lipidation of the Legionella CAAX motif proteins.

145 man embryonic kidney 293 cells that measures lipidation of the marker protein GFP-LC3 following amino

146 PR signaling pathways suppressed HCV-induced lipidation of the microtubule-associated protein light c

147 ein B output and (ii) changing the degree of lipidation of the particles with triacylglycerol so that

148 Host-dependent lipidation of these three effectors directs plasma membr

149 (FTase) catalyzes the biologically relevant lipidation of up to several hundred cellular proteins.

150 luding reduced triglyceride secretion, lower lipidation of very-low-density lipoproteins, and increas

151 Lipidation of Vtg occurs at its site of synthesis in ver

152 Deleting Atg7 or Atg5 or blocking LC3 lipidation or ATG5-ATG12 conjugation decreases ERK phosp

153 dependent of its length, its requirement for lipidation or microsomal triglyceride transfer protein e

154 In the dual lipidation pathway, bCdc42 was prenylated, but it bypass

155 Ras constructs, including key changes to the lipidation pattern of the hypervariable region, suggest

156 Phosphorylation and lipidation provide posttranslational mechanisms that con

157 Posttranslational lipidation provides critical modulation of the functions

158 Here, we introduce protein-lipidation quantitation (PLQ)-the first method for quant

159 Lipidation, raft targeting, and secretion can be blocked

160 Previously, we established a cell-free LC3 lipidation reaction to identify the ER-Golgi intermediat

161 In vitro LC3 lipidation requires energy and is subject to regulation

162 s the ATG8-PE adduct, we also show that ATG8 lipidation requires the ATG12-ATG5 conjugate.

163 but not Lsp engineered to lack its putative lipidation residue.

164 In conclusion, apoB100 bulk lipidation, resulting in conversion of LDL/HDL to VLDL,

165 any known recognition signal for C-terminal lipidation, Rit-transformed cell growth and survival in

166 However, mutation of the lipidation site did not affect the oxidase activity or t

167 gement, an aromatic belt in proximity to its lipidation site positions the highly electronegative sur

168 thin the C-terminal tail, serve as important lipidation sites and are differentially conjugated to pa

169 to increase apoE levels without altering its lipidation state may actually worsen Abeta amyloidosis,

170 as the number of phospholipid molecules or "lipidation state" of apoA-I increases.

171 The lipidation states of apolipoproteins and Abeta peptides

172 n is dependent upon the ApoE isoform and its lipidation status.

173 gh both regulated translocation and an early lipidation step of the nascent particle with cholesterol

174 s must undergo a series of posttranslational lipidation steps before they become biologically functio

175 modified dendrimer platform with and without lipidation strategy.

176 of LC3 or Atg7, a protein that mediates LC3 lipidation, suppressed HCV replication, indicating a pos

177 on these results we propose a model whereby lipidation targets Wnt-1 to secretory vesicles that deli

178 ppression of G9a induces LC3B expression and lipidation that is dependent on RNA synthesis, protein t

179 oleic acid (OA) was added to stimulate apoB lipidation; therefore, either large apoB100-lipoproteins

180 we establish a cell-free assay based on LC3 lipidation to define the organelle membrane supporting e

181 nt in ATG8 function is ATG12, which promotes lipidation upon its attachment to ATG5.

182 When apoB100 lipidation was blocked by an inhibitor of MTP (MTPI), re

183 ophagosomal and autophagosomal membranes via lipidation, was analyzed in the CCL-136 muscle cell line

184 A second conjugation reaction, Aut7/Atg8 lipidation with phosphatidylethanolamine, as well as a p

185 protein-protein interaction prevents PfAtg8 lipidation with phosphatidylethanolamine.