ライフサイエンスコーパス: lipidomics

1 rometry after direct infusion (i.e., shotgun lipidomics).

2 idimensional mass spectrometry-based shotgun lipidomics.

3 uantification of lipids is a primary goal in lipidomics.

4 hogenesis of diseases but are challenging in lipidomics.

5 seful for a diverse range of applications in lipidomics.

6 with serum total and LDL cholesterol, and AT lipidomics.

7 y protein arrays and mass spectrometry-based lipidomics.

8 analysis of lipids using MDMS-based shotgun lipidomics.

9 hy-mass spectroscopy/mass spectroscopy-based lipidomics.

10 t often used for untargeted metabolomics and lipidomics.

11 mic range of their measurement using shotgun lipidomics.

12 using mass spectrometry-based proteomics and lipidomics.

13 atography and tandem mass spectrometry-based lipidomics.

14 tleneck in high-throughput bottom-up shotgun lipidomics.

15 quencing, targeted metabolomics, and shotgun lipidomics.

16 on; this presents an analytical challenge in lipidomics.

17 on mass spectrometry (DIMS) metabolomics and lipidomics.

18 e ionization detection and mass spectrometry lipidomics.

19 on the brain lipidome, we performed Shotgun Lipidomics.

20 ification remains a significant challenge in lipidomics.

21 Lipidomics, a major part of metabolomics, constitutes th

22 Here we describe computational lipidomics, a novel analytical technique, coupling mass

23 In direct infusion/injection (or shotgun) lipidomics, accurate downstream identification and quant

24 Metabolomics and lipidomics aim to profile the wide range of metabolites

25 Current mass spectrometry-based lipidomics aims to comprehensively cover wide ranges of

26 Mass-spectrometry-based lipidomics aims to identify as many lipid species as pos

27 Lipidomics aims to quantitatively define lipid classes,

28 Although shotgun lipidomics allows for high-throughput analysis, low-abun

29 Transcriptomes and lipidomics analyses indicate that Notch activation suppr

30 Accordingly, lipidomics analyses show increased PE levels in yeast su

31 Hormone and lipidomics analyses showed higher levels of JA, JA-isole

32 Fatty acid incorporation and lipidomics analyses showed that LPIN1 knockdown blocks p

33 Here we highlight a variety of methods for lipidomics analysis at the tissue, cellular and subcellu

34 lasses prior to analysis, the "comprehensive lipidomics analysis by separation simplification" (CLASS

35 Comparative lipidomics analysis identified more than 1,000 molecular

36 Using global lipidomics analysis in experimental traumatic brain inju

37 ss spectrometry (MS) have made comprehensive lipidomics analysis of complex tissues relatively common

38 A systematic lipidomics analysis of LPO in the interaction of Arabido

39 Lipidomics analysis of lungs from post-natal day 7, day

40 s a primary hallmark of NPC1 deficiency, our lipidomics analysis revealed the buildup of several spec

41 otein level, mass spectrometry-based shotgun lipidomics analysis showed significant differences in th

42 (CLIP) in blocking MHC class II, comparative lipidomics analysis shows that human cluster of differen

43 Chiral lipidomics analysis was employed to show that a 5-LO-der

44 of the lipid concentration levels in shotgun lipidomics analysis was tracked over a period of 3.5 yea

45 extraction is usually the first step toward lipidomics analysis.

46 Using both lipidomics and a sterol response element reporter assay,

47 HDLs were isolated, and lipidomics and differential proteomics tests were perfor

48 Mass spectrometry-based lipidomics and enzymatic assays demonstrate the targetin

49 We applied mass spectrometry-based lipidomics and gene and protein expression measurements

50 ights the hypothesis generating potential of lipidomics and identifies novel region-specific lipid an

51 nalytical approach will be extended to other lipidomics and metabolomics applications.

52 - there are fewer than 200 total articles on lipidomics and metabolomics focusing on lipids - the fie

53 ratio in direct-MS analyses (e.g., "shotgun" lipidomics and MS imaging).

54 Herein, we use shotgun lipidomics and multidimensional mass spectrometry to ide

55 PGE(2) formation was analyzed by lipidomics and polymorphonuclear leukocyte (PMN) infiltr

56 sing daunting tasks in areas as different as lipidomics and proteomics.

57 Using mass spectroscopic lipidomics and subcellular fractionation, we demonstrate

58 A combined lipidomics and transcriptomics analysis was performed on

59 trospray ionization-tandem MS-based mediator lipidomics and unbiased image analysis in mouse dissocia

60 proresolving lipid mediator lipidomics and/or protein expression, and identifying as

61 rotein science, systems biology, proteomics, lipidomics, and cell biology in general.

62 Longitudinal proteomic, lipidomics, and metabolomic analyses revealed that hepat

63 The combination of metabolomics, lipidomics, and phosphoproteomics that incorporates trip

64 etry has earned a central analytical role in lipidomics, and this role will continue to grow with tec

65 S) has been used to support metabolomics and lipidomics applications to facilitate the separation and

66 In addition to such lipidomics applications, the exchange method should have

67 m (Waters) specifically for metabolomics and lipidomics applications; extracting polar metabolites an

68 A targeted lipidomics approach showed that 15(S)-hydroxyeicosatetra

69 The assessed shotgun lipidomics approach showed to be remarkably robust and r

70 Herein, we describe a shotgun lipidomics approach that exploits charge-switch derivati

71 Herein, we describe a shotgun lipidomics approach that utilizes a single-phase methyl

72 We used a lipidomics approach to generate a broad profile of fatty

73 ury, we employed a newly developed oxidative lipidomics approach to qualitatively and quantitatively

74 A targeted lipidomics approach was used to identify and quantify th

75 Using a nontargeted lipidomics approach, we demonstrate that plants lacking

76 Using a lipidomics approach, we demonstrated that eicosanoid pro

77 Using the newly developed enhanced shotgun lipidomics approach, we demonstrated the dramatic loss o

78 Using a targeted mass spectrometry-based lipidomics approach, we found that in db/db mice, PGE2/D

79 Using a targeted lipidomics approach, we observed that Toll-like receptor

80 ned to be easily adaptable for other shotgun lipidomics approaches that are currently used for mass s

81 Two recent studies in Cell apply lipidomics approaches to identify bioactive lipid mediat

82 mistry) and high throughput metabolomics and lipidomics approaches using mass spectrometry.

83 tly, there exist two mass spectrometry-based lipidomics approaches, one based on a division of lipids

84 ipids studied using metabolomic approaches - lipidomics - are an ideal subject for metabolomic measur

85 mers, particularly in an approach of shotgun lipidomics, are still missing.

86 Here, we used targeted lipidomics-based approaches to profile the time course o

87 All samples were differentiated using a lipidomics-based data workup employing multivariate data

88 s and developed a sensitive, facile, shotgun lipidomics-based method for quantification of these comp

89 available yet in some other "omics" fields, lipidomics being one of them.

90 ncil Human Nutrition Research, and Cambridge Lipidomics Biomarker Research Initiative.

91 presents a tremendous improvement for tissue lipidomics by integrating genetics, fluorescence microsc

92 Time-course data of transcriptomics and lipidomics can be queried or downloaded from http://www.

93 Lipidomics can complement genomics and proteomics by pro

94 To exploit the specificity of LCM for lipidomics, catapulted tissue patches were directly coll

95 We used lipidomics combined with genetic and biochemical assays

96 The lipidomics community is in need of benchmark reference v

97 gest that patch clamp-assisted single neuron lipidomics could be broadly applied to investigate neuro

98 This nontargeted lipidomics CTS approach was applied in both positive- an

99 Lipidomics data also show an overall reduction in lipid

100 We demonstrate that lipidomics data generated in samples from three differen

101 ocessing and visualization of LC-MS/MS-based lipidomics data.

102 of nine different multivariate metabolic and lipidomics datasets with classical toxicological paramet

103 GC-MS lipidomics demonstrate that this reduction correlated wi

104 Shotgun lipidomics demonstrated multiple alterations in hippocam

105 Comparative metabolomics and lipidomics demonstrated that acetate is used as a nutrit

106 We found lipidomics (Direct Infusion-Mass Spectrometry) data the

107 Lipidomics enables the assessment of hundreds of lipid s

108 In lipidomics epidemiological studies should avoid mixed-ge

109 g transcriptomics, metabolomics, proteomics, lipidomics, epigenetic modifications, and the microbiome

110 hromatography (LC)-MS-based metabolomics and lipidomics experiments.

111 assignment of identifications in untargeted lipidomics experiments.

112 Shotgun lipidomics exploits the unique chemical and physical pro

113 e in 2003 and the ensuing development of the lipidomics field have revealed that lipid metabolites ar

114 ing platforms continue to spur growth in the lipidomics field, more structurally unique lipid species

115 rometry (TWIM-MS) is of high interest to the lipidomics field.

116 his review, we will discuss the potential of lipidomics for cardiovascular research.

117 idimensional mass-spectrometry-based shotgun lipidomics for global analysis of fatty acids including

118 The field of lipidomics has been significantly advanced by mass spect

119 Lipidomics has emerged as a powerful technique for large

120 Lipidomics has experienced rapid progress, mainly becaus

121 ophospholipid (LPL) species based on shotgun lipidomics has not been established.

122 mass spectrometry analysis of lipids (termed lipidomics) has begun to alter our understanding of how

123 Recent advances in lipidomics have led to identification of plentiful lipid

124 We conclude that comprehensive lipidomics images generated by MALDI-MSI report accurate

125 supports both targeted and untargeted LC-MS lipidomics, implementing data acquisition, user-friendly

126 ples of the power of mass spectrometry-based lipidomics in addressing cell biological questions.

127 her, by exploiting the principles of shotgun lipidomics in combination with a novel strategy of sampl

128 -MS/MS offers new possibilities for targeted lipidomics in lipoproteins as well as for oxidative stre

129 hiatry, neurology, and neuro-oncology and of lipidomics in neurology will be reviewed.

130 nges in DNA methylation, gene expression and lipidomics in response to DR and aging in female mouse l

131 Using LC-UV-MS-MS-based lipidomics in tandem with functional screening at the si

132 The results demonstrated that untargeted lipidomics, in conjunction with chemometric tools has a

133 us mean concentrations derived from the NIST Lipidomics Interlaboratory Comparison Exercise.

134 Lipidomics is a novel and emerging research field that m

135 Thus, lipidomics is an efficient discovery tool that informs g

136 Lipidomics is an emerging field in biomedical research t

137 Modern lipidomics is largely dependent upon structural ontologi

138 Lipidomics is the comprehensive analysis of molecular li

139 most significant challenges in contemporary lipidomics lies in the separation and identification of

140 a seasoned community of wet lab scientists, lipidomics lies significantly behind proteomics in the a

141 idimensional mass spectrometry-based shotgun lipidomics (MDMS-SL) data, which are acquired directly f

142 the isotopic distribution in the context of lipidomics, metabolomics, glycoscience, or even space ex

143 The lipidomics method was applied to serum samples from 192

144 peripheral organs as determined via targeted lipidomics methods.

145 Shotgun lipidomics of adipose tissue from wild-type mice demonst

146 icle presents a novel method for small-scale lipidomics of bacterial cells by integrating extraction

147 Lipidomics of human blood plasma is an emerging biomarke

148 Lipidomics of Pxmp2(-/-)mammary fat pad showed a decreas

149 Shotgun lipidomics of skeletal muscle revealed a decreased conte

150 ts can be used for comprehensive, untargeted lipidomics of the most abundant lipid species in whole b

151 Because lipidomics offers a biologically and analytically attrac

152 Lipidomics on platelet membrane extracts showed that pso

153 ids that accumulate in obesity, we performed lipidomics on quadriceps muscles from obese mice with im

154 trometry, either by direct infusion (shotgun lipidomics) or coupled with liquid chromatography.

155 lipids were performed using the established lipidomics platform based on ultra-performance liquid ch

156 s rationale, this study presents a validated lipidomics platform to map the fecal lipidome, which int

157 ining data analysis to increase the value of lipidomics platforms to research and commercial applicat

158 ation and the application of high-throughput lipidomics platforms.

159 This study applied mass spectrometry-based lipidomics profiling to population-based cohorts and ide

160 Using combined lipidomics, proteomics and bioinformatics, we isolated a

161 Contemporary lipidomics protocols are dependent on conventional tande

162 igh-dimensional lipid analysis technologies (lipidomics) provide researchers with an opportunity to m

163 Shotgun lipidomics relies on the direct infusion of total lipid

164 crochip-based lipid extraction into cellular lipidomics research.

165 main limitations for LC-MS-based untargeted lipidomics reside in the lack of adequate computational

166 Within a gender-restricted cohort lipidomics revealed a compositional signature that indic

167 Targeted lipidomics revealed that LEI105 concentration-dependentl

168 ion with a dedicated high-resolution shotgun lipidomics routine enables both quantification and in-de

169 t ideal for high-throughput metabolomics and lipidomics screening-e.g., for clinical phenotyping, dru

170 Shotgun lipidomics showed that MUFAs were significantly reduced

171 Using untargeted and targeted lipidomics strategies, we identify two long-chain satura

172 A "shotgun" lipidomics strategy consisting of sequential functional

173 A novel mass spectrometry (MS)-based lipidomics strategy that exposes glycerophospholipids to

174 C-MS based fatty acid profiling with shotgun lipidomics strategy.

175 ent with the oxygenation pattern observed in lipidomics studies.

176 ay ionization mass spectrometry to perform a lipidomics study on these three raft preparations.

177 donic acid and found using LC-UV-MS-MS-based lipidomics that STAg produced both 15-HETE and 5,15-diHE

178 We show by using lipidomics that thrombin-activated human platelets gener

179 metry-based workflow for enhanced structural lipidomics that, in a single experiment, can yield almos

180 advance the level of analytical scripting in lipidomics to a new plateau.

181 Herein, we exploit shotgun lipidomics to demonstrate a 4-fold increase in acylcarni

182 Herein, we utilize the power of shotgun lipidomics to demonstrate that modest caloric restrictio

183 in combination with mass spectrometry-based lipidomics to discover that DDHD2 regulates brain trigly

184 Here, we used targeted serum lipidomics to identify a new panel of GPCs, and tested w

185 Herein, we exploit the power of global lipidomics to identify the critical role of peroxisomal

186 Although the application of lipidomics to platelet biology is still in its infancy,

187 We used (13)C tracers and lipidomics to probe fatty acid metabolism, including des

188 onal activation could be maintained, we used lipidomics to quantify AAMvarphi-derived eicosanoids, po

189 in combination with chemical proteomics and lipidomics, to determine the impact of acute DAGL blocka

190 Recent advances in lipidomics using mass spectrometry have greatly accelera

191 Eventually, the potential of fecal lipidomics was exemplified within a clinical context of

192 on remains a bottleneck of modern untargeted lipidomics, we developed LipidHunter, a new open source

193 ing self-resolving inflammatory exudates and lipidomics, we have identified a new pathway involving b

194 Here, by employing comprehensive lipidomics, we identify omega-3 (omega-3) fatty acid epo

195 ric data were collected, and biochemical and lipidomics were measured in plasma samples from particip

196 erent lipid classes were profiled by shotgun lipidomics with the use of a triple-quadrupole mass spec

197 Here, we describe a lipidomics workflow and open-source software package for

198 of the DMS separation in this unique shotgun lipidomics workflow is its ability to separate many isob

199 When integrated into a larger lipidomics workflow, LipidMatch may increase the probabi

200 ctable separation technique within a shotgun lipidomics workflow, with a special focus on phospholipi

201 and isomeric lipids that by standard shotgun lipidomics workflows are difficult to assess precisely,

202 to conventional LC-MS-based metabolomics and lipidomics workflows has been shown to enhance peak capa

203 nce values to assess the validity of various lipidomics workflows in providing accurate quantitative

204 ts indicate that adding CCS to databases and lipidomics workflows increases the specificity and selec