ライフサイエンスコーパス: lipoarabinomannan

1 acterial lipopolysaccharide or mycobacterial lipoarabinomannan.

2 by binding to the mannose-capped lipoglycan lipoarabinomannan.

3 in the early stage of arabinan synthesis in lipoarabinomannan.

4 its normal state and subsequent synthesis of lipoarabinomannan.

5 tic precursor of PIM4, PIM6, lipomannan, and lipoarabinomannan.

6 to phosphatidylinositol mannosides (PIMs) or lipoarabinomannan.

7 ntegrin, or with phosphatidylinositol-capped lipoarabinomannan.

8 yl-arabinogalactan-peptidoglycan complex and lipoarabinomannan.

9 gands, including zymosan, peptidoglycan, and lipoarabinomannan.

10 oglycan, arabinan, linker unit galactan, and lipoarabinomannan.

11 cell wall antigens, such as mycolic acid and lipoarabinomannans.

12 Lipoarabinomannan, a component of the BCG cell wall that

13 sing site-specific lymphocytes; detection of lipoarabinomannan, a glycolipid of MTB, in urine; the st

14 ed feature of the biosynthesis of lipomannan/lipoarabinomannan allows a significant revision of struc

15 erculosis cell envelope lipoglycans, such as lipoarabinomannan and lipomannan, but a mechanism for li

16 binds to Mycobacterium tuberculosis surface lipoarabinomannan and results in bacterial agglutination

17 ted mice contain the mycobacteria components lipoarabinomannan and the 19-kDa lipoprotein and can sti

18 ced IL-8 response mediated by mannose-capped lipoarabinomannan and the mannose receptor is independen

19 , phosphatidylinositol mannoside, arabinosyl-lipoarabinomannan, and dimycolated trehalose (cord facto

20 ates that TLR1 and TLR2 are required for ara-lipoarabinomannan- and tripalmitoyl cysteinyl lipopeptid

21 s the Xpert MTB/RIF assay), and detection of lipoarabinomannan antigen in urine.

22 alities, and a lower frequency of detectable lipoarabinomannan antigenuria and mycobacteriuria.

23 nd linear and mature branched lipomannan and lipoarabinomannan are prominent phospholipids/lipoglycan

24 Utilizing a lipoarabinomannan-based enzyme-linked immunosorbent assa

25 Within minutes, M. avium, or its cell wall lipoarabinomannan, binds to the adherent macrophages and

26 vative (PPD), antigen 85, and mannose-capped lipoarabinomannan but not to nonmycobacterial antigens.

27 bacterium tuberculosis cell wall glycolipid, lipoarabinomannan, can inhibit CD4(+) T cell activation

28 lted in the absence of lipomannan (Cg-LM-A), lipoarabinomannan (Cg-LAM) and a multi-mannosylated poly

29 d phagocytosis of Mycobacterium tuberculosis lipoarabinomannan-coated microspheres.

30 g incubation with Mycobacterium tuberculosis lipoarabinomannan, colocalization of endocytosed lipoara

31 The best ligand was mannosyl-lipoarabinomannan, followed by lipomannan, phosphatidyli

32 Lipoarabinomannan-free culture filtrate proteins of M. t

33 virulent Erdman strain of M.tb, but not the lipoarabinomannan from M. smegmatis.

34 Lipoarabinomannan from M. tuberculosis Erdman and M. lep

35 SP-D binds predominantly to lipoarabinomannan from the virulent Erdman strain of M.t

36 Selected mycobacterial antigens (Mtb41 > lipoarabinomannan > 38kd > Ag85B > Mtb39) expanded inhib

37 Although lipoarabinomannan has been found to exert effects on mac

38 loss), a rapid test detecting mycobacterial lipoarabinomannan in urine (Determine TB LAM), and a mol

39 uberculosis and its cell wall mannose-capped lipoarabinomannan induce PPARgamma expression through a

40 Mycobacterium tuberculosis mannose-capped lipoarabinomannan inhibits the release of proinflammator

41 The binding of SP-D to Erdman lipoarabinomannan is mediated by the terminal mannosyl o

42 l envelope glycosylated phosphatidylinositol lipoarabinomannan isolated from the virulent Mycobacteri

43 n of the major arabinosylated glycopolymers, lipoarabinomannan (LAM) and arabinogalactan (AG).

44 erial cell walls in two settings, as part of lipoarabinomannan (LAM) and arabinogalactan, each with m

45 esis of phosphatidylinositol (PI)-containing lipoarabinomannan (LAM) and lipomannan (LM) of Mycobacte

46 e mycobacterial components, arabinose-capped lipoarabinomannan (LAM) and soluble tuberculosis factor

47 sitol mannosides (PIM), lipomannan (LM), and lipoarabinomannan (LAM) are essential components of the

48 Lipomannan (LM) and lipoarabinomannan (LAM) are key Corynebacterineae glycoc

49 curacy of urinary and pericardial fluid (PF) lipoarabinomannan (LAM) assays in tuberculous pericardit

50 terial genes involved in lipomannan (LM) and lipoarabinomannan (LAM) biosynthesis.

51 at mycobacterial phosphatidylinositol analog lipoarabinomannan (LAM) blocks a trans-Golgi network-to-

52 zyme-linked immunosorbent assay, and urinary lipoarabinomannan (LAM) by Alere Determine TB LAM assay.

53 Here we describe how M. tuberculosis toxin lipoarabinomannan (LAM) causes phagosome maturation arre

54 to sputum diagnostics, urine Xpert and urine-lipoarabinomannan (LAM) combined identified 88% of TB bl

55 he mycobacterial cell wall glycophospholipid lipoarabinomannan (LAM) could specifically induce human

56 Urinary lipoarabinomannan (LAM) detection is a promising approac

57 crosis factor alpha [TNF-alpha] cytokines by lipoarabinomannan (LAM) from pathogenic Mycobacterium tu

58 The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as a virulenc

59 Current knowledge on the structure of lipoarabinomannan (LAM) has resulted primarily from deta

60 ion pathway for the mycobacterial lipoglycan lipoarabinomannan (LAM) in monocyte-derived antigen-pres

61 ll wall, with phosphatidylinositol anchoring lipoarabinomannan (LAM) in the cell envelope.

62 Lipoarabinomannan (LAM) is a component of the mycobacter

63 Lipoarabinomannan (LAM) is a high molecular weight, hete

64 Lipoarabinomannan (LAM) is a structurally heterogeneous

65 Lipoarabinomannan (LAM) is composed of a phosphatidylino

66 We studied the diagnostic accuracy of the lipoarabinomannan (LAM) lateral flow assay (LFA), LAM en

67 both the cell wall arabinogalactan (AG) and lipoarabinomannan (LAM) of Mycobacterium tuberculosis an

68 The glycolipid lipoarabinomannan (LAM) plays an important role in media

69 s in the context of arabinogalactan (AG) and lipoarabinomannan (LAM) respectively.

70 l lipopolysaccharide (LPS) and mycobacterial lipoarabinomannan (LAM) that lacks terminal mannosyl uni

71 We sought to determine if urine lipoarabinomannan (LAM) would improve diagnosis of pulmo

72 The biosynthesis of lipoarabinomannan (LAM), a key mycobacterial lipoglycan

73 rating the tuberculosis-specific glycolipid, lipoarabinomannan (LAM), a promising urinary biomarker f

74 cterial proteins, native antigen 85 complex, lipoarabinomannan (LAM), and Mycobacterium tuberculosis

75 cobacterial lipoglycans, lipomannan (LM) and lipoarabinomannan (LAM), are potent immunomodulators in

76 s of the M. tuberculosis surface lipoglycan, lipoarabinomannan (LAM), from the Erdman strain serve as

77 determined that a major capsular lipoglycan, lipoarabinomannan (LAM), from the Erdman strain serves a

78 results demonstrated that cell wall-derived lipoarabinomannan (LAM), mycolyl arabinogalactan-peptido

79 Lipoarabinomannan (LAM), one of the few known bacterial

80 forming the unique arabinogalactan (AG) and lipoarabinomannan (LAM), respectively.

81 f presenting mycobacterial lipids, including lipoarabinomannan (LAM), to double-negative (DN; CD4(-)

82 We tested whether mannose-capped lipoarabinomannan (LAM)-induced inhibition of CD4(+) T c

83 Significant increases in lipoarabinomannan (LAM)-specific immunoglobulin G (IgG)

84 not to a distinct CD14 ligand, mycobacterial lipoarabinomannan (LAM).

85 e bacterial LPS and mycobacterial glycolipid lipoarabinomannan (LAM).

86 ram-negative bacterial LPS and mycobacterial lipoarabinomannan (LAM).

87 e core of the key immunogenic polysaccharide lipoarabinomannan (LAM).

88 sitol-based lipoglycans, lipomannan (LM) and lipoarabinomannan (LAM).

89 sis a new 5-methylthiopentose substituent on lipoarabinomannan (LAM).

90 gainst the mycobacterial cell wall component lipoarabinomannan (LAM).

91 synthesize a family of lipomannans (LM) and lipoarabinomannans (LAM) that are abundant components of

92 osphatidylinositol mannoside, lipomannan and lipoarabinomannan levels were not altered.

93 hospho-mannopyranose and thus indirectly for lipoarabinomannan, lipomannan, and the higher-order phos

94 ever, yielded less binding to mannose-capped lipoarabinomannan (ManLAM) and even lower levels of bind

95 M.tb mannose-capped lipoarabinomannan (ManLAM) blocks phagosome maturation.

96 l cell wall glycophospholipid mannose-capped lipoarabinomannan (ManLAM) could induce human peripheral

97 The cell wall component lipoarabinomannan (ManLAM) from Mycobacterium tuberculos

98 cell wall lipoglycan known as mannose-capped lipoarabinomannan (ManLAM) in mouse macrophages costimul

99 Recent work has indicated that mannosylated lipoarabinomannan (ManLAM) isolated from Mycobacterium t

100 ed protein derivative (PPD) and mannosilated lipoarabinomannan (ManLAM) stimulation.

101 art, by binding of the mannose caps of M. tb lipoarabinomannan (ManLAM) to the macrophage mannose rec

102 at the known virulence factor mannose-capped lipoarabinomannan (ManLAM) was sufficient to induce sTNF

103 ed and more branched forms of mannose-capped lipoarabinomannan (ManLAM) with a marked reduction of th

104 and Mycobacterium tuberculosis mannosylated lipoarabinomannan (ManLAM), modulate essential interacti

105 and H37Rv cell wall, but not mannose-capped lipoarabinomannan (ManLAM), than did cells stimulated wi

106 sides (PIMs), lipomannan, and mannose-capped lipoarabinomannan (ManLAM).

107 cell wall lipoglycan known as mannose-capped lipoarabinomannan (ManLAM).

108 culosis phosphatidylinositol [mannose-capped lipoarabinomannan (ManLAM)] interfered with the phagosom

109 lipoteichoic acid (Gram-positive cocci), and lipoarabinomannan (Mycobacteria) become highly susceptib

110 e acyl side chains of known T cell antigens, lipoarabinomannan, phosphatidylinositol mannoside, and g

111 osphatidylinositol-containing lipomannan and lipoarabinomannan, replaced instead by a novel truncated

112 A subset of IFN-gamma-producing lipoarabinomannan-responsive T cells coexpressed the cyt

113 lysaccharides, capsular polysaccharides, and lipoarabinomannans that contain the Manalpha1-2Man disac

114 One immunoglobulin M (IgM) MAb bound to lipoarabinomannan, the second IgM MAb bound to mycolyl-a

115 yl-arabinogalactan-peptidoglycan complex and lipoarabinomannan; thus, its synthesis has attracted con

116 ds and lipoglycans such as mycolic acids and lipoarabinomannan to T cells.

117 -infected mice, confirming the occurrence of lipoarabinomannan trafficking to T cells in vivo.

118 Furthermore, lipoarabinomannan was associated with T cells after thei

119 Lipoarabinomannan was the most potent mycobacterial lipi

120 e supramolecular structure of mannose-capped lipoarabinomannan, we designed and synthesized a set of

121 hatidylinositol mannoside and mannose-capped lipoarabinomannan, were potent inhibitors.

122 of two polysaccharides, arabinogalactan and lipoarabinomannan, which are found in the cell wall comp

123 idyl-myo-inositol mannoside, lipomannan, and lipoarabinomannan, which are key glycolipids/lipoglycans

124 dyl-myo-inositol mannosides, lipomannan, and lipoarabinomannan, which are key glycolipids/lipoglycans

125 ch attention has been paid to mannose-capped lipoarabinomannan, which mediates phagocytosis and intra

126 arabinomannan, colocalization of endocytosed lipoarabinomannan with the gpCD1b1 isoform was observed