ライフサイエンスコーパス: lipocalin 2

1 olate siderophore, binds to the host protein lipocalin 2.

2 ounter-regulated by the presence of iron and lipocalin 2.

3 h a striking structural resemblance to human lipocalin 2.

4 IL-1beta and IL-17 also individually induce lipocalin 2.

5 (neutrophil gelatinase-associated lipocalin/lipocalin 2), a secreted glycoprotein that binds to MMP-

6 ain Salmonella by promoting the induction of lipocalin 2, a host antimicrobial factor that inhibits b

7 s survival advantage is counter-regulated by lipocalin 2, a siderophore-binding host protein, which r

8 Lipocalin 2 action was enhanced by iron-siderophore.

9 Lipocalin 2, an iron-siderophore-binding protein, conver

10 We found lipocalin 2 and numerous other innate defense genes to b

11 skin lesions, protein and mRNA expression of lipocalin 2 and other innate defense genes (hBD2, elafin

12 an overcome metal ion starvation mediated by lipocalin-2 and calprotectin via alternative pathways, I

13 ression of antimicrobial proteins, including lipocalin-2 and calprotectin, which sequester essential

14 hil recruitment and down-regulating elevated lipocalin-2 and cathepsin D expression.

15 xpressed at the RNA level (TFF1, TFF2, TFF3, lipocalin 2, and galectin 3) showed a good concordance b

16 eries of the roles of ferroportin, hepcidin, lipocalin 2, and members of the six transmembrane epithe

17 F9, IL-6, IL-19, CCL20, S100A7/A8/A9, DEFB4, lipocalin 2, and peptidase inhibitor 3 (p < 0.05), indic

18 s well gender-neutral (H19 fetal liver mRNA, lipocalin 2, and ubiquitin D) genes.

19 g others suppressor of cytokine signaling-3, lipocalin-2, and alpha1-antichymotrypsin.

20 id-A3, chemokine ligands (Ccl2, Ccl7, Ccl9), lipocalin-2, and matrix metalloproteinase-3 and -12 of i

21 Lipocalin 2 antagonized these effects at a point upstrea

22 ed by the immobilization of rabbit polygonal lipocalin-2 antibody on gold nanoparticles attached on g

23 These data characterize lipocalin 2 as an epithelial inducer in Ras malignancy a

24 m of MMA-associated kidney disease, identify lipocalin-2 as a biomarker of increased oxidative stress

25 sion of the IL-17 target genes IL-6 and 24p3/lipocalin-2 as a readout, functional reconstitution of s

26 Finally, we identify lipocalin-2 as the key secreted factor downstream of Tcf

27 dentified an acute phase response gene, 24p3/lipocalin 2, as a novel IL-17-induced gene.

28 We demonstrate that similar to lipocalin 2, Bet v 1 is capable of binding iron via cate

29 d hypomethylated genes (trefoil factor 2 and lipocalin 2) between pancreatic and breast cancer cell l

30 We found that lipocalin 2 could also convert 4T1-Ras-transformed mesen

31 ion of IL-1beta alone could reconstitute the lipocalin 2 deficiency in TLR4 knockout animals and resc

32 Lipocalin 2-deficient animals have impaired lung bacteri

33 observed to be Dectin-1 and IL-22 dependent, lipocalin 2-deficient mice did not demonstrate impaired

34 phimurium is unaffected by E. coli Nissle in lipocalin 2-deficient mice.

35 that STAT1 is required for IFNgamma-induced lipocalin-2 expression in murine adipocytes.

36 ion of Tfrc (transferrin receptor) and Lcn2 (lipocalin 2)), facilitate glucose import (e.g. Hk2 (hexo

37 8; CCL20/FCH, 8.36; PI3 [elafin]/FCH, 15.40; lipocalin 2/FCH, 6.94, human beta-defensin 2 [DEFB4A]/FC

38 d in classical pancreatic carcinomas such as lipocalin 2, galectin 3, claudin 4, and cathepsin E.

39 Lipocalin 2, haptoglobin, serum amyloid A3, stearoyl-CoA

40 These findings demonstrate that lipocalin 2 has at least two functions related to tumori

41 (C5) that secretes relatively high levels of lipocalin 2 (human NGAL) induced suppression of hematopo

42 cornea and, in the conjunctiva, sPLA(2)-IIA, lipocalin 2, IGFBP3, multiple MCH class II proteins, and

43 atic inflammation-related proteins including lipocalin-2 in db/db mice were attenuated by CR.

44 NA) antibodies up-regulate the expression of lipocalin-2 in glomerular mesangial cells.

45 g/ml, IQR 0-11.1; n = 14), urinary levels of lipocalin-2 in SLE patients were significantly higher (n

46 NA antibodies promote the local secretion of lipocalin-2 in the kidneys of patients with systemic lup

47 The presence of lipocalin-2 in the urine of patients with LN correlated

48 We conclude that lipocalin 2 is a crucial component of mucosal immune def

49 inct at the molecular level and suggest that lipocalin 2 is a new therapeutic target for breast cance

50 Lipocalin 2 is highly expressed in the lung where it exe

51 In this study, we found that lipocalin 2 is rapidly and robustly induced by Klebsiell

52 These findings indicate that urinary lipocalin-2 is a potential marker of the presence and se

53 One of these genes, lipocalin 2, is a putative in vivo estrogen target gene

54 Lipocalin 2 (LCN-2) is an innate immune protein that is

55 usly secretion of the iron chelating protein lipocalin 2 (LCN2) and protons, which acidify the urine.

56 We have previously identified lipocalin 2 (Lcn2) as a cytokine playing a critical role

57 We identified lipocalin 2 (Lcn2) as a gene induced by dexamethasone an

58 We have recently characterized the role of lipocalin 2 (Lcn2) as a new adipose-derived cytokine in

59 Here, we identify lipocalin 2 (lcn2) as an inducible factor that is secret

60 ough molecular and genetic analyses in mice, lipocalin 2 (LCN2) as an osteoblast-enriched, secreted p

61 We identified lipocalin 2 (LCN2) as both a marker of deactivated macro

62 hils rely on the siderophore-binding protein lipocalin 2 (Lcn2) in a "tug-of-war" for iron.

63 Lipocalin 2 (LCN2) is a novel adipokine that negatively

64 The innate immune protein lipocalin 2 (Lcn2) is able to specifically bind Ent and

65 We have previously demonstrated that lipocalin 2 (LCN2) is an innate immunity protein that bi

66 how that a mutant form (K3Cys) of endogenous lipocalin 2 (LCN2) is filtered by the kidney but can byp

67 Here, we report that lipocalin 2 (Lcn2) promotes breast cancer progression, a

68 Secreted lipocalin 2 (Lcn2) sequesters the Escherichia coli sider

69 Upregulation of S100A8, S100A9, and lipocalin 2 (LCN2) were confirmed by Western blots, and

70 Lipocalin 2 (Lcn2), a member of the lipocalin family, is

71 In this study, we report that lipocalin 2 (Lcn2), a recently characterized adipokine/c

72 Lipocalin 2 (LCN2), a siderophore-binding protein, is in

73 ulating levels of the secreted glycoprotein, lipocalin 2 (Lcn2), an adipokine previously associated w

74 Lipocalin 2 (Lcn2), an innate immune protein, has emerge

75 However, Ent is bound by the host protein lipocalin 2 (Lcn2), preventing bacterial reuptake of afe

76 oprotection markers, including COX-2 itself, lipocalin 2 (LCN2), tissue inhibitor of metalloproteinas

77 gainst K. pneumoniae, which was dependent on lipocalin 2 (LCN2).

78 Lipocalin 2 (Lcn2; 24p3; neutrophil gelatinase-associate

79 Lipocalin 2 (LCN2; also known as NGAL) is a secreted gly

80 ine and secreting the bacteriostatic protein lipocalin 2 (LCN2; also known as NGAL).

81 Lipocalin 2 (Lcn2; siderocalin, 24p3) plays a central ro

82 he antimicrobial siderophore-binding peptide Lipocalin-2 (Lcn2) are observed in inflammatory bowel di

83 ich immunoassay (IA) was developed for human lipocalin-2 (LCN2) by functionalizing a KOH-treated poly

84 Lipocalin-2 (LCN2) emerged as a relevant adipokine invol

85 Lipocalin-2 (Lcn2) is a biomarker for many inflammatory-

86 Lipocalin-2 (LCN2) is secreted from adipocytes, and its

87 thelicidin antimicrobial protein (Camp), and lipocalin-2 (Lcn2) mRNA expression giving rise to cells

88 Lipocalin-2 (LCN2) promotes malignant development in man

89 Lipocalin-2 (LCN2) was originally isolated from human ne

90 over 100 different cytokines, we found that Lipocalin-2 (LCN2) was the most substantially elevated p

91 -2), inducible nitric oxide synthase (Nos2), lipocalin-2 (Lcn2), MIP-1alpha, MIP-1beta, and keratinoc

92 levels of a specific inflammatory cytokine, lipocalin-2 (LCN2), were elevated in the plasmas of pati

93 regulated factors is the acute phase protein lipocalin-2 (LCN2).

94 ukemic mice and CML patients showed elevated lipocalin 2 levels compared with healthy individuals.

95 Among SLE patients, urinary lipocalin-2 levels were significantly higher in those wi

96 Lipocalin 2 (Lpc-2) was the best protein biomarker of se

97 rtened colons, and increased fecal levels of lipocalin 2), metabolic syndrome, and an inability to cl

98 bulin, ceruloplasmin, complement components, lipocalin-2, metallothionein, serine protease inhibitor-

99 that use catecholate-type siderophores, and lipocalin 2(-/-) mice are highly susceptible to infectio

100 previous studies indicate that reduction of lipocalin 2 (mouse 24p3) expression by either anti-sense

101 bial protein siderocalin (SCN; also known as lipocalin 2, neutrophil gelatinase-associated lipocalin/

102 Recently, the secreted protein 24p3 (lipocalin-2, neutrophil gelatinase-associated lipocalin

103 bial protein siderocalin (SCN; also known as lipocalin-2, neutrophil gelatinase-associated lipocalin,

104 tubular damage, manifested by production of lipocalin-2, occur later in the disease process.

105 Although lipocalin 2 production was observed to be Dectin-1 and I

106 in this model and mucosal reconstitution of lipocalin 2 protein in these animals resulted in rescue

107 pus erythematosus (SLE), and whether urinary lipocalin-2 represents a marker of kidney involvement in

108 Importantly, exogenous lipocalin 2 rescued viral exacerbation of S. aureus infe

109 e neutrophil peptides cathelicidin LL-37 and lipocalin 2 restricted growth of the organism, the latte

110 transcription, translation and secretion of lipocalin 2; secreted lipocalin 2 then limits bacterial

111 8 signaling is required for the induction of lipocalin 2 secretion and iron sequestration in the sple

112 ory factors such as dietary iron and luminal lipocalin 2 should be taken into consideration for optim

113 Lipocalin 2 (siderocalin, NGAL, 24p3), a siderophore-bin

114 s unique genes, such as guanosine deaminase, lipocalin 2, synaptotagmin 4, and latrophilin 2, whose t

115 wer circulating concentrations of HNP1-3 and lipocalin 2 than south Asian and white participants.

116 ation and secretion of lipocalin 2; secreted lipocalin 2 then limits bacterial growth by sequestratin

117 ratory data with urinary and serum levels of lipocalin-2 were assessed.

118 vercome iron restriction by the host protein lipocalin 2, which counteracts some siderophores, is ess

119 ys identified numerous biomarkers, including lipocalin-2, which was then used to monitor the response