ライフサイエンスコーパス: lipoic acid

1 two diabetic groups (with and without alpha-lipoic acid).

2 amins biotin and pantothenic acid, and alpha-lipoic acid.

3 E) cells and the reduction of this damage by lipoic acid.

4 ed to achieve tight, specific binding of the lipoic acid.

5 tive mitochondrial dysfunction is reduced by lipoic acid.

6 compounds demonstrated cross-reactivity with lipoic acid.

7 e capacity through daily administration of R-lipoic acid.

8 y volunteers (n = 43) for reactivity against lipoic acid.

9 poic acid, and synthetic molecular mimics of lipoic acid.

10 end reactive groups) appended onto a single lipoic acid.

11 lar to the normal physiological oxidation of lipoic acid.

12 at SIRT1, SIRT2, SIRT3, and SIRT4 can remove lipoic acid.

13 uced by the oxidative stress scavenger alpha-lipoic acid.

14 d be preserved by the insulin-like effect of lipoic acid.

15 plus lipoic acid, (3) HFD, and (4) HFD plus lipoic acid.

16 lipoamide, the reduced protein-bound form of lipoic acid.

17 ation, a high-fat diet with or without alpha-lipoic acid (1.65 g/kg) was given to the mice and to non

18 enzoic acid) porphyrin (10 mg/kg), and alpha-lipoic acid (100 mg/kg).

19 sed by preincubation with NAC (1 h) or alpha-lipoic acid (24 h) but not vitamin E.

20 weeks: (1) normal diet, (2) normal diet plus lipoic acid, (3) HFD, and (4) HFD plus lipoic acid.

21 R-lipoic acid (30 mg/kg) prevented hyperglycemia, reduced

22 linded manner to irbesartan 150 mg/d (n=14), lipoic acid 300 mg/d (n=15), both irbesartan and lipoic

23 ing diets supplemented with or without alpha-lipoic acid (400 mg/kg) for 11 months of diabetes.

24 obtained by Ugi-reaction between ferulic (or lipoic acid), a melatonin-like isocyanide, formaldehyde,

25 nin, a naturally occurring indole, and alpha-lipoic acid, a naturally occurring dithiol, were also in

26 t is involved in the endogenous synthesis of lipoic acid, a potent mitochondrial antioxidant.

27 To examine the effect of alpha-lipoic acid, a potent natural antioxidant, on atheroscle

28 Further analysis revealed that lipoic acid, a required cofactor covalently attached to

29 milarity between SAc and the reduced form of lipoic acid, a step which is similar to the normal physi

30 alpha-Lipoic acid, a thiol antioxidant, has been shown to have

31 ieve this goal, we combined the structure of lipoic acid, a universal antioxidant, with an appropriat

32 Administration of lipoic acid abrogates diabetic nephropathy in animal mod

33 alpha-Lipoic acid administration for the entire duration of di

34 nd 70%, respectively, in diabetes, and alpha-lipoic acid administration inhibited these increases.

35 The effect of alpha-lipoic acid administration on retinal 8-hydroxy-2'deoxyg

36 generation, since it is reversed by systemic lipoic acid administration.

37 Male SD rats were pretreated with alpha-lipoic acid (ALA) and dihydrolipoic acid (DHLA) or appro

38 Alpha lipoic acid (ALA) and vitamin C (Vit-C) are very importa

39 alpha-lipoic acid (ALA) is a potent antioxidant that is used i

40 eating A-T cells with the antioxidant, alpha lipoic acid (ALA), restored mitochondrial respiration ra

41 ons at a much lower concentration than alpha-lipoic acid (ALA).

42 n of mixed tocopherols (666 IU/d) plus alpha-lipoic acid (ALA; 600 mg/d) or matching placebos for 6 m

43 gest that the lipoyl protein domain (but not lipoic acid alone) plays a regulatory role in the enzyma

44 ral antioxidant agents (ascorbic acid, alpha-lipoic acid, alpha-tocopherol, Mn(III)-tetrakis(4-benzoi

45 Lipoic acid also plays a critical role in stabilizing an

46 hondria, lipoic acid synthase produces alpha-lipoic acid, an antioxidant and an essential cofactor in

47 sartan, an angiotensin receptor blocker, and lipoic acid, an antioxidant, to affect endothelial funct

48 , the enzyme that catalyzes the synthesis of lipoic acid, an essential cofactor for several mitochond

49 trast to other eukaryotes, which manufacture lipoic acid, an essential cofactor for several vital deh

50 formation in human liver microsomes by alpha-lipoic acid, an inhibitor of NADPH: p450 reductase, supp

51 h proteins artificially substituted with the lipoic acid analogue xenobiotic 6-bromohexanoic acid (6B

52 s found that these enzymes could incorporate lipoic acid analogues including octanoic and hexanoic ac

53 phiphilic polyethylene glycol segment, and a lipoic acid anchoring group.

54 ies in AMA-positive sera that recognize free lipoic acid and a carrier-conjugated form of lipoic acid

55 d disulfide from asparagusic or, preferably, lipoic acid and a guanidinium cation polymerize into pol

56 on with the mitochondrial antioxidants alpha-lipoic acid and coenzyme Q(10) also suppresses Bak expre

57 malized by treatment with antioxidants alpha-lipoic acid and D-alpha-tocopherol and, surprisingly, PK

58 d as interacting with the dithiolane ring of lipoic acid and discriminating against the entry of biot

59 Both lipoic acid and glutaredoxins act in the reverse manner

60 the introduction of controllable numbers of lipoic acid and histamine anchors, along with hydrophili

61 combine two distinct metal-chelating groups, lipoic acid and imidazole, for the surface functionaliza

62 Lipoic acid and its reduced form, dihydrolipoic acid, ar

63 Mass spectral analysis of the lipoic acid and lipoamide derivatives confirmed both the

64 tramolecular selenotrisulfide derivatives of lipoic acid and lipoamide.

65 ected a very slow LplA-catalyzed transfer of lipoic acid and octanoic acid from their acyl carrier pr

66 Lipoic acid and resveratrol were identified as being ben

67 Water soluble AuNCs were synthesized using lipoic acid and then thoroughly characterized.

68 ssible) thiol groups like disulfides such as lipoic acid and thiol stabilizing ligands coordinatively

69 s lipoylation system; the relative levels of lipoic acid and xenobiotic incorporation may be determin

70 anges and the Nrf2 inducers DL-sulforaphane, lipoic acid, and curcumin all replicate them without oxi

71 ased by 67%, 44%, and 75% in the irbesartan, lipoic acid, and irbesartan plus lipoic acid groups, res

72 vatives of potent antioxidant vitamin, alpha-lipoic acid, and related analogues were designed, synthe

73 Dihydrolipoic acid, lipoic acid, and resveratrol reduced microphthalmia-asso

74 yethylene glycol (PEG), lipoylated PEG, free lipoic acid, and synthetic molecular mimics of lipoic ac

75 rference (RNAi) reduced endogenous levels of lipoic acid, and the activities of critical components o

76 Alpha-lipoic acid appears to be effective as well.

77 Interestingly, SQ2 (mono lipoic acid appended), SQ5 and SQ6 (conjugated with hexy

78 ptable, and self-healing, those derived from lipoic acid are rigid, resilient, and brittle.

79 y complex I and enzymatic complexes carrying lipoic acid as a cofactor (pyruvate dehydrogenase, 2-oxo

80 Diabetic rats were treated with 0.5% alpha-lipoic acid as a diet supplement or with hydroxyethyl st

81 e data have implications for patients taking lipoic acid as a dietary supplement.

82 S II pathway defects resulted in the loss of lipoic acid attachment to subunits of three key mitochon

83 nd the subsequent reductive acylation of the lipoic acid-bearing domain (LBD) from the 24-meric trans

84 Here we show that the lipoylated lipoic acid-bearing domain (lip-LBD) (residues 1-84) of

85 pose a mechanism in which the closure of the lipoic acid binding site is triggered by the formation o

86 tein lipoyl synthase (LipA) is essential for lipoic acid biosynthesis via sulfur insertions into a pr

87 ly linked to carbon-sulfur bond formation in lipoic acid biosynthesis, although in vitro lipoate bios

88 CS1, molybdenum cofactor biosynthesis; LIAS, lipoic acid biosynthesis; CDK5RAP1, 2-methylthio-N(6)-is

89 lfur (FeS) clusters, molybdopterin, thiamin, lipoic acid, biotin, and the thiolation of tRNAs.

90 cid scavenging requires not only ligation of lipoic acid but also a lipoyl relay pathway in which an

91 Treating diabetic rats with alpha-lipoic acid but not HES-DFO partially improved sciatic n

92 tic can be incorporated into PDC in place of lipoic acid by the exogenous lipoylation system; the rel

93 such that unnatural probes much larger than lipoic acid can be recognized.

94 We also show that lipoic acid can be reduced through a Sec-independent mec

95 tramolecular selenotrisulfide derivatives of lipoic acid can serve as an important asset in the study

96 The relative level of glutathionylated lipoic acid closely paralleled the degree of enzyme inhi

97 o the lysine residue that normally binds the lipoic acid cofactor of PDC-E2, reacts as well or better

98 ulting from enhanced oxidative damage to the lipoic acid cofactor of pyruvate dehydrogenase and alpha

99 As in yeast, lipoic acid cofactor was damaged in human D444V-homozygo

100 Treatment with exogenous lipoic acid compensated for some of these defects.

101 Remarkably, alpha-lipoic acid completely prevented the increase in plasma

102 difications of the disulfide bond within the lipoic-acid-conjugated PDC-E2 moiety, i.e., by an electr

103 ternative oxidase and decreased abundance of lipoic acid-containing components during several of the

104 t the relative incorporation of both 6BH and lipoic acid could be regulated by the balance between AT

105 mic treatment with either HC-030031 or alpha-lipoic acid could completely prevent hypersensitivity if

106 of a DLDH that carries its own substrate (a lipoic acid covalently attached to a lipoyl protein doma

107 treatment with irbesartan or irbesartan plus lipoic acid decreased 8-isoprostane levels.

108 n of either insulin or the antioxidant alpha-lipoic acid decreased proteinuria and oxidative stress,

109 xS15 is shown to be especially important for lipoic acid-dependent enzymes in mitochondria, highlight

110 Pretreatment with R-alpha-lipoic acid effectively protected ARPE-19 cells from acr

111 oligated with this zwitterion-terminated bis(lipoic) acid exhibit great colloidal stability over a wi

112 hia coli, two pathways for the attachment of lipoic acid exist, a de novo biosynthetic pathway depend

113 hway for de novo synthesis and attachment of lipoic acid exists in yeast.

114 l azides and photo-cross-linkers in place of lipoic acid, facilitating imaging and proteomic studies.

115 LplA1(Ct) is capable of utilizing exogenous lipoic acid for the lipoylation Therefore, host-derived

116 erichia coli and mitochondria that transfers lipoic acid from lipoyl-acyl carrier protein to the lipo

117 respiration due to the inability to generate lipoic acid from mitochondrially synthesized fatty acids

118 alpha-ketoglutarate dehydrogenase protected lipoic acid from modification by the electrophilic lipid

119 years ago as an enzyme activity that cleaved lipoic acid from small lipoylated molecules and from pyr

120 Lipoate-protein ligases are used to scavenge lipoic acid from the environment and attach the coenzyme

121 lated and biotinylated substrates as well as lipoic acid from two 2-oxoacid dehydrogenases and an iso

122 l coordinating ligands where we combined two lipoic acid groups, bis(LA)-ZW, (as a multicoordinating

123 irbesartan, lipoic acid, and irbesartan plus lipoic acid groups, respectively, compared with the plac

124 The lipoic acid hapten specificity of the reactive antibodie

125 The metabolic thiol antioxidant alpha-lipoic acid has been suggested to be of therapeutic valu

126 e that the long-term administration of alpha-lipoic acid has beneficial effects on the development of

127 syl acceptors with a longer spacer (C8-O-C8)-lipoic acid have a higher tendency to mimic a solution-p

128 ligands: (i) bis(LA)-PEG, which presents two lipoic acids (higher coordination) appended onto a singl

129 ments studied, N-acetyl-L-cysteine and alpha-lipoic acid hold the most promise.

130 3xTg-AD mice fed 0.23% w/v lipoic acid in drinking water for 4 weeks showed an insu

131 Lipoic acid in LplA was bound in the same position as bi

132 ays for synthesis and covalent attachment of lipoic acid in prokaryotes.

133 our genes in the synthesis and attachment of lipoic acid in Saccharomyces cerevisiae.

134 in proving the crucial role of protein-bound lipoic acid in the reaction mechanism of the 2-oxoacid d

135 ochondrial RNase P, Rpm2, is not modified by lipoic acid in the wild-type strain, and it is imported

136 report that the nutritional supplement alpha-lipoic acid inhibits cystine stone formation in the Slc3

137 Lipoic acid is a covalently attached cofactor essential

138 Lipoic acid is a covalently bound cofactor found through

139 Our results suggest that dietary alpha-lipoic acid is a promising protective agent for reducing

140 Lipoic acid is a sulfur-containing cofactor required for

141 Lipoic acid is an essential cofactor for mitochondrial m

142 Lipoic acid is an essential cofactor of alpha-keto acid

143 Lipoic acid is an essential protein bound cofactor that

144 Lipoic acid is known to modulate the redox status of the

145 These results indicate that lipoic acid is not only assembled on the dehydrogenase l

146 Collectively, its functions explain why lipoic acid is required for cell growth, mitochondrial a

147 responses in primary biliary cirrhosis, with lipoic acid itself forming a component of the dominant a

148 (wt/vol) in drinking water], and/or R-alpha-lipoic acid (LA) [0.2% or 0.1% (wt/wt) in diet].

149 coordinating ligands that present one or two lipoic acid (LA) anchors, a hydrophilic polyethylene gly

150 ior insult was investigated by supplementing lipoic acid (LA) during their 6 months of GC (R+LA).

151 n previously that the dithiol compound alpha-lipoic acid (LA) exerts antiinflammatory effects by inhi

152 imple peptide coupling chemistry, one or two lipoic acid (LA) groups and poly(ethylene glycol) (PEG)

153 tion of ligands comprising either one or two lipoic acid (LA) groups chemically linked to a zwitterio

154 alpha-Lipoic acid (LA) has been found to attenuate diabetic pe

155 alpha-Lipoic acid (LA) has been shown to improve memory functi

156 In diabetic patients, alpha-lipoic acid (LA) improves skeletal muscle glucose transp

157 the antioxidants vitamin E (VE) and R-alpha-lipoic acid (LA) in streptozotocin-induced diabetic rats

158 alpha-Lipoic acid (LA) is a cofactor for mitochondrial alpha-k

159 cephalic neurons and co-treatment with alpha-lipoic acid (LA) or one of several other antioxidants pr

160 t 2 mo of dietary supplementation with alpha-lipoic acid (LA) prevented early glomerular injury in no

161 LipA requires Fe-S clusters for lipoic acid (LA) synthesis and a DeltasufT strain had ph

162 f administration of the antioxidant DL-alpha-lipoic acid (LA) to streptozotocin-injected diabetic rat

163 We investigated the role of (R)-alpha-lipoic acid (LA) vs. glutathione and ascorbic acid in tu

164 ether dietary supplementation with (R)-alpha-lipoic acid (LA) was effective at reducing oxidative str

165 hSMVT) has been suggested to transport alpha-lipoic acid (LA), a potent antioxidant and anti-inflamma

166 ligand exchange on hydrophobic CdSe QDs with lipoic acid (LA)-based ligands and their facile QD trans

167 o polar and aqueous media using multidentate lipoic acid (LA)-modified ligands.

168 mitochondrial antioxidant precursor R-alpha-lipoic acid (LA).

169 molecule that contains the prosthetic group lipoic acid (LA).

170 cation, old rats were treated with (R)-alpha-lipoic acid (LA; 40 mg/kg i.p. up to 48 h), a disulfide

171 vol) in the drinking water] and/or (R)-alpha-lipoic acid [LA, 0.5% (wt/wt) in the chow] improved thes

172 letion by RNAi or gene knockout also reduces lipoic acid levels and drastically decreases protein lip

173 Since free lipoamide and lipoic acid levels were shown to be undetectable in M. s

174 beta-ketoacyl synthase and exhibits lowered lipoic acid levels.

175 Escherichia coli lipoic acid ligase (LplA) catalyzes ATP-dependent covale

176 In the PRIME step, Escherichia coli lipoic acid ligase (LplA) site-specifically attaches a p

177 h rational design, we redirected a microbial lipoic acid ligase (LplA) to specifically attach an alky

178 atekeeper residue, tryptophan 37, in E. coli lipoic acid ligase (LplA), expands substrate specificity

179 ved from the natural Escherichia coli enzyme lipoic acid ligase (LplA).

180 d by a mutant of the Escherichia coli enzyme lipoic acid ligase (LplA).

181 C. trachomatis serovar L2 and show that the lipoic acid ligase LplA1(Ct) is capable of utilizing exo

182 Escherichia coli lipoic acid ligase site-specifically ligates a trans-cyc

183 -PRIME utilizes a mutant of Escherichia coli lipoic acid ligase, LplA(W37V), which can catalyze the c

184 ye resorufin, starting from Escherichia coli lipoic acid ligase.

185 anel of fluorophores that can be targeted by lipoic acid ligase.

186 diae show the presence of two genes encoding lipoic acid ligases and one gene encoding a lipoate synt

187 The two distinct lipoic acid ligases in Chlamydia trachomatis serovar L2,

188 ninhydrin, alloxan, dehydroascorbate, DTNB, lipoic acid/lipoamide, S-nitrosoglutathione, selenodiglu

189 r (iii) that are activated by strain such as lipoic acid/lipoamide.

190 egulated Ang II receptors differently: alpha-Lipoic acid lowered Ang II binding after 24 h, and vitam

191 na is impaired and may be corrected by alpha-lipoic acid (LPA), a drug that inhibits vascular histopa

192 Thus, the use of host-derived lipoic acid may be a critical process for in vivo replic

193 t mitochondria-targeted antioxidants such as lipoic acid may be an effective strategy for reducing or

194 for the lipoylation Therefore, host-derived lipoic acid may be important for intracellular growth an

195 Therefore, thiamine or lipoic acid may constitute potential therapeutic agents

196 c chloride-injected animals, suggesting that lipoic acids may be of use in preventing or attenuating

197 Mechanistic details of lipoic acid metabolism are unclear in eukaryotes, despit

198 Although a complete pathway of lipoic acid metabolism has been established in Escherich

199 sm has been established in Escherichia coli, lipoic acid metabolism in other bacteria is more complex

200 acillus subtilis requires three proteins for lipoic acid metabolism, all of which are members of the

201 Both to further our understanding of lipoic acid metabolism, and to improve LplA's utility as

202 les discussed in this review include biotin, lipoic acid, methylthioether modifications found in some

203 t conjugated form(s) of native or xenobiotic lipoic acid mimics contribute to the initiation and perp

204 In the absence of lipoic acid modification, the dehydrogenases are inactiv

205 egy to prepare AuNPs monofunctionalized with lipoic acid modified DNA oligos.

206 can function in utilization of host-derived lipoic acid-modified peptides.

207 E2 is glutathionylation, in which the lysine-lipoic acid moiety is further modified with glutathione

208 Recently, we replaced the lipoic acid moiety of PDC-E2 with a battery of synthetic

209 ent of pyruvate dehydrogenase, replacing the lipoic acid moiety with synthetic structures designed to

210 ic acid 300 mg/d (n=15), both irbesartan and lipoic acid (n=15), or matching placebo (n=14) for 4 wee

211 ants ascorbate, ascorbate 2-phosphate, alpha-lipoic acid, N-acetyl-L-cysteine and glutathione increas

212 Neither the antioxidant dexlipotam (R-lipoic acid) nor the p38 MAP kinase inhibitor SB239063 c

213 c rats, treatment with the antioxidant alpha-lipoic acid normalized the amount of leukostasis but not

214 Supplementation of the culture medium with lipoic acid offered some protection against oxidative da

215 ing the effects of dietary administration of lipoic acid on a HFD-induced obesity model in terms of (

216 his study was to examine the effect of alpha-lipoic acid on retinal capillary cell apoptosis and the

217 catalyzes ATP-dependent covalent ligation of lipoic acid onto specific lysine side chains of three ac

218 of yeast cells, labeled by LplA with either lipoic acid or bromoalkanoic acid, and the most efficien

219 not improved by treatment with either alpha-lipoic acid or HES-DFO.

220 and shown to catalyze the transfer of either lipoic acid or octanoic acid from their acyl carrier pro

221 mutations in lipB are auxotrophic for either lipoic acid or octanoic acid.

222 Antioxidants, including N-acetylcysteine, lipoic acid, or quercetin, only minimally induced the in

223 Fe(II), lipoic acid, pectin, epigallocatechin and thiamine are a

224 dual reduction in autoantibodies against the lipoic acid-peptide, i.e., the primary tolerance-breakin

225 dant defence system and it is suggested that lipoic acid plays a pivotal part in defending the organe

226 strates in addition to its normal substrates lipoic acid plus ATP.

227 Application of the antioxidant alpha-lipoic acid potently prevents glucose-induced oxidative

228 e II synthase for production of octanoate (a lipoic acid precursor) as well as longer fatty acids suc

229 ration of octanoyl-acyl carrier protein, the lipoic acid precursor, as well as longer chain fatty aci

230 Treating diabetic rats with alpha-lipoic acid prevented the diabetes-induced increase in t

231 In addition, a product is required for lipoic acid production, which is needed for the activity

232 tive to damage in diabetic mice with reduced lipoic acid production.

233 , but whether lower production of endogenous lipoic acid promotes diabetic nephropathy is unknown.

234 ells in sensitivity to acrolein toxicity and lipoic acid protection.

235 lipoyl-ACP:protein N-lipoyl transferase and lipoic acid protein ligase are expressed maximally in th

236 rminal sequences of lipoic acid synthase and lipoic acid protein ligase in intraerythrocytic stages o

237 st, whereas the second pathway consisting of lipoic acid protein ligase is located in the parasite's

238 propanethiol, glutathione, homocysteine, and lipoic acid provided no activity.

239 ared with enzyme expressed in the absence of lipoic acid (rDLDH(-LA)) or with enzyme lacking the firs

240 ioxidants epigallocatechin gallate and alpha-lipoic acid reduces polyglutamine aggregation.

241 chanism must exist for modification of other lipoic acid requiring enzymes (e.g. pyruvate dehydrogena

242 ific to the dehydrogenases in that the third lipoic acid-requiring enzyme of Escherichia coli, the gl

243 model to examine the therapeutic efficacy of lipoic acids (ROS-scavenging antioxidants).

244 tivities of the LipB and LipA proteins and a lipoic acid scavenging pathway catalyzed by the LplA pro

245 We report that lipoic acid scavenging requires not only ligation of lip

246 del of an expanded, three-enzyme pathway for lipoic acid scavenging that seems widespread in the Firm

247 n to utilize two lipoate-protein ligases for lipoic acid scavenging, whereas only one of the ligases

248 Anti-lipoic acid specific antibodies were detected in 81% (79

249 tants N,N-diethylethylenediamine (DEDA) onto lipoic acid stabilized Au (Au-LA) clusters with matching

250 ion with the AMPK activators AICAR and alpha-lipoic acid substantially prevented all of those changes

251 ir nondiabetic apoE(-/-) controls with alpha-lipoic acid supplement than in those without it.

252 Lipoic acid supplementation also restored myocardial asc

253 Lipoic acid supplementation led to important changes in

254 alpha-Lipoic acid supplementation represents an achievable adj

255 ptidase, inhibition of aldose reductase plus lipoic acid supplementation, and insulin therapy with an

256 stress, which is significantly attenuated by lipoic acid supplementation.

257 Lipoic acid synthase (LASY) is the enzyme that is involv

258 absence, we have generated mice deficient in lipoic acid synthase (Lias).

259 otein fusions of the N-terminal sequences of lipoic acid synthase and lipoic acid protein ligase in i

260 Lipoic acid synthesis comprising lipoic acid synthase and lipoyl-ACP:protein N-lipoyl tra

261 are lysine 2,3-aminomutase, biotin synthase, lipoic acid synthase and the activating enzymes for pyru

262 Here, we crossed mice heterozygous for lipoic acid synthase deficiency (Lias(+/-)) with Ins2(Ak

263 These results suggest that lipoic acid synthase deficiency increases oxidative stre

264 The putative lipoic acid synthase LipA(Ct), encoded by ctl0815, is ca

265 In mitochondria, lipoic acid synthase produces alpha-lipoic acid, an anti

266 es revealed that the genes/proteins encoding lipoic acid synthase, lipoyl-ACP:protein N-lipoyl transf

267 luding aconitase, respiratory complex I, and lipoic acid synthase, were diminished following depletio

268 ced by the pathway is the sole precursor for lipoic acid synthesis and attachment.

269 Lipoic acid synthesis comprising lipoic acid synthase an

270 anoyltransferase catalyzes the first step of lipoic acid synthesis in Escherichia coli, transfer of t

271 The third protein, LipL, is essential for lipoic acid synthesis, but had no detectable octanoyltra

272 Thus, octanoate (C8), the precursor for lipoic acid synthesis, must also be a product of mitocho

273 nehe is a hypomorphic allele of Lipoic acid Synthetase (Lias), the enzyme that catalyzes

274 ccus aureus, we determine that the bacterial lipoic acid synthetase LipA suppresses macrophage activa

275 Conversely, the antioxidant alpha-lipoic acid, that protected against the loss of glutathi

276 se abnormalities were prevented by long-term lipoic acid therapy.

277 lowed a molecular comparison of the need for lipoic acid to be covalently attached to the lipoyl doma

278 1 mutant is rescued by addition of exogenous lipoic acid to host cells, suggesting that L. monocytoge

279 This study examines the ability of lipoic acid to increase brain glucose uptake and lead to

280 Administration of irbesartan and/or lipoic acid to patients with the metabolic syndrome impr

281 ponent, in contrast with the ability of free lipoic acid to serve as substrate for the dihydrolipoyl

282 l means instead of chemical reduction of the lipoic acid, to promote the transfer of CdSe-ZnS QDs to

283 Lipoic acid treatment in mice on HFD prevented several H

284 However, the roles of these proteins in lipoic acid utilization or biosynthesis have not yet bee

285 Treatment with irbesartan and/or lipoic acid was associated with statistically significan

286 The selenotrisulfide derivative of lipoic acid was found to serve as an effective substrate

287 The protein expressed without lipoic acid was indistinguishable from the wild-type pro

288 Lipoic acid was more effective in stimulating an insulin

289 The selenotrisulfide derivative of lipoic acid was significantly stable at or below pH 8.0

290 These protective effects of alpha-lipoic acid were accompanied by a reduction of plasma gl

291 lipoic acid and a carrier-conjugated form of lipoic acid were also identified.

292 Essentially, a total of 23 xenobiotics and lipoic acid were coupled to the 12-mer peptide backbones

293 rolein and the protective effects of R-alpha-lipoic acid were examined with a variety of previously d

294 uctures in the absence and presence of bound lipoic acid were solved at 2.1 A resolution.

295 ihydrolipoic acid (the reduced form of alpha-lipoic acid), which contains free sulfhydryl groups as N

296 tor binding in cell membranes, whereas alpha-lipoic acid, which does not contain free sulfhydryl grou

297 1 by reducing the binding ability of PDP1 to lipoic acid, which is covalently attached to the L2 doma

298 molecular image formed by the association of lipoic acid with the immunodominant PDC-E2 peptide.

299 rs the nature of the disulfide groups in the lipoic acid, yielding a different product mixture than w

300 enase (E2-PDH) with a fatty acid derivative, lipoic acid, yielding the metabolic protein lipoyl-E2-PD