ライフサイエンスコーパス: lipolytic

1 orescent PLA2 assay showed that hVPLA2 had a lipolytic action first on the outer plasma membrane and

2 PVN inhibited the lipolytic action of 0.1 microM isoproterenol by 88%, whi

3 We conclude that the lipolytic action of TNF-alpha is influenced by glucose i

4 Thus, the lipolytic action(s) of HSL at the LD surface requires PK

5 ) mobilization and determine the site of its lipolytic action, we performed time-lapse confocal micro

6 ood coagulation reactions independent of its lipolytic action.

7 er, these observations suggest that both the lipolytic actions of LPL and LPL-induced VLDL catabolism

8 esults provide novel insight into caffeine's lipolytic actions through autophagy in mammalian liver a

9 Akey step in lipolytic activation of adipocytes is the translocation

10 Given recent evidence for lipolytic activation of peroxisome proliferator-activate

11 sed hearts, consistent with a rate-dependent lipolytic activation of peroxisome proliferator-activate

12 ipase are continuously colocalized following lipolytic activation.

13 horylation of perilipin A engenders a 7-fold lipolytic activation.

14 iminished levels of COX-2 metabolites during lipolytic activation.

15 domain (residues 389-448) to achieve maximal lipolytic activation.

16 Similarly, despite post-heparin plasma lipolytic activities of 4495 +/- 534 and 4844 +/- 1336 n

17 enzamidine suggests that the proteolytic and lipolytic activities of PLA2 proceed through different m

18 adipocyte identity were increased, and basal lipolytic activities were significantly augmented in adi

19 surface-exposed passenger domain exhibiting lipolytic activity (aa 62 to 330).

20 Total lipolytic activity after intensive treatment was unchang

21 effects of WAT-ECs on adipocytes, improving lipolytic activity and insulin sensitivity and reducing

22 children were accompanied by decreased basal lipolytic activity and significantly enhanced stromal va

23 mutant of pancreatic sPLA(2) with decreased lipolytic activity as compared to wild-type sPLA(2).

24 nonpolar lipids, Tgl4p and Tgl5p lose their lipolytic activity but retain their side activity as lys

25 and properties of lipases affect survival of lipolytic activity during aboral gastrointestinal transi

26 rminus, and the significance of PlaB-derived lipolytic activity for L. pneumophila intracellular repl

27 However, the nature of the lipolytic activity has remained obscure.

28 videnced by normal catecholamine release and lipolytic activity in response to cold stimulation.

29 d uptake of HDL particles independent of its lipolytic activity in vitro.

30 Lipolytic activity in whole wheat flour (WWF) is largely

31 To determine whether lipolytic activity is required for this effect, we also

32 on of perilipins at the LD surface regulates lipolytic activity of ATGL.

33 Lipolytic activity of EL, however, seems to be most impo

34 We have investigated the lipolytic activity of human serum using isolated rat adi

35 This results in decreased lipolytic activity of the enzyme.

36 These data link the anti-lipolytic activity of the HCV core protein with altered

37 McaP is involved in both the binding and the lipolytic activity of the molecule and demonstrate that

38 2 of McaP, predicted to be important for the lipolytic activity of the protein, resulted in loss of h

39 fects of these four stereoisomers toward the lipolytic activity of three microbial lipases: Fusarium

40 cles, along with favorable effects on plasma lipolytic activity through lipoprotein lipase-mediated c

41 of EL (EL-EL) was expressed and had similar lipolytic activity to EL.

42 n of PLA2, that is, a strong increase in the lipolytic activity upon binding to the surface of phosph

43 Partial purification of this lipolytic activity using gel filtration and ion-exchange

44 Lipolytic activity was absent in the null mutants, where

45 Exercise-induced AT lipolytic activity was significantly reduced in atATGL-K

46 ated that VAT-ECs provoked a decrease in the lipolytic activity, adipokine secretion, and insulin sen

47 ters, BatA, and demonstrate that it displays lipolytic activity, aids in intracellular survival, is e

48 and represses Foxo1 and Cgi58, activators of lipolytic activity, and forced expression of miR-145 att

49 , a metabolic homeostatic factor with strong lipolytic activity, are decreased in obese individuals.

50 hat two HL monomer subunits are required for lipolytic activity, consistent with an HL homodimer.

51 In addition to the increase in lipolytic activity, cytokine treatment was demonstrated

52 ne the smallest structural unit required for lipolytic activity, HL was subjected to radiation inacti

53 o exhibit dramatically attenuated stimulated lipolytic activity, indicating that perilipin is require

54 Aside from its lipolytic activity, LpL promotes lipoprotein uptake by i

55 up V and X PLA2s showed strong transcellular lipolytic activity, whereas group IIA PLA2 exhibited muc

56 The 148M mutant protein has reduced lipolytic activity, with attendant increased cellular tr

57 tprandial TG and reduced post-heparin plasma lipolytic activity.

58 es even though they secreted as much or more lipolytic activity.

59 stable, with reduced cleavage and conserved lipolytic activity.

60 hesive properties of McaP do not require its lipolytic activity.

61 n of approximately 80 kDa contributes to the lipolytic activity.

62 olin-1 null mice exhibit markedly attenuated lipolytic activity.

63 ophospholipases and known inhibitors of this lipolytic activity.

64 ating that perilipin is required for maximal lipolytic activity.

65 s no correlation between bridge function and lipolytic activity.

66 cause of the upregulation of genes promoting lipolytic activity.

67 olism, regardless of the donor and degree of lipolytic activity.

68 Exposure of fat cells to lipolytic agents or external FFA results is a rapid intr

69 ot prevent the changes in pHi caused by FFA, lipolytic agents, or insulin.

70 ubstrate specific lipase that contributes to lipolytic and haemolytic activity in vitro and is requir

71 hin the active site, demonstrated attenuated lipolytic and haemolytic phenotypes when compared with t

72 These data clearly indicate that the lipolytic and hepatic responses to hypoglycemia are driv

73 3-L1 cells which may have contributed to the lipolytic and insulin-like activities observed in this s

74 man liver and adipose tissue, possesses both lipolytic and lipogenic activity in vitro and localizes

75 ed to undergo fragmentation and fusion under lipolytic and lipogenic conditions, respectively.

76 he diets appear to mediate these changes via lipolytic and lipogenic pathways in adipose tissue.

77 ed with reduced expression of genes encoding lipolytic and lipogenic proteins.

78 differences exist in adipocyte responses to lipolytic and lipogenic stimuli, in adipocyte apoptosis,

79 trates for the first time that EL has both a lipolytic and nonlipolytic function in HDL metabolism in

80 nal transduction pathways mediating the anti-lipolytic and prostaglandin D2/flushing pathways are dis

81 ially in strain CcI3, with more esterolytic, lipolytic and proteolytic enzymes having signal peptides

82 The production and release of lipolytic and proteolytic extracellular enzymes by P. ac

83 cortisol, endogenous glucose production, and lipolytic and symptom responses.

84 tory activity of full-length Angptl4 reveals lipolytic and thermogenic properties with therapeutic re

85 growth, but at the expense of diabetogenic, lipolytic, and hepatosteatotic consequences.

86 onents that are generated through oxidative, lipolytic, and proteolytic activities lead to the format

87 t in the endoplasmic reticulum seems to lack lipolytic as well as acyltransferase activity as shown b

88 lar impact of dysfunctional PPARgamma on the lipolytic axis and to explore whether these defects are

89 Here, we show that the lipolytic barrier of Plin5-enriched LDs, either prepared

90 Despite removal of lipolytic bursts, plasma FFAs (0.31 mM) and glycerol (0.

91 This correlated with a decreased lipolytic capacity of GR-deficient adipocytes under post

92 We demonstrate that ABHD5, a lipolytic co-activator, is ectopically expressed in CRC-

93 and ALBP constitute a functionally important lipolytic complex.

94 r LD fusion that is involved in a reversible lipolytic cycle in adipocytes.

95 ng or cardiac dysfunction than hearts with a lipolytic defect due to ATGL deficiency.

96 At the molecular level, the lipolytic defects in white fat were caused by impaired p

97 endothelial-bound lipolytic enzymes in human lipolytic deficiency states.

98 1A vesicles, suggesting that TgLCAT controls lipolytic degradation of Rab vesicles for cargo release.

99 rtmannin completely prevented insulin's anti-lipolytic effect but only minimally blocked [Ca2+]i's ef

100 This finding indicates that the anti-lipolytic effect of [Ca2+]i may be mediated by the activ

101 ated the mechanisms responsible for the anti-lipolytic effect of intracellular Ca2+ ([Ca2+]i) in huma

102 in adipose tissue from R6/2 mice, as was the lipolytic effect of isoproterenol.

103 We find that the lipolytic effect of leptin is mediated through the actio

104 Indeed, CST mimicked the lipolytic effect of the alpha-AR blocker phentolamine on

105 Zeng et al. reveal that the lipolytic effect of the hormone leptin is mediated by sy

106 perilipin (which has been implicated in the lipolytic effect of TNF-alpha) was not affected by gluco

107 ibition attenuated protein levels of the key lipolytic effectors hormone-sensitive lipase and adipose

108 ponectin levels increased sensitivity to the lipolytic effects of adrenergic receptor agonists.

109 We used microdialysis to study the in situ lipolytic effects of dobutamine (selective beta1-agonist

110 Glucocorticoid treatment mimicked the lipolytic effects of fasting, although with slower kinet

111 polysis was due to a suppression of the anti-lipolytic effects of insulin in adipocytes after chronic

112 irectionally similar to the androgen-induced lipolytic effects on visceral adiposity and equal in mag

113 pathetic neurons, which, in turn, attenuates lipolytic energy mobilization by adipocytes.

114 adipocytes causes redistribution of the key lipolytic enzyme ATGL to lipid droplets and increases li

115 esterase or bile salt-dependent lipase) is a lipolytic enzyme capable of hydrolyzing cholesteryl este

116 In particular, annotation of the lipolytic enzyme group (at least 110 members total) has

117 adipose triglyceride lipase (ATGL), the key lipolytic enzyme in the first step of TG breakdown.

118 In contrast, exposing LDL(-) to the key lipolytic enzyme lipoprotein lipase (LPL) reversed these

119 sly uncharacterized pathway in which the key lipolytic enzyme LPL can act on circulating lipoproteins

120 lpha phospholipase A(2) (PLA(2)IValpha) is a lipolytic enzyme that catalyzes the hydrolysis of membra

121 Hepatic lipase is a lipolytic enzyme that has been suggested to have a role

122 rate successful expression and delivery of a lipolytic enzyme to the vascular endothelium for ultimat

123 indings reveal how cancer cells can co-opt a lipolytic enzyme to translate their lipogenic state into

124 Hepatic lipase (HL) is an endothelial-bound lipolytic enzyme which functions as a phospholipase as w

125 hat the promotor region of the rate-limiting lipolytic enzyme, adipose triglyceride lipase (ATGL), ha

126 A2 (PLA2), a small (13.8 kDa) Ca2+-dependent lipolytic enzyme, is rich in functional and structural c

127 d in mouse tears, where it may function as a lipolytic enzyme, modifying tear film lipids.

128 parvoviral virion gains entry by deploying a lipolytic enzyme, phospholipase A(2) (PLA(2)), that is e

129 (eva) expression and decreased expression of lipolytic enzymes (hormone-sensitive lipase, lipoprotein

130 d lipolysis with increased levels of the key lipolytic enzymes adipose triglyceride lipase (ATGL) and

131 These signals modulate the activity of lipolytic enzymes and accessory proteins, allowing for m

132 cell-surface glycosaminoglycan matrix where lipolytic enzymes and lipoprotein receptors reside.

133 isms of inhibition toward six representative lipolytic enzymes belonging to distinct lipase families

134 DSL/SGNH family II, and alipC clustered with lipolytic enzymes from family V.

135 eful in the replacement of endothelial-bound lipolytic enzymes in human lipolytic deficiency states.

136 nct physiological roles of these two similar lipolytic enzymes in lipoprotein metabolism.

137 to regulate the actions of gastrointestinal lipolytic enzymes in order to control the uptake of diet

138 Dietary triacylglycerol is acted upon by lipolytic enzymes in the stomach and the proximal small

139 particles, thereby indicating involvement of lipolytic enzymes in their generation.

140 The genome of Myxococcus xanthus encodes lipolytic enzymes in three different families: patatin l

141 lipase A2 (PLA2) family of proteins includes lipolytic enzymes that liberate the sn-2 fatty acyl chai

142 The Green Recovery strategy utilizes lipolytic enzymes under the control of promoters induced

143 ted phosphatase, protease, or one of several lipolytic enzymes were not defective in vivo.

144 res the exquisitely regulated interaction of lipolytic enzymes with regulatory, accessory, and scaffo

145 cate that StnA represents a new subfamily of lipolytic enzymes with the specific binding pocket locat

146 bstantial similarity with the GDSL family of lipolytic enzymes, particularly the Moraxella bovis phos

147 action also triggers activation of bacterial lipolytic enzymes, the effects of nisin and PLA2 on the

148 lacrimal glands express mRNAs encoding other lipolytic enzymes, the present study was conducted to lo

149 characterization of interface specificity of lipolytic enzymes.

150 _4569 encodes a member of the GDSL family of lipolytic enzymes.

151 ce resonance energy transfer (FRET) assay of lipolytic enzymes.

152 mber of the GDSL (Gly-Asp-Ser-Leu) family of lipolytic enzymes.

153 This strategy may be applicable to other lipolytic enzymes.

154 AMP levels and downstream phosphorylation of lipolytic enzymes.

155 ze, and fat mass and increased expression of lipolytic enzymes.

156 Altogether, our results show that the lipolytic factor ABHD5 suppresses SRM-dependent spermidi

157 h ethanol causes acute pancreatitis (AP) and lipolytic fatty acid (FA) generation worsens AP, the con

158 In vitro, collagen I limited the lipolytic flux between acinar cells and adipocytes and p

159 ity of acute exacerbations of CP by reducing lipolytic flux between adipocytes and acinar cells.

160 220, that interacts with ATGL to inhibit its lipolytic function and promote triglyceride storage.

161 tests showed that Bhmt(-/-) mice had normal lipolytic function.

162 Our aim was to study the role of acute lipolytic generation of fatty acids on local severity an

163 ytica 5ST, and the characterization of three lipolytic genes and their translated protein.

164 Furthermore, augmented expression of FAO and lipolytic genes in FL-PGC-1alpha(-/-) white adipose tiss

165 elective beta2-agonist) on glycerol release (lipolytic index) in abdominal subcutaneous AT in 10 obes

166 ert, although how adipocytes integrate these lipolytic inputs is unknown.

167 aired lipid deposition coupled with impaired lipolytic lipid mobilization.

168 ve been made in describing the structure and lipolytic mechanism of human pancreatic triglyceride lip

169 a-hydroxyacyl-CoA dehydrogenase, a marker of lipolytic metabolism; and lactate dehydrogenase, a marke

170 nate from plasma lipoproteins, show signs of lipolytic modifications, and associate with cholesterol

171 , LXRalpha) was increased, whereas that of a lipolytic nuclear factor PPARalpha was reduced in SH.

172 structure-activity studies of anticoagulant, lipolytic, or inflammatory activities.

173 selectively eliciting the therapeutic, anti-lipolytic pathway while avoiding the activation of the p

174 We sequenced 12 lipolytic-pathway genes in Old Order Amish participants

175 crobial activity, as well as proteolytic and lipolytic phenomena, decisive steps in such a ripening p

176 of phosphorylation on two components of the lipolytic process, the TG-lipase and the lipid droplet,

177 ulating their receptor-mediated clearance or lipolytic processing and the production of hepatic very

178 dothelial cell molecule that facilitates the lipolytic processing of chylomicrons has never been clea

179 protein 1 (GPIHBP1) plays a key role in the lipolytic processing of chylomicrons.

180 LPL, the enzyme responsible for the lipolytic processing of triglyceride-rich lipoproteins,

181 coprotein, binds LPL and is required for the lipolytic processing of triglyceride-rich lipoproteins.

182 lipase (LPL) avidly and is required for the lipolytic processing of triglyceride-rich lipoproteins.

183 l-anchored glycoprotein, and its role in the lipolytic processing of triglyceride-rich lipoproteins.

184 ggest that GPIHBP1 is a key platform for the lipolytic processing of triglyceride-rich lipoproteins.

185 e required neither HL binding to the LRP nor lipolytic processing.

186 ich lipoproteins along capillaries and their lipolytic processing.

187 to test the hypothesis that Pla2g1b and its lipolytic product lysophospholipid suppress hepatic fat

188 Overall, the results indicate that lipolytic products can activate PPARalpha and PPARdelta

189 idative genes by elevating cAMP, but whether lipolytic products can modulate gene expression is not k

190 e that there is escape, or spillover, of the lipolytic products of LPL action on triglyceride-rich li

191 Little is known about the fate of the lipolytic products produced by the action of lipoprotein

192 Equations were developed to quantify all the lipolytic products, and either referred to acyl groups p

193 ably caused by the accumulation of insoluble lipolytic products, appeared at the surface of the globu

194 th regard to primary sequence, have distinct lipolytic properties (triglyceride lipase vs. phospholip

195 ly localized on lipid droplets and regulates lipolytic protein kinase A signaling by acting upstream

196 ecreased lipid droplet size, increased basal lipolytic rate and alterations in adiponectin and leptin

197 The addition of RSG reduced the lipolytic rate and TNF-alpha secretion.

198 d flow (ATBF) is an important determinant of lipolytic rate in vivo, we hypothesised that hypercortis

199 Further, the lipolytic rate increased by approximately 2- to 2.5-fold

200 nhanced the phosphorylation of Lsdp1 and the lipolytic rate of the lipase, demonstrating a prominent

201 In addition, lipolytic rate was assessed by glycerol release assay an

202 glucose production, suppress adipose tissue lipolytic rate, stimulate skeletal muscle glucose uptake

203 n basal lipogenic rate and increase in basal lipolytic rate.

204 repression of Adrb3 expression and decrease lipolytic rate.

205 and protein level and a parallel increase in lipolytic rate.

206 was significantly related to adipose tissue lipolytic rates and protein kinase A signaling in adipos

207 stingly, overexpression of ATGL restored the lipolytic rates in cells with silenced HSL or CGI-58, in

208 lterations in both adipose tissue (increased lipolytic rates) and hepatic (increased VLDL-TG secretio

209 of the lipid droplet, a critical step in the lipolytic reaction.

210 iglyceride-fatty acid cycling, regulation of lipolytic reactions, and glyceroneogenesis.

211 nces in the surface properties that regulate lipolytic reactivity are a predictable function of surfa

212 in POMC IR KO mice, consistent with impaired lipolytic regulation resulting in fatty liver.

213 al conceptual change in the understanding of lipolytic regulation.

214 PPARgamma is required for activation of the lipolytic regulatory network, dysregulation of which is

215 pase (MAGL) drives tumorigenesis through the lipolytic release and remodeling of free fatty acids.

216 lation of sympathetic inputs induces a local lipolytic response and depletion of white adipose mass.

217 This abnormal lipolytic response is exacerbated by a state of positive

218 Upon prolonged fasting, the impaired lipolytic response resulted in abnormal substrate utiliz

219 The decreased lipolytic response seen in the aP2-/- mice was not assoc

220 ng MRAP fat specifically exhibited increased lipolytic response to ACTH.

221 failed to augment the activation of PKA and lipolytic response to ACTH.

222 ference was associated with enhanced ex vivo lipolytic response to catecholamines and with greater le

223 C57BL/6 Pparg2-KO mice exhibited more active lipolytic response to catecholamines than 129S6/SvEv Ppa

224 that glucose metabolism is required for the lipolytic response to TNF-alpha but not for early signal

225 sible for the PKA-independent portion of the lipolytic response.

226 gion of perilipin abrogates the PKA-mediated lipolytic response.

227 a PPARgamma-dependent regulatory node of the lipolytic response.

228 ic women, 2) autonomic symptom awareness and lipolytic responses appear to be relatively increased in

229 oglycemia and ANS drive, lipid oxidation and lipolytic responses can be increased in type 1 diabetic

230 Analysis is done of pharmacological lipolytic responses combined with protein and mRNA expre

231 lysis even in the presence of forskolin, and lipolytic responses were correlated with phosphorylation

232 cortisol, endogenous glucose production, and lipolytic responses were reduced by 40-80%.

233 isms of endogenous glucose production (EGP), lipolytic responses, and ketogenesis were also significa

234 Galphaq-deficient adipocytes display reduced lipolytic responses, shown to reflect a newly discovered

235 hormone, endogenous glucose production, and lipolytic responses.

236 with long-standing obesity suggest a reduced lipolytic sensitivity to catecholamines in subcutaneous

237 Regulation of lipolysis and lipolytic signaling by CD36 was reproduced with adipose

238 ially expressed in the NAS liver, suggesting lipolytic-specific regulatory effects by Notch1 signalin

239 -type mice, but fail to respond maximally to lipolytic stimuli.

240 nvestigate the separate contributions of the lipolytic versus ligand-binding function of hepatic lipa

241 delineate the separate contributions of the lipolytic versus ligand-binding function of HL to plasma