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1 egardless of whether they are hydrophilic or lipophilic.
2 tron-withdrawing but at the same time highly lipophilic.
4 lyurethane films did not exhibit leaching of lipophilic additives after rinsing with a direct water j
6 sized trimethylammonium salts and reversible lipophilic aggregation of the host:guest complex provide
7 ing an antigen or adjuvant cargo linked to a lipophilic albumin-binding tail by a solubility-promotin
10 sed size-selective precipitation to separate lipophilic allyl-benzyl-capped silicon nanoparticles int
11 m metabolism and the combination of fusing a lipophilic amine to a NOX inhibiting dye shows promise f
14 antigen rOspA from Borrelia burgdorferi, and lipophilic analogue norAbuMDP-Lys(B30) as adjuvant, are
16 ups into oligonucleotides, most notably with lipophilic anchors, enabled a widespread usage of DNA as
17 analysis (PCA) was applied to the spectra of lipophilic and aqueous extracts of 20 monovarietal authe
18 a one-step procedure to a variety of chiral lipophilic and conformationally rigid amines and heteroc
21 t(DACH)(OAc)(OPal)(ox)] (1), containing both lipophilic and hydrophilic axial ligands, was applied to
22 ed the interaction of thirteen commonly used lipophilic and hydrophilic mediators with the yeast Sacc
24 hen a greater proportion of their surface is lipophilic and is consequently protected by the physical
27 s an effective strategy because tree bark is lipophilic and readily adsorbs and collects POPs from th
30 -dimensional structure of the SGQs formed by lipophilic, and hydrophilic, 8ArG derivatives with eithe
31 between Cl(-) in the nanospheres and a more lipophilic anion in the sample, such as ClO4(-) and NO3(
32 the best selectivity for chloride over major lipophilic anions such as salicylate ( [Formula: see tex
34 fusion of leukocytes loaded ex vivo with the lipophilic antifungal posaconazole could improve deliver
39 and in combination, on the concentrations of lipophilic antioxidants (vitamin E and gamma-oryzanol),
40 d brown rice increased the concentrations of lipophilic antioxidants in whole grain rice but decrease
44 armacophores bound to an affinity-generating lipophilic appendage, a polyethylene glycol-based linker
45 methyl acceptor isoprenylcysteine, which is lipophilic, are recognized within the same active site i
46 ciently enters cells by incorporation of the lipophilic aromatic pdppz ([2,3-h]dipyrido[3,2-a:2',3'-c
47 modified analogs of warfarin with additional lipophilic aromatic rings, up to 100-fold greater potenc
53 tracted thin film device using a hydrophilic lipophilic balance (HLB) coating, and an open bed config
54 icron thymol emulsions with high hydrophilic-lipophilic balance (HLB) surfactants via spontaneous emu
56 rs support a strong role for the hydrophilic-lipophilic balance of the graft copolymer in achieving s
57 e last two featuring an improved hydrophilic/lipophilic balance, exhibited excellent activity profile
60 lers were prepared by applying a hydrophilic-lipophilic balanced (HLB)-polyacrylonitrile (PAN) coatin
63 ctive compounds into silicone oil, acting as lipophilic binder of glassy carbon paste electrode, with
64 tructures reveal a conical, rather large and lipophilic binding site and are the starting point for s
66 or simultaneous delivery of flavour oils and lipophilic bioactive compounds in transparent beverages.
68 Liposomes are suitable for encapsulating lipophilic bioactive compounds, enhancing compound solub
71 nsic probe, is generally applicable to other lipophilic bioactives, whenever they have observable env
72 the generation of a precursor of a potential lipophilic bioisostere of gamma-aminobutyric acid (GABA)
74 Despite their different nature (THMs are lipophilic), both of them have an affinity for fatty che
75 d-state nitrate selective electrode based on lipophilic carbon nanotubes (f-MWCNTs) as an ion-to-elec
76 noid-binding protein (IRBP) is a specialized lipophilic carrier that binds the all-trans and 11-cis i
78 lly to mitochondria is by covalent linking a lipophilic cation such as an alkyltriphenylphosphonium m
79 aining up to two ionophores in addition to a lipophilic cation-exchanger, overlaid on an electropolym
80 ess this issue, we report the development of lipophilic cationic vancomycin analogues possessing exce
82 ical basis for mitochondrial accumulation of lipophilic cations, synthetic chemistry strategies to ta
83 hown to positively differentiate from highly lipophilic CETP inhibitors in its complete elimination f
85 , which contain a hydrophobic xanthone core, lipophilic chains, and cationic amino acids, displayed v
86 The DCF affinity appears to depend on the lipophilic character of organoclays in correlation to th
94 irculatory disturbance-related diseases; its lipophilic components play important roles in this appli
98 rocyanidins (water soluble pigments) to more lipophilic compounds has the advantage of increased bioa
99 pplication to enhance the delivery of highly lipophilic compounds is limited due to lack of any charg
101 were studied regarding their hydrophilic and lipophilic compounds, as well as their antioxidant prope
109 e, bioaccumulation factors for metabolizable lipophilic contaminants may be higher in Antarctic than
111 a sulfhydryl bond is cleaved to release the lipophilic cytotoxic moiety into the endosome, which pas
112 3, 3-Diindolylmethane-14 (DIM-14), a novel lipophilic derivative of DIM, has demonstrated anticance
114 in-B (a cytolytic peptide), valproic acid (a lipophilic drug), and amyloid-beta (a peptide associated
116 o fenestrations suggested to be pathways for lipophilic drugs and provide deeper insight into the mol
117 OVS with sperm at a nanoscale level, using a lipophilic dye (FM4-64FX) and three-dimensional SR/SIM,
120 cellular fractionation, immunocytochemistry, lipophilic dye fluorescence microscopy, thin-section ele
122 erves emission from fluorescent proteins and lipophilic dyes in membrane integrity preserved tissues.
123 demonstrate that trans-cis isomerization of lipophilic dyes is a useful parameter to monitor packagi
124 lactam-containing EZH2 inhibitors focused on lipophilic efficiency (LipE) improvement, which provided
126 hilicity with maintained or increased ligand lipophilic efficiency (LLE) compared to previously repor
127 ent in the antagonist bioactivity and ligand lipophilic efficiency (LLE) parameter were the principal
128 This compound displays a 5-unit increase in lipophilic efficiency from the fragment hit, excellent k
130 sful application of both structure-based and lipophilic-efficiency-focused drug design resulted in am
132 pt cellular function; these include a highly lipophilic element that promotes strong membrane interac
137 e banana cultivars showed similar amounts of lipophilic extractives (ca. 0.4% of dry material weight)
139 The application of both methods to real lipophilic extracts from tomato (Solanum lycopersicum L.
140 e not systematically observed in the natural lipophilic extracts from tomato, green and red peppers,
144 Polybrominated diphenyl ethers (PBDEs) are lipophilic flame retardants that bioaccumulate in humans
146 at optimised parameters yielded 8.3g/100g of lipophilic fraction containing 0.2 and 2.2g of cannabidi
148 the most valuable metabolites present in the lipophilic fraction of Protected Geographical Indication
151 e skin mycobiomes in healthy adults, showing lipophilic fungi Malassezia predominate in most skin sit
152 during stimulation of BAT thermogenesis, the lipophilic gas xenon preferentially accumulates in BAT,
153 rast, diffusivity of NH3, a smaller but less lipophilic gas, was considerably slower than in pure wat
154 hydrophobicity and substitution geometry of lipophilic groups play important roles in compound-lipid
160 ese signals, we identified a set of putative lipophilic hormone receptors, known as nuclear hormone r
163 difluoromethyl group, as it is considered a lipophilic hydrogen bond donor that may act as a bioisos
165 hinone IIA (TSA) are the most widely-studied lipophilic ingredients, but low oral bioavailability lim
167 id amphipathic fusion inhibitors (RAFIs) are lipophilic inverted-cone-shaped molecules thought to ant
168 t ion-exchange properties and are doped with lipophilic ionophores originally developed for chemical
171 (-) (BArf =B(3,5-C6 H3 (CF3 )2 )4 ) to give lipophilic Lambda- and Delta-3 a-d(3+) 3 BArf (-) , whic
172 w a biophysical scheme based on the use of a lipophilic Laurdan dye for examining MIN6 cell membranes
174 ulted in a series of compounds with improved lipophilic ligand efficiency (LLE) consistent with the r
177 onstrate that using our previously described lipophilic ligand painting strategy, red blood cells (RB
179 ceptors (NRs) regulate physiology by sensing lipophilic ligands and adapting cellular transcription a
180 inding site explains the need for relatively lipophilic ligands and describes another example of an a
182 pic screens and genome sequencing are highly lipophilic (logP approximately 5.7) bases with membrane
183 ereas adult skin is predominantly obligatory lipophilic Malassezia, suggesting that fungal communitie
186 ls were indeed perfused and stained with the lipophilic membrane dye; however, the vessels were only
187 nfocal microscopy and the use of fluorescent lipophilic membrane dyes have boosted the discoveries th
188 enhanced the in vitro DFO permeation across lipophilic membranes, similarly as shown by ex vivo perm
192 vivo We show here that peptides tagged with lipophilic moieties self-assemble into nanoparticles unt
195 o referred to as coenzyme Q, is a widespread lipophilic molecule in both prokaryotes and eukaryotes i
196 FDA-approved arsenic trioxide, with the most lipophilic molecule in the series showing the best growt
207 solid-state anion selective electrodes using lipophilic multiwalled carbon nanotubes (f-MWCNTs) as th
208 cationic amphiphilic motif represented by a lipophilic n-octyl side chain at position 1 and a positi
209 tionship of these compounds, we suggest that lipophilic N6 and bulky C2 substituents can promote stab
210 n initial series of studies, three different lipophilic nalmefene derivatives were evaluated: the pal
213 al hours after a firing event, and given the lipophilic nature of these compounds, it was expected th
214 ted by their lower molecular weight and more lipophilic nature, leading to similar binding efficiency
216 In addition, ACT compound loaded with a lipophilic NIR dye to the microdroplet component was sho
217 ng chain fatty acid (heptadecanoic acid) and lipophilic nutraceutical (Coenzyme Q10) was investigated
218 at the bioavailability of the fatty acid and lipophilic nutraceutical in small intestinal tissues was
219 e particularly suitable for encapsulation of lipophilic nutraceuticals because of their ability to fo
223 a cation exchanger) and chromoionophore I (a lipophilic optical pH indicator) are printed on filter p
224 ification means the liberation of persistent lipophilic organic pollutants (PLOPs) into blood from th
225 clic peptidomimetic molecules bearing both a lipophilic P2 isoindoline carbamate and a P1/P1' acylsul
226 lation influences skin permeability and that lipophilic particles smaller than 6 nm can embed in lipi
231 reated milk, but little has been studied for lipophilic phenolic compounds that are to be encapsulate
233 t time the use of a visible light activated, lipophilic photoacid polymer in an ion-sensing membrane
235 ,r,a]per ylene-7,14-dione), the fluorescent, lipophilic pigment associated with the photoreceptor pro
237 sence of a large though apparently saturable lipophilic pocket in the CBR binding site region interac
240 r conformations and interactions: filling of lipophilic pockets to gain affinity or selectivity, addi
241 his notion, we determined whether the common lipophilic pollutants benzo[a]pyrene and diesel exhaust
242 tation for T cell activation is inhibited by lipophilic pollutants through profound interference with
247 by a 2-, 3-, or 4-pyridine and obtained less lipophilic, potent, and selective S1P1 agonists (e.g., 2
248 obtained in vitro on this dye as a membrane/lipophilic probe and as a peptide fluorescent label.
251 oducing a hydrophilic group to interrupt the lipophilic, promiscuous pharmacophore and promote intera
254 Modification of oxaliplatin (OXA) into a lipophilic Pt(IV) complex [Pt(DACH)(OAc)(OPal)(ox)] (1),
257 enhanced suitability for incorporation into lipophilic regions of liposomes and subsequent in vitro
261 ized poly(vinyl chloride) (PVC) and an inert lipophilic salt, tridodecylmethylammonium-dinonylnaphtha
264 olimus (also known as biolimus A9), a highly lipophilic sirolimus analogue, into the vessel wall over
265 hought to regulate the availability of small lipophilic Smoothened repressors whose identity is unkno
267 found to promote the loss of insufficiently lipophilic species from the ionophore-doped ISMs into aq
268 2) showed improved selectivity over the most lipophilic species, Na(+) and K(+), by more than two ord
269 rat adrenal glomerulosa cells confirmed that lipophilic statins acutely inhibited aldosterone, but no
272 imiting enzyme of the mevalonate pathway, by lipophilic statins such as simvastatin and atorvastatin
276 potential by attaching a positively charged lipophilic substituent would enhance the antitumor activ
278 uorescence lifetime-based nanoprobe based on lipophilic sulforhodamine, which stains 2D and 3D cell m
279 otif, a common feature is that many of these lipophilic systems display CNS and/or neurological activ
280 selected pharmacophoric requirements in the lipophilic tail, a parallel synthetic approach was appli
281 ral elements of a zwitterionic headgroup and lipophilic tail, a variety of chemotypes have been found
283 lt was prepared with weakly coordinating and lipophilic tetrakis(pentafluorophenyl)borate anion stabl
284 of apoAI with that of apoAII, which is more lipophilic than apoAI, using HDL-[(3)H]CE labeled with [
285 se, thus suggesting greater effectiveness of lipophilic than hydrophilic/phenolic antioxidants under
289 W) pastas, enriched respectively with either lipophilic (tocochromanols, carotenoids) or hydrophilic/
294 ondrial H2S levels in vivo MitoA comprises a lipophilic triphenylphosphonium (TPP) cation coupled to
295 e-insensitive, high-affinity, and moderately lipophilic TSPO ligands that may serve as leads for PET
296 tionship studies suggest that PCIH acts as a lipophilic vehicle for the transport of its intact INH m
298 antially increase the bioavailability of the lipophilic vitamin, and thus can serve in the oral deliv
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