ライフサイエンスコーパス: lipoteichoic acid

1 o sensitize to TLR2 ligands (peptidoglycan + lipoteichoic acid).

2 esponses that were stimulated by IL-1beta or lipoteichoic acid.

3 (a diacylated bacterial lipopeptide) and to lipoteichoic acid.

4 and this expression was inducible by LPS or lipoteichoic acid.

5 esidues from the cell wall teichoic acid and lipoteichoic acid.

6 ionic ligands such as lipopolysaccharide and lipoteichoic acid.

7 -alanylation of membrane-associated D-alanyl-lipoteichoic acid.

8 l-Dcp in the incorporation of D-alanine into lipoteichoic acid.

9 pha-toxin stimulation following priming with lipoteichoic acid.

10 the phosphocholine residues of pneumococcal lipoteichoic acid.

11 kbone structure in their membrane-associated lipoteichoic acid.

12 - to 3-fold) with gram-positive bacteria and lipoteichoic acid.

13 ollowing exposure to either peptidoglycan or lipoteichoic acid.

14 ive shock was induced by coadministration of lipoteichoic acid (3 mg/kg intravenously) and peptidogly

15 be inhibited by laminin and by streptococcal lipoteichoic acid, a molecule previously implicated as t

16 In addition, lipoteichoic acid, a PAMP produced by Gram-positive bact

17 onferring responsiveness to endotoxin and to lipoteichoic acid, a product of Gram-positive bacteria,

18 to P. aeruginosa but not to the response to lipoteichoic acid, a specific ligand of TLR2.

19 ylic acid (poly I:C), a TLR3 ligand; but not lipoteichoic acid, a TLR2 ligand, upregulate macrophage

20 ternalization of S. aureus and its component lipoteichoic acid, accompanied by a marked defect in tum

21 Bacterial lipoteichoic acid activates the platelet-activating fact

22 LPS, Gram-positive bacterial wall component lipoteichoic acid and bacterial heat shock protein Gro-E

23 forms of LPS was competed for efficiently by lipoteichoic acid and by rough mutant (Ra and Rc) forms

24 iver, lung) caused by a) coadministration of lipoteichoic acid and peptidoglycan (Gram-positive shock

25 overed that two cell wall components, namely lipoteichoic acid and peptidoglycan of the Gram-positive

26 ative (lipopolysaccharide) or Gram-positive (lipoteichoic acid and peptidoglycan) shock 24 hrs later.

27 delta potentiates PAFR expression induced by lipoteichoic acid and pneumococci.

28 ated LL-37 to quench macrophage responses to lipoteichoic acid and poly(I:C) signaling via TLR2 and T

29 nd IFN-gamma-pretreated macrophages, whereas lipoteichoic acid and synthetic unmethylated deoxycytidi

30 with the TLR4 agonist LPS and TLR2 agonists lipoteichoic acid and zymosan.

31 obial ligands for TLR2 (peptidoglycan [PGN], lipoteichoic acid) and TLR4 (lipopolysaccharide), by pro

32 osis by microbial products through the TLR2 (lipoteichoic acid) and/or TLR4 (LPS) pathway.

33 Bacterial LPS, lipoteichoic acid, and hsp60 also competed against iodin

34 to bacterial LPS (endotoxin), lipoproteins, lipoteichoic acid, and other acylated microbial products

35 be inhibited by the bacterial products LPS, lipoteichoic acid, and peptidoglycan.

36 Bacterial lipopolysaccharides, lipoteichoic acid, and synthetic amphipathic helical pep

37 ll components, such as lipopolysaccharide or lipoteichoic acid, and viral nucleic acids, such as doub

38 ty to a broad range of LPS structures and to lipoteichoic acid, and, moreover, MD-2 enhances the resp

39 eptidoglycan cell wall, wall-teichoic acids, lipoteichoic acids, and capsular polysaccharide.

40 udies suggested a possible role for purified lipoteichoic acid as a vaccine target for eliciting prot

41 e activity of particles with adherent LPS or lipoteichoic acid as would be expected if alarmins are s

42 emistry and genetics of polyglycerophosphate lipoteichoic acid biosynthesis but it has remained uncle

43 r insights into the functional redundancy of lipoteichoic acid biosynthesis enzymes in Bacillus subti

44 sCD14, sPGN, smooth LPS, ReLPS, lipid A, and lipoteichoic acid but not by dextran, dextran sulfate, h

45 s, Gram-negative bacteria, and Gram-positive lipoteichoic acid, but not to Gram-positive bacteria, pe

46 crophages were stimulated in vitro with LPS, lipoteichoic acid, CD40 ligand, or low molecular mass hy

47 e bacteria and their LPS, peptidoglycan, and lipoteichoic acid components.

48 mmation in response to S. pneumoniae and its lipoteichoic acid, demonstrate that S. pneumoniae binds

49 the TLR2-specific agonist, peptidoglycan or lipoteichoic acid, did not cause an inflammatory respons

50 d heat-inactivated Staphylococcus aureus and lipoteichoic acid differentially alter expression of the

51 macrophages, the epithelial-cell response to lipoteichoic acid does not require Toll-like receptor 2

52 dies, proinflammatory molecules such as LPS, lipoteichoic acid, dsRNA, TNF-alpha, and IFN-gamma can i

53 mination in HL-60 cells exposed to LPS, TNF, lipoteichoic acid, f-MLP, or hydrogen peroxide, which ar

54 ation of diacylglycerol and the cessation of lipoteichoic acid formation in B. subtilis.

55 erotype C and D capsule polysaccharides mask lipoteichoic acid from detection by agglutinating antibo

56 Similarly, E. faecalis capsule masks lipoteichoic acid from detection, which correlates with

57 ide (LPS) from Gram-negative bacteria and to lipoteichoic acid from Gram-positive bacteria.

58 s and bacterial cell wall components such as lipoteichoic acid from Gram-positive bacteria.

59 murium strains, as well as LPS, lipid A, and lipoteichoic acid from Pseudomonas aeruginosa and Lister

60 popolysaccharide (LPS) (Gram-negative rods), lipoteichoic acid (Gram-positive cocci), and lipoarabino

61 r products including Gram-positive bacteria (lipoteichoic acid), Gram-negative bacteria (lipopolysacc

62 e immunization against clumping factor A and lipoteichoic acid have all proven unsuccessful in clinic

63 A (PspA), choline binding protein A (CbpA), lipoteichoic acid, immunoglobulin A1 (IgA1) protease, pn

64 ds, including LPS in gram-negative bacteria, lipoteichoic acid in gram-positive bacteria, and phospho

65 D-alanine into membrane-associated D-alanyl-lipoteichoic acid in Lactobacillus casei requires the 56

66 oic acid in the S. pneumoniae cell wall, and lipoteichoic acid in the S. pneumoniae membrane were pre

67 acellular HlpA formed soluble complexes with lipoteichoic acid in vitro and bound readily to heparan

68 rane products of S. pneumoniae that included lipoteichoic acid induced disruption of the epithelial b

69 onserved (poly)glycerolphosphate backbone of lipoteichoic acid is a major antigenic target of the hum

70 ork constitutes the first demonstration that lipoteichoic acid is sufficient to induce expression of

71 ed alditol repeats of cell-wall teichoic and lipoteichoic acids is 3:2; and (iii) 50% of the mature c

72 The biosynthesis of lipoteichoic acids is a potential target for the develop

73 acL (previously known as RafX) as a putative lipoteichoic acid ligase required for LTA assembly.

74 Gram-positive bacteria, lipopolysaccharide, lipoteichoic acid, lipid A and muramyl dipeptide elicit

75 lly involved in the inflammatory response to lipoteichoic acid, lipopeptides, and glycans from a vari

76 oreover, after challenge with peptidoglycan, lipoteichoic acid, live or heat-killed Staphylococcus au

77 The D-alanylation of lipoteichoic acid (LTA) allows the Gram-positive organis

78 dltA exhibited a loss of D-alanyl esters in lipoteichoic acid (LTA) and a loss of intrageneric coagg

79 NO production by macrophages in response to lipoteichoic acid (LTA) and a synthetic lipopeptide (Pam

80 his inhibition is mediated by staphylococcal lipoteichoic acid (LTA) and acts selectively on keratino

81 Macrophage stimulation by lipoteichoic acid (LTA) and hemoglobin (Hb) requires Tol

82 overed that two cell wall components, namely lipoteichoic acid (LTA) and peptidoglycan (PepG) of the

83 ureus and the bacterial cell wall components lipoteichoic acid (LTA) and peptidoglycan (PGN) induced

84 us, its exoproducts, or cell wall components lipoteichoic acid (LTA) and peptidoglycan (PGN).

85 yldiacylglycerol, a cell membrane anchor for lipoteichoic acid (LTA) and predicted product of the Iag

86 Lipoteichoic acid (LTA) and wall teichoic acid (TA) isol

87 ns two distinct teichoic acid (TA) polymers, lipoteichoic acid (LTA) and wall teichoic acid (WTA), wh

88 molecules of Gram-positive bacteria such as lipoteichoic acid (LTA) and whether gelsolin's interacti

89 rol transferase gene that is responsible for lipoteichoic acid (LTA) biosynthesis in Lactobacillus ac

90 ol transferase gene that plays a key role in lipoteichoic acid (LTA) biosynthesis in Lactobacillus ac

91 oteins responsible for the esterification of lipoteichoic acid (LTA) by D-alanine.

92 tion with either lipopolysaccharide (LPS) or lipoteichoic acid (LTA) by using a custom microarray, re

93 PS-mimetic molecules-taxol from yew bark and lipoteichoic acid (LTA) from gram-positive bacterial cel

94 It is known that lipoteichoic acid (LTA) from Gram-positive cariogenic ba

95 mally to other bacterial substrates, such as lipoteichoic acid (LTA) from Staphylococcus aureus, whic

96 ylococcus aureus-derived cell-wall component lipoteichoic acid (LTA) governs the second phase of immu

97 The D-alanylation of membrane-associated lipoteichoic acid (LTA) in gram-positive organisms requi

98 To define the role of lipoteichoic acid (LTA) in innate immunity to gram-posit

99 cell wall components peptidoglycan (PGN) and lipoteichoic acid (LTA) induced the secretion of proinfl

100 Here, we show that S. aureus lipoteichoic acid (LTA) inhibits platelet aggregation ca

101 Lipoteichoic acid (LTA) is a Gram-positive cell surface

102 Lipoteichoic acid (LTA) is a major component of the cell

103 Lipoteichoic acid (LTA) is an amphiphilic molecule from

104 Lipoteichoic acid (LTA) is an essential bacterial membra

105 Lipoteichoic acid (LTA) is an important cell wall compon

106 Lipoteichoic acid (LTA) is an important cell wall compon

107 Lipoteichoic acid (LTA) is an important cell wall polyme

108 Lipoteichoic acid (LTA) is an important cell wall polyme

109 Lipoteichoic acid (LTA) is an important cell wall polyme

110 In Staphylococcus aureus RN4220, lipoteichoic acid (LTA) is anchored in the membrane by a

111 Staphylococcus aureus lipoteichoic acid (LTA) is composed of a linear 1,3-link

112 Type 1 lipoteichoic acid (LTA) is present in many clinically im

113 a leading cause of gram-positive sepsis, and lipoteichoic acid (LTA) may be important in causing gram

114 oactive adduct to the teichoic acid (TA) and lipoteichoic acid (LTA) of the surface of Streptococcus

115 ect of purified lipopolysaccharide (LPS) and lipoteichoic acid (LTA) on expression and function of TL

116 Lipoteichoic acid (LTA) purified from 2 strains of virid

117 osine triphosphate (ATP) and the TLR2 ligand lipoteichoic acid (LTA) selectively and synergistically

118 R are co-expressed by pulp fibroblasts under lipoteichoic acid (LTA) stimulation.

119 haride (LPS) and the Gram-positive bacterial lipoteichoic acid (LTA) substantially upregulated transc

120 esponse to the TLR2/6 agonist staphylococcal lipoteichoic acid (LTA) was abolished only in the index

121 uctose homopolymer levan, and a glucosylated lipoteichoic acid (LTA) was identified in a micellar fra

122 eveloped a method for obtaining pneumococcal lipoteichoic acid (LTA) with none, one, or two acyl chai

123 Lipoteichoic acid (LTA), a cell wall polymer of gram-pos

124 Lipoteichoic acid (LTA), a cell wall ribitol polymer fro

125 ient mice to demonstrate that staphylococcal lipoteichoic acid (LTA), a constituent of Gram-positive

126 Lipoteichoic acid (LTA), a glycerol phosphate polymer, i

127 Lipoteichoic acid (LTA), a glycerol phosphate surface po

128 In contrast, lipoteichoic acid (LTA), a predominant surface glycolipi

129 ), a critical MC differentiation factor, and lipoteichoic acid (LTA), a Toll-like receptor 2 ligand.

130 (PAMP), including lipopolysaccharide (LPS), lipoteichoic acid (LTA), and Pam(3)Cys, a bacterial lipo

131 a, IL-8, their combination, endotoxin (LPS), lipoteichoic acid (LTA), and staphyloccocal enterotoxin

132 n was observed in S. pneumoniae, TLR2 ligand lipoteichoic acid (LTA), and TLR4 ligand pneumolysin (PL

133 nce of bacterial lipopolysaccharide (LPS) or lipoteichoic acid (LTA), histones are released from the

134 tivation by soluble peptidoglycan (sPGN) and lipoteichoic acid (LTA), main stimulatory components of

135 accharide (III-PS), group B antigen (GB-Ag), lipoteichoic acid (LTA), or Escherichia coli lipopolysac

136 de (III-PS), group B polysaccharide (GB-PS), lipoteichoic acid (LTA), or peptidoglycan (PG).

137 (TLR) 4 and TLR2 receptors recognize LPS or lipoteichoic acid (LTA), respectively.

138 roducts such as lipopolysaccharide (LPS) and lipoteichoic acid (LTA), suggesting a role for SR-AI/II

139 Upon incubation with lipoteichoic acid (LTA), the major cell wall component o

140 The TLR 2 ligand, lipoteichoic acid (LTA), the TLR 4 ligand, LPS, and the

141 wing relatively short exposure times to LPS, lipoteichoic acid (LTA), thymidine homopolymer phosphoro

142 an and Wood), as well as S. aureus cell wall lipoteichoic acid (LTA), were incubated in thrombin-inhi

143 eins (Slps), including SlpA, SlpB, SlpX, and lipoteichoic acid (LTA), which interact with pattern rec

144 in keratinocytes exposed to S. aureus and to lipoteichoic acid (LTA).

145 lve the binding of this protein to cell wall lipoteichoic acid (LTA).

146 surface markers lipopolysaccharide (LPS) and lipoteichoic acid (LTA).

147 Lipoteichoic acids (LTA) are polymers of alternating uni

148 Lipoteichoic acids (LTA), cell wall components of gram-p

149 on of highly conserved cell wall components (lipoteichoic acid [LTA] and peptidoglycan [PGN]), which

150 choic acid, WTA) or to membrane glycolipids (lipoteichoic acid, LTA).

151 ined ligands for toll-like receptor (TLR) 2 (lipoteichoic acid; LTA), TLR3 (polyIC), TLR4 (lipopolysa

152 Lipoteichoic acids (LTAs) are Gram-positive bacterial ce

153 Lipoteichoic acids (LTAs) are membrane-anchored molecule

154 Wall teichoic acids (WTAs) and membrane lipoteichoic acids (LTAs) are the major polyanionic poly

155 Lipoteichoic acids (LTAs) belong to the immunostimulator

156 uman recombinant mannose-binding protein and lipoteichoic acids (LTAs) by enzyme-linked immunosorbent

157 h comprising part structures of the complete lipoteichoic acid molecule with two PCho residues.

158 ptor agonists, including lipopolysaccharide, lipoteichoic acid, muramyl dipeptide, and heat shock pro

159 In general, TLR-2s are presumed to recognize lipoteichoic acid of Gram-positive microbes-and TLR-4s,

160 ulin (Ig) G2 subtype, recognized ChoP on the lipoteichoic acid of Streptococcus pneumoniae and on the

161 gnificantly less hydrophobic, contained less lipoteichoic acid on its surface, and demonstrated reduc

162 fically, two inflammatory bacterial ligands, lipoteichoic acid or LPS (agonists of glial TLR2 and TLR

163 Activation of neutrophils with LPS, lipoteichoic acid, or N-palmitoyl-S-[2,3-bis(palmitoylox

164 strate interactions between SPLUNC1 and LPS, lipoteichoic acid, or polymyxin B.

165 We found that inflammatory stimuli (LPS, lipoteichoic acid, or TNF-alpha) caused an increase in c

166 that prolong neutrophil life span, including lipoteichoic acid, peptidoglycan, dexamethasone, and gra

167 l sulfoxide (as described previously) before lipoteichoic acid/peptidoglycan (n = 7).

168 ed with ODQ (as described previously) before lipoteichoic acid/peptidoglycan (n = 9).

169 In vivo, administration of lipoteichoic acid/peptidoglycan or lipopolysaccharide re

170 injury, and hepatocellular injury caused by lipoteichoic acid/peptidoglycan or lipopolysaccharide.

171 even TLR ligands were tested in this system: lipoteichoic acid/peptidoglycan, zymosan, poly (I:C), LP

172 Gram-positive human pathogen with a complex lipoteichoic acid (pnLTA) structure.

173 dies, proinflammatory molecules such as LPS, lipoteichoic acid, polyinosinic-polycytidylic acid (poly

174 to beta-1,3-glucan, lipopolysaccharide, and lipoteichoic acid, polysaccharides found on cell surface

175 tured human pulp fibroblasts stimulated with lipoteichoic acid produce all the proteins required for

176 activation of TLR2 from bacterial products (lipoteichoic acid) produced by commensal bacteria at the

177 nase in the diacylglycerol cycle that drives lipoteichoic acid production.

178 LtaA (lipoteichoic acid protein A), a predicted membrane perme

179 ternalization of S. aureus and its component lipoteichoic acid requires the COOH-terminal cytoplasmic

180 sure of macrophages to a mixture of HlpA and lipoteichoic acid resulted in a synergistic response in

181 ontrast, plots from py-GC/DMS of lipid A and lipoteichoic acid showed poor matches to plots for a Gra

182 tion with TLR agonists Staphylococcus aureus lipoteichoic acid (SLTA; TLR2 ligand) and Escherichia co

183 vation guided the neuronal growth toward the lipoteichoic acid-stimulated fibroblasts.

184 results, which showed expression of C5aR in lipoteichoic acid-stimulated pulp fibroblasts.

185 ss efficient in killing vaccinia virus after lipoteichoic acid stimulation than wild-type cells.

186 prototypical Gram-positive bacterium with a lipoteichoic acid structure containing repeating units o

187 hat the presence of extracellular domains of lipoteichoic acid synthase (LtaS) and the beta-lactam re

188 ession of ltaSa, encoding a stress-activated lipoteichoic acid synthase, and sigma(X) functions prima

189 minal domains of two transmembrane proteins, lipoteichoic acid synthase, LtaS, and O-acyteltransferas

190 ted by bacterial cell-wall motifs, including lipoteichoic acid-T (LTA-T).

191 vity of the potent bacterial lipids, LPS and lipoteichoic acid, that stimulate host innate immune res

192 In contrast to purified, natural lipoteichoic acid, the (poly)glycerolphosphate conjugate

193 ated HEK/TLR4 cells, while peptidoglycan and lipoteichoic acid (TLR2 ligands) activated HEK/TLR2 cell

194 e peptides in response to TLR2 activation by lipoteichoic acid (TLR2/6 activator) or palmitoyl (3)-Cy

195 atterns presented by lipopolysaccharides and lipoteichoic acid, TLR4 is a candidate gene for resistan

196 Whereas Staphylococcus aureus (Sa) lipoteichoic acid treatment confirmed that many late-res

197 ngly, the composition of membrane-associated lipoteichoic acid was not affected.

198 The TLR2 activation by PGN, but not by lipoteichoic acid, was abolished by muramidase digestion

199 hus preserving its function as an anchor for lipoteichoic acid, which is a primary mediator of adhere

200 ther bacterial components, including LPS and lipoteichoic acid, with higher affinities than for PCP,

201 proteins (srtA), or the glycolipid anchor of lipoteichoic acid (ypfP) bound GFP-CWT similar to wild-t