ライフサイエンスコーパス: lipoxygenase

1 and its 13-hydroperoxide (LOOH) catalysed by lipoxygenase.

2 nd its conversion to bioactive lipoxins by 5-lipoxygenase.

3 pid oxidation via autoxidation or induced by lipoxygenase.

4 ion of endogenous enzymes such as lipase and lipoxygenase.

5 vels of NF-kappaB, AKT, ERK1/2, COX-2, and 5-lipoxygenase.

6 ar ratio of a key SPM biosynthetic enzyme, 5-lipoxygenase.

7 d to the values obtained at pH 9 for soybean lipoxygenase.

8 d regulators of axon degeneration, including lipoxygenases.

9 dels involving autoxidation and oxidation by lipoxygenases.

10 metabolism, others being cyclooxygenases and lipoxygenases.

11 can catalyze lipid peroxidation similarly to lipoxygenases.

12 satetraenoic acid (15(S)-HETE), the major 15-lipoxygenase 1 (15-LO1) metabolite of arachidonic acid,

13 the peroxidation of linoleic acid by soybean lipoxygenase 1.

14 15-Lipoxygenase-1 (15-LOX-1), which is crucial to productio

15 elial cells (HAECs) and determine whether 15-lipoxygenase-1 (15LO1) binding with phosphatidylethanola

16 oleic acid peroxidation catalyzed by soybean lipoxygenase-1 (EC 1.13.11.12, Type 1).

17 Human 15-lipoxygenase-1 (h-15-LOX-1) is a mammalian lipoxygenase

18 f IR treatment on urease, trypsin inhibitor, lipoxygenase-1 and lipoxygenase-3 activities were invest

19 was sufficient for complete inactivation of lipoxygenase-1 and lipoxygenase-3, regardless of the moi

20 We employed soybean lipoxygenase-1 as a model system to investigate the impa

21 teric (or cooperative) inhibition of soybean lipoxygenase-1 of longer alkyl protocatechuates is rever

22 eptor, 5-lipoxygenase-activating protein, 15-lipoxygenase-1, prostaglandin D2, and proinflammatory cy

23 Induction of eicosanoid (12-lipoxygenase (12-LO) and cyclooxygenase 2 (COX2))- and r

24 12-Lipoxygenase (12-LO) is activated by high-fat diets and

25 in inflammatory fluids, and platelet-type 12-lipoxygenase (12-LO), expressed by platelet MPs.

26 cribed in part to increased expression of 12-lipoxygenase (12-LOX) and its arachidonate metabolite 12

27 n, metabolism of arachidonic acid (AA) by 12-lipoxygenase (12-LOX) may play a significant role in reg

28 N chemoattractant and a metabolite of the 12-lipoxygenase (12-LOX) pathway.

29 show for the first time that platelet 12(S)-lipoxygenase (12-LOX), a highly expressed oxylipin-produ

30 ALOX12 is a gene encoding arachidonate 12-lipoxygenase (12-LOX), a member of a nonheme lipoxygenas

31 We previously showed that 12-lipoxygenase (12-LOX), which is required to generate the

32 s (Noxes) nor mitochondria, but rather 12/15-lipoxygenase (12/15-LO) are pivotal ROS sources involved

33 The 12/15-lipoxygenase (12/15-LO) enzyme is upregulated in the bra

34 WT mice high fat diet feeding induced 12/15-lipoxygenase (12/15-LO) expression in the endothelium an

35 12/15-Lipoxygenase (12/15-LO) is an enzyme widely distributed

36 vincing body of evidence suggests that 12/15-lipoxygenase (12/15-LO) plays a role in atherosclerosis.

37 osis, here we investigated the role of 12/15-lipoxygenase (12/15-LOX) in TF expression.

38 12/15-Lipoxygenase (12/15-LOX) is induced in beta-cells and ma

39 ither 90 nM recombinant Sema3A, or the 12/15-lipoxygenase (12/15-LOX) metabolites 12-HETE and 12-HPET

40 g target between species, such as with 12/15-lipoxygenase (12/15-LOX), which contributes to ischemic

41 The 12/15-lipoxygenase (12/15LO) enzyme is widely distributed with

42 traplantar carrageenan are metabolites of 12-lipoxygenases (12-LOX), particularly hepoxilins (HXA(3)

43 Here, we show that 13-lipoxygenase (13-LOX) accomplishes a key role in the des

44 Exploiting a series of 13-lipoxygenase (13-lox) mutants in Arabidopsis (Arabidopsi

45 nhibition, and remarkable inhibition against lipoxygenase (13.07+/-2.73-74.21+/-5.61%) at 100mugml(-1

46 of several proteins is induced including 15-lipoxygenase (15-LO), a lipid-peroxidating enzyme and th

47 us studies have suggested that activating 15-lipoxygenase (15-LOX) is a promising strategy to interve

48 turated phosphatidylethanolamines (PE) by 15-lipoxygenases (15-LO) that normally use free polyunsatur

49 The enzyme 15-lipoxygenase-2 (15-LOX-2) is highly expressed in large a

50 EGCs expressed 15-lipoxygenase-2 and produced high levels of 15-HETE, whic

51 rease, trypsin inhibitor, lipoxygenase-1 and lipoxygenase-3 activities were investigated.

52 complete inactivation of lipoxygenase-1 and lipoxygenase-3, regardless of the moisture contents of t

53 Arachidonate-5-lipoxygenase (5-LO) activity and increased leukotriene B

54 mmatory leukotrienes (LTs) are produced by 5-lipoxygenase (5-LO) aided by 5-LO-activating protein (FL

55 The enzymes 5-lipoxygenase (5-LO) and glycogen synthase kinase (GSK)-3

56 C), but they also suppress the activity of 5-lipoxygenase (5-LO) at clinically feasible concentration

57 y as novel soluble epoxide hydrolase (sEH)/5-lipoxygenase (5-LO) dual inhibitors.

58 nases (COX), and leukotrienes, produced by 5-lipoxygenase (5-LO) have been implicated in cancer progr

59 5-Lipoxygenase (5-LO) is a protein widely distributed in t

60 prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO) is currently pursued as potential ph

61 The enzyme 5-lipoxygenase (5-LO) is key in the synthesis of leukotrie

62 5-Lipoxygenase (5-LO) is the key enzyme in leukotriene bio

63 Lipid mediators derived from 5-lipoxygenase (5-LO) metabolism can activate both pro- an

64 cysLTs), are lipid mediators formed by the 5-lipoxygenase (5-LO) pathway of arachidonic acid metaboli

65 hough Alox5 expression and the presence of 5-lipoxygenase (5-LO) protein in BMDMs was observed, the a

66 Mice that are deficient for the enzyme 5-lipoxygenase (5-LO), and therefore lack LTs, exhibit a d

67 flammatory mediator produced by the enzyme 5-lipoxygenase (5-LO), is associated with the development

68 ng prostaglandin E2 synthase (mPGES)-1 and 5-lipoxygenase (5-LO), key enzymes linking inflammation wi

69 tant to both airway remodeling [TGF-beta1, 5-lipoxygenase (5-LO)] and airway-hyperresponsiveness (AHR

70 ducts of the biosynthetic crossover of the 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) pathwa

71 Potential pro-inflammatory 5-lipoxygenase (5-LOX) inhibition potential (IC50 0.76-0.9

72 The enzyme 5-lipoxygenase (5-LOX) initiates biosynthesis of the proin

73 oxidized to proinflammatory eicosanoids by 5-lipoxygenase (5-LOX) on the nuclear envelope.

74 inhibitors of the cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) pathways.

75 We reported earlier that arachidonate 5-lipoxygenase (5-Lox) plays an important role in the surv

76 nic acid in a 2-step reaction catalyzed by 5-lipoxygenase (5-LOX) requiring the formation of 5-HPETE

77 pha-demethylase (CYP51 or Erg11) and human 5-lipoxygenase (5-LOX) with improved potency against 5-LOX

78 CNB-001 is a potent inhibitor of 5-lipoxygenase (5-LOX), decreases 5-LOX expression, and in

79 Propofol attenuated the production of 5-lipoxygenase (5-LOX)-related arachidonic acid (AA) deriv

80 eved through intracellular localization of 5-lipoxygenase (5-LOX): nuclear 5-LOX favors the biosynthe

81 We previously reported that the enzyme 5-Lipoxygenase (5LO) acts as a modulator of Abeta peptides

82 Here, we evaluated the role of 5-lipoxygenase (5LO) and its chemotactic metabolite leukot

83 The 5-lipoxygenase (5LO) enzyme is upregulated in Alzheimer di

84 5-Lipoxygenase (5LO) is a key enzyme in leukotriene (LT) b

85 rovide in vitro experimental evidence that 5-Lipoxygenase (5LO) is as an endogenous regulator for GSA

86 5-Lipoxygenase (5LO) is upregulated in Alzheimer's disease

87 tress up-regulates the ALOX5 gene product, 5-lipoxygenase (5LO), herein we investigated its role in m

88 Two members of the 9-lipoxygenase (9-LOX) oxylipin pathway, 9-hydroxyoctadeca

89 9-Lipoxygenases (9-LOXs) initiate fatty acid oxygenation,

90 nal mechanistic studies, we demonstrate that lipoxygenases act cell autonomously within neurons to re

91 Although deletion of the 5-lipoxygenase activating protein (FLAP) did not influence

92 drug discovery program in search of novel 5-lipoxygenase activating protein (FLAP) inhibitors focuse

93 5-lipoxygenase activating protein (FLAP) is abundantly pre

94 ovascular disease, and an inhibitor of the 5-lipoxygenase activating protein (FLAP) is in clinical de

95 5-Lipoxygenase activating protein (FLAP) plays a critical

96 nase (ALOX5) and its partner, arachidonate 5-lipoxygenase-activating protein (ALOX5AP), are involved.

97 of a novel series of oxadiazole-containing 5-lipoxygenase-activating protein (FLAP) inhibitors are de

98 proteins, coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP), can support 5LO

99 GSK2190915, a potent 5-lipoxygenase-activating protein inhibitor, prevents the

100 5-Lipoxygenase-activating protein rescues activity of 5-li

101 serine proteinases, histamine 4-receptor, 5-lipoxygenase-activating protein, 15-lipoxygenase-1, pros

102 cysLT synthesis by MK886, an inhibitor of 5-lipoxygenase-activating protein, reduced the response of

103 e pronounced effect on trypsin inhibitor and lipoxygenase activities of soaked soybeans as compared t

104 Changes in lipids, lipoxygenase activity and fishy odour development in the

105 n AERD may lead to dysregulated control of 5-lipoxygenase activity by PGE(2), whereas adherent platel

106 high throughput technique for comparisons of lipoxygenase activity from various rice varieties.

107 modified FOX assay were studied to determine lipoxygenase activity in rice grain.

108 tions of hydroperoxy fatty acid derived from lipoxygenase activity in the range of 0.1-1.5 muM.

109 rbituric acid reactive substances values and lipoxygenase activity increased throughout 18 days of ic

110 Inhibition of 15-lipoxygenase activity reduced PD1n-3 DPA and augmented i

111 Physical characteristics, lipoxygenase activity, hydroperoxide lyase activity; lin

112 n in the presence of copper ions and inhibit lipoxygenase activity.

113 ylation at a CpG site in the arachidonate 12-lipoxygenase (ALOX12) gene in children having persistent

114 ' analysis, we identified an arachidonate 12-lipoxygenase (ALOX12)-12-hydroxyeicosatetraenoic acid (1

115 peroxidase 4 (GPX4) and arachidonic acid 15-lipoxygenase (ALOX15) are antagonizing enzymes in the me

116 d the potential of targeting arachidonate 15-lipoxygenase (ALOX15) in treating alcoholic liver diseas

117 ith the expression levels of arachidonate 15-lipoxygenase (ALOX15), and SAT1-induced ferroptosis is s

118 with elevated expression of arachidonate 15-lipoxygenase (ALOX15).

119 mined that the gene encoding arachidonate 15-lipoxygenase (Alox15/15-LO) is essential for the surviva

120 Genotype at rs1864414 in the arachidonate 5-lipoxygenase ALOX5 was also associated with decreased ri

121 leukotriene-generating enzyme arachidonate 5-lipoxygenase (Alox5) abrogates neutrophil pro-metastatic

122 om the same pathway, in which arachidonate 5-lipoxygenase (ALOX5) and its partner, arachidonate 5-lip

123 the Sp1-binding motif in the arachidonate 5-lipoxygenase (ALOX5) gene promoter (either 5/5, 5/x, or

124 om the membrane-targeting PLAT (polycystin-1/lipoxygenase/alpha-toxin) domain to the active site via

125 Plant and animal lipoxygenases also contain a 100-150-amino acid N-termin

126 es revealed that betalains interact with the lipoxygenase amino acids involved in substrate binding a

127 Silencing of lipoxygenase pathways (5-lipoxygenase and 12/15-lipoxygenase), which are importan

128 Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B4 production.

129 tinociceptive effect whereas inhibitors of 5-lipoxygenase and cyclooxygenase augmented the DOR antino

130 otential therapeutic benefits of combining 5-lipoxygenase and cyclooxygenase inhibitors for maximal p

131 olites and enzyme transcripts involving both lipoxygenase and cyclooxygenase pathways are increased i

132 Possibly targeting specific lipoxygenase and cyclooxygenase pathways that are activa

133 nzymes involved in the biochemical response (lipoxygenase and cyclooxygenase).

134 H2O2; and was able to inhibit phospholipase, lipoxygenase and cyclooxygenase, three pro-inflammatory

135 Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of

136 es (>1.5-fold expression) in arachidonate 15-lipoxygenase and gamma-glutamyltransferase transcripts w

137 am cell differentiation markers including 15-lipoxygenase and lectin-type oxidized LDL receptor-1 bot

138 3 and the leukotriene-synthesizing enzymes 5-lipoxygenase and leukotriene-C4-synthase.

139 he pro-inflammatory enzymes (ciclooxygenase, lipoxygenase and phospholipase A2).

140 bitory activity of pro-inflammatory enzymes (lipoxygenase and phospholipase) was described.

141 5-lipoxygenase-1 (h-15-LOX-1) is a mammalian lipoxygenase and plays an important role in several infl

142 emoval of phospholipids, and inactivation of lipoxygenase and trypsin inhibitors, as compared to isop

143 hanol was the most effective in inactivating lipoxygenase and trypsin inhibitors, retarding lipid oxi

144 e differential increases in oxylipin-pathway lipoxygenases and auxin-responsive transcript levels in

145 t 12-LOX, excellent selectivity over related lipoxygenases and cyclooxygenases, and possess favorable

146 xisting PH and resulted in downregulation of lipoxygenases and insulin-like growth factor-1 receptor.

147 use inhibitors of 12-lipoxygenase as well as lipoxygenases and PLA(2) largely blocked the DOR- or AA-

148 t, yet iconic C-H activation enzyme classes, lipoxygenases and prokaryotic alcohol dehydrogenases.

149 the role of the intracellular polycystin-1, lipoxygenase, and alpha-toxin (PLAT) signature domain of

150 erived from the COX-2, cytochrome P450, 5/15-lipoxygenase, and non-enzymatic oxidative pathways were

151 acetylcholinesterase, butyrylcholinesterase, lipoxygenase, and tyrosinase; the enzymes linked to neur

152 tients had a lower level of expression of 12-lipoxygenase ( approximately 30%) and reduced MaR1 (LAP

153 ing AMPK abolished cellular production of 15-lipoxygenase arachidonic acid metabolites in IL-4-stimul

154 They found that lipoxygenases are like Transformer toys, being converted

155 This study establishes inhibition of 12/15-lipoxygenase as a viable strategy for first-line stroke

156 aptic transmission, because inhibitors of 12-lipoxygenase as well as lipoxygenases and PLA(2) largely

157 thanolamine-specific phospholipase D, and 12-lipoxygenase, as well as type I metabotropic glutamate r

158 macological blockade of either iPLA2gamma or lipoxygenases attenuated mPTP opening in failing hearts.

159 e developed for the cyclooxygenase (COX) and lipoxygenase branches of arachidonic acid metabolism, an

160 -mediated expression of three defense genes, lipoxygenase, catalase 3 and polygalacturonase-inhibitor

161 13-Lipoxygenases catalyze the first step of lipid oxidation

162 requisite for life on dry land, requires the lipoxygenase-catalyzed oxidation of the essential fatty

163 eased in the ischemic mouse brain, and 12/15-lipoxygenase colocalized with a marker for oxidized lipi

164 ant implications for rapid screening for low-lipoxygenase containing rice cultivars in rice breeding

165 ated serum LTB4 and synovial expression of 5-lipoxygenase correlated with increased disease severity

166 arachidonic acid (AA) metabolic pathways of lipoxygenase, cyclooxygenase, and epoxygenase, 12-lipoxy

167 5-Lipoxygenase-deficient (5-LOX(-/-)) mice, which display

168 xpression is partially reduced in infected 5-lipoxygenase-deficient [knockout (KO)] mice.

169 Analysis of 13-lipoxygenase-deficient mutant lines showed that only one

170 LI and isolated monocytes produced RvD2 in a lipoxygenase-dependent manner.

171 ce by repressing an interleukin-1- and 12/15-lipoxygenase-dependent neutrophil recruitment cascade th

172 malaxation levels hindered the formation of lipoxygenase derived volatiles (hexanal, 1-hexanol, (Z)-

173 Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dua

174 ants to release volatile compounds comprised lipoxygenase-derived green leaf volatiles and a number o

175 ulant phospholipid surface enriched in 12/15-lipoxygenase-derived hydroxyeicosatetraenoic acid-phosph

176 ouse DRG neurons lacking expression of 12/15-lipoxygenase display protection of axons in this context

177 fluence pro-inflammatory, cyclooxygenase and lipoxygenase eicosanoid products.

178 showed previously that deletion of the 12/15-lipoxygenase enzyme (12/15-LO, Alox15 gene) in NOD mice

179 Human genetics have implicated the 5-lipoxygenase enzyme in the pathogenesis of cardiovascula

180 infection model of GAS in mice lacking the 5-lipoxygenase enzyme to determine the role of endogenous

181 in configuration is examined for the soybean lipoxygenase enzyme.

182 Lipoxygenase enzymes initiate diverse signaling pathways

183 a-alkynyl arachidonic acid were reacted with lipoxygenase enzymes that introduce oxygen at different

184 2 (PHKG2) regulation of iron availability to lipoxygenase enzymes, which in turn drive ferroptosis th

185 are the substrates for lipid peroxidation by lipoxygenase enzymes.

186 s, including metabolites of cyclooxygenases, lipoxygenases, epoxygenases, and other sources.

187 utathione peroxidase 4P< 0.01] and increased lipoxygenase expression (arachidonate 12-lipoxygenaseP<

188 ity or other TRPV1 affecting enzymes such as lipoxygenase, extracellular signal-regulated kinases-1/2

189 lipoxygenase (12-LOX), a member of a nonheme lipoxygenase family of dioxygenases.

190 Recently we cloned two catalase-lipoxygenase fusion protein genes (a and b) from the cor

191 In corals a catalase-lipoxygenase fusion protein transforms arachidonic acid

192 A promoter polymorphism in the 5-lipoxygenase gene affects gene expression and response t

193 lipoxygenation of DHA by human macrophage 12-lipoxygenase (hm12-LOX) gave 14-hydro(peroxy)-docosahexa

194 ntagonists of the type 1 cysLT receptor or 5-lipoxygenase, implying that bronchoconstriction and MC a

195 oleic acid co-oxidation initiated by soybean lipoxygenase in a micelle system.

196 rom 2 groups of enzymes, cyclooxygenases and lipoxygenases, inhibit [and the omega-6 (n-6) LC-PUFA me

197 on (27%), NO production (20%), ROS (32%) and lipoxygenase inhibition (IC50=31.24muM) compared to FS.

198 The IC50 value for lipoxygenase inhibition was almost twice as low after el

199 CO increased phagocytosis was blocked by 15-lipoxygenase inhibition, and SPM stimulated phagocytosis

200 ed using LPS treated RAW 264.7 cell line and lipoxygenase inhibition.

201 ction observed in various settings following lipoxygenase inhibitor treatment.

202 that were abrogated by anti-PlGF Ab or the 5-lipoxygenase inhibitor zileuton.

203 Multiple structurally distinct lipoxygenase inhibitors as well as mouse DRG neurons lac

204 viorally in rats in vivo, NRM infusion of 12-lipoxygenase inhibitors significantly reduced DOR-induce

205 droxyl radicals, and most of them are potent lipoxygenase inhibitors.

206 We therefore determined the nature of the lipoxygenase interaction with the polar-end of a paramag

207 Wheat lipoxygenase is very weakly active compared to the other

208 Oxidation of the linoleate moiety by lipoxygenases is proposed to facilitate enzymatic cleava

209 um-independent phospholipase A2, 12/15 and 5-lipoxygenase) is expressed in mouse submandibular glands

210 Phospholipase A2/5-lipoxygenase/leukotriene-B4 (PLA2/5-LOX/LTB4) axis is an

211 eonatally sensitized mice showed increased 5-lipoxygenase levels, whereas adult mice expressed more g

212 P failed to decrease the parasitic load in 5-lipoxygenase (LO)-deficient macrophages.

213 -2, we co-expressed in human macrophages a 5-lipoxygenase (LOX) 3'UTR-luciferase reporter vector toge

214 ity to scavenge free radicals and to inhibit lipoxygenase (LOX) activity.

215 ies to scavenge free radicals and to inhibit lipoxygenase (LOX) activity.

216 rane-bound arachidonic acid, stimulating the lipoxygenase (LOX) and COX pathways also amplified by MY

217 n enzymes including cyclooxygenase (COX) and lipoxygenase (LOX) has revealed far lower values.

218 ization of the key SPM biosynthetic enzyme 5-lipoxygenase (LOX) in vascular cells.

219 ium-labeled (d(5))-DHA that was blocked with lipoxygenase (LOX) inhibitor.

220 Lipoxygenase (Lox) mediated oxidation of polyunsaturated

221 observed significant increases in spinal 12-lipoxygenase (LOX) metabolites, in particular, hepoxilin

222 In Arabidopsis, NAE18:2 may be oxidized by lipoxygenase (LOX) or hydrolyzed by fatty acid amide hyd

223 ra virgin olive oil (EVOO) aroma through the lipoxygenase (LOX) pathway.

224 ther fatty acid amide hydrolase (FAAH) or by lipoxygenase (LOX) to low levels during seedling establi

225 synthesized across the cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP450) pathway

226 he first enzyme of the oxylipin pathway, the lipoxygenase (LOX), leading to a faster accumulation of

227 gnals derived from a single Zea mays (maize) lipoxygenase (LOX), ZmLOX10, are critical for both direc

228 Lipoxygenase (LOX)-catalysed degradation of polyunsatura

229 Lipoxygenases (LOX) are non-heme metal enzymes, which ox

230 Lipoxygenases (LOX) play critical roles in mammalian bio

231 oxidation under basal conditions, while a 13-lipoxygenase (LOX2) and free radical-catalyzed lipid oxi

232 nt lines showed that only one of the four 13-lipoxygenases, LOX6, is responsible and essential for st

233 A novel inhibitor of 12/15-lipoxygenase, LOXBlock-1, protected neuronal HT22 cells

234 he increased expression of genes encoding 13-lipoxygenases (LOXs) and phospholipase A-Igamma3 (At1g51

235 Human lipoxygenases (LOXs) are a family of iron-containing enz

236 Lipoxygenases (LOXs) are a key part of several signaling

237 12/15-Lipoxygenases (LOXs) in monocytes and macrophages genera

238 ling elicits anti-inflammatory responses, 15-lipoxygenase may either support or inhibit inflammatory

239 e pathways, augmenting leukotriene and other lipoxygenase mediator synthesis.

240 Here, we determined that 12/15-lipoxygenase-meditated (12/15-LO-mediated) enzymatic lip

241 ted gene expression data demonstrated that 5-lipoxygenase metabolites correlated with the pathogenic

242 as well as increased concentration of the 12-lipoxygenase metabolites hepoxilin A(3) and 12-hydroxyei

243 results suggest that the concentrations of 5-lipoxygenase metabolites of arachidonic acid, 5-hydroxye

244 Cyclooxygenase and lipoxygenase metabolites prostaglandin E2 (vasodilator)

245 ogenic phase of the infection, whereas 12/15-lipoxygenase metabolites were associated with the resolu

246 s revealed increased arachidonic acid and 12-lipoxygenase metabolites.

247 ase-activating protein rescues activity of 5-lipoxygenase mutations that delay nuclear membrane assoc

248 Retinal ganglion cell axons from 12/15-lipoxygenase-null mice were similarly protected from deg

249 y was ineffective, whereas blocking either 5-lipoxygenase of the lipoxygenase pathway or the cyclooxy

250 ygenase, cyclooxygenase, and epoxygenase, 12-lipoxygenase of the lipoxygenase pathway primarily media

251 ALOX15 (12/15-lipoxygenase) orthologs have been implicated in maturati

252 The human 12/15-lipoxygenase orthologue, ALOX12, is expressed in cavitar

253 ssociated proteins, resveratrol synthase, 9s-lipoxygenase, pathogenesis-related proteins were identif

254 detailed picture of volatile products of the lipoxygenase pathway (mainly C6-aldehydes) and of glucos

255 of proinflammatory lipid mediators of the 5-lipoxygenase pathway are significantly higher in MIAC th

256 These findings suggest the PLA(2)-AA-12-lipoxygenase pathway as a primary signaling cascade for

257 hereas blocking either 5-lipoxygenase of the lipoxygenase pathway or the cyclooxygenase pathway enhan

258 ase, and epoxygenase, 12-lipoxygenase of the lipoxygenase pathway primarily mediated DOR inhibition o

259 st cancer cells produce metabolites of the 5-lipoxygenase pathway such as leukotriene B4 to activate

260 rom polyunsaturated fatty acids, through the lipoxygenase pathway, in different proportion according

261 aled a dramatic increase in epoxygenase- and lipoxygenase-pathway-derived lipid mediators in spontane

262 Silencing of lipoxygenase pathways (5-lipoxygenase and 12/15-lipoxyge

263 ose that PPARalpha in B cells and/or tumor 5-lipoxygenase pathways represents new targets for pharmac

264 bition was able to shunt metabolism of AA to lipoxygenase pathways, augmenting leukotriene and other

265 ted through the impact on cyclooxygenase and lipoxygenase pathways.

266 tored eicosanoids in cyclooxygenase-1 and 12-lipoxygenase pathways.

267 series of endogenous plant enzymes, such as lipoxygenases, peroxidases and glycosidases, including m

268 in A(3), including phospholipase A(2) and 12-lipoxygenase, potently interfere with P. aeruginosa-indu

269 ein b, establishing its role in cleaving the lipoxygenase product 8R-hydroperoxy-eicosatetraenoic aci

270 The 12-lipoxygenase product hepoxilin A3 mediates the migration

271 ,14-eicosatetraenoic acid (5-oxo-ETE) is a 5-lipoxygenase product that acts via the selective OXE rec

272 ,14-eicosatetraenoic acid (5-oxo-ETE) is a 5-lipoxygenase product that is a potent granulocyte chemoa

273 rall capacity of whole blood to synthesize 5-lipoxygenase products; these genotype-related changes in

274 putum supernatant concentrations of selected lipoxygenases products: 5-,12-,15-hydroxyeicosatetraenoi

275 Lipoxygenases retain their catalytic ability upon immobi

276 nst the LOX paralogs, platelet-type 12-human lipoxygenase, reticulocyte 15-human lipoxygenase type-1,

277 ange complex to detect low concentrations of lipoxygenase rice grain products.

278 The enzyme soybean lipoxygenase (SLO) has served as a prototype for hydroge

279 pical nonadiabatic tunneling system, soybean lipoxygenase (SLO), it has remained unclear whether the

280 ve kinetic isotope effects (KIE) for soybean lipoxygenase (sLOX) oxygenation of linoleic acid (LA, 18

281 een determined at pH 6.5 for three different lipoxygenases, soybean, horse bean and wheat and compare

282 injections of 15-HETE or an inhibitor of 15-lipoxygenase (the enzyme that produces 15-HETE); colons

283 In lipoxygenases, the topologically conserved C-terminal do

284 ahexaenoic acid was converted by platelet 12-lipoxygenase to 13S,14S-epoxy-maresin, which was further

285 blockage of a key SPM biosynthesis enzyme 15-lipoxygenase type 1.

286 12-human lipoxygenase, reticulocyte 15-human lipoxygenase type-1, and epithelial 15-human lipoxygenas

287 lipoxygenase type-1, and epithelial 15-human lipoxygenase type-2, and >100-fold selectivity against o

288 In summary, we found that PUFA oxidation by lipoxygenases via a PHKG2-dependent iron pool is necessa

289 Finally, 5-lipoxygenase was discovered as an additional molecular t

290 Here we show that the activity of 12/15-lipoxygenase was increased in the ischemic mouse brain,

291 reaction catalysed by soybean and horse bean lipoxygenases was observed with 2,6-di-tert-butyl-4-meth

292 Animals lacking 5-lipoxygenase were significantly more vulnerable to intra

293 eta), and 12-HETE synthesis (arachidonate 12-lipoxygenase) were significantly up-regulated.

294 oxygenase pathways (5-lipoxygenase and 12/15-lipoxygenase), which are important enzymes for specializ

295 lished through immobilization of the enzyme, lipoxygenase, which catalyzes the production of redox ac

296 SHV miRNA cluster probably targets enzyme 15-lipoxygenase, which is involved in lipoxin A4 synthesis.

297 duced by inhibitors of cyclooxygenase and 12-lipoxygenase, which metabolize arachidonic acid to gener

298 ein conformation upon interaction of soybean lipoxygenase with a fatty acid surrogate, oleyl sulfate

299 gion (Gly(332), Leu(336), and Phe(337)) of a lipoxygenase with catalytic manganese (13R-MnLOX).

300 resulted as the most potent inactivators of lipoxygenase, with IC50 values of 41.4 and 40.1muM, resp