ライフサイエンスコーパス: listeriolysin

1 ent a pH-sensor (as in similar toxins, e.g., Listeriolysin).

2 The hemolysin, listeriolysin 0 (LLO), produced by Listeria monocytogene

3 micked by Listeria monocytogenes and soluble listeriolysin, a pore-forming hemolysin derived from it,

4 he host response is markedly attenuated in a listeriolysin-deficient (Deltahly) mutant despite its ab

5 trations that inhibited hemolysis by ALO and listeriolysin did not prevent these toxins from binding

6 ene hly (encoding the pore-forming cytolysin listeriolysin) is under negative regulation by readily m

7 I molecules present three nonamer peptides, listeriolysin (LLO) 91-99, p60 217-225, and p60 449-457,

8 ; however, WTLM and L. monocytogenes lacking listeriolysin O (DeltahlyLM) induce similar levels of cy

9 anomer peptides amino acids (aa) 91 to 99 of listeriolysin O (LLO 91-99) and aa 217 to 225 of the p60

10 by the cholesterol-dependent cytolysin (CDC) listeriolysin O (LLO) acts within the infected cell, (ii

11 ast two critical secreted virulence factors: listeriolysin O (LLO) and a broad-specificity phospholip

12 Listeriolysin O (LLO) and a phosphatidylinositol-specifi

13 Listeriolysin O (LLO) and ActA are essential virulence d

14 Listeria monocytogenes requires listeriolysin O (LLO) and ActA, the products of hly and

15 tron microscopy that LM expressing truncated listeriolysin O (LLO) and amino acid fragments 311 to 66

16 on the expression of two secreted proteins: listeriolysin O (LLO) and phosphatidylcholine-preferring

17 virulence factors of Listeria monocytogenes, listeriolysin O (LLO) and phosphatidylinositol-specific

18 91 to 99 (aa91-99) immunodominant peptide of listeriolysin O (LLO) and to the aa217-225 immunodominan

19 n host cells by using the pore-forming toxin listeriolysin O (LLO) and two phospholipase C enzymes.

20 ) that are deficient in the virulence factor listeriolysin O (LLO) are highly attenuated and are thou

21 the Listeria monocytogenes virulence factor listeriolysin O (LLO) enhances the immunogenicity and an

22 Listeriolysin O (LLO) is a cholesterol-dependent cytolys

23 The pore-forming toxin listeriolysin O (LLO) is a major virulence factor implic

24 The pore-forming toxin listeriolysin O (LLO) is a major virulence factor secret

25 Listeriolysin O (LLO) is a pore-forming cytolysin that m

26 The Listeria monocytogenes protein listeriolysin O (LLO) is a pore-forming protein essentia

27 Listeriolysin O (LLO) is a pore-forming toxin of the cho

28 Listeriolysin O (LLO) is a pore-forming toxin that media

29 Listeriolysin O (LLO) is a secreted pore-forming protein

30 Listeriolysin O (LLO) is a secreted pore-forming toxin o

31 ved cells tested, the pore-forming cytolysin listeriolysin O (LLO) is absolutely required for lysis o

32 Listeriolysin O (LLO) is an essential determinant of pat

33 Listeriolysin O (LLO) is an essential virulence factor f

34 ould be attributed partially to insufficient listeriolysin O (LLO) production, indicating a requireme

35 mediated, and a nonamer CTL epitope from the listeriolysin O (LLO) protein has been identified in BAL

36 ,258) fused to the first 441 residues of the listeriolysin O (LLO) protein.

37 ytogenes and its secreted pore-forming toxin listeriolysin O (LLO) to identify key signaling events a

38 uction of the hly-encoded secreted hemolysin listeriolysin O (LLO) was also found to significantly en

39 Listeriolysin O (LLO), a cholesterol-binding cytolysin o

40 Among these is listeriolysin O (LLO), a pore-forming hemolysin that is

41 We prove in this study that listeriolysin O (LLO), a pore-forming molecule and a maj

42 e with an Escherichia coli strain expressing listeriolysin O (LLO), a pore-forming toxin from L. mono

43 which is dependent on the pore-forming toxin listeriolysin O (LLO), followed by rupture.

44 the Listeria monocytogenes virulence factor, listeriolysin O (LLO), induces an immune response that c

45 of L. monocytogenes, the pore-forming toxin listeriolysin O (LLO), is sufficient to induce L. monocy

46 ore-forming cholesterol-dependent cytolysin, listeriolysin O (LLO), mediates bacterial escape from ve

47 gen which secretes a pore-forming cytolysin, listeriolysin O (LLO), necessary for intracellular growt

48 Here, the pore-forming protein listeriolysin O (LLO), secreted by Listeria monocytogene

49 We report here that the CDC listeriolysin O (LLO), secreted by the facultative intra

50 e of macrophages from liposomes that contain listeriolysin O (LLO), the hemolytic protein of Listeria

51 ment of mice with a neutralizing mAb against listeriolysin O (LLO), the pore-forming toxin of Listeri

52 r PrfA, including the pore-forming cytolysin listeriolysin O (LLO), two phospholipases C (PlcA and Pl

53 rane is initiated by the secreted haemolysin listeriolysin O (LLO), which is essential for vacuolar e

54 amino acid 91 to 99 (aa91-99) sequence from listeriolysin O (LLO).

55 tion through the secreted pore-forming toxin listeriolysin O (LLO).

56 intracellular life cycle that is mediated by listeriolysin O (LLO).

57 lls via the action of the pore-forming toxin listeriolysin O (LLO).

58 osol by secreting the pore-forming cytolysin listeriolysin O (LLO).

59 om the phagosome using a secreted cytolysin, listeriolysin O (LLO).

60 otein with a truncated, nonhemolytic form of listeriolysin O (LLO).

61 actions of the pore-forming virulence factor listeriolysin O (LLO).

62 diated by the bacterial pore-forming protein listeriolysin O (LLO).

63 as a fusion protein joined to a nonhemolytic listeriolysin O (LLO).

64 (PI-PLC), a broad-range phospholipase C, and listeriolysin O (LLO).

65 T cells is the secreted bacterial hemolysin, listeriolysin O (LLO).

66 pecific for the L. mono cytogenes-encoded Ag listeriolysin O (LLO).

67 T cell populations specific for listeriolysin O (LLO)91-99, the immunodominant epitope r

68 CD8+ T cells specific for the immunodominant listeriolysin O (LLO91-99) epitope provide immunity to L

69 Mice immunized with listeriolysin O 91-99-coated BMDCs are protected against

70 that pH-sensitive liposomes containing both listeriolysin O and gelonin were more effective than con

71 pression of the phagosome-lysing pore former listeriolysin O and on type I IFN receptor signaling.

72 atural L. monocytogenes-derived soluble Ags (listeriolysin O and p60) revealed that tethering of thes

73 HD-5 was very effective against listeriolysin O but less effective against the other tox

74 In in vitro experiments, co-encapsulated listeriolysin O enabled liposomal gelonin-mediated B16 c

75 lipid biosynthesis, enhanced the toxicity of listeriolysin O expressed in the host cell cytosol, lead

76 smid containing the invasin gene Inv and the listeriolysin O gene HlyA, which encode two bacterial fa

77 irement for the essential pore-forming toxin listeriolysin O in mediating escape from phagocytic vacu

78 cytoplasmic entry of Listeria facilitated by listeriolysin O is an essential feature not only of the

79 The pore-forming protein listeriolysin O mediates escape from host vacuoles and u

80 -2Kb-restricted CD8 T cells specific for the listeriolysin O molecule mediate significant immunity in

81 cua and a mutant strain of L. monocytogenes (listeriolysin O negative), which do not enter the cytoso

82 provided only pore-forming activity because listeriolysin O of Listeria monocytogenes could substitu

83 Nonetheless it is possible that listeriolysin O potentiates the effect(s) of an other mo

84 These data suggest that listeriolysin O production by infecting L. monocytogenes

85 single LFn fusion protein containing NP and listeriolysin O protein epitopes in tandem mount a CTL r

86 r30 linked in frame to the L. monocytogenes listeriolysin O signal sequence and driven by the hly pr

87 train was constructed in which expression of listeriolysin O was placed under the inducible control o

88 accounted for by a decrease in LM-specific (listeriolysin O(91-99) tetramer(+)) effector CD8(+) T ce

89 aracterize changes in SUMOylation induced by listeriolysin O, a bacterial toxin that impairs the host

90 Immunization with listeriolysin O, a potent inducer of cell death, also pr

91 Cellular immune responses specific for listeriolysin O, a secreted bacterial protein required f

92 ree of these exotoxins: anthrolysin O (ALO), listeriolysin O, and pneumolysin.

93 xpression of other critical virulence genes (Listeriolysin O, and two phospholipases plcA and plcB) i

94 when the matrix protein was coexpressed with listeriolysin O, but not when expressed alone.

95 ndent cytolysin (CDC) family, which includes listeriolysin O, perfringolysin O, and streptolysin O.

96 specific cells were similar to those against listeriolysin O, the immunodominant Ag of L. monocytogen

97 n with WT, heat-killed, or mutant Lm lacking listeriolysin O, the pore-forming hemolysin that promote

98 apsulated inside pH-sensitive liposomes with listeriolysin O, the pore-forming protein that mediates

99 production of the critical virulence factor, listeriolysin O, was compromised by FA modulation, sugge

100 Infection with listeriolysin O-expressing, cytosolic Bacillus subtilis

101 on uninfected cells and may be triggered by listeriolysin O-mediated activation of host response mec

102 nocytogenes and induced a subset of effector listeriolysin O-specific CD11a(+) CD8(+) T cells in sple

103 However, significant levels of Gag and listeriolysin O-specific CD8(+) T cells were observed in

104 se animals is characterized by activation of listeriolysin O-specific CD8(+) T cells, which are capab

105 with L. monocytogenes dal dat/pRRR generated listeriolysin O-specific effector and memory CD8(+) T ce

106 erum samples were tested for IgG antibody to listeriolysin O.

107 rotein Ags: hen egg white lysozyme, OVA, and listeriolysin O.

108 s not limited to CD8+ T cells that recognize listeriolysin O.

109 ecame ill had elevated levels of antibody to listeriolysin O.

110 partially dependent on the virulence factor listeriolysin O; however, WTLM and L. monocytogenes lack

111 l liver kinase-1) to the microbial adjuvant, listeriolysin-O, and used Lm to deliver the Ags and elic

112 Lm-listeriolysin-O-fetal liver kinase-1 was able to eradica

113 Here, we demonstrate that Listeriolysin S (LLS), a virulence factor only present i