ライフサイエンスコーパス: listeriolysin O

1 rotein Ags: hen egg white lysozyme, OVA, and listeriolysin O.

2 s not limited to CD8+ T cells that recognize listeriolysin O.

3 ecame ill had elevated levels of antibody to listeriolysin O.

4 erum samples were tested for IgG antibody to listeriolysin O.

5 Mice immunized with listeriolysin O 91-99-coated BMDCs are protected against

6 accounted for by a decrease in LM-specific (listeriolysin O(91-99) tetramer(+)) effector CD8(+) T ce

7 aracterize changes in SUMOylation induced by listeriolysin O, a bacterial toxin that impairs the host

8 Immunization with listeriolysin O, a potent inducer of cell death, also pr

9 Cellular immune responses specific for listeriolysin O, a secreted bacterial protein required f

10 that pH-sensitive liposomes containing both listeriolysin O and gelonin were more effective than con

11 pression of the phagosome-lysing pore former listeriolysin O and on type I IFN receptor signaling.

12 atural L. monocytogenes-derived soluble Ags (listeriolysin O and p60) revealed that tethering of thes

13 ree of these exotoxins: anthrolysin O (ALO), listeriolysin O, and pneumolysin.

14 xpression of other critical virulence genes (Listeriolysin O, and two phospholipases plcA and plcB) i

15 l liver kinase-1) to the microbial adjuvant, listeriolysin-O, and used Lm to deliver the Ags and elic

16 HD-5 was very effective against listeriolysin O but less effective against the other tox

17 when the matrix protein was coexpressed with listeriolysin O, but not when expressed alone.

18 ; however, WTLM and L. monocytogenes lacking listeriolysin O (DeltahlyLM) induce similar levels of cy

19 In in vitro experiments, co-encapsulated listeriolysin O enabled liposomal gelonin-mediated B16 c

20 lipid biosynthesis, enhanced the toxicity of listeriolysin O expressed in the host cell cytosol, lead

21 Infection with listeriolysin O-expressing, cytosolic Bacillus subtilis

22 Lm-listeriolysin-O-fetal liver kinase-1 was able to eradica

23 smid containing the invasin gene Inv and the listeriolysin O gene HlyA, which encode two bacterial fa

24 partially dependent on the virulence factor listeriolysin O; however, WTLM and L. monocytogenes lack

25 irement for the essential pore-forming toxin listeriolysin O in mediating escape from phagocytic vacu

26 cytoplasmic entry of Listeria facilitated by listeriolysin O is an essential feature not only of the

27 anomer peptides amino acids (aa) 91 to 99 of listeriolysin O (LLO 91-99) and aa 217 to 225 of the p60

28 by the cholesterol-dependent cytolysin (CDC) listeriolysin O (LLO) acts within the infected cell, (ii

29 ast two critical secreted virulence factors: listeriolysin O (LLO) and a broad-specificity phospholip

30 Listeriolysin O (LLO) and a phosphatidylinositol-specifi

31 Listeriolysin O (LLO) and ActA are essential virulence d

32 Listeria monocytogenes requires listeriolysin O (LLO) and ActA, the products of hly and

33 tron microscopy that LM expressing truncated listeriolysin O (LLO) and amino acid fragments 311 to 66

34 on the expression of two secreted proteins: listeriolysin O (LLO) and phosphatidylcholine-preferring

35 virulence factors of Listeria monocytogenes, listeriolysin O (LLO) and phosphatidylinositol-specific

36 91 to 99 (aa91-99) immunodominant peptide of listeriolysin O (LLO) and to the aa217-225 immunodominan

37 n host cells by using the pore-forming toxin listeriolysin O (LLO) and two phospholipase C enzymes.

38 ) that are deficient in the virulence factor listeriolysin O (LLO) are highly attenuated and are thou

39 the Listeria monocytogenes virulence factor listeriolysin O (LLO) enhances the immunogenicity and an

40 Listeriolysin O (LLO) is a cholesterol-dependent cytolys

41 The pore-forming toxin listeriolysin O (LLO) is a major virulence factor implic

42 The pore-forming toxin listeriolysin O (LLO) is a major virulence factor secret

43 Listeriolysin O (LLO) is a pore-forming cytolysin that m

44 The Listeria monocytogenes protein listeriolysin O (LLO) is a pore-forming protein essentia

45 Listeriolysin O (LLO) is a pore-forming toxin of the cho

46 Listeriolysin O (LLO) is a pore-forming toxin that media

47 Listeriolysin O (LLO) is a secreted pore-forming protein

48 Listeriolysin O (LLO) is a secreted pore-forming toxin o

49 ved cells tested, the pore-forming cytolysin listeriolysin O (LLO) is absolutely required for lysis o

50 Listeriolysin O (LLO) is an essential determinant of pat

51 Listeriolysin O (LLO) is an essential virulence factor f

52 ould be attributed partially to insufficient listeriolysin O (LLO) production, indicating a requireme

53 mediated, and a nonamer CTL epitope from the listeriolysin O (LLO) protein has been identified in BAL

54 ,258) fused to the first 441 residues of the listeriolysin O (LLO) protein.

55 ytogenes and its secreted pore-forming toxin listeriolysin O (LLO) to identify key signaling events a

56 uction of the hly-encoded secreted hemolysin listeriolysin O (LLO) was also found to significantly en

57 Listeriolysin O (LLO), a cholesterol-binding cytolysin o

58 Among these is listeriolysin O (LLO), a pore-forming hemolysin that is

59 We prove in this study that listeriolysin O (LLO), a pore-forming molecule and a maj

60 e with an Escherichia coli strain expressing listeriolysin O (LLO), a pore-forming toxin from L. mono

61 which is dependent on the pore-forming toxin listeriolysin O (LLO), followed by rupture.

62 the Listeria monocytogenes virulence factor, listeriolysin O (LLO), induces an immune response that c

63 of L. monocytogenes, the pore-forming toxin listeriolysin O (LLO), is sufficient to induce L. monocy

64 ore-forming cholesterol-dependent cytolysin, listeriolysin O (LLO), mediates bacterial escape from ve

65 gen which secretes a pore-forming cytolysin, listeriolysin O (LLO), necessary for intracellular growt

66 Here, the pore-forming protein listeriolysin O (LLO), secreted by Listeria monocytogene

67 We report here that the CDC listeriolysin O (LLO), secreted by the facultative intra

68 e of macrophages from liposomes that contain listeriolysin O (LLO), the hemolytic protein of Listeria

69 ment of mice with a neutralizing mAb against listeriolysin O (LLO), the pore-forming toxin of Listeri

70 r PrfA, including the pore-forming cytolysin listeriolysin O (LLO), two phospholipases C (PlcA and Pl

71 rane is initiated by the secreted haemolysin listeriolysin O (LLO), which is essential for vacuolar e

72 amino acid 91 to 99 (aa91-99) sequence from listeriolysin O (LLO).

73 tion through the secreted pore-forming toxin listeriolysin O (LLO).

74 intracellular life cycle that is mediated by listeriolysin O (LLO).

75 lls via the action of the pore-forming toxin listeriolysin O (LLO).

76 osol by secreting the pore-forming cytolysin listeriolysin O (LLO).

77 om the phagosome using a secreted cytolysin, listeriolysin O (LLO).

78 otein with a truncated, nonhemolytic form of listeriolysin O (LLO).

79 actions of the pore-forming virulence factor listeriolysin O (LLO).

80 diated by the bacterial pore-forming protein listeriolysin O (LLO).

81 as a fusion protein joined to a nonhemolytic listeriolysin O (LLO).

82 (PI-PLC), a broad-range phospholipase C, and listeriolysin O (LLO).

83 T cells is the secreted bacterial hemolysin, listeriolysin O (LLO).

84 pecific for the L. mono cytogenes-encoded Ag listeriolysin O (LLO).

85 T cell populations specific for listeriolysin O (LLO)91-99, the immunodominant epitope r

86 CD8+ T cells specific for the immunodominant listeriolysin O (LLO91-99) epitope provide immunity to L

87 on uninfected cells and may be triggered by listeriolysin O-mediated activation of host response mec

88 The pore-forming protein listeriolysin O mediates escape from host vacuoles and u

89 -2Kb-restricted CD8 T cells specific for the listeriolysin O molecule mediate significant immunity in

90 cua and a mutant strain of L. monocytogenes (listeriolysin O negative), which do not enter the cytoso

91 provided only pore-forming activity because listeriolysin O of Listeria monocytogenes could substitu

92 ndent cytolysin (CDC) family, which includes listeriolysin O, perfringolysin O, and streptolysin O.

93 Nonetheless it is possible that listeriolysin O potentiates the effect(s) of an other mo

94 These data suggest that listeriolysin O production by infecting L. monocytogenes

95 single LFn fusion protein containing NP and listeriolysin O protein epitopes in tandem mount a CTL r

96 r30 linked in frame to the L. monocytogenes listeriolysin O signal sequence and driven by the hly pr

97 nocytogenes and induced a subset of effector listeriolysin O-specific CD11a(+) CD8(+) T cells in sple

98 However, significant levels of Gag and listeriolysin O-specific CD8(+) T cells were observed in

99 se animals is characterized by activation of listeriolysin O-specific CD8(+) T cells, which are capab

100 with L. monocytogenes dal dat/pRRR generated listeriolysin O-specific effector and memory CD8(+) T ce

101 specific cells were similar to those against listeriolysin O, the immunodominant Ag of L. monocytogen

102 n with WT, heat-killed, or mutant Lm lacking listeriolysin O, the pore-forming hemolysin that promote

103 apsulated inside pH-sensitive liposomes with listeriolysin O, the pore-forming protein that mediates

104 train was constructed in which expression of listeriolysin O was placed under the inducible control o

105 production of the critical virulence factor, listeriolysin O, was compromised by FA modulation, sugge