ライフサイエンスコーパス: littermate

1 e >/=10-mo-old vs. 0% age-matched Kcne3(+/+) littermates).

2 thy at age 20 weeks compared with their db/m littermates.

3 knock-out mice but preserved in heterozygous littermates.

4 p3L351P Casp1/11-/- mice and Il1b-/- Il18-/- littermates.

5 from Arc-deficient mice and their wild-type littermates.

6 ccular branching similar to those in control littermates.

7 or (A2AR) knockout mice, and their wild-type littermates.

8 ed FOXO1 and compared the results to control littermates.

9 n Fut2(-/-)(low) mice, and no shunting in wt littermates.

10 body weight decrease compared with wild-type littermates.

11 -binding protein (LFABP) than their wildtype littermates.

12 es from Emu-myc mice compared with wild-type littermates.

13 ke (DNM1L) protein-knockout mice or their WT littermates.

14 earing loss as compared with their wild-type littermates.

15 rol, and Cd63(-/-) mice with their wild-type littermates.

16 the area-at-risk in comparison with their WT littermates.

17 al gestational increase seen in Hsd11b2(+/+) littermates.

18 gnificantly better than their wild type (WT) littermates.

19 rotarod test when compared to wild type (WT) littermates.

20 IL-17A expression was evaluated in wild-type littermates.

21 ons compared with asbestos-exposed wild-type littermates.

22 ice compared with their ICER/CREM-sufficient littermates.

23 ng leptin levels compared to their wild-type littermates.

24 tery in CCR9 knockout mice and their CCR9+/+ littermates.

25 used by ovariectomy that occurred in control littermates.

26 ase subunits alpha/beta) gene with wild-type littermates.

27 ocyte survival compared with their wild type littermates.

28 ek-old male tg mice and their wild-type (WT) littermates.

29 icient mice compared to those in Nrp2-intact littermates.

30 elastic) in DA D2R KO mice compared with WT littermates.

31 red with age-matched hyperglycemic ApoE(-/-) littermates.

32 g-Abeta+Tau mice compared with nontransgenic littermates.

33 ficient mice compared with control wild-type littermates.

34 to a level similar to that in non-transgenic littermates.

35 C mouse model of DCM compared with wild-type littermates.

36 halamus compared with that seen in wild-type littermates.

37 ant mice (58%) versus 4 of 43 (9%) wild-type littermates.

38 ment compared with apoe(-/-) cd93-sufficient littermates.

39 her repolarization dispersion than wild-type littermates.

40 n the intestine compared with wild-type (WT) littermates.

41 (-/-) mice than in their SOD1(G85R)-MIF(+/+) littermates.

42 fered between villin-TLR4 and wild-type (WT) littermates.

43 n these mice to match that of wild-type (WT) littermates.

44 ce, which were compared with their wild-type littermates.

45 animals live as long as their non-engrafted littermates.

46 groups, and data were compared to wild-type littermates.

47 transport in cKO mice compared with control littermates.

48 ognitive impairment as compared to wild type littermates.

49 axia-associated mutation and their wild-type littermates.

50 e cytokine levels were low and comparable to littermates.

51 ygous mice were comparable to wild-type (WT) littermates.

52 lls (RGCs) of Tg-TBK1 mice than in wild-type littermates.

53 f ADMA, SDMA and BAIB, compared to wild-type littermates.

54 n Tg hearts compared with its wild type (WT) littermates.

55 ba(-/-) embryos in comparison with wild-type littermates.

56 ceptible to DSS colitis than their wild-type littermates.

57 d C57BL6/129 background) and their wild-type littermates.

58 mice retained more fat than their wild type littermates.

59 rrow into NHD13 mice or their wild-type (WT) littermates.

60 ce, global HCN1 knockouts and their wildtype littermates.

61 the colon of Muc4(-/-) mice compared with WT littermates.

62 plantation sites of p53(d/d) mice and floxed littermates.

63 nfiltration in the lung tissue than their WT littermates.

64 subsequent postnatal development in control littermates.

65 sduced with the EHITSN relative to wild-type littermates.

66 ion rate were obtained in D3R KO mice and WT littermates.

67 ced motivation in D2R-OEdev mice and control littermates.

68 ld-type (WT)] and Actn3(-/-) [knockout (KO)] littermates.

69 NF) but produced no significant change in WT littermates.

70 anning this interval in Tsk2/+ and wild-type littermates.

71 phrin in diabetic mice compared with control littermates.

72 r-hydroxylated compared with their wild-type littermates.

73 ersensitivity, in contrast to wild-type (WT) littermates.

74 after APAP overdose compared to ASMase(+/+) littermates.

75 pletely absent from healthy nontumor-bearing littermates.

76 significantly higher in mutant mice than WT littermates.

77 sion in Bmpr2(+/-) mice but not in wild-type littermates.

78 null (itga1(-/-)) and wild-type (itga1(+/+)) littermates.

79 with a significant rise in BP relative to WT littermates.

80 in SOD1(G86R) muscle compared with wild-type littermates.

81 eration induced by DMM compared with control littermates.

82 l allele in Bmpr2 (Bmpr2(+/-)) and wild-type littermates.

83 LTP, compared to age-matched wild-type (WT) littermates.

84 of Ghsr-null mice than in that of wild-type littermates.

85 on developed AF more frequently than control littermates.

86 to the titers in wild-type and heterozygote littermates.

87 (-/-) mice were smaller than their wild-type littermates.

88 ild-type (Cdc73(+/+) and Cdc73(+/+)/PTH-Cre) littermates.

89 mia, and nephropathy that are present in ZDF littermates.

90 nza viruses of human origin as nontransgenic littermates.

91 eir activity and sleep compared to wild-type littermates.

92 hen compared to the nonmutant il17a knockout littermates.

93 -deficent embryos in comparison with control littermates.

94 that was not different from that in control littermates.

95 ormal and cone ERG(absent) RPGRIP1 (ins/ins) littermates.

96 ared with macrophages from placebo-implanted littermates.

97 henomena decline with age, but are stable in littermates.

98 threonine kinase 1-knockout mice or their WT littermates.

99 nine and urea levels compared with wild type littermates.

100 cing of ATXN2Q127 mice versus wild-type (WT) littermates.

101 nchyme cells, in comparison with Osr2(RFP/+) littermates.

102 at 4 weeks post-IRI compared with wild-type littermates.

103 ch more sensitive to IR than their wild-type littermates.

104 operoxidase activity compared with wild-type littermates.

105 mulation of hepatic BMP compared to chow-fed littermates.

106 and serum in R6/2 mice compared to wild-type littermates.

107 Erk5 (fl/fl) mice compared to wild type (WT) littermates.

108 versican, in Vcan (hdf/+) mice and wild-type littermates.

109 D for 20 weeks as compared to wild-type (WT) littermates (37 +/- 3 versus 48 +/- 2 gm) due to increas

110 sgenic (SIRT2-Tg) mice, and their respective littermates (8 to approximately 12 weeks old).

111 ized Cyp27b1-KO mice compared with wild-type littermates (+898 and +219%).

112 s of RenTgMK mice compared to wild-type (WT) littermates, accompanied with increased expression of EC

113 and glucose tolerance compared with control littermates after 10 weeks of a high-fat diet in male mi

114 ed in Nrp2(-/-) mice compared with wild-type littermates after delayed-type hypersensitivity reaction

115 Wild-type littermates (age matched) served as controls.

116 d less of an impact than in AHR heterozygous littermates, although some protection was seen.

117 rom passive interactions with the mother and littermates and (2) sensory feedback arising from sponta

118 ygous Notch2HCS mice and sex-matched control littermates and analyzed by flow cytometry.

119 e, had lower body weight than wild-type (wt) littermates and gray fur.

120 serum calcium concentrations than wild-type littermates, and Cdc73(+/-) mice also had increased mean

121 -) mice were smaller compared with wild type littermates, and male Pgam5(-/-) mice were born at sub-M

122 ower SGN density compared to their wild-type littermates, and more apoptosis was evident in the mutan

123 omozygous CNP-hEGFR mice versus heterozygous littermates, and neurofibroma number and size increased

124 ermis of Tg animals, compared with wild-type littermates, and we observed no spontaneous tumor format

125 as compared with age-matched non-transgenic littermates, and western blots showed increased lysosoma

126 reased intestinal tumor burden compared with littermate Apc (Min/+) mice.

127 MET currents of heterozygous littermates appear normal.

128 72H (KPC) mice, and their respective healthy littermates as control, and Cd63(-/-) mice with their wi

129 detected between Tg-TBK1 mice and wild-type littermates as they aged (P > 0.05).

130 ollected from pups at week 5 (W5), and their littermates at week 39 (W39).

131 we found that, compared with their wild-type littermates, BAP1(+/-) mice exposed to low-dose asbestos

132 1-conditional knockout (or wild-type control littermate) bone marrow were fed western diet for 8 week

133 icotine dose-response curve compared with WT littermates but that alpha4 KO failed to show nicotine p

134 LEC14A-KO mice compared with that seen in WT littermates, but tumor-bearing CLEC14A-KO mice died soon

135 induced in Fn14(-/-) and Fn14(+/+) wild-type littermates by administering 3% dextran sodium sulfate (

136 ed thicker skin in comparison with wild-type littermates consistent with a hyperproliferative epiderm

137 gained less body weight compared to wildtype littermate control (M-JAK2(+/+)) mice and were protected

138 y remarkably enhanced survival compared with littermate control (WT) B cells.

139 of inflammation were similar between CF and littermate control animals through evaluation of broncho

140 n survival compared with offspring nursed by littermate control dams.

141 eural tubes isolated from E9.0 EpoR-null and littermate control embryos validated our in vitro findin

142 T cell-specific Etv5-deficient and littermate control mice demonstrated that IL-10 producti

143 im-trained transgenic GRK5 and nontransgenic littermate control mice exhibited similar increases in c

144 sed sensitivity to evoked pain compared with littermate control mice expressing normal human hemoglob

145 in Cpt2M(-/-) hearts 2.3-fold compared with littermate control mice fed a ketogenic diet, yet it did

146 lifespan of long-lived Ames dwarf and normal littermate control mice in a genotype and sex-specific m

147 ne was administered in Ts65Dn and normosomic littermate control mice, and produced similar behavioral

148 ed from adult male type 2 diabetic and their littermate control mice.

149 were assessed in Fam13a(-/-) and Fam13a(+/+) littermate control mice.

150 ific LKB1 knock out mice and their wild type littermate control mice.

151 similar liver parasite burden compared with littermate control mice.

152 eceptor rescue compared with vehicle-treated littermate control mice.

153 cell proliferation in CD18(-/-) relative to littermate control PLN, demonstrating that these cells p

154 lated in HDAC4 cKO compared to levels in the littermate controls (0.2-0.44-fold change, n = 4 in 2 se

155 (Tg) mice and of age-matched non-transgenic littermate controls (Ctrl) mice.

156 rmal in both transgenic models compared with littermate controls (n=5).

157 deletion of RGS4 (RGS4(-/-)) and the normal littermate controls (RGS4(+/+)).

158 her bacterial burdens in lungs compared with littermate controls after intrapulmonary pneumococcal in

159 % of contractile function versus 35+/-15% in littermate controls and 28+/-8% in cTnIS200A (n=5).

160 TM cellularity in treated mice compared with littermate controls and indicated that this increase is

161 d much lower than the RVSP values seen in WT littermate controls and mice with pulmonary endothelial

162 the mutant hearts after injury compared with littermate controls and was directly regulated by GATA4.

163 exaggerated glycosuria relative to wild-type littermate controls at comparable blood glucose concentr

164 lls (TF(mye), LysM.Cre(+/-)TF(flox/flox)) to littermate controls during direct (bacterial pneumonia,

165 n in myeloid cells (Syk(My)) versus Syk(f/f) littermate controls in a 24-hour study.

166 a stark reminder of the importance of using littermate controls in all mouse research.

167 d Npr2(+/)(-);Ldlr(-/)(-) mice and wild-type littermate controls to examine the valvular effects of d

168 n the mdr1a (-/-) mouse model of colitis and littermate controls using PICRUSt on 16S rRNA sequencing

169 Mutant tissues and wild-type or heterozygous littermate controls were analyzed by histologic immunost

170 susceptible to tumor growth than were their littermate controls when challenged with the established

171 rance and insulin sensitivity (compared with littermate controls) after eating a high-fat diet.

172 ested decreased cardiac function relative to littermate controls, and alpha1C L-type calcium channel

173 gastrointestinal motility in these mice and littermate controls, and analyzed epithelial cell prolif

174 and expression of c-MYC protein compared to littermate controls, and eventually developed prostatic

175 on to the same extent as their nontransgenic littermate controls, as a result of the excessive activa

176 Compared with nontransgenic littermate controls, monocytes of TLR10 transgenic mice

177 eloid cells) had significantly lower BP than littermate controls, whereas basal BP was unaltered in C

178 ed with age-matched Ctnnb1(L(ex3)/+):PB-Cre4 littermate controls, which only have stabilized beta-cat

179 showed no signs of fibrosis when compared to littermate controls.

180 i2a(-/-)) mice compared with their wild-type littermate controls.

181 els at 3-4 months of age compared to matched littermate controls.

182 ecretion was reduced compared with wild-type littermate controls.

183 ox4 transgenic mice, compared with wild-type littermate controls.

184 in 2+tRNAi(Met) mice compared with wild-type littermate controls.

185 human Gnptab stuttering mutation compared to littermate controls.

186 levated arterial blood pressure, compared to littermate controls.

187 ed HdhQ(150/150) animals relative to matched littermate controls.

188 2 phosphorylation and activity compared with littermate controls.

189 b1(L(ex3)/+):PB-Cre4 and R26hAR(L/+):PB-Cre4 littermate controls.

190 near growth rate to that seen in pair-fed WT littermate controls.

191 throcyte enucleation in their BM compared to littermate controls.

192 cal tricuspid aortic valves or all wild-type littermate controls.

193 proliferation for up to 4 days compared with littermate controls.

194 cal performance compared with wild-type (WT) littermate controls.

195 male chow-fed mice, compared with GHR-intact littermate controls.

196 r rates of cell proliferation than wild-type littermate controls.

197 nfarcts and fewer neurological deficits than littermate controls.

198 re also observed in both NaV 1.7(Nav1.8) and littermate controls.

199 mice cochleae compared with their wild-type littermate controls.

200 and body weight acquisition compared to the littermate controls.

201 abnormal age-related involution compared to littermate controls.

202 r but not the axial skeleton compared to the littermate controls.

203 ose tissue and skeletal muscle compared with littermate controls.

204 rd-/+), as compared to their female wildtype littermate controls.

205 lial-selective Epas1 knockout mice and their littermate controls.

206 nd decreased motor coordination, compared to littermate controls.

207 macrophage-specific loss of TRPC3 and their littermate controls.

208 n in beta-ENaC-Tg mice compared to wild-type littermate controls; identified locations of airway obst

209 y, from Nr1d1(-/-) mice and their Nr1d1(+/+) littermates (controls) and analyzed expression NLRP3, in

210 SL-Kras(G12D);Pdx1-Cre mice and Cre-negative littermates (controls).

211 ker movements and passive stimulation by the littermates cooperate, with comparable efficiency, in dr

212 ker movements and passive stimulation by the littermates cooperate, with comparable efficiency, in dr

213 control level, Podo-GC-A KO mice and control littermates did not differ in BP, GFR, or natriuresis un

214 ) allele in Cre-expressing cells and control littermates expressing a wild-type Notch2 transcript.

215 We report that, relative to wild-type littermates, female DISC1(D453G) mice exhibited novelty-

216 ing C57BL6/J Ahr(-/+) and Ahr(-/-) co-housed littermates followed by 18 days of genotypic segregation

217 e (-/-) Tlr7 (-/-) and Apoe (-/-) Tlr7 (+/+) littermates, followed by feeding them an atherogenic die

218 re examined and compared with wild-type (WT) littermates following intranasal exposure to HDM allerge

219 degree of cardiac iron uptake than wild-type littermates following iron dextran injection.

220 ly, isolating preadolescent female mice from littermates for <24 hr increased first spike latency (FS

221 In comparison to their WT littermates, Foxp2+/- mice vocalized less, produced shor

222 Hsd11b2(+/+), Hsd11b2(+/-), and Hsd11b2(-/-) littermates from heterozygous (Hsd11b(+/-)) matings at e

223 kout (Foxp2+/-) mice and their wildtype (WT) littermates from juvenile to adult ages, and observe sev

224 tage of palatal shelf elevation in wild-type littermates, Golgb1 mutant embryos exhibit increased cel

225 mice (EGFR(podKO)) and their wild-type (WT) littermates had similar levels of hyperglycemia and poly

226 In comparison with wild-type littermates, hCD39 transgenic mice were protected from a

227 Compared with wild-type littermates, HNF-1beta mutant mice exhibited polyuria an

228 4R KO mice was not different from that in WT littermates in either context.

229 hium responsivity relative to wild-type (WT) littermates in tail suspension, an antidepressant-predic

230 ed thrombus formation compared with wildtype littermates in tumor-bearing mice.

231 r in peripheral organs compared with control littermates, indicating that GATA3 controls the maturati

232 striction for 2 weeks, compared with control littermates, inducible renal tubular NEDD4-2 knockout (N

233 Compared with kidneys of newborn control littermates, kidneys of newborn mutant mice exhibited di

234 Compared with control littermates, knockout mice showed impaired glucose toler

235 Relative to wild-type littermates, knockout mice showed no gross pathologies.

236 not a complete loss of tau in the Mapt(-/-) littermates, led to a significant reduction of DA neuron

237 eeding protocol, matched mLipin-1KO mice and littermate loxP control (WT) mice were pair-fed with eit

238 movements) and exogenous (stimulation by the littermates) mechanisms cooperate in driving cortical ac

239 ta mice (Ins2(+/C96Y)) compared with control littermate mice (Ins2(+/+)), and this was associated wit

240 and Nf1(Flox/-); Ink4a/Arf(Flox/Flox) paired littermate mice to model tumors from NF1-wild-type and N

241 knockouts (APNko), and their wild-type (WT) littermate mice were continuously exposed to placebo or

242 a potassium channel blocker, were studied in littermate mice with normal and reduced Pitx2c mRNA by e

243 cortex in LysMcreTNF(fl/fl) mice compared to littermate mice, whereas no TNF(+) leukocytes were detec

244 Compared with wild-type littermates, mice possessing one allele of Tie2 suffered

245 B(hi) to FcgammaR(-/-)Rag1(-/-) or Rag1(-/-) littermates; mice were given different antibodies agains

246 ass and exhibited less strength than control littermates, no differences in muscle mass or strength w

247 nt mice was indistinguishable from wild-type littermates on a regular chow.

248 PLZF(-/-) mice, wild-type littermates, or mixed bone marrow chimeras were treated

249 PP/PS1) and healthy controls (wild-type (WT) littermates) over 4 hours.

250 than that in parathyroid glands of wild-type littermates (P<0.0001).

251 Relative to WT littermates, PDE11A KO mice show reduced expression of R

252 ion of PMCA1 (PMCA1(cko) ) and their control littermates (PMCA1(loxP/loxP) ) were studied at the orga

253 's movements under conditions simulating the littermates' position in the litter, and spontaneous whi

254 g the R92Q troponin-T mutation and wild-type littermates received an oral lifelong treatment with ran

255 om the lungs of Kras(LA1) mice and wild-type littermates, respectively, and performed global proteomi

256 Both tactile signals arising from the littermate's movements under conditions simulating the l

257 Compared with control littermates, Sf1Gck(-/-) mice displayed increased white

258 ceral hypersensitivity compared with control littermate Sox9(flox/flox) mice.

259 delta (1.0 to 4.0 Hz) power rebound like WT littermates, spontaneous waking fails to induce a delta

260 dopamine transients is observed with age in littermates, suggesting premature ageing of dopamine syn

261 entified in Atxn2-/- knockout mice versus WT littermates, suggesting that loss-of-function is not a s

262 movements with touch and stimulation by the littermates, support: (1) a twofold higher level of cort

263 oups of mice were studied: (1) control mice, littermates that are negative for hNox4 transgene but Cr

264 Ecl mice and their littermates that did not express the mutation (controls)

265 Littermates that expressed full-length EGFR were used as

266 induced colitis compared with wild-type (WT) littermates that was evaluated by survival rate, body we

267 ale SOD1(G37R) mice and their wild-type (WT) littermates: the soleus (S and FR MU); and the extensor

268 mice and show that, compared with wild-type littermates, these mice exhibit elevated UCP1 expression

269 manifestations in D1CT-7, but not wild-type littermates; these effects were countered by the benchma

270 h homozygous mice are smaller than wild type littermates throughout development.

271 t volumes at 24 hours and 5 days compared to littermates (TNFfl/fl).

272 re more likely than uninephrectomized normal littermates to exhibit renal impairment because of the c

273 mune system were as susceptible as wild-type littermates to T cell-dependent experimental autoimmune

274 luated the responses of Tg mice and their WT littermates to the Food and Drug Administration-approved

275 of GFAP(+) astrocytes when compared with the littermate TSG-6(+/-) mice.

276 hs of age, ssTnI mice or their nontransgenic littermates underwent aortic constriction (TAC).

277 9 deficient (pcsk9 (-/-)) and wild-type (WT) littermates underwent partial inferior vena cava (IVC) l

278 ic MK2 knockout mice compared with wild-type littermates upon induction of experimental autoimmune en

279 ucing interferon-beta (TRIF) double knockout littermates, we define the role of toll-like receptors (

280 end-stage male SOD1(G93A) rats and wild-type littermates, we investigated relative Q versus S pathway

281 S1dE9 transgenic AD mice and their wild-type littermates, we observed that the human Abeta originated

282 omozygous (Scn8a(D/D))), and WT (Scn8a(+/+)) littermates were compared at 3 weeks of age, the time of

283 3R, or D4R KO mice) and their wild-type (WT) littermates were exposed to a series of fixed-ratio (FR)

284 Livers of FRGN19(+) mice and their FRGN littermates were fully repopulated with human hepatocyte

285 Diabetic rats and their non-diabetic littermates were housed in a 12:12 hour light-dim light

286 wild-type [(WT) Scx(flx/+) or Scx(flx/flx)] littermates were killed at postnatal days 7-56 (P7-P56).

287 protein [CC10]-IL-13 Tg) mice and wild-type littermates were used in this study.

288 ec46Ala-Gpx4(+/-) mice, but not their female littermates, were subfertile.

289 us proliferation compared with unmanipulated littermates, whereas crypt proliferation was decreased.

290 orris water maze compared to their wild-type littermates, which was rescued by chemogenetic locus coe

291 ongoing spontaneous pain when compared with littermate wild-type mice.

292 KO mice and their Cre-negative GR(flox/flox) littermates [wild type (WT)].

293 l AMI were compared between control mice and littermates with endothelial-restricted inactivation of

294 ng VEGF(HSA-/-) and non-ablated (VEGF(f/f) ) littermates with running wheels for 14 days.

295 in mice with Nf1 haploinsufficiency than in littermates with wild-type Nf1,but this model is insuffi

296 pr2(+/)(-);Ldlr(-/)(-) mice versus wild-type littermates, with increased valve thickening, myofibroge

297 ndistinguishable from their wild-type/floxed littermates, with no differences in lean mass, skeletal

298 is was applied to miR-223 deficient mice and littermate (WT) controls.

299 ore insulin resistant than their DHT-exposed littermate WTs.

300 o the host epithelium compared with cohoused littermate Zg16(+/+) The more penetrable Zg16(-/-) mucus