ライフサイエンスコーパス: little or no

1 the clinical benefit of PDT to regions with little or no access to electricity or medical infrastruc

2 replication-competent provirus, but exhibit little or no active viral gene expression and effectivel

3 lar sized pore-formers at pH 5, while having little or no activity at pH 7, as intended.

4 rom loaded microsomes, whereas BPA exhibited little or no activity at these targets.

5 found to be highly selective for Mnk2, with little or no activity for Mnk1.

6 oxylate-terminated CDs (CD-CO2(-)) displayed little or no activity, and the electrostatic interaction

7 coli and Pseudomonas aeruginosa lysates had little or no activity.

8 sence of aqueous buffer, most enzymes retain little or no activity; however, "water-free" enzymes wou

9 However, autistic observers showed little or no adaptation, although their simultaneity cur

10 three donors in a CD4-dependent manner, but little or no alpha4beta7 binding was detected.

11 In contrast, many investigations report little or no alteration in brain activity associated wit

12 ce of these genes in environments exposed to little or no antibiotics, and on the relationship betwee

13 splants with normal function usually exhibit little or no antibody specific for the transplant donor

14 Interestingly, the compounds have little or no antiviral activity on the replication of ot

15 ynthetic transformations that otherwise have little or no apparent relationship.

16 There is little or no association between tea consumption and end

17 ironment in utero and in early childhood had little or no association with asthma but was associated

18 However, little or no attention has been paid to the stabilizatio

19 Little or no attention is placed on the environmental im

20 porate as much information as possible, with little or no attention paid to the issue of statistical

21 respectful woman-centred care have received little or no attention.

22 s, whereas the vast majority of them receive little or no attention.

23 ressed in the expression of 12-LOX exhibited little or no bacteremia and survived an otherwise lethal

24 latent, characterized by drug tolerance and little or no bacterial replication.

25 thways involving multiple spin states having little or no barrier.

26 87]) but not nonfatal stroke; aspirin showed little or no benefit for all-cause or cardiovascular mor

27 linically diagnosed subjects with AD confers little or no benefits over time.

28 inducing short endocytic dwell times produce little or no beta-arrestin signalling, whereas those eli

29 onal logistic models indicates that there is little or no bias from uncontrolled time-constant reside

30 ired for ERK-IQGAP1 binding, and contributes little or no binding energy to this interaction, challen

31 selective for differentiated hPS cells, had little or no binding on pluripotent cells, but preferent

32 Similarly, little or no binding to alpha4beta7 on transfected 293T

33 Very little or no Bmx mRNA was expressed in human cardiomyocy

34 l fibre-Purkinje cell glutamatergic synapse, little or no Ca(2+) entry takes place through postsynapt

35 polymeric substrates suggest that AnBgl1 has little or no capacity to bind to and to adsorb cellulose

36 fection by these viruses to cells expressing little or no CD4 in vivo.

37 of one-carbon metabolic processes exhibited little or no change after supplementation in low-vitamin

38 Fundus autofluorescence showed little or no change except in severe cases in which the

39 ut not in the town (7.1% vs 7.2%); there was little or no change in asthma prevalence in the villages

40 At higher ratios, little or no change in entrainment or synchronization wa

41 unable to produce the ORF113 protein showed little or no change in its growth rate in vitro, in its

42 or gamma subunit knuckle domain resulted in little or no change in Na(+) self-inhibition.

43 also suggests that promoter escape involves little or no change in the interaction of sigmaR2 with R

44 erior TPS with elevation larger than 4000 m, little or no change over the southeastern TPS, and incre

45 Little or no circulating non-transferrin-bound iron resu

46 s, and a large number of other viruses, with little or no clinical signs of disease.

47 tients), which assessed self-monitoring with little or no co-intervention.

48 ective in inducing membrane curvature showed little or no coclustering with tetherin in superresoluti

49 ed primarily on minimizing Type I error with little or no concern about concomitant increases in Type

50 t underlie homologous characters occurs with little or no concomitant change in the adult phenotype.

51 ical shifts arise from states where there is little or no conformational bias.

52 t XTRPM6 regulates radial intercalation with little or no contribution from XTRPM7 in the region late

53 sensitive cones (S-cones) in the retina make little or no contribution to luminance signals, leading

54 e of robust cardiomyogenesis and others with little or no contribution to myocytes).

55 uced clinical advances, it has thus far made little or no contribution to our understanding of popula

56 ing initially overdense flat interfaces with little or no control over the interaction.

57 xation of C60 molecules, albeit usually with little or no control over their long-range order.

58 mal use of medications often executable with little or no cost to the patient.

59 ant bacteria can in many cases be reduced at little or no cost.

60 Due to little or no cross sensitivity to other ions (e.g., Mg(2

61 These species have little or no cytotoxic activity in several bioassays.

62 dormancy of Mycobacterium tuberculosis, with little or no cytotoxicity toward mammalian cells.

63 ations at low micromolar concentration, with little or no cytotoxicity.

64 ore tolerant to sulfite toxicity, exhibiting little or no damage.

65 ly in Europe, the USA, Japan, and China, but little or no data are available from the Middle East, So

66 the systematic derivation of properties with little or no dependence on model parameterization.

67 proximity, fusion occurs spontaneously, with little or no dependence on the number of DNA hybrids for

68 onstrate that fMRI-based motion decoding has little or no dependence on the underlying functional org

69 n for frequencies over 200 Hz, the AP showed little or no depression.

70 gap junction plaques or, if they do, produce little or no detectable junctional coupling.

71 These mice had little or no detectable viral replication, comparable to

72 Mutations at Y216 (to W, I, and A) indicate little or no difference in electron paramagnetic resonan

73 food varied among the source materials, but little or no difference was observed among the soil type

74 , PFOS: 0.28-2.1 ng g(-1) wet-weight), with little or no differences when comparing 2013 or 2014 fis

75 et of the vinblastine analogues that display little or no differential in activity against a matched

76 m, causing disease of variable severity with little or no direct systemic effects.

77 graphic hypotheses, the femur was subject to little or no directional selection despite having shorte

78 iverse major groove ICLs that induce severe, little or no distortion in the DNA.

79 idemiology, yet many epidemiologists receive little or no education in the conceptual underpinnings o

80 -sotalol, thioridazine, and erythromycin) to little or no effect (haloperidol, moxifloxacin, and vera

81 rate biomass in the mesocosms, but there was little or no effect of the phenotype.

82 Five mutations with little or no effect on ABCB4 expression at the bile cana

83 ture and AAA-related mortality rates but had little or no effect on all-cause mortality rates.

84 Deviation from the CentC consensus has little or no effect on binding of cenH3.

85 alanine abolish silencing in vivo, but have little or no effect on binding of Sir3 to nucleosomes or

86 versely, mutations N97S, D95V, and D129G had little or no effect on Ca(2+) binding to the N-domain bu

87 noid ligands tested, at the same time having little or no effect on ERK1/2 phosphorylation mediated b

88 sruption of other zebrafish rab5 genes shows little or no effect on expression of markers of dorsal o

89 rait (dw) in peach (Prunus persica) that has little or no effect on fruit development.

90 ected 2893 splicing QTLs, most of which have little or no effect on gene-level expression.

91 xpression of EXTL2 in the same cell line had little or no effect on heparan sulfate chain length.

92 tic cells or nestin-cre-expressing cells had little or no effect on HSCs or restricted progenitors.

93 The PKA inhibitor H89 had little or no effect on inflammatory mediators modulated

94 spects of terminal dendrite development with little or no effect on major dendrite patterning.

95 At equivalent TSS, cluster exposure had little or no effect on malic acid concentration.

96 Maternal nutrition has little or no effect on many nutrients in human milk; for

97 cis QTLs that affect protein abundance with little or no effect on messenger RNA or ribosome levels,

98 eased mPGES1 mRNA and protein levels but had little or no effect on mPGES2 or cPGES mRNA.

99 he proapoptotic proteins Bim and BAD but had little or no effect on other Bcl-2 family members.

100 of selective M3 receptor blockers that have little or no effect on other muscarinic receptor subtype

101 viates pausing at polyproline sequences, has little or no effect on other stalling peptides.

102 there was low-strength evidence that P4P had little or no effect on patient health outcomes and a pos

103 ressure on the response of these sensors had little or no effect on potential, sensitivity, or limit

104 metastasis in two orthotopic models, but had little or no effect on primary tumor growth.

105 There was little or no effect on sensitivity to suramin and pyrido

106 Metformin had no effect on cIMT and little or no effect on several surrogate markers of card

107 versification; some adaptive radiations have little or no effect on speciation, or even a negative ef

108 removed by null mutation, these peptides had little or no effect on stress-induced sleep.

109 ven at concentrations up to 10,000 mug/L had little or no effect on sugar utilisation, alcohol produc

110 curring in response to these stimuli but had little or no effect on that of p38 MAPK or PI3K.

111 ly blocked KSHV lytic replication but showed little or no effect on the antiapoptotic and antiautopha

112 ncreased the variability of spike times with little or no effect on the average firing rate.

113 Inhibition of DBR1 had little or no effect on the formation of minus-strand str

114 P-2 (Ad-Ii-TRP-2) or GP100 (Ad-Ii-GP100) had little or no effect on the growth of s.c. B16 melanomas,

115 Thus, temperature had little or no effect on the hydrolytic rate in dilute sub

116 trated that propargylglycine (PAG, 1 mm) had little or no effect on the NPV caused by PGF2alpha or LY

117 sion of hTetherin in hematopoietic cells had little or no effect on the number of MoMLV-infected sple

118 nge of 1 to 50 muM (IC50 = 3.4 muM), but had little or no effect on the physiological Ca(2+) spiking

119 he same manipulations in mature animals have little or no effect on the same property.

120 e of both proteins during postnatal life has little or no effect on the survival and function of cone

121 However, mutations of these residues had little or no effect on toxin block of the alpha9alpha10

122 ubstitutions detected in cancer genomes have little or no effect on tumour progression (passenger mut

123 us 7 infection upstream of uncoating but had little or no effect on virus attachment to the cell surf

124 -fostering [4] and parental absence [5] have little or no effect on vocal development.

125 however, deletion of LGR5 in stem cells has little or no effect on Wnt/beta-catenin signaling or cel

126 hin seconds when applied externally, but had little or no effect when applied internally for up to 15

127 We found that lidocaine also has little or no effect when applied intracellularly in whol

128 ine delivery after the onset of epidemic has little or no effect, regardless of the population demogr

129 ent and the allele from the other parent has little or no effect.

130 xamined, whereas GRFT and SVN displayed only little or no effect.

131 in with other alanine mutations in TM IV had little or no effect.

132 these assays, the other compounds tested had little, or no, effect.

133 rom adsorbed humic molecules; however showed little or no effects for monovalent NaCl.

134 ug uptake and high stability over time, with little or no effects on NPSC viability, morphology, reac

135 urface and mRNA expression in MM cells, with little or no effects on the basal expression of the MICB

136 relapsing-remitting multiple sclerosis have little or no efficacy in progressive multiple sclerosis

137 red trials with experimental drugs that have little or no established efficacy or safety data.

138 While in agreement with previous studies, little or no evidence for clonal (SF3B1 mutation) involv

139 We observed little or no evidence of association between maternal se

140 We observed little or no evidence of associations between low prenat

141 formation, while hairpin formation exhibits little or no evidence of friction.

142 ning to improve posture as most patients had little or no evidence of structural bony changes even wh

143 Little or no evidence suggesting more or less than addit

144 We and others have found little or no evidence that these cells differentiate int

145 We used the Delphi method when little or no evidence was available.

146 nostic accuracy of tests for celiac disease, little or no evidence was identified to inform most of t

147 t, those with only 1 of these exposures have little or no excess risk after controlling for conventio

148 e vocalizations have been thought to undergo little or no experience-dependent acoustic changes durin

149 erties of genes and gene products containing little or no experimental annotation.

150 eactions, but the literature reports provide little or no experimental evidence for this.

151 plication to the thousands of chemicals with little or no exposure data.

152 ession (ZII+) interdigitated with stripes of little or no expression (ZII-).

153 ession (ZII+) interdigitated with stripes of little or no expression (ZII-).

154 tion of endothelial cells, whereas there was little or no expression in synovium from healthy donors.

155 nlike B cells, circulating monocytes express little or no FcgammaRIIb.

156 s, either alone or in combination, generated little or no force in the I3 muscle.

157 y for general health-care professionals with little or no formal mental health training.

158 different adaptors, suggesting that there is little or no free, activated Arf at the membrane and tha

159 ed and subsequent site dissociation required little or no further ATP hydrolysis.

160 omic analysis revealed a deep divergence and little or no gene flow between Apis and Bombus gut symbi

161 Little or no genetic association with disease behaviour

162 een to be capable of occurring abruptly with little or no genetic change, with involvement of the ext

163 tic region, the transition was gradual, with little or no genetic input from incoming farmers [7].

164 evolutionary change, for example if there is little or no genetic variance in number of grandoffsprin

165 ticularly useful for proteomic studies where little or no genomic context is known, such as with envi

166 Diabetic rats treated with SSTR2a needed little or no glucose infusion compared with untreated ra

167 otential; (ii) near-maximal glycolysis, with little or no glycolytic reserve; (iii) marked ketogenesi

168 e quickly to the red chromophore and produce little or no green chromophore are most useful.

169 We detected little or no H1N1pdm replication in animals that receive

170 g patients who are ethnic minorities or have little or no health insurance.

171 The mutants produce little or no hemozoin (Hz), the detoxification by-produc

172 suggested that many 'sporadic' cancers show little or no heritability.

173 n automated and high-throughput fashion with little or no human intervention required.

174 expressed at the plasma membrane, transport little or no I(-) These residues are conserved throughou

175 We found that tumours with little or no immune infiltration were associated with di

176 The designs elicit little or no immune response and provide potent prophyla

177 rmining region (CDR) methionine residues had little or no impact on antigen binding of the antibody.

178 ogues (NA) may suppress HBV replication with little or no impact on cccDNA, hence lifelong treatment

179 system, we found that local realignment had little or no impact on SNP calling, but increased sensit

180 D1-suppressed cells with anti-miR-206/21 had little or no impact on the level of activated ERK 1/2 or

181 ings and likely reduce patient anxiety, with little or no impact on the quality of care.

182 supraphysiological levels (0.4 ppm) had very little or no impact on worm expulsion.

183 Little or no improvement is obtained when using meta-dat

184 to CO2 and climate, as this model simulates little or no increase in drought frequency.

185 eurodegenerative diseases, in which there is little or no infiltration of blood-derived immune cells

186 ndex values (between 0.50 and 0.64) elicited little or no inflammation at low (22cm(2)) or high (220c

187 g, whereas the AC413/rAmy C-terminal Tyr had little or no influence on binding.

188 nt allergenic proteins are standardized with little or no information about compositional differences

189 location of the stimulus, but they provided little or no information about orientation independently

190 ble socialtaxis settings, where agents share little or no information and rely on simple computations

191 er to the thermodynamically stable forms but little or no information is supplied about their complex

192 als, as well as the transformation products, little or no information was available.

193 erable conservation among hBests, hBest1 has little or no interaction with other hBests or mTMEM16A.

194 domains (TADs), interspersed with regions of little or no interaction, in interphase nuclei.

195 locations, renew in different ways, and show little or no interconversion.

196 the other pathway produces class II COs with little or no interference.

197 ania, Kenya, Uganda), whereas others receive little or no investments (Sierra Leone, Central African

198 ismutase (SOD1), G85R SOD1YFP and G93A SOD1, little or no lipofuscin was detected in motor neuron cel

199 ymphomas and Burkitt lymphomas often express little or no LMP1.

200 Immunofluorescence experiments showed little or no localization of cMyBP-C(C10mut) to the C-zo

201 ontrast, the enteric nervous system displays little or no loss of cholinergic neurons.

202 which have increased drought tolerance, with little or no loss of nutrient uptake.

203 acterize protein interaction interfaces with little or no lysine residues.

204 bosomal DNA (rDNA) array, however, undergoes little or no meiotic recombination.

205 mes, but cultivated tomato trichomes contain little or no methylketones.

206 le crabs released outside the Channel showed little or no migration.

207 l amides with a variety of nucleophiles with little or no modification.

208 ceded by a small bias, instead of perceiving little or no motion--as suggested by the minimal-motion

209 For example, many larvae display little or no movement.

210 ve to individual-level events, when there is little or no mutation, and when there are many groups re

211 and flow was observed even in subjects with little or no nausea.

212 red in mouse embryonic stem cells expressing little or no NEAT1 RNA, suggesting that PS-ASOs can serv

213 , cotton pollen, and cotton nectar contained little or no neonicotinoids resulting from insecticide s

214 Cochlear removal in older animals results in little or no neuron death.

215 lity to be targeted for cellular uptake with little or no non-specific binding.

216 There was little or no non-specific desensitization when lung mast

217 able of transactivating Notch but exhibiting little or no Notch cis-inhibition capacity.

218 advertisements for foods and beverages with little or no nutritional value likely contributes to poo

219 patients with post-cholecystectomy pain and little or no objective abnormalities on investigation, s

220 s in the genome of a model organism may have little or no observable impact on its wild type phenotyp

221 According to current dogma, there is little or no ongoing neurogenesis in the fully developed

222 Quiescent galaxies with little or no ongoing star formation dominate the populat

223 eria that live in regions of the oceans with little or no oxygen.

224 At 12 hours, all "ghost" cells exhibited little or no p-eEF2 staining, although not every neuron

225 a peripheral injury and/or inflammation but little or no pain.

226 arly pancreatic fibrosis can be initiated by little or no pancreatic necrosis.

227 s growth factors outside the PDGF family but little or no PDGFs, promoted formation of a unique SFK-P

228 n telomeric repeat sequence, where it causes little or no perturbation of DNA structure or stability.

229 the more epidemic periphery, which exhibits little or no postmonsoon outbreak in a pattern typical o

230 rofitable harvesting to extinction even with little or no price increase; and some high-value declini

231 periencing a first episode of psychosis with little or no prior antipsychotic exposure, and how poten

232 ction in the many real-life situations where little or no prior knowledge is available about the char

233 Surprisingly, adult human beta-cells express little or no PRLR.

234 30L, 30-IXAla, 30-620A, or 30-622A contained little or no processed viral DNA.

235 documentation, an interface for users, with little or no programming experience, to 'talk' to the se

236 r wall, whereas gata4(+) cardiomyocytes have little or no proliferation hierarchy during regeneration

237 ted for an extended polypeptide chain having little or no propensity to form persistent structures.

238 till regarded as scientific curiosities with little or no prospect of generating practical to use med

239 antigen-specific CD4 T cells have conferred little or no protection.

240 spleen tissue from clinically ill mice with little or no PrP-res detectable, similar short incubatio

241 All mutants, except Q56I, showed little or no [PSI+] transmission barrier from the refere

242 ce daily in the morning for 8 days, produced little or no quantifiable systemic exposure to the paren

243 with oxidized S (e.g., disulfide) exhibited little or no reactivity toward Hg(0)aq either at pH 7.

244 Here, in 40 kindergartners who had received little or no reading instruction, we examined the relati

245 ext] of observable genome, in which there is little or no recombination.

246 In contrast, little or no reduction in binding was seen following sub

247 b or in Clec4n(-/-) mice was associated with little or no reduction in lung-draining lymph node cells

248 Single mutants had little or no reduction in overall fertility, whereas dou

249 ure and are highly drought tolerant but show little or no reduction in shoot nitrogen concentrations

250 en a success or has picked-up sequences with little or no relationship to the query.

251 (BACs) containing Spirodela DNA inserts with little or no repetitive elements as probes for multicolo

252 ation in NS5A was more limited but exhibited little or no requirement for expression of functional NS

253 wly appointed consultant paediatricians have little or no research experience; less than 5% of contra

254 inhA promoters), and three genes contributed little or no resistance (gyrB, tlyA, and the ahpC promot

255 sting that local protection of reefs affords little or no resistance to extreme heat.

256 iagnosis of peripheral T-cell lymphoma, with little or no response, whereas the other 4 were followed

257 mall object darker than the background, with little or no responses to static flicker, vertically elo

258 h and rupture rates and very small UIAs have little or no risk for rupture.

259 ikely to provoke seizures, while others pose little or no risk.

260 IgaB appears to play little or no role in adherence or invasion but is requir

261 irectly activated DCs are considered to play little or no role in T cell immunity.

262 ty of this transformation, with MoaC playing little or no role in the pyranopterin formation.

263 cts not present in the folded structure play little or no role in the self-assembly mechanism.

264 PKA-mediated phosphorylation of RyRS2808 has little or no role in these alterations.

265 nd occurrence of lymph node metastases while little or no Runx2 phosphorylation was seen in normal pr

266 of the ore zone and down-gradient wells have little or no Se oxyanions.

267 d, the posterior color-biased regions showed little or no selectivity for object shape or for particu

268 The deoxyribozymes have little or no selectivity for the amino acid identities n

269 trary to S. meliloti, S. fredii HH103 showed little or no sensitivity to Medicago NCR247 and NCR335 p

270 er than 1 kbp, of which 3,761 are novel with little or no sequence homology in any existing databases

271 to correctly identify analogous folds where little or no sequence homology information is.

272 licable to cellular mRNA IRES that also have little or no sequences/structures in common.

273 e ore body, whereas two other transects show little or no sign of reduction in the down-gradient regi

274 nectaries, but pin6 lateral nectaries showed little or no signal for these reporters.

275 cted with the 263K hamster prion strain have little or no signs of mitochondrial dysfunction at the d

276 Genes escaping XCI show little or no silencing during early propagation of XCI.

277 where there is partial fast inactivation but little or no slow inactivation.

278 the most common, and often is expressed with little or no somatic mutation, and restricted IGHD and I

279 Conventional chemotherapy has little or no specificity for cancer cells, normally resu

280 "molecular ruler." Second, the method yields little or no spurious signal even with highly abundant c

281 ytes and nonpermeabilized WT myocytes showed little or no staining, without striation.

282 Readers with little or no statistical knowledge would be expected to

283 y than Pol delta in the absence of PCNA, but little or no stimulation was observed in the presence of

284 ependent of the value of m and n, suggesting little or no strain caused by the interface between them

285 Trials primarily included adolescents with little or no substance use.

286 In contrast, there was little or no such protective effect in the town populati

287 As a result, little or no sunlight reaches the surface for over a yea

288 Thus, lipid-anchored syb2 provides little or no support for exocytosis, and anchoring syb2

289 With this device only little or no supporting electrolytes are needed, making

290 s awareness of hypoglycemia, preferably with little or no symptomatic or even asymptomatic hypoglycem

291 however, approximately 25% of patients show little or no symptomatic response.

292 The O states of different amides show little or no temporal correlation, even if adjacent resi

293 rugs (ACV and ACVP) and blank LCP NPs showed little or no therapeutic effect.

294 or cVMS in a range of aquatic organisms show little or no toxic effects up to solubility limits in wa

295 cles (nC60), fullerol, TiO2, and CeO2 showed little or no toxicity.

296 ide (fault hanging wall), with comparatively little or no uplift of the mountainside (fault footwall)

297 ied: 49% of Veterans had Rapid Recovery with little or no use of care; 15% had a Steady Recovery with

298 i MAbs 17b and 19e were neutralizing despite little or no virion binding.

299 ds and/or optic canal decompression provided little or no vision return (P = .05).

300 , which will be grown on marginal lands with little or no water input.