ライフサイエンスコーパス: liver X receptor

1 olog of the mammalian vitamin D receptor and liver X receptor.

2 upregulation of key lipogenic enzymes by the liver X receptor.

3 eta secretion, suggesting the involvement of liver X receptor.

4 These effects were mediated by liver X receptors.

5 g tissue-specific modulation of estrogen and liver X receptors.

6 rtant model for the vertebrate vitamin D and liver X receptors.

7 genase 1 and reduced foam cell formation via liver X receptor, a potent combination for treating athe

8 ing cholesterol efflux via activation of the liver X receptor-ABCA1 (LXR-ABCA1) pathway.

9 erference reduced the expression of ABCG1 in liver X receptor-activated macrophages and caused a para

10 ontrast, lipodystrophy (aP2-SREBP-1c436) and liver X receptor activation (T0901317), which increase d

11 progenitors by reconstituted HDL infusion or liver X receptor activation remain promising approaches

12 lesterol efflux pathways by HDL infusions or liver X receptor activation results in suppression of he

13 , whereas on upregulation of transporters by liver X receptor activation, PM sterol was shifted to th

14 s mediated both by TNFalpha signaling and by liver X receptor activation.

15 rophages and lymphocytes but no induction by liver X receptor activation.

16 n CC via suppression of the inflammasome and liver X receptor activation.

17 Treatment of macrophages with an liver X receptor activator results in up-regulation of A

18 e proliferator-activated receptor (PPAR) and liver X receptor activators increase ABCA12 expression i

19 n inflammatory signaling and derepression of liver X receptor activity.

20 Based on this screen, we formulated a liver X receptor agonist (GW3965) and abolished its live

21 biosynthesis pathways by cotreatment with a liver X receptor agonist further augmented forskolin-ind

22 A liver X receptor agonist markedly increases macrophage r

23 Stimulation of ABCA1 expression with liver X receptor agonist or overexpression of heterologo

24 ctivity by approximately 5-fold and that the liver X receptor agonist T0901317 (a known activator of

25 e cancer LNCaP cell lines with the synthetic liver X receptor agonist T0901317 decreased the percenta

26 l subjects was induced by treatment with the liver X receptor agonist TO-901317.

27 This conversion was Abeta-dependent, because liver-X receptor agonist treatment to promote Abeta degr

28 Liver X receptor agonists also inhibited the proliferati

29 Dissociated sterol-based liver X receptor agonists as therapeutics for chronic in

30 rolling tumor cell proliferation; therefore, liver X receptor agonists may have utility as antitumori

31 ndent cancers, we investigated the effect of liver X receptor agonists on prostate and breast cancer

32 Functionally, the liver X receptor agonists TO901317 and GW3965, two known

33 We found previously that liver X receptor agonists, which regulate intracellular

34 tly with sensitivity to growth inhibition by liver X receptor agonists.

35 cholesterol and by ABC transporter-inducing liver X receptor agonists.

36 s, whereas the HDL pathway is upregulated by liver X receptor agonists.

37 Liver X receptor alpha (LXR alpha) agonists and a high c

38 e present study, we investigated the role of liver X receptor alpha (LXR(alpha)) and LXR(beta) in the

39 Dysregulation of liver X receptor alpha (LXRalpha) activity has been link

40 The nuclear hormone receptors liver X receptor alpha (LXRalpha) and LXRbeta function a

41 s with many NRs, while L2 interacts with the liver X receptor alpha (LXRalpha) and the estrogen recep

42 Here we show the unexpected role of liver X receptor alpha (LXRalpha) as a direct transcript

43 Knockdown of liver X receptor alpha (LXRalpha) inhibited ABC transpor

44 activation of TLR-mediated innate immune and liver X receptor alpha (LXRalpha) signaling pathways.

45 nuclear hormone receptor for oxysterols, the liver X receptor alpha (LXRalpha), regulates cholesterol

46 -sensitive transcription factor SREBP-1c and liver X receptor alpha (LXRalpha).

47 enic transcription factors, most prominently liver x receptor alpha (LXRalpha).

48 level, and its expression is upregulated by liver X receptor alpha (LXRalpha).

49 ion of the anti-atherogenic nuclear receptor liver X receptor alpha (LXRalpha; Nr1h3) and its downstr

50 Recently, we identified an enrichment of liver X receptor alpha and beta (LXRalpha/beta) in the n

51 o 6-fold increases in foam cells of mRNA for liver X receptor alpha and cholesterol efflux factors AB

52 me proliferator-activated receptor alpha and liver X receptor alpha as well as with the circadian osc

53 e proliferator-activated receptor gamma, and liver X receptor alpha but was unable to reduce accumula

54 The level of liver X receptor alpha expression correlated directly wi

55 Retroviral expression of liver X receptor alpha in human breast cancer MDA-MB435S

56 ome proliferator-activated receptor alpha or liver X receptor alpha knockout mice were exposed to str

57 PP diet stimulated the hepatic expression of liver X receptor alpha mRNA.

58 ic gluconeogenesis primarily by upregulating liver X receptor alpha through the natriuretic peptide p

59 Although liver X receptor alpha was induced, there was no detecta

60 er for the nuclear hormone receptor known as liver X receptor alpha, (LXRalpha [NR1H3]), which is the

61 ased, as are key lipid metabolism regulators liver X receptor alpha, peroxisome proliferator-activate

62 BP) alpha, C/EBPbeta, C/EBPdelta, PPARgamma, liver X receptor alpha, sterol regulatory element-bindin

63 ompanied by a significant stimulation of the liver X receptor alpha-ATP-binding cassette transporter

64 317 induces dramatic up-regulation of p27 in liver X receptor alpha-overexpressing MDA-MB435S cells.

65 alpha activity (z = 2.0, P = 6.6 x 10(-7)), liver X receptor alpha/beta agonism (z = 2.1, P = 2.8 x

66 The liver X receptors alpha and beta (LXRalpha and LXRbeta)

67 2-related factor 2 (NRF2) but not on nuclear liver X receptors alpha and beta (LXRalpha,beta), peroxi

68 MASs serve as ligands for liver X receptors alpha and beta(LXRalpha and LXRbeta),

69 hese influences of HLP might be mediated via liver-X receptor alpha (LXRalpha)/ATP-binding cassette t

70 In addition, nuclear liver x receptor-alpha (LXRa), also regulated by TH, ind

71 mRNA and protein expression by up-regulating liver X receptor-alpha (LXRalpha) in macrophages.

72 have shown that the nuclear hormone receptor liver X receptor-alpha (LXRalpha) is a major transcripti

73 epatic DNL was due to coactivation by Vpr of liver X receptor-alpha (LXRalpha) with increased express

74 We determined that ATF6 induces liver X receptor-alpha (LXRalpha), an Mertk-inducing tra

75 r-activated receptor-alpha (PPAR-alpha), and liver X receptor-alpha (LXRalpha).

76 l regulatory element-binding protein-1c, and liver X receptor-alpha and the expression of their targe

77 ncoupling protein-1, or transcription factor liver X receptor-alpha.

78 CD68, SR-AI, liver-X-receptor-alpha, and PPARgamma were regulated in

79 liferator-activated receptor (PPAR)gamma and liver-X-receptor-alpha, and the cholesterol efflux pump

80 reased activity of RXR heterodimer partners, liver X receptor and peroxisome proliferator-activated r

81 gmented when fed an HFD providing ligands to liver X receptor and peroxisome proliferator-activated r

82 A1 transcription includes the binding of the liver X receptor and retinoid X receptor (LXR/RXR) heter

83 ells, which express low levels of endogenous liver X receptors and are insensitive to T0901317, sensi

84 C on ISR gene expression were independent of liver X receptors and sterol-response element-binding pr

85 ions between TLR-signalling pathways and the liver-X receptor and peroxisome proliferator-activated r

86 tor-activated receptor, retinoid X receptor, liver X receptor, and activating protein-1.

87 erator-activated receptor alpha (PPARalpha), liver X receptor, and their obligate heterodimer partner

88 some proliferator-associated receptor gamma, liver X receptor, and vitamin D receptor in shaping the

89 ocused reviews on estrogen receptors, PPARs, liver X receptors, and the PPARgamma coactivator-1 (PGC-

90 Liver X receptors antagonize TLR4-dependent gene activat

91 Estrogen receptors, PPARs, and liver X receptors are members of the nuclear receptor su

92 Previous studies identified liver X receptor as the transcription factor controlling

93 xisome proliferator-activated receptor-gamma/liver X receptor/ATP-binding cassette transporter A1 pat

94 ATF-1 coinduces heme oxygenase-1 (HO-1) and Liver X receptor beta (LXR-beta).

95 overy of a novel, potent, orally efficacious liver X receptor beta (LXRbeta) agonist (17).

96 two members of the nuclear receptor family, liver X receptor beta (LXRbeta) and thyroid hormone rece

97 Recent studies have implicated liver X receptor beta (LXRbeta) in key neurodevelopmenta

98 trates a key role for the oxysterol receptor liver X receptor beta (LXRbeta) in the etiology of diabe

99 Liver X receptor beta (LXRbeta) is a member of the nucle

100 were associated with increased expression of liver X receptor beta (LXRbeta), a nuclear receptor that

101 However, deletion of the nuclear receptor, liver X receptor beta (LXRbeta), had an adverse effect o

102 tors are estrogen receptor beta (ERbeta) and liver X receptor beta (LXRbeta).

103 The x-ray crystal structures of the human liver X receptor beta ligand binding domain complexed to

104 Hepatic triglyceride and liver X receptor, carbohydrate response element-binding

105 is via two receptors: retinoic acid receptor/liver X receptor (cholesterol efflux to lumen) and retin

106 n 2 (SREBP2) target genes, and activation of liver X receptor-controlled genes.

107 A synthetic agonist of the Liver X receptor depleted cholesterol in GBM cells, slow

108 Upregulation of liver X receptor dramatically reduced foam cell formatio

109 e transcription through the cis-acting GLUT4-liver X receptor element (LXRE) promoter element.

110 hat include a sterol regulatory element, two liver X receptor elements, and a number of conserved GC

111 responsive promoter elements but not through liver X receptor elements.

112 ts on other related nuclear receptors (i.e., liver X receptor, farnesoid X receptor, estrogen recepto

113 Liver X receptors function as central transcriptional re

114 me proliferator-activated receptors, and the liver X receptor have demonstrated significant potential

115 is minimal, regulatory regions responsive to liver X receptor have remained elusive, but no longer; t

116 Stigmasterol also activated the liver X receptor in a cell-based reporter assay.

117 It is believed that 27HC, acting through the liver X receptor in macrophages and possibly other cells

118 that GX sPLA(2) suppresses activation of the liver X receptor in macrophages, resulting in reduced ex

119 roxisome proliferator-activated receptor and liver X receptor in the control of lipid-dependent gene

120 me proliferator-activated receptor gamma and liver X receptors in coordination with retinoid X recept

121 ated by oxidized low-density lipoprotein and liver X receptors indicates coordinated and reciprocal c

122 vivo in multiple tissues in response to the liver X receptor ligand T0901317.

123 hages are stimulated by cholesterol loading, liver X receptor ligands, and cyclic AMP, and N-glycosyl

124 Liver X receptor (LXR) activates fatty acid synthase (FA

125 In contrast to FXR, this study showed that liver X receptor (LXR) activation by LXR agonists and ad

126 roliferators-activated receptors (PPARs) and liver X receptor (LXR) activation improved epidermal per

127 ipid-remodeling enzyme LPCAT3 in response to liver X receptor (LXR) activation promoted SREBP-1c proc

128 We reported earlier that liver X receptor (LXR) activation promotes cellular chol

129 proliferator-activated receptors (PPARs) and liver X receptor (LXR) activators improve permeability b

130 Liver X receptor (LXR) activators stimulate keratinocyte

131 We have identified a novel liver X receptor (LXR) agonist (2) that activates the LX

132 he increase was mimicked by treatment with a liver X receptor (LXR) agonist and required the transcri

133 Enhancing cholesterol efflux using the liver X receptor (LXR) agonist GW3965 significantly decr

134 A liver X receptor (LXR) agonist induced expression of ABC

135 an nuclear receptors, the benzenesulfonamide liver X receptor (LXR) agonist N-(2,2,2-trifluoroethyl)-

136 The liver X receptor (LXR) agonist TO901317 inhibited the sy

137 rying amounts of cholesterol, treated with a liver X receptor (LXR) agonist, or injected intravenousl

138 urvival, rendering these tumors sensitive to Liver X receptor (LXR) agonist-dependent cell death.

139 , including serum, oxysterols, and synthetic liver X receptor (LXR) agonists.

140 r C-23 positions, were designed as potential liver X receptor (LXR) agonists.

141 Liver X receptor (LXR) alpha and beta are members of the

142 Liver X receptor (LXR) alpha and LXRbeta function as phy

143 CCAAT/enhancer binding protein (CEBP) alpha, liver X receptor (LXR) and H3K4me3 and microRNA target i

144 osynthesis is transcriptionally regulated by liver X receptor (LXR) and its gene target, sterol regul

145 investigated the regulation of mouse SCD1 by liver X receptor (LXR) and its role in plasma lipoprotei

146 ctivation of C3 expression mainly depends on liver X receptor (LXR) and partly on Toll-like receptor

147 This review summarizes evidence that the liver X receptor (LXR) and peroxisome proliferator-activ

148 hepatocyte nuclear factor (HNF)-4alpha, and liver X receptor (LXR) and the transcription factors ste

149 Cholesterol sulfate, a liver X receptor (LXR) antagonist, had marked attenuatio

150 receptor (PPAR) alpha, beta/delta, gamma and liver X receptor (LXR) are members of the nuclear recept

151 express a specific subset of NRs, including liver X receptor (LXR) beta and peroxisome proliferator-

152 ptional downregulation required the putative liver X receptor (LXR) binding site in the human GLUT4 g

153 he GLUT4 promoter was dependent on the GLUT4 liver X receptor (LXR) binding site.

154 element binding protein 2 (SREBP-2) and the liver X receptor (LXR) control antagonistic transcriptio

155 e we show that the sterol-responsive nuclear liver X receptor (LXR) helps maintain cholesterol homeos

156 differentiation due to the formation of RXR/liver X receptor (LXR) heterodimers, which induced expre

157 is report, we reveal a novel function of the liver X receptor (LXR) in preventing APAP-induced hepato

158 ransporter ABCA1, and its upstream regulator Liver X receptor (LXR) in the macrophages exposed to oxL

159 endent) reverse cholesterol transport (RCT), liver X receptor (LXR) is an attractive target for the t

160 The nuclear hormone receptor liver X receptor (LXR) is induced by insulin and is a ke

161 Liver X receptor (LXR) is known to promote hepatic lipog

162 mary metabolite of cholesterol and an ER and liver X receptor (LXR) ligand, increases ER-dependent gr

163 d the effect on HIV infection of a synthetic liver X receptor (LXR) ligand, N-(2,2,2-trifluoro-ethyl)

164 overexpressing HSL increased the efficacy of liver X receptor (LXR) ligands on StAR expression and st

165 To examine the therapeutic potential of liver X receptor (LXR) ligands, APP23 mice were fed HF d

166 The nuclear receptors liver X receptor (LXR) LXRalpha and LXRbeta are differen

167 e show that SIRT1 is a positive regulator of liver X receptor (LXR) proteins, nuclear receptors that

168 we show that activation of nuclear receptor liver X receptor (LXR) sensitized mice to lithogenic die

169 Expression of genes related to liver X receptor (LXR) signaling changed during progress

170 ated pathway functioned independently of the liver X receptor (LXR) sterol-sensing machinery that is

171 ription regulation retinoid X receptor (RXR)-liver X receptor (LXR) system.

172 cholesterol homeostasis, some of them being liver X receptor (LXR) target genes.

173 ing cassette transporter ABCG1, a macrophage liver X receptor (LXR) target, has been shown to stimula

174 PP)-activated receptor alpha (PPARalpha) and liver X receptor (LXR) through regulation of genes invol

175 s synthetic agonists induce fatty liver, the liver X receptor (LXR) transcription factor remains a ta

176 regulation of IDOL by the sterol-responsive liver X receptor (LXR) transcription factors, induction

177 Ligand activation of the liver X receptor (LXR), a member of the nuclear hormone

178 Liver X receptor (LXR), a nuclear hormone receptor, is a

179 Activation of the liver X receptor (LXR), a nuclear receptor known to up-r

180 imulates the transcriptional activity of the liver X receptor (LXR), a nuclear receptor that coordina

181 -hydroxycholesterol, a natural ligand of the liver X receptor (LXR), and the LXR synthetic agonist T0

182 tion of Akr1b7 by PXR was independent of the liver X receptor (LXR), another nuclear receptor known t

183 or-activated receptor gamma (PPARgamma), and liver X receptor (LXR), are potent inhibitors of TLR-ind

184 gulated by thyroid hormone receptor (TR) and liver X receptor (LXR), both of which control hepatic ch

185 SREBP-1c gene expression is induced by the liver X receptor (LXR), but CA-FoxO1 did not block the a

186 ntly the oxysterols, the natural ligands for liver X receptor (LXR), induced these genes via upregula

187 Of the two isoforms of Liver X receptor (LXR), LXRbeta has been shown to have m

188 Synthetic agonists for the Liver X Receptor (LXR), members of the nuclear hormone r

189 Oxysterols, via activation of liver X receptor (LXR), regulate keratinocyte differenti

190 A1), which is regulated by activation of the liver X receptor (LXR), was suppressed in epithelial cel

191 ic cells triggers the lipid-sensing receptor liver X receptor (LXR), which in response upregulates th

192 ol synthesis, and 2) decreased expression of liver X receptor (LXR)-alpha, LXR-beta, and ATP-binding

193 B mediates their beneficial effects, in both liver x receptor (LXR)-dependent and independent manners

194 oxysterols recruit protumor neutrophils in a liver X receptor (LXR)-independent, CXCR2-dependent mann

195 ession of atherosclerotic plaques in part by liver X receptor (LXR)-mediated induction of the chemoki

196 SMILE in the regulation of nuclear receptor liver X receptor (LXR)-mediated sterol regulatory elemen

197 crease in expression of the nuclear receptor liver X receptor (LXR).

198 gus-derived compound, as an inhibitor of the liver X receptor (LXR).

199 hinulin B (NeoB) as a novel inhibitor of the liver X receptor (LXR).

200 We observed enrichment for liver X receptor (LXR)/retinoid X receptor (RXR) and far

201 ular cholesterol to apoA-I and is induced by liver X receptor (LXR)/retinoid X receptor (RXR) transcr

202 n of nuclear receptors (NRs), especially the liver X receptor (LXR)/retinoid X receptor heterodimer,

203 deregulation of the miR-155 target gene the liver X receptor (LXR)alpha in lung fibroblasts and macr

204 ulfonamides were identified in a HTS as dual liver X receptor (LXR, NR1H2, and NR1H3) ligands, and th

205 Liver X receptors (LXR) alpha and beta are nuclear oxyst

206 The liver X receptors (LXR) alpha and beta are regulators of

207 Liver X receptors (LXR) are oxysterol-activated nuclear

208 Liver X receptors (LXR) are stimulated by cholesterol-de

209 eptor agonists showed that activation of the liver X receptors (LXR) dramatically promoted lipid accu

210 s, which are ligands for the nuclear hormone liver X receptors (LXR), decrease amyloid beta (Abeta) s

211 The accumulation of desmosterol, a known liver-X receptor (LXR) activator, was associated with in

212 The nuclear receptor liver-X-receptor (LXR) directly regulates expression of

213 liferator activated receptor (PPAR)gamma and liver-X-receptor (LXR)alpha; and the cholesterol efflux

214 Liver X receptor (LXRalpha) and RNA polymerase II (RNA P

215 uclear receptor family transcription factors Liver X Receptors (LXRalpha and -beta) are expressed in

216 Liver X receptors (LXRalpha and LXRbeta) are important r

217 The liver X receptors (LXRalpha and LXRbeta) are members of

218 Here, we show the role of the liver X receptors (LXRalpha and LXRbeta) in preventing a

219 As liver X receptors (LXRalpha,beta) regulate genes linked

220 "cholesterol-sensing" nuclear receptors, the liver X receptors (LXRalpha/LXRbeta), protects against a

221 due to the simultaneous coactivation of the liver X receptor, LXRalpha, a nuclear hormone receptor w

222 The liver X receptors, LXRalpha (NR1H3) and LXRbeta (NR1H2),

223 Liver X receptors (LXRs) activate triglyceride synthesis

224 Liver X receptors (LXRs) alpha and beta are nuclear rece

225 Liver X receptors (LXRs) alpha and beta are transcriptio

226 Liver X receptors (LXRs) and farnesoid X receptor (FXR)

227 egulated by nuclear receptors, including the liver X receptors (LXRs) and peroxisome-proliferator rec

228 Here, we provide evidence that activation of liver X receptors (LXRs) and retinoid X receptors (RXRs)

229 table to accumulation of excess cholesterol, liver X receptors (LXRs) and the farnesoid X receptor (F

230 The farnesoid X receptor (FXR) and the liver x receptors (LXRs) are bile acid-activated recepto

231 Liver X receptors (LXRs) are cholesterol-sensing nuclear

232 Liver X receptors (LXRs) are determinants of hepatic ste

233 Liver X receptors (LXRs) are involved in maintaining nor

234 The liver X receptors (LXRs) are ligand-activated transcript

235 Liver X receptors (LXRs) are ligand-activated transcript

236 The liver X receptors (LXRs) are ligand-dependent transcript

237 Liver X receptors (LXRs) are lipid-activated nuclear rec

238 Liver X receptors (LXRs) are members of the nuclear rece

239 Liver X receptors (LXRs) are nuclear receptors involved

240 Liver X receptors (LXRs) are nuclear receptors that are

241 The liver X receptors (LXRs) are nuclear receptors that play

242 The liver X receptors (LXRs) are nuclear receptors with esta

243 Liver X receptors (LXRs) are one class of nuclear recept

244 Liver X receptors (LXRs) are regulators of cholesterol m

245 Liver X receptors (LXRs) are transcription factors invol

246 Liver X receptors (LXRs) are transcriptional regulators

247 The liver X receptors (LXRs) are transcriptional regulators

248 Liver X receptors (LXRs) are transcriptional regulators

249 Liver X receptors (LXRs) broadly limit cholesterol accum

250 Liver X receptors (LXRs) centrally control reverse chole

251 Liver X receptors (LXRs) exert key functions in lipid ho

252 Ligand-dependent SUMOylation of liver X receptors (LXRs) has been found to suppress TLR4

253 Liver X receptors (LXRs) have been identified as sterol

254 The liver X receptors (LXRs) have been known as sterol senso

255 Liver X receptors (LXRs) have previously been implicated

256 report studies investigating the role of the liver X receptors (LXRs) LXRalpha and LXRbeta in carbohy

257 Recent studies in rodent models suggest that liver X receptors (LXRs) may play an important role in t

258 Liver X receptors (LXRs) play a critical role in regulat

259 that acts in a coupled metabolic cycle with Liver X Receptors (LXRs) to increase brain apolipoprotei

260 retinoid-related orphan receptors (RORs) and liver X receptors (LXRs) were postulated to have distinc

261 oliferator activated receptor (PPAR) family, liver X receptors (LXRs), and farnesoid X receptor (FXR)

262 Idol is a direct target for regulation by liver X receptors (LXRs), and its expression is responsi

263 Proliferator-Activated Receptors (PPARs) and Liver X Receptors (LXRs), are lipid-sensing receptors th

264 hat specific cholestenoic acids activate the liver X receptors (LXRs), enhance islet-1 expression in

265 rally occurring hydroxysterol agonist of the liver X receptors (LXRs), members of the nuclear recepto

266 Activation of liver X receptors (LXRs), one cellular mechanism to regu

267 ptors (PPARs), farnesoid X receptors (FXRs), liver X receptors (LXRs), retinoid-related orphan recept

268 ng through transcription factors such as the liver X receptors (LXRs), sterol regulatory element-bind

269 rly all of the transrepression activities of liver X receptors (LXRs), they can be selectively recrui

270 - to 11-fold) requires two binding sites for liver X receptors (LXRs), which are nuclear receptors th

271 ammation, processes that can be modulated by liver x receptors (LXRs).

272 d via SREBPs nor was it sterol-activated via liver X receptors (LXRs).

273 he control of nuclear receptors, such as the liver X receptors (LXRs).

274 y 1, group H, members 2 and 3 (also known as liver X receptors [LXRs]) regulate genes involved in cho

275 ession and failure to appropriately activate liver X receptor-mediated (LXR-mediated) pathways, ultim

276 ocorticoid production, likely by suppressing liver X receptor-mediated activation of steroidogenic ac

277 rotein-dependent gene expression and promote liver X receptor-mediated responses.

278 LA(2) antagonizes StAR promoter activity and liver X receptor-mediated StAR promoter activation.

279 xisome proliferator-activated receptors, and liver X receptors, modulate lipid metabolism.

280 Liver X receptors or LXRs are key modulators of macropha

281 1 cholesterol transporter by agonists of the liver X receptor/peroxisome proliferator-activated recep

282 enhanced the ability of GX sPLA2 to suppress liver X receptor reporter activity.

283 Identification and characterization of four liver X receptor response elements in the intron downstr

284 rophages, resulting in reduced expression of liver X receptor-responsive genes including ATP-binding

285 and ATP-binding cassette transporter G1 are liver X receptor-responsive macrophage genes that promot

286 lving inhibition of matrix metalloproteases, liver X receptor/retinoid X receptor, nuclear factor ery

287 Many liver X receptor/RXR-related genes (e.g., Scd-1 and Sreb

288 Based on these results, modulation of the liver X receptor signaling pathway is a new target for c

289 t occur in response to insulin signaling and liver X receptor signaling would be predicted to increas

290 otide phosphodiesterase activity secreted by liver X receptor-stimulated human macrophages.

291 of lipidated ApoE, through the activation of liver X receptors, stimulates Abeta degradation.

292 -fed L-sIDOL mice had elevated expression of liver X receptor target genes and proinflammatory genes

293 ulatory element 2, and up-regulation of many liver X receptor target genes.

294 expression of transcription factors such as liver X Receptor, the sterol regulatory element binding

295 oxisome proliferator-activated receptors and liver X receptor, these proteins sense the presence of u

296 oxisome proliferator-activated receptors and liver X receptors, this family of transcription factors

297 roxisome proliferator-activated receptor and liver X receptor transcription factors.

298 PPARdelta expression (but not other PPARs or liver X receptors), whereas PPARdelta knockdown by siRNA

299 acons for additional factors, exemplified by liver X receptors, which drive both cell-specific gene e

300 e pathway is sensitive to transrepression by liver X receptors, while the CaMKII-dependent pathway is