ライフサイエンスコーパス: liver development

1 tify microRNA (miR)-337-3p as a regulator of liver development.

2 port that Cited2 is required for mouse fetal liver development.

3 ctivity has the opposite effect and enhances liver development.

4 originate from hepatoblasts during embryonic liver development.

5 been shown to be crucial for early embryonic liver development.

6 lo, which exhibits severe defects in gut and liver development.

7 y) we have found a new role for Wt1 in mouse liver development.

8 iferation upon PHx but did not reverse fatty liver development.

9 elial Arnt plays a pivotal role in embryonic liver development.

10 s and organogenesis, especially in embryonic liver development.

11 esis, but are redundant for an early step of liver development.

12 biosynthesis of lipids during early skin and liver development.

13 and in embryonic erythropoiesis during fetal liver development.

14 gate the effect of exogenous FGFs on ex vivo liver development.

15 tes a physiological role of FGF during early liver development.

16 ment that might be crucial for physiological liver development.

17 atenin corresponded to cell proliferation in liver development.

18 s known about the molecular aspects of avian liver development.

19 in regulating growth zone activities during liver development.

20 y examining FGF signaling during early mouse liver development.

21 ular matrices) and TNFalpha is important for liver development.

22 ough activation of the PXR gene during fetal liver development.

23 sed to elucidate the role of beta-catenin in liver development.

24 nzo-p-dioxin as well as regulation of normal liver development.

25 bryos die at mid-gestation from a failure of liver development.

26 ignaling, methionine deficiency and impaired liver development.

27 in the hepatic diverticulum at the onset of liver development.

28 oma (Rb)-like protein, p107, during prenatal liver development.

29 e the pattern of E2F binding during prenatal liver development.

30 nic day 12.5 and is associated with abnormal liver development.

31 2.8 is the first such factor associated with liver development.

32 ortance of cyclin D1-CDK4 function in normal liver development.

33 uated in order to assess the consequences on liver development.

34 tumor suppressor mechanism during postnatal liver development.

35 about the contribution of Hippo signaling to liver development.

36 to a highly proliferative stage of postnatal liver development.

37 This is a key advance in bioartificial liver development.

38 tes previously inaccessible aspects of human liver development.

39 which differentiate into HSCs and PFs during liver development.

40 tial for normal biliary tubulogenesis during liver development.

41 ular competence, which are indispensable for liver development.

42 and a functional receptor instructing early liver development.

43 ue to severe anemia attributed to defects in liver development.

44 that SECs influence HSC localization during liver development.

45 red for Sp1 activation/Mediator during mouse liver development.

46 rotein function antagonistically to regulate liver development.

47 e 10) reduces PIP3 levels and leads to fatty liver development.

48 ng an instructive role of the vasculature in liver development.

49 mbly of the RNA Polymerase II complex during liver development.

50 d temporal expression of beta-catenin during liver development.

51 -fetoprotein and albumin activation early in liver development and alpha-fetoprotein reactivation dur

52 hepatocyte differentiation during mammalian liver development and also crucial for metabolic regulat

53 ntiation of liver progenitor cells underlies liver development and bile duct formation as well as liv

54 5' UTR to promote cell proliferation during liver development and carcinogenesis.

55 se iPS cells retain full potential for fetal liver development and describe a procedure that facilita

56 utility of zebrafish as a model for studying liver development and disease, and provide valuable tool

57 study, we created an in vitro model of human liver development and disease, physiology, and metabolis

58 for studying the mechanisms underlying human liver development and disease, testing the efficacy and

59 ch, offering innovative methods for studying liver development and disease.

60 ignaling is another important determinant in liver development and function and promotes cell-cell cy

61 a) is a well established master regulator of liver development and function.

62 d double mutants did not show any defects in liver development and function.

63 of Srebfs and methionine metabolism impacts liver development and function.

64 iched transcription factor, is essential for liver development and function.

65 d targets of miR-30a are known regulators of liver development and function.

66 F-kappaB) plays a critical role during fetal liver development and hepatic oncogenesis.

67 proliferation and survival during embryonic liver development and hepatocellular carcinogenesis.

68 ses of the contribution of HNF-4alpha toward liver development and hepatocyte differentiation.

69 r factor 4alpha (HNF4alpha) is essential for liver development and hepatocyte function.

70 esults identify miR-337-3p as a regulator of liver development and highlight how tight quantitative c

71 ction, providing an opportunity for studying liver development and host determinants of HCV susceptib

72 As differentially expressed throughout fetal liver development and in adult liver.

73 tivity during hepatocyte differentiation and liver development and in response to drug induction.

74 c mesenchymal cells that play vital roles in liver development and injury.

75 We focused on CRD-BP expression during rat liver development and liver regeneration, because c-myc

76 n vivo remain largely unknown, especially in liver development and liver tumorigenesis.

77 The expression of CYP3A4 changes during liver development and may be affected by the administrat

78 cannabinoid receptor (Cnr) activity disrupts liver development and metabolic function in zebrafish (D

79 We analyzed the cooperation of RB and p53 in liver development and pathogenesis of hepatocellular car

80 n signaling is involved in the regulation of liver development and physiology.

81 critical transcription factor that controls liver development and plays an important role in hepatic

82 ned to explore differentiation during normal liver development and regeneration after toxic injury.

83 Liver development and regeneration share the requirement

84 t play critical roles at different phases of liver development and regeneration, and underscore the i

85 During liver development and regeneration, hepatocytes undergo

86 signaling is a known regulatory pathway for liver development and regeneration, we studied the role

87 time-dependent role for wnt signaling during liver development and regeneration.

88 catenin signaling plays an important role in liver development and regeneration.

89 t study, we examined PDGFRalpha signaling in liver development and regeneration.

90 hogenesis of other hepatic cell types during liver development and regeneration.

91 transcription factor that controls embryonic liver development and regulates tissue-specific gene exp

92 esults indicate that IKK-beta is crucial for liver development and regulation of NF-kappaB activity a

93 MSCs prevent HFD-induced fatty liver development and restore glycogen storage in hepato

94 examine the localization of YAP during fetal liver development and show that higher levels of YAP are

95 Both repression of AFP during liver development and silencing in the brain, where AFP

96 cting reports about the role of Notch during liver development and suggest that Notch acts by coordin

97 that neither RelA nor TNFR-1 is required for liver development and that RelA protects the embryonic l

98 erlap in the genes and pathways that control liver development and those that regulate liver regenera

99 al polyploidization events occur during both liver development and throughout adult life.

100 cularly important, possibly through impaired liver development and/or infection in early life, in det

101 ANGPTL3 is expressed early during liver development, and expression is maintained in adult

102 hepatic stem cells from adults, for studying liver development, and for cell therapy based on hepatic

103 nic livers, metabolic genes during postnatal liver development, and growth/inflammation and metabolic

104 Abnormal yolk utilization, brain and liver development, and overall growth were observed in l

105 erved role for Notch signaling in vertebrate liver development, and support the zebrafish as a model

106 regulating Hex, a homeobox gene required for liver development, and the earliest stages of hepatogene

107 Gata4 and Gata6 display an earlier block in liver development, and thus completely lack liver buds.

108 dentity of miRNAs and their functions during liver development are largely unknown.

109 anscription factors known to be important in liver development are not induced during liver regenerat

110 Moreover, processes that are key to liver development are often co-opted during pathogenesis

111 eta) pathways have been implicated in normal liver development as well as in cancer formation.

112 enin, a key component of the Wnt pathway, in liver development as well as its normal distribution in

113 dynamic patterns of individual miRNAs during liver development, as well as miRNA networks that could

114 delta, and retinoid X receptor beta; and (c) liver development associated with CCAAT/enhancer binding

115 peak expression of beta-catenin during early liver development at Embryonic day 10 (E10)-E12, followe

116 reduced AFP gene expression during embryonic liver development, at a time in which fetal hepatocytes

117 oxylase mRNA is tightly regulated during rat liver development, both temporally and spatially support

118 Polyploidization occurs mainly during liver development, but also in adults with increasing ag

119 SCs) undergo dramatic expansion during fetal liver development, but attempts to expand their numbers

120 cyte nuclear factor 6 (HNF6) is required for liver development, but its role in adult liver metabolis

121 specific Shp deletion protects against fatty liver development by suppressing expression of peroxisom

122 morphogenesis, suggesting that the defect in liver development contributed to embryonic lethality.

123 sterol 7-hydroxylase mRNA evolves during rat liver development, correlated this with its total liver

124 expressed during the proliferative phase of liver development, correlating with expression of the fi

125 that liver restoration after hepatectomy and liver development differ dramatically with regard to tra

126 ripotent stem cells in hepatology, including liver development, disease modeling, host-pathogen inter

127 ignals appear to initiate distinct phases of liver development during mammalian organogenesis.

128 ifferentiation markers showing commitment to liver development, even under conditions that normally s

129 Although during early liver development full-length beta-catenin is the predom

130 and signaling programs precisely coordinate liver development, has begun to elucidate the molecular

131 The hepatic vasculature is essential for liver development, homeostasis and regeneration, yet the

132 t advances in the role of Notch signaling in liver development, homeostasis, and disease.

133 that HNF3beta plays a critical role in early liver development; however, our studies demonstrate that

134 y and involved in pivotal processes, such as liver development, immunoregulation, regeneration, and a

135 show here that E-cadherin is dispensable for liver development, implying that HNF4alpha regulates add

136 Decades of research on liver development in mice and other vertebrates offer va

137 We describe failed liver development in response to reduced SMN levels, in

138 ndergoes rapid changes in the pathway toward liver development in utero since it is also the major si

139 ough VEGF-A signaling and may play a role in liver development in vivo.

140 However, none reliably mimic human liver development, including parallel formation of hepat

141 increased expression during early postnatal liver development is associated with HCC progression in

142 ion and demethylation, whereas in vivo fetal liver development is characterized predominantly by deme

143 During adolescence, liver development is completed and children's livers nor

144 Thus, temporal activation of PDGFRalpha in liver development is important in hepatic morphogenesis.

145 The function of microRNA (miRNA) in liver development is unknown.

146 (AFP), a protein highly induced during fetal liver development, is down-regulated by retinoids in the

147 -enriched factor expressed very early during liver development, is sufficient to confer transcription

148 Cytokinesis can fail during normal postnatal liver development, leading to polyploid hepatocytes.

149 s are a valuable tool for the study of human liver development, liver injury, and hepatic repopulatio

150 Additionally, defects in liver development may underlie some congenital and perin

151 Moreover, aberrations in liver development observed in these mice were identical

152 tion in response to injury without effect on liver development or hepatocyte proliferation.

153 CCN1 is not required for liver development or regeneration, since these processes

154 , such as CYP3A4, is markedly reduced during liver development or regeneration.

155 Introducing concepts critical to liver development, organization, and physiology sets the

156 techniques to establish a timeline for fatty liver development over 20 weeks.

157 ocyte proliferation, which may be crucial in liver development, regeneration following partial hepate

158 t role in hepatic homeostasis, especially in liver development, regeneration, and cancer, and loss of

159 stellate cells, as well as their function in liver development, regeneration, and cancer.

160 eta-catenin activation is observed in normal liver development, regeneration, and liver cancer.

161 ial for hepatocyte entry into mitosis during liver development, regeneration, and liver cancer.

162 ively associated with cellular growth during liver development, regeneration, and oncogenesis but wit

163 s have implications in mechanisms concerning liver development, regeneration, and oncogenesis.

164 and TAZ activation have been associated with liver development, regeneration, and tumorigenesis.

165 ate determination and differentiation during liver development remains unclear.

166 ties in Klf6(-/-) mice obfuscate its role in liver development since these two processes are linked i

167 Our work provides fresh insights into liver development, suggesting that microbial-derived cue

168 During liver development, TfR2 was up-regulated and TfR1 was do

169 via enhanced CD36 expression, provoke fatty liver development that in turn leads to hepatic insulin

170 ession and regulation of beta-catenin during liver development that might be crucial for physiologica

171 During and after liver development, the activation of YAP/TAZ induced by

172 We examined, during wild-type fetal liver development, the expression of the Rel family memb

173 During subsequent liver development, the progenitor cells expressed HepPar

174 During liver development, the Ser/Thr phosphorylated RBMY is ex

175 expression parallels c-myc expression during liver development; the protein is present in fetal and n

176 bility in DNA methylation state during human liver development, these regions become highly unmethyla

177 LATS2 are redundantly required during mouse liver development to repress YAP and TAZ in both the bil

178 for changes in methylation during postnatal liver development to test the hypothesis that developmen

179 nts the advantages of zebrafish for studying liver development, underscoring how studies in zebrafish

180 ulation of xenobiotic responses during fetal liver development was analyzed using a fetal hepatocyte

181 Fatty liver development was associated with transcriptional ac

182 The control of liver development was originally defined by classical hi

183 gy to identify genes involved in early mouse liver development we have isolated Praja1, a gene with s

184 ole of APC loss and enhanced Wnt activity in liver development, we examined APC mutant and wnt induci

185 To determine the role of Foxm1b in liver development, we have generated Foxm1b -/- mice tha

186 To discover novel modifiers of liver development, we performed a chemical genetic scree

187 tional gene ablation during a later phase of liver development, we show here that deletion of both Fo

188 lar features to those observed during normal liver development, we sought to investigate the role of

189 AT1), a key enzyme of TG synthesis, in fatty liver development, we studied mice with global and liver

190 jury, 70% partial hepatectomy, and postnatal liver development were used.

191 During postnatal liver development, when transgenic p-21 protein becomes

192 m1b -/- hepatoblasts contributed to abnormal liver development with significant reduction in the numb