ライフサイエンスコーパス: liver-specific

1 ptional repression of AFP gene by ZBTB20 was liver-specific.

2 Whereas liver-specific 11beta-HSD1 KO mice developed a full Cush

3 mal1 in Apoe(-/-) and Ldlr(-/-) mice and its liver-specific ablation in Apoe(-/-) (L-Bmal1(-/-)Apoe(-

4 e have generated a combined mouse model with liver-specific ablation of GHR in which we restored live

5 Liver-specific ablation of LKB1 causes increased glucose

6 Liver-specific ablation of Mfn2 in mice led to numerous

7 Here we now show that constitutive liver-specific ablation of Notch signaling, or its acute

8 Liver-specific ablation of p31(comet) causes insulin res

9 neogenesis, we provide genetic evidence that liver-specific ablation of SIK2 alone has no effect on g

10 In mice, congenital liver-specific ablation of the GH receptor (GHR) results

11 Liver-specific ablation of the IR (L-Insulin Receptor KO

12 Liver-specific ablation of three FoxOs (L-FoxO1,3,4) pre

13 Administration as an inactive prodrug with liver-specific action compared with other INS-sensitive

14 rimary human hepatocyte spheroids maintain a liver-specific activity and architecture and are thus su

15 encodes the bile salt export pump (BSEP), a liver-specific adenosine triphosphate (ATP)-binding cass

16 Liver-specific adhesion molecules CXCR6 and CD49a have b

17 enic mouse line was established expressing a liver-specific Ahr-A78D on a Cre(Alb)/Ahr(flox/flox) bac

18 uper IDOL [sIDOL]) in C57Bl/6J mice from the liver-specific albumin promoter (L-sIDOL transgenics).

19 Liver-specific Albumin-Cre;Vps34(f/f) mice developed hep

20 In the present study, we used liver-specific (albumin-Cre) LKB1 knockout mice (LKB1(-/

21 Additionally, liver-specific AMPK alpha1 and alpha2 subunit KO and WT

22 NMP in wild type (alpha1alpha2(lox/lox)) and liver-specific AMPK knock-out mice (alpha1alpha2(lox/lox

23 To test the role of the liver, specific and exclusive deletion of hepatic CB1 re

24 Incidence risk ratios for liver-specific and overall mortality for NAFLD were 1.94

25 Interestingly, liver specific Ant2 knockout mice are leaner and resista

26 ating a fertile field for the development of liver-specific autoimmunity.

27 on-induced increases in blood ketone levels, liver-specific autophagy-deficiency significantly attenu

28 esponse was able to inhibit proliferation of liver-specific autoreactive T cells and prevent AIH.

29 Conditional, liver-specific beta-catenin knockdown (KD) mice and thei

30 Liver-specific beta-catenin knockout (beta-Catenin-LKO)

31 Female liver-specific beta-catenin knockout (KO) mice and wild-

32 The liver-specific bile salt export pump (BSEP) is crucial f

33 ciency in diet-induced obesity, we generated liver-specific BIM-knockout (BLKO) mice.

34 Here we used both Bmal1(-/-) and acute liver-specific Bmal1-depleted mice to study the role of

35 Furthermore, the liver-specific BVRA KO mice exhibited increased plasma g

36 Interestingly, liver-specific BVRA KO mice had increased GSK3beta activ

37 ethylnitrosamine (DEN)-induced HCCs, whereas liver-specific c-Fos expression leads to reversible prem

38 Animals with a liver-specific cIAP1 and total cIAP2 deficiency efficien

39 n signalling triggers the association of the liver-specific class II PI3K isoform gamma (PI3K-C2gamma

40 Liver-specific Clk2 knockout mice fed a high-fat diet ex

41 rolaemic, and that COMMD1-deficient dogs and liver-specific Commd1 knockout mice have elevated plasma

42 the deleterious effects of MET deletion, the liver-specific conditional loss of Egfr facilitated rath

43 To test this hypothesis, we generated novel liver-specific, conditional CD40 transgenic mice, and we

44 Notably, liver-specific constitutive activation of HIF-2alpha, bu

45 Wild-type and liver-specific constitutively activated human AHR transg

46 halamus after repeated administration of the liver-specific contrast agent gadoxetic acid.

47 ive copper overload caused by mutations in a liver-specific copper-transporting ATPase, ATP7B.

48 Here, by studying the liver-specific Cpr-null (LCN) mouse, we examined whether

49 SCC is also elevated in the urine of the liver-specific Ctr1(-/-) knockouts, which have normal AT

50 and pro-inflammatory cytokines than the non-liver-specific CXCR6- fraction.

51 We generated mice with either liver-specific deletion (Ppp1r3b(Delta)(hep) ) or liver-

52 We developed mice with liver-specific deletion of ALR (ALR-L-KO) using the albu

53 We created mice with liver-specific deletion of ALR to study its function.

54 We developed mice with liver-specific deletion of ALR, and showed that it is re

55 Interestingly, liver-specific deletion of Cdk1 is well tolerated, and l

56 lucose homeostasis, we generated mice with a liver-specific deletion of Ces3/Tgh expression (L-TGH kn

57 with defective hepatic metabolism due to the liver-specific deletion of cytochrome P450 oxidoreductas

58 We used mice with liver-specific deletion of Fak and investigated the role

59 As such, global or liver-specific deletion of FcRn results in resistance to

60 Liver-specific deletion of Foxo1 (L-IRFoxo1DKO) rescues

61 ese defects were normalized with concomitant liver-specific deletion of Foxo1.

62 egradation of CUGBP1, we generated mice with liver-specific deletion of Gank.

63 al mediator of hepatic lipid metabolism, and liver-specific deletion of HDAC3 leads to fatty liver.

64 Hepatic TG was also decreased by liver-specific deletion of Hig2 in mice with floxed Hig2

65 Mice with homozygous liver-specific deletion of Hnf1beta revealed that a comp

66 It is well established that liver-specific deletion of Insig1 leads to higher hepati

67 xpression in MYC-driven hepatoblastomas, and liver-specific deletion of Lin28a/b reduced tumor burden

68 bsence of interaction between both proteins, liver-specific deletion of LRP1 results in increased VWF

69 ce were treated with synthetic LXR agonists, liver-specific deletion of LXRalpha eliminated the detri

70 Liver-specific deletion of LXRalpha in mice substantiall

71 ditionally, in a pro-atherogenic background, liver-specific deletion of LXRalpha increased atheroscle

72 groups describe the effects of germline and liver-specific deletion of Mir122a, the predominant live

73 Liver-specific deletion of MKP-1 enhances gluconeogenesi

74 Moreover, mice with liver-specific deletion of MPC2 were protected from deve

75 dicted by the results of previously reported liver-specific deletion of murine Pcyt1a.

76 cer, we created a mouse model with biallelic liver-specific deletion of Pten and Grp78 mediated by Al

77 We show here that liver-specific deletion of Pten, which leads to activati

78 Using knockdown or liver-specific deletion of Sab, we aimed to elucidate th

79 We compared mice with liver-specific deletion of Sirt1 (Sirt1LKO) mice with th

80 Accordingly, liver-specific deletion of the autophagy gene Atg7 incre

81 hepatic metabolism, we generated mice with a liver-specific deletion of the Mfn1 gene (Mfn1LKO) and m

82 lized complex genetic manipulations to drive liver-specific deletion of the Rbpj gene in conjunction

83 Here, we evaluated mice harboring a liver-specific deletion of Trib1 (Trib1_LSKO) to elucida

84 er disease and dyslipidemia similar to HDAC3 liver-specific deletion.

85 roduction, we analyzed mouse lines harboring liver-specific deletions of genes encoding HIF-prolyl-hy

86 uggest potential application of Lac-GLN as a liver-specific delivery vehicle for anti-miR therapy.

87 Liver-specific depletion of AMOTL2 enlarged mouse liver

88 t, despite severe hepatosteatosis, mice with liver-specific depletion of Hdac3 have higher insulin se

89 Here we show that liver-specific depletion of nuclear receptors RORalpha a

90 Liver-specific depletion of RetSat in dietary obese mice

91 diabetes, or metabolic syndrome, as well as liver-specific disorders such as fatty liver, nonalcohol

92 Finally, control mice and mice with liver-specific disruption of Nr1h4 (liver FXR-knockout m

93 We used AlfpCre mice to create mice with liver-specific disruption of Trp53 (AlfpCre(+)Trp53(Delt

94 Liver-specific disruption of Trp53 consistently induced

95 To address this, we generated the liver-specific dominant-negative (DN) TCF7L2 (TCF7L2DN)

96 nctionally characterize a previously unknown liver-specific enhancer-promoter element in the wild-typ

97 transcription factors, are retained more at liver-specific enhancers than at promoters and ubiquitou

98 The different levels of liver-specific enzyme elevation, hepatic inflammation, a

99 c liver disease as measured by elevations of liver-specific enzymes and/or by histopathology.

100 s and transient elevation of serum levels of liver-specific enzymes indicative for a hepatic inflamma

101 arkers and are significantly associated with liver-specific expressed genes.

102 examine the consequence of effect of chronic liver-specific expression of a dominant-active form of I

103 Two previous studies of liver-specific expression of constitutive active IKK2 (I

104 Liver-specific expression of dominant-active IDOL is ass

105 the liver, we generated transgenic mice with liver-specific expression of luciferase and performed bi

106 Adenovirus-mediated liver-specific expression of SIRT1 or a phosphor-defecti

107 We show that liver-specific expression of the intracellular domain of

108 humanized HAEIII mouse models with inducible liver-specific expression of Thr309Lys-mutated FXII exhi

109 Liver-specific expression of wild-type or a DNA-binding-

110 ansgenic expression system by combination of liver-specific expression, mifepristone induction and Cr

111 CA) as the two most potent inhibitors of the liver-specific fatty acid transport protein 5 (FATP5).

112 Compared with negative littermates, liver-specific FBPase transgenic mice had 50% less adipo

113 Here we demonstrate that mice with global or liver-specific FcRn deletion exhibit hypoalbuminemia, al

114 In liver-specific FoxO knock-out mice, SREBP-1c expression

115 , ChIP-seq was performed with chromatin from liver-specific FoxO1 knockout and wild-type mice.

116 cholesterol diet (HFC)-on wildtype (WT) and liver-specific Foxo1/3/4 triple knockout mice (LTKO).

117 f human hepatocyte spheroid architecture and liver-specific functionality, have hampered a widespread

118 alysis revealed significant up-regulation of liver-specific functions, whereas pathways related to pr

119 r housekeeping/cellular maintenance genes or liver-specific functions.

120 ion in hepatocytes and lead to inhibition of liver-specific functions.

121 steatosis, both of which were reproduced by liver-specific G0S2 knockdown.

122 KLF6 binds to the liver-specific Gck promoter and activates a GCK promoter

123 aller livers with fewer hepatocytes, reduced liver-specific gene expression and proliferation.

124 improved morphological organization, higher liver-specific gene expression levels, increased metabol

125 fibronectin promoted albumin production and liver-specific gene expression of Huh-7.5 cells, compare

126 of DNA replication, cell cycle control, and liver-specific genes, indicating that Med1 alone is nece

127 The resultant hiPSC-EB-HLCs expressed liver-specific genes, secreted hepatic proteins such as

128 Here, we show by generation of liver-specific Gln synthetase (GS)-deficient mice that G

129 fy LPS- and ActivinA-induced upregulation of liver specific glucocorticoid receptor and Smad2/3 repor

130 ry genes we performed nanostring analysis on liver-specific GR knockout (LGRKO) mice in the presence

131 nce of ammonia homeostasis and establish the liver-specific GS KO mouse as a model with which to stud

132 Liver-specific GS-deficient mice showed increased locomo

133 se production in hepatocytes isolated from a liver-specific GSD Ia mouse model (L-G6pc(-/-) mice) and

134 Liver tissues from mice with liver-specific hemizygous disruption of Ppargc1a placed

135 Mice with liver-specific hemizygous or homozygous disruption of Pp

136 We also find a highly significant excess of liver-specific heteroplasmies involving nonsynonymous ch

137 t on hepatic HIF-1 because mice deficient in liver-specific HIF-1alpha experience hyperoxia-induced d

138 wild-type animals but are reduced by 60% in liver-specific HIF-1alpha knockout mice treated with DMO

139 Interestingly, mice with liver-specific Hig2 deletion also display improved gluco

140 Liver-specific Hnf4a knockout mice exhibited a 90% decre

141 ion and cell cycle control only in the acute liver-specific Hnf4alpha-null mouse.

142 Mice with liver-specific homozygous or heterozygous Arid1a loss we

143 However, ectopic expression of liver-specific human microRNA 122 (miR-122) further boos

144 rast to this established mode of action, the liver-specific human miR-122 binds at two sites within t

145 w, we summarise the current understanding of liver-specific immune responses and provide an outlook o

146 ole of NKT cells in perpetuating the loss of liver-specific immune tolerance will be discussed.

147 Using liver-specific inactivation in mice, we show that the TA

148 Liver-specific inactivation of Bmal1 led to elevated pla

149 Liver-specific inactivation or global null-mutation of C

150 Conversely, liver-specific inducible CEACAM1 expression prevented hy

151 Using a mouse model with liver-specific inducible Xbp1s expression, we demonstrat

152 uring several key features of PBC, including liver-specific inflammation focused on portal tract area

153 associated with high glucagon responses, and liver-specific inhibition of NIK led to lower glucagon r

154 g insulin effects in the liver, we generated liver-specific insulin receptor knockout (LIRKO) and IR/

155 Their selective, liver-specific insulin resistance was associated with in

156 Finally, in obese mice with liver-specific IRE1alpha deficiency, reconstitution of I

157 d IRS2 gene double-knockout (H-DKO) mice and liver-specific IRS1 and IRS2 double-knockout (L-DKO) mic

158 y regulates mRNA and protein expression of a liver specific isoform of Insig-2, Insig-2a, which in tu

159 In this issue, Webb et al. show that the liver-specific isoform of phosphofructokinase-1 forms fi

160 Liver-specific JNK1/2 deletion led to tumor reduction an

161 Liver-specific KAP1 knockout (KO) led to strikingly sexu

162 Studies in liver-specific Klf15-knockout mice suggested a non-hepat

163 at diet-treated wild-type mice and FoxO1/3/4 liver-specific knock-out mice.

164 Furthermore, transient liver-specific knockdown of LPCAT3 in mice affected PPAR

165 We created a mouse model of liver-specific knockdown of p70 S6 kinase (S6K) (L-S6K-K

166 In murine models, liver-specific knockdown of TRAP80 ameliorated liver ste

167 are downregulated in hepatocytes from GCN5L1 liver specific knockout mice and their upstream regulato

168 Here we compare a liver-specific knockout (KO) mouse model with total KO m

169 Our data show that Sesn3 liver-specific knockout mice exhibit insulin resistance

170 Using AMPK liver-specific knockout mice, we demonstrate that the Se

171 c polyploidy, we examined livers from Dicer1 liver-specific knockout mice, which are devoid of mature

172 stasis and tumor development, we created two liver-specific knockout mouse models with the deletion o

173 n, we inhibit hepatic lipogenesis in mice by liver-specific knockout of acetyl-CoA carboxylase (ACC)

174 ng, using mice and primary hepatoblasts with liver-specific knockout of Lats1 and Lats2 kinase, the d

175 Additionally, liver-specific knockout of NCOR, but not SMRT, causes me

176 Knockdown or liver-specific knockout of Sab abrogated this effect and

177 Liver-specific knockout or adenovirus-mediated overexpre

178 DIO FGF21 liver-specific knockout, but not FGF21 adipose-specific

179 9a8-inducible global-knockout (ZIP8-iKO) and liver-specific-knockout (ZIP8-LSKO) mice and observed ma

180 We assessed LR in liver-specific knockouts of Wntless (Wls-LKO), a protein

181 We show that the liver-specific KO mice fully recapitulate the severe iro

182 Likewise, mice harboring liver-specific Lats2 conditional knockout (Lats2-CKO) di

183 Strikingly, we found that liver-specific lincRNA gene promoters are more highly sp

184 Liver-specific lipin-1 deficiency in mice exacerbates th

185 In the present study, using a liver-specific lipin-1-deficient (lipin-1LKO) mouse mode

186 d healthy controls (n = 23), we discovered a liver-specific lncRNA (RP11-484N16.1) on chromosome 18 t

187 We found that MCD diet-fed, liver-specific LRH-1 knockout mice (Lrh-1(-/-) ) do not

188 The current study showed that liver-specific LRP1 knock-out (hLrp1(-/-)) mice displaye

189 We studied liver-specific Lrp5/6 KO (Lrp-LKO) mice where Wnt-signal

190 Application of CCL-1 to mice with liver-specific luciferase expression in a diet-induced m

191 g-term culture confirmed the presence of the liver-specific markers, hepatocyte nuclear factor 4alpha

192 in-Lactate-Etiology score but not with other liver-specific markers.

193 Down-regulation of the liver-specific MAT1A gene, encoding S-adenosylmethionine

194 Hepatic stellate cells are liver-specific mesenchymal cells that play vital roles i

195 Hepatic stellate cells (HSCs) are liver-specific mesenchymal cells that play vital roles i

196 d glucose tolerance and insulin signaling in liver-specific Mfn2 KO mice.

197 regulated in different malignancies, whereas liver-specific microRNA (miR)-122, a bona fide tumor sup

198 C virus (HCV) replication is dependent on a liver-specific microRNA (miRNA), miR-122.

199 miR-122, an abundant liver-specific microRNA (miRNA), regulates cholesterol m

200 ion of hepatitis C virus, which requires the liver-specific microRNA (miRNA)-122, the interactions of

201 For proof-of-concept, miR-122, a liver-specific microRNA associated with many liver disea

202 The abundant, liver-specific microRNA miR-122 forms extensive base-pai

203 on is dependent on microRNA 122 (miR-122), a liver-specific microRNA that recruits Argonaute 2 to the

204 lls support the entire HCV life cycle if the liver-specific microRNA, miR-122, is expressed along wit

205 The liver-specific microRNA, miR-122, stabilizes hepatitis C

206 Hepatitis C virus subverts liver-specific microRNA, miR-122, to upregulate viral RN

207 As the liver-specific microRNA-122 (miR-122) is required for HC

208 aviviridae family, recruits two molecules of liver-specific microRNA-122 (miR-122) to the 5' end of i

209 epatitis C virus (HCV) uniquely requires the liver-specific microRNA-122 for replication, yet global

210 Liver-specific miR-122 binds to sites in the 5'-UTR of h

211 ntly, the mortality rates of male and female liver-specific miR-122 knockout (LKO) mice were signific

212 depletion on liver pathobiology by treating liver-specific miR-122 knockout (LKO) mice with the hepa

213 passenger strand of the abundantly expressed liver-specific miR-122.

214 cterized the primary transcript of the human liver-specific MIR122 using Northern blot, quantitative

215 miR-122 is an abundant, liver-specific miRNA that is an unusual host factor for

216 MicroRNA-122 (miR-122), a pivotal liver-specific miRNA, has been implicated in several liv

217 MicroRNA-122, an abundant and conserved liver-specific miRNA, regulates hepatic metabolism and f

218 nd horizontally transferred a mature form of liver-specific miRNA-122.

219 Liver-specific mortality and overall mortality among NAF

220 Liver-specific mortality values were calculated.

221 d CREBH processing and apoA-IV expression in liver-specific MTP knock-out mice.

222 iglycerides) orthologs using adenoviruses in liver-specific MTP-deficient (L-MTP(-/-)) mice that have

223 We report that liver-specific Mttp knockout mice (Mttp-LKO) exhibit bot

224 Its replication is dependent upon a small, liver-specific noncoding RNA, miR-122.

225 Liver-specific Nrf1 (NF-E2-p45-related factor 1) knockou

226 or this phenotype, we generated an inducible liver-specific Nrf1 knockout mouse line using animals ha

227 Here, using mice with a liver-specific null mutation of Sirt1, we have identifie

228 Liver-specific OATP1B1 and OATP1B3 are uptake carriers f

229 At the whole animal level, the liver-specific overexpression of fortilin reduced PRX1 p

230 Conversely, liver-specific overexpression of GSNOR in obese mice mar

231 By contrast, liver-specific overexpression of human ZIP8 (adeno-assoc

232 Global or liver-specific overexpression of miR-26a in mice fed a h

233 Conversely, the liver-specific overexpression of Ppp1r3b enhanced hepati

234 -specific deletion (Ppp1r3b(Delta)(hep) ) or liver-specific overexpression of Ppp1r3b The Ppp1r3b del

235 Cholestasis was induced in wildtype and liver-specific p38alpha knockout mice by bile duct ligat

236 arks 99% of hepatic stellate cells (HSCs), a liver-specific pericyte population, to demonstrate that

237 The gene encoding the liver-specific peroxisomal enzyme alanine:glyoxylate ami

238 g to regression of the fibrotic phenotype in liver-specific Phb1 knockout mice.

239 hepatocyte viability and maintenance of the liver-specific phenotype in vitro.

240 Liver-specific PPARdelta activation increases, whereas h

241 e, regeneration is significantly impaired in liver-specific PPARgamma null mice in the setting of die

242 suppressed, but rather modestly augmented in liver-specific PPARgamma null mice maintained on a norma

243 er regeneration is impaired, regeneration in liver-specific PPARgamma null mice with chronic hepatic

244 ve responses to PH are modestly augmented in liver-specific PPARgamma null mice, thus providing addit

245 cytes and were preserved in hepatocytes from liver-specific PPARgamma(-/-) mice, indicating that PPAR

246 er replaced the entire B domain and a hybrid liver-specific promoter (HLP) mediated 10-fold higher hF

247 vector consisting of a bioengineered capsid, liver-specific promoter and factor IX Padua (factor IX-R

248 man WT GCase (hGCase) expression driven by a liver-specific promoter and is also homozygous for the I

249 xylase (Pah) complementary DNA (cDNA) from a liver-specific promoter coupled to a de novo designed he

250 deno-associated virus-5 (AAV5) vector with a liver-specific promoter driving expression of a codon-op

251 HS-CRM8 is introduced upstream of a minimal liver-specific promoter in an adenoassociated virus (AAV

252 otype 8 vector expressing feline IDUA from a liver-specific promoter.

253 e IL-12 or luciferase under the control of a liver-specific promoter.

254 We suppressed the expression of a liver-specific protein, cell death-inducing DFFA-like ef

255 binding by liver transcription factors than liver-specific protein-coding gene promoters.

256 etabolic activity and the ability to secrete liver-specific proteins, whereas hepatocytes derived fro

257 In liver-specific Pten(-/-) mice shortly after induction of

258 We quantified liver-specific rates of hepatic gluconeogenesis and subs

259 Viral-mediated liver-specific RB deletion in vivo led to the induction

260 nstructive in human disease, we compared our liver-specific RB-loss gene signature to existing profil

261 This suggests the lack of common liver-specific reference probes for both S. lateralis an

262 We generated a liver-specific Repin1 knockout mouse (LRep1(-/-)) and sy

263 enic conditions, leading to hepatosteatosis; liver-specific restoration of XBP1s reverses the defects

264 Pharmacological inhibition and liver-specific RNAi knockdown of HSD1 significantly impa

265 Viable constitutive and tamoxifen inducible liver-specific RNase H1 knockout mice that expressed no

266 Similar observations were made in liver-specific RORgamma-deficient mice.

267 These pathologies are suppressed by liver-specific Sestrin2 reconstitution, mTORC1 inhibitio

268 Mechanistically, we demonstrate that liver-specific Shp deletion protects against fatty liver

269 ith hepatic polyploidy, miR-122 is the first liver-specific signal identified; our data demonstrate t

270 Liver-specific SIRT1 knockout (SIRT1 LKO) mice and their

271 al component of NR treatment was revealed in liver-specific Sirt1 knockout mice (Sirt1(hep-/-) ), whe

272 We performed partial hepatectomy in WT and liver-specific Sirt1-deficient mice and analyzed the exp

273 tion of SIRT1 was demonstrated in vivo using liver-specific SIRT1-deficient mice, where the effect of

274 T3 in control of Gadd45b was confirmed using liver-specific Stat3-null mice.

275 This study demonstrates that liver-specific Stat5-null mice develop severe hepatic st

276 d in cleaved caspase-3 in control but not in liver-specific Stat5-null mice.

277 Liver-specific STS induction or estrogen/estrogen sulfat

278 ular membrane, and induction of autoreactive liver-specific T cells was detected.

279 epatic gluconeogenesis, a recent study using liver-specific Tcf7l2(-/-) mice suggested the opposite.

280 d by Von Hippel-Lindau (Vhl) disruption in a liver-specific temporal fashion.

281 an alternate cancer model, we have generated liver-specific, Tet-on-inducible transgenic lines expres

282 s have implications for our understanding of liver-specific tolerance and autoimmunity and for the de

283 In-vivo, liver specific Tp53 loss increases the conversion of 5-F

284 ulatory elements containing patterns from 12 liver-specific transcription factor binding sites was as

285 parallels with Taf10(-/-) animals carrying a liver-specific transcription factor II D (TFIID) defect

286 g protein, hepatocyte specific (CREBH), is a liver-specific transcription factor localized in the end

287 ctivator involved in energy metabolism and a liver-specific transcription factor, respectively.

288 nscription factor binding occupancy of three liver-specific transcription factors between crosses of

289 Although several liver-specific transcription factors have been identifie

290 These motifs are either known as liver-specific transcription factors or have an importan

291 s accessible in chromatin and allowing other liver-specific transcription factors to bind and stimula

292 After identifying a digital signature of 10 liver-specific transcripts, we used a cross-validated lo

293 sms of Sestrin 3 (Sesn3), we generated Sesn3 liver-specific transgenic and knockout mice.

294 biochemical assessments of energy balance in liver-specific transgenic FBPase mice and negative contr

295 Moreover, using liver-specific TRbeta1-KO mice, we demonstrate that hypo

296 These liver-specific triply null mice, designated LTKO, exhibi

297 ORC1) in whole-body physiology, we generated liver-specific Tsc1 (L-Tsc1 KO) knockout mice.

298 nderstand in vivo functions of WWOX, we used liver-specific Wwox(hep-/-) and total Wwox(-/-) mice mod

299 Liver-specific Xbp1 knockout mice (Xbp1(LKO)) and Xbp1(f

300 esponse after BDL was further evaluated with liver-specific Yap conditional deletion in mice.