ライフサイエンスコーパス: lncRNA

1 lncRNAs are remarkably versatile molecules that interact

2 lncRNAs may act as an enhancer or suppressor to inflamma

3 We found 11 lncRNA loci that, upon recruitment of an activator, medi

4 Among them, 16 lncRNAs were identified as putative target mimics of cas

5 There were 864 genes, 7 miRNAs and 17 lncRNAs differentially expressed between infected and no

6 o the observed recurrent deregulation of 235 lncRNAs.

7 A total of 3045 lncRNAs were differentially expressed between the paired

8 We identified 318 lncRNAs responsive to cold and/or drought stress, which

9 erforming gene expression profiling of 4,383 lncRNAs in 82 liver samples from individuals with NASH (

10 rference (CRISPRi) platform targeting 16,401 lncRNA loci in seven diverse cell lines, including six t

11 When the 8-lncRNA signature was combined with plasma miRNA data and

12 Of the 1,970 lncRNAs available for analysis on the gene expression ar

13 printed gene located at 14q32 that encodes a lncRNA, and the decreased MEG3 expression has been repor

14 d of chondrocyte gene regulation involving a lncRNA.

15 the first proof of concept that targeting a lncRNA to transcriptionally activate SMN2 can be combine

16 Bone marrow reconstitutions showed that a lncRNA expressed across all progenitors was required for

17 anism might better explain how low-abundance lncRNAs transcribed from noncoding DNA function in organ

18 To accelerate lncRNA annotation, the GENCODE consortium has developed

19 In addition, lncRNA-KRTAP5-AS1 and lncRNA-TUBB2A could act as competi

20 Among lncRNAs identified from this screen, we demonstrate that

21 These results demonstrate an lncRNA-mediated mechanism by which a transcriptional fac

22 We identified an lncRNA that can play an important regulatory role in liv

23 from patients with IPMNs and suggest that an lncRNA-based blood test may have utility as a diagnostic

24 Our results uncover an lncRNA-mediated mechanism for HIF-1 activation and estab

25 aken together, our results have uncovered an lncRNA-based mechanism that modulates TGF-beta/Smad3 sig

26 We analyzed lncRNA expression profiles in mouse hearts at postnatal

27 In addition, lncRNA-KRTAP5-AS1 and lncRNA-TUBB2A could act as competing endogenous RNAs to

28 ization of transcriptional (mRNA, miRNA, and lncRNA) and epigenetic (DNA methylation, H3K4me3, H3K79m

29 our analysis provides insights into mRNA and lncRNA networks in rainbow trout skeletal muscle and the

30 ed in all fractions, with intron, snoRNA and lncRNA interactions enriched in the nucleus.

31 that involves AP2 transcription factors and lncRNAs.

32 irmed translation of miRNA target mimics and lncRNAs that produce trans-acting or phased small-interf

33 s (ncRNAs), including microRNAs (miRNAs) and lncRNAs, which have been shown to exert critical regulat

34 ic analysis of ribosome-associated mRNAs and lncRNAs demonstrates that nutrient availability and tran

35 dentified differentially regulated mRNAs and lncRNAs in juvenile rainbow trout exposed to E2.

36 -induced signals integrate enhancers/SEs and lncRNAs to increase expression of genes involved in VSMC

37 Major substrates of PAP1 are the snoRNAs and lncRNAs.

38 Depletion of the annotated lncRNA, IFNG-AS1, or one IFNG enhancer-associated lncRNA

39 nment-free program that accurately annotates lncRNAs based on a Random Forest model trained with gene

40 To deliver the anti-lncRNA to the acidic (pH approximately 6) tumor microenv

41 protein-coding transcript and the antisense lncRNA increase dramatically in sporozoites.

42 ral and sequence components of the antisense lncRNA.

43 pseudogene as a model system, that antisense lncRNAs interact first with a 5' UTR-containing promoter

44 Of particular interest are lncRNAs upstream of the master chondrocyte transcription

45 A, IFNG-AS1, or one IFNG enhancer-associated lncRNA abrogates IFNG expression by memory T cells, indi

46 pplied to a disease with no known associated lncRNA (isolated disease) and to lncRNA with no known as

47 hod (NLCFA) integrating correlations between lncRNA, protein coding genes and noncoding miRNAs.

48 chnology that leverages interactions between lncRNA and PRC2.

49 tal methods to identify associations between lncRNAs and diseases are expensive and time-consuming.

50 to reveal the potential associations between lncRNAs and diseases.

51 we identified an additional Polycomb-binding lncRNA, COLDWRAP.

52 further identified fragments of PRC2-binding lncRNAs that are enriched with these sequence features,

53 Through that, PRC2-binding lncRNAs were found to be associated with a set of distin

54 Candidate lncRNAs related to metastasis, such as HAND2-AS1, were f

55 identified and characterized 8,603 candidate lncRNAs.

56 tissue-specific expression characteristics, lncRNAs hold strong promise as novel biomarkers and ther

57 uld be generalized to study and characterize lncRNAs conserved in other species and tissue types.

58 PN1 and MATR3 through regulation of a common lncRNA target with downstream impact on paraspeckle morp

59 rst reference catalog of 682 high-confidence lncRNAs based on analysis of strand-specific RNA-seq dat

60 at brain tissues revealed a set of conserved lncRNAs.

61 ted the expression patterns of the conserved lncRNAs at different time points during rat brain growth

62 iferation by identifying DANCR as a critical lncRNA widely overexpressed in human cancers.Significanc

63 e novel information on the ability to detect lncRNAs in plasma from patients with IPMNs and suggest t

64 were also implemented, and the top 5 disease-lncRNA associations were reported for each disease.

65 We also survey how disrupted lncRNA function can contribute to malignant transformati

66 To elucidate lncRNA function in human disease, we have developed a no

67 ch for epigenetically controlled endothelial lncRNAs yielded lncRNA n342419, here termed MANTIS, as t

68 novel and functionally important endothelial lncRNAs.

69 we show that in primary human erythroblasts, lncRNAs transcribed from the LTR retrotransposons of ERV

70 ghlight the contribution of rapidly evolving lncRNAs to species-specific developmental mechanisms.

71 transcript 1 (MALAT1) is a broadly expressed lncRNA involved in many aspects of cellular processes.

72 The POU2F2 and TRIM28 co-expressed lncRNA landscape characterized here may shed light into

73 e applied to prioritize aberrantly expressed lncRNAs for functional validation in other diseases and

74 rt, for the first time, aberrantly expressed lncRNAs in MDS and further prioritize biologically relev

75 nalysed to identify differentially expressed lncRNAs and a functional network was constructed to pred

76 Interrogation of known transcription factor-lncRNA interactions, transcription factor-gene interacti

77 through which Zbtb7b recruits the brown fat lncRNA 1 (Blnc1)/heterogeneous nuclear ribonucleoprotein

78 mary, ALT joins PAN/nut1/T1.1 as a bona fide lncRNA of KSHV with potentially important roles in viral

79 In this study, we established a role for lncRNAs in chondrocyte differentiation.

80 The connection from lncRNA to miRNA and DNA methylation facilitates the acut

81 t remains challenging to identify functional lncRNA loci and distinguish among these and other mechan

82 we provide a valuable resource of functional lncRNAs and biomarkers associated with HCC tumorigenesis

83 We have generated lncRNA expression profiles from the CD34+ haematopoietic

84 Finally, elevated expression of H19 lncRNA due to promoter demethylation was observed in cel

85 In the heart, lncRNAs have been implicated in the regulation of develo

86 tion in both euchromatic and heterochromatic lncRNA-based gene silencing processes.

87 We review here how lncRNAs control the function and homeostasis of cell pop

88 Eprn illustrates how lncRNAs may introduce species-specific network modulatio

89 e we review the current understanding of how lncRNAs help coordinate gene expression to modulate cell

90 nerate a comprehensive atlas of 27,919 human lncRNA genes with high-confidence 5' ends and expression

91 n the expression profiles of conserved human lncRNAs and protein-coding genes, and produced 79 co-exp

92 ysis revealed a total of 351 conserved human lncRNAs corresponding to 646 rat lncRNAs.

93 Among these human lncRNAs, 140 were newly identified by our study, and 246

94 We identified lncRNA MFI2-AS1 as best candidate in the training set.

95 termination and peptidic analysis identified lncRNAs that produce peptides, including several deeply

96 sets, from four patient cohorts identifying lncRNA DNM3OS, MEG3, and MIAT overexpression and their r

97 Alterations in lncRNA expression and their mutations promote tumorigene

98 ifferentiation, we speculate that changes in lncRNAs might contribute to the phenotypic changes in Jo

99 lineage, whereas the other leukemia-induced lncRNAs were dispensable in the normal setting.

100 our study reveals a number of STAT3-induced lncRNAs suggesting that the interplay between the coding

101 e we identify MIR31HG as a hypoxia-inducible lncRNA and therefore we name it LncHIFCAR (long noncodin

102 Given that intergenic lncRNA have substantially less sequence conservation pat

103 s species, evolutionary conserved intergenic lncRNAs are likely to be functional.

104 by our study, and 246 were present in known lncRNA databases; however, the majority of the lncRNAs t

105 vel lncRNAs and accurately quantifying known lncRNAs is not trivial from massive RNA-seq data.

106 Our findings suggested that LTR lncRNAs transcribed from many of the 4000 copies of ERV-

107 s identified a highly up-regulated mammalian lncRNA, FOXD3-AS1, known as linc1623 in mice, in the set

108 ble region 5 (AR5) region of Foxp3 Like many lncRNAs, Flicr's molecular effects are subtle, but by cu

109 ression network analysis of mRNA with miRNA, lncRNA and virus genes identified key elements within th

110 Most lncRNA studies are highly dependent on high-throughput s

111 However, because most lncRNAs are currently uncharacterized, the identificatio

112 all this transcription is unclear since most lncRNAs are quickly targeted for destruction during synt

113 ormation on the combined influence of mRNAs, lncRNAs and miRNAs on cellular signal transduction netwo

114 ific interaction network identified multiple lncRNAs predicted to play a role in metastasis.

115 d biological analyses, we identified a novel lncRNA, BMP/OP-Responsive Gene (BORG), whose expression

116 cRNA with no known associated disease (novel lncRNA).

117 Therefore, predicting novel lncRNA-disease associations would contribute to dissect

118 We identified 731 known and 325 novel lncRNAs in the muscles biopsies.

119 ne genome annotation to include 10 374 novel lncRNAs and 58 640 mRNA transcripts.

120 However, discovering novel lncRNAs and accurately quantifying known lncRNAs is not

121 We have identified novel lncRNAs in ovarian cancer that are differentially expres

122 In addition, we address new areas of lncRNA biology, such as the functions of enhancer RNAs,

123 ttle is understood about the contribution of lncRNA to epithelial-to-mesenchymal transition (EMT), wh

124 h demand; and would benefit the detection of lncRNA biomarkers for disease diagnosis, treatment, and

125 rovide critical insight into the dynamics of lncRNA expression, function, and mechanism during oligod

126 ges and prospects for further elucidation of lncRNA mechanisms.

127 be recognized and the molecular mechanism of lncRNA-mediated gene regulation remains largely unexplor

128 studies to synthesize emerging principles of lncRNA function, emphasizing how they facilitate diversi

129 important role for selective termination of lncRNA transcription in both euchromatic and heterochrom

130 Better understanding of lncRNA regulation of inflammation will provide novel tar

131 a mechanistic explanation for the ability of lncRNAs to regulate the expression of numerous genes dis

132 Our orthologous analysis of lncRNAs in human and rat brain tissues revealed a set of

133 ere, we performed an orthologous analysis of lncRNAs in human and rat brain tissues.

134 ed the emerging functions and association of lncRNAs in different types of cancer and discussed their

135 we provide a genome-wide characterization of lncRNAs, highlighting their intraspecies conservation an

136 this review, we discuss the contribution of lncRNAs in the development and activation of immune cell

137 However, the functions and contributions of lncRNAs remain largely unknown.

138 s physiological processes and dysfunction of lncRNAs could be a prevalent cause in human diseases.

139 Genome-wide expression of lncRNAs and mRNAs was determined using microarray.

140 ccRCC, which supports further integration of lncRNAs in molecular cancer classifications.

141 We then identified a list of lncRNAs that were differentially expressed between pairs

142 ile understanding the molecular mechanism of lncRNAs.

143 or samples have identified a large number of lncRNAs associated with various types of cancer.

144 we establish dynamic expression profiles of lncRNAs at different stages of oligodendrocyte developme

145 a human articular chondrocyte repertoire of lncRNAs from normal hip cartilage donated by neck of fem

146 view recent literature regarding the role of lncRNAs in transcriptional control of inflammatory respo

147 To determine the potential role of lncRNAs, we employed next generation sequencing to exami

148 has been identified, the functional roles of lncRNAs are only beginning to be recognized and the mole

149 wledge and future prospects for the roles of lncRNAs in the immune system and autoimmune disease.

150 Although a large set of lncRNAs has been identified, the functional roles of lnc

151 d disease have been revealed for a subset of lncRNAs, the function of the vast majority remains untes

152 rized, the identification of novel oncogenic lncRNAs is difficult.

153 Although oscillating lncRNAs exist in plants, their functional characterizati

154 Importantly, other lncRNAs or artificially synthesized RNA molecules that c

155 P. lncRNA AK017368 promotes proliferation and suppresses di

156 Analogous interactions in vivo would permit lncRNAs to mediate the juxtaposition of two or more DNA

157 Analysis of predicted lncRNAs from two test datasets demonstrated UClncR's acc

158 bal network random walk model for predicting lncRNA-disease associations (GrwLDA) to reveal the poten

159 erved human lncRNAs corresponding to 646 rat lncRNAs.

160 NONCODING RNA (FLORE), a circadian-regulated lncRNA that is a NAT of CDF5.

161 ermed MANTIS, as the most strongly regulated lncRNA.

162 ily conserved and significantly Pi-regulated lncRNAs.

163 a lineage-specific Linc-RAM as a regulatory lncRNA required for tissues-specific chromatin remodelli

164 tionally annotate known and novel regulatory lncRNAs.

165 re, we identify new fission yeast regulatory lncRNAs that are targeted, at their site of transcriptio

166 ional approaches to identify disease-related lncRNAs are in high demand; and would benefit the detect

167 and further prioritize biologically relevant lncRNAs using the NLCFA.

168 of stage-specific oligodendrocyte-restricted lncRNAs, including a conserved chromatin-associated lncO

169 As a result, lncRNAs may serve as novel diagnostic and therapeutic ta

170 Here we report that the long non-coding RNA (lncRNA) HOTAIR (for HOX Transcript Antisense Intergenic

171 ified a rodent-specific long non-coding RNA (lncRNA) linc1281, hereafter Ephemeron (Eprn), that modul

172 ression of an antisense long non-coding RNA (lncRNA) that has previously been shown to promote var ge

173 Clustering by mRNA, long non-coding RNA (lncRNA), and miRNA expression converged to identify subs

174 Iw1 is a long noncoding RNA (lncRNA) containing an inverted repeat (IR) with >80% ide

175 layer of complexity, the long noncoding RNA (lncRNA) Flicr (Foxp3 long intergenic noncoding RNA) is a

176 ted in the intron of the long noncoding RNA (lncRNA) LINC00305 by searching the GWAS database.

177 isense growth-associated long noncoding RNA (lncRNA) located between Hoxd1 and Hoxd3 In this study, w

178 How the protein and long noncoding RNA (lncRNA) regulatory networks act in concert to regulate k

179 ranscription of DANCR, a long noncoding RNA (lncRNA) that is widely overexpressed in human cancer.

180 to determine the role of long noncoding RNA (lncRNA), metastasis-associated lung adenocarcinoma trans

181 eviously uncharacterized long noncoding RNA (lncRNA), SMN-antisense 1 (SMN-AS1), represses SMN2 expre

182 modulation by miRNAs and long-noncoding RNA (lncRNA).

183 A (20-23 nucleotides) to long noncoding RNA (lncRNA, more than 200 nucleotides).

184 COPD) development, while long noncoding RNA (lncRNAs) have been shown to cause COPD.

185 Long non-coding RNAs (lncRNAs) are a family of novel genes that regulate gene

186 Although long non-coding RNAs (lncRNAs) are non-protein-coding transcripts by definitio

187 e, Y chromosome-linked long non-coding RNAs (lncRNAs) are poorly characterized and the potential link

188 Long non-coding RNAs (lncRNAs) have been implicated in the regulation of diver

189 ate, a large number of long non-coding RNAs (lncRNAs) have been recently discovered through functiona

190 For example, although long non-coding RNAs (lncRNAs) have been shown to critically regulate gene exp

191 eening hypoxia-related long non-coding RNAs (lncRNAs) in PDK1-positive tissue, we find that lncRNA H1

192 n of a wide variety of long non-coding RNAs (lncRNAs) in the genomes of several organisms.

193 The expression of long non-coding RNAs (lncRNAs) is dysregulated in hepatocellular carcinoma (HC

194 vidence indicates that long non-coding RNAs (lncRNAs) play crucial roles in epigenetic and transcript

195 Long non-coding RNAs (lncRNAs) play key roles in human diseases, including can

196 Although long non-coding RNAs (lncRNAs) regulate various cellular events, their functio

197 Long non-coding RNAs (lncRNAs) regulating gene expression at the chromatin lev

198 elming number of human long non-coding RNAs (lncRNAs) reported so far, little is known about their ph

199 xpanded the catalog of long non-coding RNAs (lncRNAs) with varying evolutionary conservation, lineage

200 lar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs), undergo trans-splicing and polyadenylation.

201 tely present in human long, non-coding RNAs (lncRNAs).

202 NAs) from the class of long non-coding RNAs (lncRNAs).

203 ant subset of them are long non-coding RNAs (lncRNAs).

204 ene expression such as long non-coding RNAs (lncRNAs).

205 Long noncoding RNAs (lncRNAs) affect gene regulation through structural and r

206 Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene exp

207 Long noncoding RNAs (lncRNAs) are emerging as key factors in various fundamen

208 Long noncoding RNAs (lncRNAs) are increasingly recognized as vital components

209 Long noncoding RNAs (lncRNAs) are involved in diverse biological processes an

210 Long noncoding RNAs (lncRNAs) are known to be important in regulating healthy

211 Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nt with limited

212 Many long noncoding RNAs (lncRNAs) are unstable and rapidly degraded in the nucleu

213 nockdown of overlapping long noncoding RNAs (lncRNAs) blocks AngII-induced genes associated with grow

214 Long noncoding RNAs (lncRNAs) have been associated with HCC, but a comprehens

215 Thousands of long noncoding RNAs (lncRNAs) have been discovered, yet the function of the v

216 Long noncoding RNAs (lncRNAs) have been reported to play diverse roles in bio

217 Long noncoding RNAs (lncRNAs) have emerged as critical regulators of inflamma

218 evidence indicates that long noncoding RNAs (lncRNAs) have important roles in various physiological p

219 s described the role of long noncoding RNAs (lncRNAs) in cardiac pathologies.

220 ttle is known about how long noncoding RNAs (lncRNAs) interact with target loci in the context of chr

221 A subset of long noncoding RNAs (lncRNAs) is spatially correlated with transcription fact

222 microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) play crucial roles in the development of a dise

223 have demonstrated that long noncoding RNAs (lncRNAs) play important roles in many human diseases.

224 function of most human long noncoding RNAs (lncRNAs) remains unclear.

225 Long noncoding RNAs (lncRNAs) reside and function primarily inside the nucleu

226 Recently, long noncoding RNAs (lncRNAs) that are natural antisense transcripts (NATs) t

227 and accumulation of the long noncoding RNAs (lncRNAs) XACT and XIST on active X chromosomes in both e

228 of loci that transcribe long noncoding RNAs (lncRNAs), some of which are known to carry out critical

229 regulating hippocampal long noncoding RNAs (lncRNAs), whose expression correlates with hippocampal v

230 e produces thousands of long noncoding RNAs (lncRNAs)-transcripts >200 nucleotides long that do not e

231 localization of single long noncoding RNAs (lncRNAs).

232 loged, particularly for long noncoding RNAs (lncRNAs).

233 tence of multiple viral long noncoding RNAs (lncRNAs).

234 iption units encoding "long noncoding RNAs" (lncRNAs).

235 We review the involvement of noncoding RNAs, lncRNAs in particular, in development of Barrett's esoph

236 This identified several lncRNAs essential for leukemia maintenance, and found th

237 ols (n = 23), we discovered a liver-specific lncRNA (RP11-484N16.1) on chromosome 18 that showed sign

238 miRNAs, which are in turn bound by specific lncRNAs acting as competing endogenous RNAs (ceRNAs), re

239 as constructed to predict those CAF-specific lncRNAs involved in metastasis.

240 the functional significance of many specific lncRNAs, support grows for the notion that the act of tr

241 ta suggests that aberrant levels of specific lncRNAs are intimately involved in network modules that

242 s per lincRNA locus), as well as 402 spliced lncRNAs that are antisense to protein-coding (PC) genes.

243 targeting of HOTAIR in cancer, but targeting lncRNAs in vivo has proven to be difficult.

244 lass of functionally important cancer/testis lncRNAs whose structure and function have undergone posi

245 By screening an Arabidopsis thaliana lncRNA custom-made array we identified CDF5 LONG NONCODI

246 Collectively, our findings demonstrate that lncRNA SNHG1 can function both in cis and in trans with

247 cRNAs) in PDK1-positive tissue, we find that lncRNA H19 is responsible for glycolysis and BCSC mainte

248 We found that lncRNA AK017368 is highly expressed in skeletal muscle c

249 We further found that lncRNA knockdown can perturb complex transcriptional net

250 ed TGF-beta/Smad3 signaling, suggesting that lncRNA-rSBE may be a general mechanism used by cells to

251 We further demonstrate that lncRNAs overlapping expression quantitative trait loci (

252 Recent studies indicated that lncRNAs are emerging as crucial regulators in cancer pro

253 Recent evidence indicates that lncRNAs play important roles in directing the developmen

254 ng genetic and expression data, we show that lncRNAs overlapping trait-associated single nucleotide p

255 Studies have shown that lncRNAs are expressed in a highly lineage-specific manne

256 oth un-stranded and stranded RNA-seq so that lncRNAs overlapping with other genes can be predicted an

257 Our studies also suggest that lncRNAs can be therapeutically targeted to minimize post

258 ed a mechanistic link between Zbtb7b and the lncRNA regulatory pathway through which Zbtb7b recruits

259 We propose that the interaction between the lncRNA, its binding protein MYH9, and the coding gene FO

260 Finally, the lncRNA plasmacytoma variant translocation 1 (PVT1) was i

261 A role for the lncRNA Haglr in the control of postnatal growth could no

262 vealed that the T allele of rs9517723 in the lncRNA LOC107984558 was significantly associated with oc

263 The input of the LDAP server is the lncRNA sequence.

264 Moreover, the Rroid locus, but not the lncRNA itself, controlled the identity and function of I

265 Functional studies of the lncRNA HOTAIR (HOX transcript antisense RNA) provide com

266 the Il1a gene also result in mutation of the lncRNA sequence and a predicted alteration of its second

267 Moreover, we find that the lncRNA and promoter-spanning transcript interaction are

268 Here, we demonstrate that the lncRNA growth arrest-specific 5 (GAS5) suppresses TGF-be

269 Among them, the lncRNA maternally expressed gene 3 (Meg3) was found to b

270 T1 regulates the activity of p53 through the lncRNA-protein interaction.

271 lead us to propose a new mechanism where the lncRNA regulates the availability of free PRC2 at the pr

272 elomeres were shown to form hybrids with the lncRNA TERRA, yet the formation and distribution of thes

273 In the present work we assessed the lncRNAs complement of Schistosoma mansoni, the blood flu

274 ntial co-regulatory relationship between the lncRNAs and their potential target genes using the 'cis'

275 cRNA databases; however, the majority of the lncRNAs that have been identified are not yet functional

276 ctors (TFs) across the genome, but how these lncRNA-TF gene duplexes regulate tissue development and

277 es relevant to the traits, implicating these lncRNAs in multiple diseases.

278 pression by memory T cells, indicating these lncRNAs have biologic function.

279 Two of these lncRNAs are upregulated during chondrogenic differentiat

280 The expression of some of these lncRNAs correlates with ischemic time.

281 provided the functional annotation of these lncRNAs in humans and rats.

282 Some of these lncRNAs may have important functions in cardiac hyperpla

283 Depletion of one of these lncRNAs, LOC102723505, which we termed ROCR (regulator o

284 This lncRNA, which we named lnc18q22.2 based on its chromosom

285 The locus encoding this lncRNA, which we termed Rroid, directly interacted with

286 Thus, lncRNA secondary structure may regulate IL-1alpha expres

287 associated lncRNA (isolated disease) and to lncRNA with no known associated disease (novel lncRNA).

288 Taken together, lncRNA AK017368 promotes proliferation and inhibits diff

289 Results showed that two lncRNAs (GAS5 and SRA) aided in differentiating IPMNs fr

290 tionally characterize a novel ultraconserved lncRNA, THOR (ENSG00000226856), which exhibits expressio

291 on the gene expression array used, 39 unique lncRNAs were identified as differentially expressed in C

292 n nuclear surveillance of naturally unstable lncRNAs to prevent their accumulation, transport to the

293 nsive structural characterization of a viral lncRNA and interactions with its protein partners in dis

294 Our results reveal a mechanism by which lncRNA MALAT1 acts as a proto-oncogene in hepatocellular

295 response to injury, and a paradigm by which lncRNAs encoding small polypeptides can modulate general

296 ng the diverse molecular mechanisms by which lncRNAs tune highly contextualized transcriptional progr

297 nally characterized, and the extent to which lncRNAs control NF-kappaB expression is unknown.

298 of putative small open reading frames within lncRNAs are translated.

299 atures in different tetraploid species; yet, lncRNAs slightly differ from coding transcripts.

300 cally controlled endothelial lncRNAs yielded lncRNA n342419, here termed MANTIS, as the most strongly