ライフサイエンスコーパス: lobe

1 including two separated lobes (the N- and C-lobes).

2 asing levels of emphysema in the right lower lobe.

3 l (apicoposterior) segment of the left upper lobe.

4 targeting seizure foci, such as the temporal lobe.

5 with a low-grade tumor in the right temporal lobe.

6 nding projections to the SGN/V and the vagal lobe.

7 sparse than elsewhere in the medial temporal lobe.

8 central brain, ventral nerve cord and optic lobe.

9 the parietal lobe followed by the occipital lobe.

10 l also showed associations with the anterior lobe.

11 n regions located within the medial temporal lobe.

12 e largest decreases observed in the parietal lobe.

13 o-occipital junction and the medial parietal lobe.

14 rtically converged organization of the optic lobe.

15 ect motion detection in the Drosophila optic lobe.

16 eft thalamus and bilateral inferior parietal lobe.

17 n are still unclear, especially in the optic lobe.

18 ring the development of the Drosophila optic lobe.

19 of CaM but not the weakly binding N-terminal lobe.

20 virtual lesion to the left anterior temporal lobe.

21 by actively excising and digesting germ cell lobes.

22 damage predominated in frontal and temporal lobes.

23 s of the majority of the primary lymph gland lobes.

24 brain in the frontal, temporal, and parietal lobes.

25 omains including the central linker and both lobes.

26 m) neutrophils with a high number of nuclear lobes.

27 etry) flanked by two Cas1 lobes and two Cas3 lobes.

28 ty in distinct regions of the human temporal lobes.

29 ominantly affecting the frontal and temporal lobes.

30 e subcortex, frontal, parietal and occipital lobes.

31 Pol epsilon contains two flexibly tethered lobes.

32 ssive atrophy of the frontal and/or temporal lobes.

33 he formation of new alveoli in the remaining lobes.

34 nplace issues of mutual coupling and grating lobes.

35 positive lobes compared with tumor-negative lobes.

36 ith air trapping, predominately in the upper lobes.

37 n inferior prefrontal and occipital/parietal lobes.

38 ly affected region was the parieto-occipital lobes (100%), however, other atypical regions involved w

39 structural stability by clamping the NTR to Lobe 2 of the ATPase domain.

40 r atypical regions involved were the frontal lobes (30.4%), temporal lobes (8.69%), basal ganglia (22

41 on Cohort Study, including 233 (85.0%) right lobes, 40 (14.6%) left lobes, and 1 (0.5%) left lateral

42 ved were the frontal lobes (30.4%), temporal lobes (8.69%), basal ganglia (22%), cerebellum(17.39%),

43 In the Drosophila optic lobes, 800 retinotopically organized columns in the medu

44 ronounced involvement of the medial temporal lobe, abnormal cerebrospinal fluid amyloid-beta1-42 valu

45 of substantial overlap between transmission lobes across successive junctions creates a gate-tunable

46 aptic input to the CSDns within the antennal lobe (AL), an olfactory network targeted by the CSDns, a

47 with structural abnormalities of the frontal lobe, amygdala, and insula.

48 ctural abnormalities in frontal and temporal lobes, amygdala, and insula are less consistent.

49 bly focal involvement of the medial temporal lobe and a slow steady progression, likely representing

50 ships (i.e. episodic memory: medial temporal lobe and angular gyrus; semantic memory: left anterior t

51 s have multiple motor units within the optic lobe and are organized in a mosaic manner.

52 The percentage of emphysema in each lung lobe and both lungs was correlated with 6 parameters - a

53 rmation in which its open Ca(2+)-activated C-lobe and closed N-lobe cooperate to recognize a mixed al

54 ther than within the visual, medial temporal lobe and default mode networks, whereas during task it w

55 Moreover, tau deposits in the temporal lobe and distributed heteromodal areas were tightly nest

56 ctions modulates odor tuning in the antennal lobe and drives synergistic interactions between two eco

57 e on neuropsychological tests of the frontal lobe and executive functioning, the Trail Making Test, a

58 antennal nerve, in projections of the dorsal lobe and in the gnathal ganglion suggest that tyramine r

59 reduced gray matter volume in the occipital lobe and left cerebellar lobule VIIb, which is functiona

60 er, the functional organization of the optic lobe and neural control of the various body patterns by

61 ns were chiefly associated with the anterior lobe and posterior lobule HVI.

62 ; language: left posterior superior temporal lobe and supramarginal gyrus; executive functions: bilat

63 volume loss in the thalamus, medial temporal lobe and temporal neocortex.

64 s may have multiple motor units in the optic lobe and that these are organized in a mosaic manner.

65 by stimulating different parts of the optic lobe and that various subsets of these components can be

66 nding sites within the small sub-domain of N-lobe and the C-lobe of HECT domain.

67 eak clusters') were in the anterior temporal lobe and the precentral gyrus.

68 of M. tuberculosis infection burdens in lung lobes and extrapulmonary organs than did the control gro

69 Mutant leaf cells lacked interdigitation of lobes and F-actin did not uniformly decorate the nuclear

70 e after enucleation and biopsied the frontal lobes and optic nerves of a macaque experimentally infec

71 asticity among local neurons in the antennal lobes and projection neurons to LHN connections, the mod

72 lvement of the frontal and anterior temporal lobes and the presence of asymmetry could be useful in d

73 wofold axis of symmetry) flanked by two Cas1 lobes and two Cas3 lobes.

74 obe, orbitofrontal cortex, anterior temporal lobe, and caudate nucleus than PCA, and PCA showed more

75 less severe atrophy of the lateral temporal lobe, and lower mean (SD) cerebrospinal fluid levels of

76 s causes adaptions in the striatum, parietal lobe, and prefrontal and visual cortices in the brain th

77 stimuli are first processed in the antennal lobe, and then transferred to the mushroom body and late

78 mainly ending medially to those of the vagal lobe, and those from the commissural nucleus ventrolater

79 astrocyte-like glia in the Drosophila optic lobe, and through a RNAi screen, they identify a transme

80 ing 233 (85.0%) right lobes, 40 (14.6%) left lobes, and 1 (0.5%) left lateral section.

81 nd in brain regions without AmTAR1-IR (optic lobes, antennal lobes), indicating that other tyramine-s

82 ol of the various body patterns by the optic lobe are largely unknown.

83 The cerebellar floccular and parafloccular lobes are housed in fossae of the periotic region of the

84 Thus, two temporal lobe areas extend the core face-processing network into

85 ssociated conformational changes to both CaM lobes as indicated by amide chemical shifts of the amino

86 a method for classification and analysis of lobes at two-cell junctions and three-cell junctions, re

87 cal studies that the human anterior temporal lobe (ATL) is a semantic representational hub.

88 ociations between cognition, medial temporal lobe atrophy (MTA), lesion volumes, and global white mat

89 ing the Scheltens' scale for medial temporal lobe atrophy (MTA), the Koedam's scale for posterior atr

90 performed a genome-wide association study of lobe attachment in a multiethnic sample of 74,660 indivi

91 lastat for detection of PCa on a patient and lobe basis, using visual and semiquantitative (tumor-to-

92 discriminated high-grade disease from normal lobes better.

93 lasses of Firmicutes inhabited East and West Lobe Bonney at depths of 30 m.

94 The cellular and molecular control of a lobed cell morphology is currently thought to involve PI

95 In fields of lobing cells, anticlinal microtubules are not correlated

96 7/VCP-binding motif interacts with the inter-lobe cleft in the N-domain of p97.

97 and posterior cingulate, insula and temporal lobes (Cohen's d effect sizes: -0.10 to -0.14).

98 ntly higher visual score and TBR in positive lobes compared with tumor-negative lobes.

99 Stimulations in the medial temporal lobe components of the DN evoked relatively late effects

100 vorticity suppresses formation of the third lobe, consequently reducing flame stretch.

101 A helical scaffold in the C-lobe constitutes the inositol phosphate-binding site, wh

102 A second lobe contains the ORC2/3 subunits.

103 ts open Ca(2+)-activated C-lobe and closed N-lobe cooperate to recognize a mixed alpha/310 helix in A

104 d by similar interaction effects on temporal lobe cortical thickness (whole-brain voxelwise analysis:

105 wk displayed intensive and widespread (>/= 1 lobe) cortical (18)F-FET uptake.

106 ns, the flame kernel separates through third lobe detachment, corresponding to high strain rates that

107 cts of socioeconomic disadvantage on frontal lobe development (with implications for functioning) dur

108 s a preferred posterior to anterior temporal lobe direction, consistent across participants.

109 he tau deposits were grouped in the temporal lobe, distributed in heteromodal areas, medial and visua

110 p helices, the beta protrusion, and the beta lobe domains to close the promoter DNA binding channel a

111 r results reveal that in the insect antennal lobe, due to circuit interactions, distinct neural ensem

112 n 50 glomerular compartments in the antennal lobe, each of which represents a discrete olfactory info

113 which, along with the participation of the N-lobe, endows high specificity to this protein.

114 e use of LITT for a variety of extratemporal lobe epilepsies.

115 are altered in experimental mesial temporal lobe epilepsy (mTLE) and whether their integration diffe

116 The cause of mesial temporal lobe epilepsy (MTLE) is often unknown.

117 Mesial temporal lobe epilepsy (mTLE) is the most common focal epilepsy i

118 patients with drug-resistant mesial temporal lobe epilepsy (mTLE).

119 Seizures in temporal lobe epilepsy (TLE) disturb brain networks and lead to c

120 GNIFICANCE STATEMENT Development of temporal lobe epilepsy (TLE) generally takes years after an initi

121 Temporal lobe epilepsy (TLE) is the most frequent form of focal e

122 lated in the DG of individuals with temporal lobe epilepsy (TLE) or AD and correlate with performance

123 Medically refractory unilateral temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS-TLE,

124 o localize hippocampal pathology in temporal lobe epilepsy (TLE), but has rarely been evaluated in pa

125 ther parallels between human medial temporal lobe epilepsy and a naturally occurring condition in wil

126 transcriptomic signature of chornic temporal lobe epilepsy and the drugs that reverse it.

127 were observed only in patients with temporal lobe epilepsy and were recorded exclusively from mesiote

128 We studied 43 patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis and

129 insights for why some patients with temporal lobe epilepsy continue to experience postoperative seizu

130 Temporal lobe epilepsy is common and can be difficult to treat ef

131 rom mice with epilepsy (pilocarpine-temporal lobe epilepsy model) and 100 healthy control hippocampi,

132 and neocortex of rats with chronic temporal lobe epilepsy to demonstrate that subsets of cells disch

133 is study evaluated a mouse model of temporal lobe epilepsy to test which pathological changes in the

134 two patients with pharmacoresistant temporal lobe epilepsy will not be rendered completely seizure-fr

135 ed febrile seizures group developed temporal lobe epilepsy with mesial temporal sclerosis.

136 mpal lesions, 30 patients with extratemporal lobe epilepsy, and 30 healthy controls on two tasks: bin

137 In a mouse model of temporal lobe epilepsy, multicellular calcium imaging revealed th

138 roinflammation, aggravating stroke, temporal lobe epilepsy, neuropathic pain, and various neurodegene

139 gation of temporal lobe seizures in temporal lobe epilepsy, using diffusion tensor imaging and automa

140 to contribute to the development of temporal lobe epilepsy.

141 y one-third of patients with mesial temporal lobe epilepsy.

142 on in the pathophysiology of mesial temporal lobe epilepsy.

143 operative seizures in patients with temporal lobe epilepsy.

144 ossy fiber axons, both hallmarks of temporal lobe epilepsy.

145 s in experimental models of chronic temporal lobe epilepsy.

146 veolar liquid clearance in isolated pig lung lobes ex vivo and reduced edema in a volume overload in

147 The N-lobe exhibits a remarkable degree of conservation with p

148 t viral cross-class transmissions, involving lobe-finned fish, shark and frog FLERVs.

149 ccipital division of the braincase in a stem lobe-finned fish.

150 m was most commonly observed in the parietal lobe followed by the occipital lobe.

151 a positive effect of simvastatin on frontal lobe function and a physical quality-of-life measure.

152 the hydrophobic pockets located at both CaM lobes further enhanced CaM-HVR complex stability.

153 lack most of the approximately 500 antennal lobe glomeruli found in wild-type ants.

154 bers of odorant receptors (ORs) and antennal lobe glomeruli.

155 f Purkinje cells recorded from the posterior lobe hemisphere in awake cats.

156 LB) have both been associated with occipital lobe hypometabolism on (18)F-FDG PET, whereas relative s

157 turally contiguous region of DnaK, involving lobe IIA of the nucleotide binding domain, the inter-dom

158 plex is composed of an ORC1/4/5 motor module lobe in an organization reminiscent of the DNA polymeras

159 was significantly decreased in the occipital lobe in both presymptomatic (mean BOLD change 1.1% [SD 0

160 ons without AmTAR1-IR (optic lobes, antennal lobes), indicating that other tyramine-specific receptor

161 terior Parietal Cortex and Inferior Parietal Lobe, indicating increases of cortical involvement durin

162 reprocedure chest x-ray showed a right lower lobe infiltrate.

163 Experimental evidence indicates that the lobes integrate visual and vestibular information and co

164 increased cytosolic Ca(2+), calcified CaM N lobe interacts with helix B in place of PIP2 to limit ex

165 tal cortex (RLPFC) and the inferior parietal lobe (IPL).

166 The noncatalytic lobe is anchored to the motor of the helicase, whereas t

167 evelopment of tau beyond the mesial temporal lobe is associated with, and may be dependent on, amyloi

168 Previous studies have shown that the optic lobe is the motor command center for dynamic body patter

169 The optic lobe is thought to play a key role in controlling the ex

170 dicated that the general folding in N- and C-lobes is conserved with A. thaliana IP5 2-K.

171 o contextual learning; the anterior temporal lobe, known to be an amodal hub for semantic processing

172 displaceable binding potential)) in temporal lobes, lateralising according to their clinical syndrome

173 nt, as breeders have selected for entire and lobed leaf morphs resulting from a single locus, okra (l

174 es in an experiment with humans with frontal lobe lesions, asking whether behavioral impairments can

175 001) involving the occipital lobes, temporal lobes, limbic system, cerebellum, and frontoparietal cor

176 opulation of electrons in a radio galaxy jet/lobe, located at a significant distance away from the ce

177 -onset group, and more focal medial temporal lobe loss in the late-onset group.

178 pographically organized, those of the facial lobe mainly ending medially to those of the vagal lobe,

179 teraction preference, which, in the temporal lobe, mapped onto a fine-grain pattern of object, body,

180 t revealed a large consolidative right lower lobe mass with surrounding inflammation ( Fig 1A ).

181 d cortical grey matter rCBF in the occipital lobe (mean difference -11.1 mL/100 g per min, 95% CI -2.

182 l codes are used in conjunction with frontal lobe mechanisms to plan routes during navigation.

183 ioteuthis lessoniana Most areas in the optic lobe mediated predominately ipsilateral expansion of chr

184 from visual projection neurons of the optic lobe medulla, completing a three-legged circuit that we

185 Both in the occipital and temporal lobe, metabolites with higher physiological concentratio

186 ial prefrontal cortex, and superior temporal lobe, mostly on the left side.

187 of individual neurons in the medial temporal lobe (MTL) are attenuated, delayed, and lengthened.

188 The medial temporal lobe (MTL) contains "concept cells" that respond invaria

189 erformance of 31 patients with mediotemporal lobe (MTL) epilepsy and hippocampal lesions, 30 patients

190 ven the critical role of the medial temporal lobe (MTL) in episodic memory, age-related changes in MT

191 The medial temporal lobe (MTL) is an early site of tau accumulation and MTL

192 tau proteins and atrophy of medial temporal lobe (MTL) structures crucial to memory formation.

193 en interest in the idea that medial temporal lobe (MTL) structures might be especially important for

194 te the alERC/pmERC and other medial temporal lobe (MTL) subregions.

195 cate that tau tangles in the medial temporal lobe (MTL) underlie episodic-memory impairments in AD de

196 euronal ensembles within the medial temporal lobe (MTL).

197 nsverse and longitudinal modes with a single lobe, near-diffraction-limited far field.

198 The temporal lobe network (TLN), and subcortical network (SCN), and s

199 unction could erode the function of temporal lobe networks and ultimately contribute to cognitive agi

200 that (i) cerebellar efferents target frontal lobe neurons involved in forming action representations

201 n some cases is already present in the optic lobe neurons of T. brassicae.

202 by disrupting the interaction of the carboxy-lobe of calmodulin with a calmodulin-binding domain in t

203 y contrast, expression of either the N- or C-lobe of CaM abrogated estrogen-stimulated transcription

204 binding to Akt(PHD) displaces the C-terminal lobe of CaM but not the weakly binding N-terminal lobe.

205 hin the small sub-domain of N-lobe and the C-lobe of HECT domain.

206 the C-terminal region, and reveals how the N lobe of PINK1 binds ubiquitin via a unique insertion.

207 ion of an interface formed between the large lobe of the kinase domain and the regulator of G protein

208 By electrically stimulating the optic lobe of the oval squids and observing their body pattern

209 The two lobes of CaM bind to the same site on two separate ER-al

210 connected to the main core protein shell via lobes of density.

211 eotide binding between the separate N- and C-lobes of HsIPMK.

212 plex, the third optic neuropil, in the optic lobes of insects.

213 egion, and others spread between the N and C lobes of the kinase domain.

214 second trimester, extensively involving all lobes of the left lung.

215 within the medullary zone and the secondary lobes of the lymph gland.

216 urons with dendrites in the alpha and alpha' lobes of the mushroom body, which drive negatively reinf

217 rwent multilineage regeneration, reforming a lobe often indistinguishable from undamaged ones.

218 A chest x-ray demonstrated a right-upper-lobe opacity.

219 ral tegmental area (SN/VTA), medial temporal lobe, or subsequent memory performance.

220 eater hypometabolism in the medial occipital lobe, orbitofrontal cortex, anterior temporal lobe, and

221 th SUVRCB (Pearson r: from 0.51 for temporal lobe [P = 0.002] to 0.82 for precuneus [P < 0.0001]) in

222 istinct glomerulus in the posterior antennal lobe (PAL).

223 rior P2 component over the parieto-occipital lobe peaked significantly earlier for the unique than fo

224 Individual prostate lobes plus periurethral prostatic ducts were evaluated a

225 d in CD vs HC in the right inferior parietal lobe post-cocaine and in the left superior frontal gyrus

226 Upper lobe-predominant emphysema has emerged as an important p

227 on disease, eight type C with right temporal lobe presentations, and 11 unclassifiable including eigh

228 Descending facial lobe projections to the medial funicular nucleus were al

229 olecules of Cas1 (Cas2/32:Cas14) into a four-lobed propeller-shaped structure, where the two Cas2 dom

230 primary gustatory centers (facial and vagal lobes) received sensory projections from the facial and

231 theta power are seen across lateral temporal lobe recording sites and persist throughout the remainde

232 ndard uptake value ratios in mesial temporal lobe regions (amygdala, hippocampus/choroid plexus regio

233 e aphasia; (iii) widespread temporal/frontal lobe regions of the left hemisphere and expressive aphas

234 orse aphasia, particularly when key temporal lobe regions were isolated into segregated modules.

235 ate how in vivo tau accumulation in temporal lobe regions, Abeta, and MTL atrophy contribute to episo

236 y was augmented in the left temporal/frontal lobe regions, as well as left inferior-parietal and cing

237 TCA was induced by laparoscopic liver lobe resection combined with arterial catheter blood wit

238 l thus allows direct control of the temporal lobe seizure threshold via endogenous pathways, providin

239 hippocampus, we control the risk of temporal lobe seizures during a specific time period.

240 Focal temporal lobe seizures in humans and in several experimental epil

241 n the generation and propagation of temporal lobe seizures in temporal lobe epilepsy, using diffusion

242 Whereas the anterior temporal lobe served as the major network hub for face processing

243 er classical calpain or atypical small optic lobe (SOL) calpain 2 d after 5-HT treatment or paired st

244 associative LTF is blocked by dn small optic lobe (SOL) calpain.

245 cancer susceptibility in a complex dose- and lobe-specific manner.

246 on of early tauopathy in the medial temporal lobe, specifically in the entorhinal cortex, and to a le

247 y areas and moving laterally on the temporal lobe: spectral features are found in the core of A1, mix

248 with no or reduced TB dissemination to other lobes, spleen, or liver/kidney; in contrast, the control

249 so explains how autophosphorylation in the N lobe stabilizes structurally and functionally important

250 The amygdala is a medial temporal lobe structure implicated in social and emotional regula

251 found across neocortical and mesial temporal lobe structures.

252 ably induces seizure-like events in temporal lobe structures.

253 Among temporal lobe subregions, episodic memory was most strongly relat

254 nterior segment of the right upper pulmonary lobe suggestive of alveolar hemorrhage.

255 CFTR binding to isolated calmodulin domains/lobes suggests a mechanism for the role of CFTR as a mol

256 er this occurs in structures in the temporal lobe, supplying cortical inputs to the hippocampus.

257 dered completely seizure-free after temporal lobe surgery.

258 The medial temporal-lobe system is essential for the formation and retrieval

259 In the fruit fly optic lobe, T4 and T5 cells represent the first direction-sele

260 hway, including the dorsal anterior temporal lobe (TEd), object-sensitive neurons are intermixed with

261 tabolism (P < 0.001) involving the occipital lobes, temporal lobes, limbic system, cerebellum, and fr

262 ssociative areas in the frontal and parietal lobe than primary regions of sensorimotor and visual fun

263 single cell expressed corazonin in the optic lobes that belonged to the group of medial AME interneur

264 ial charges by measuring the size of orbital lobes that best overlap with the wavefunction around an

265 r nuclei are uniquely structured as multiple lobes that establish a highly constrained nuclear enviro

266 zinc metallo-enzyme, including two separated lobes (the N- and C-lobes).

267 aterally, the lateral aspect of the temporal lobe, the temporo-parieto-occipital junction and the med

268 gions were the inferior and lateral temporal lobes, the same regions where the first signs of increas

269 against predominantly the C-terminal ATPase lobe through conserved electrostatic interactions.

270 lied electrical stimulation within the optic lobe to investigate the neural basis of body patterning

271 atically impairs development of the antennal lobe to which ORNs project.

272 ocerebrum and the other that exits the optic lobes toward the supraesophageal ganglion.

273 pathways termed medial and lateral antennal lobe tracts (m-ALT and l-ALT).

274 cts had lateralized atrophy of most temporal lobe tracts, and hippocampal volumes in HS-TLE correlate

275 mmunohistochemistry demonstrate that damaged lobes underwent multilineage regeneration, reforming a l

276 r devices, deviations from the main Gaussian lobe up to 25 microns from the focus and down to the 5 x

277 The lesion was extending from the left lower lobe up to the apical (apicoposterior) segment of the le

278 partments, that compose the adult MB's alpha lobe, using a dataset of isotropic 8 nm voxels collected

279 al information from the medulla of the optic lobe via the anterior optic tubercle (AOTU) and bulb (BU

280 executive functions governed by the frontal lobes via actions on D1 and D2 receptors.

281 A total of 89.8% of EBV subjects had target lobe volume reduction greater than or equal to 350 ml, m

282 were assessed at 3 and 6 months, and target lobe volume reduction on chest computed tomography at 3

283 ed variability of caudate nucleus or frontal lobe volumes.

284 The temporal lobe was involved in 71.9% of operations.

285 Temporal lobe was the most common NHS location (16 of 51 pure NHS

286 f prostate lesions across multiple prostatic lobes was conducted that included internal BPA dosimetry

287 mis and left lobule V of cerebellar anterior lobe were additionally activated for dual-task performan

288 hange and the beta band power in the frontal lobe were found to differ the most between the two state

289 Volumetric reductions of frontal lobes were largest in the ADHD+ODD group, possibly under

290 ch liver parenchyma as possible in the right lobe while avoiding large vessels, on imager-generated p

291 an medial frontal cortex and medial temporal lobe while subjects held up to three items in memory.

292 sue characteristics of preoperative temporal lobe white matter tracts known to be important in the ge

293 elevated FTP uptake in the anterior temporal lobe with a leftward asymmetry that was not observed in

294 an revealed a 2.5-cm mass in the right upper lobe with multiple mediastinal lymph node disease ( Fig

295 inal extension with actin and its C-terminal lobe with the myosin heavy chain.

296 cal computation within glomeruli in antennal lobes with axons of projection neurons connecting to a d

297 sifications (definition 1) or as one or more lobes with five or more bilateral nodular ossifications

298 visual scores more accurately discriminated lobes with GS </= 3 + 3 from >/= 3 + 4, whereas TBRs dis

299 ructural organization of honeybees' antennal lobes with their behavioural performances over the cours

300 the infection site of the right caudal lung lobe, with no or reduced TB dissemination to other lobes