ライフサイエンスコーパス: local anesthetic

1 sensitive anatomy, and monitor the spread of local anesthetic.

2 eural toxicity in association with high-dose local anesthetic.

3 s inhibited by bupivacaine, a tertiary amine local anesthetic.

4 f 47 patients who initially were not given a local anesthetic.

5 ly obtained to measure concentrations of the local anesthetic.

6 using paravertebral block supplemented with local anesthetic.

7 transsulcular probing (TSP) after injecting local anesthetic.

8 m to improve outcome, unlike the intrathecal local anesthetics.

9 and neostigmine to potentiate the effects of local anesthetics.

10 as the ability to potentiate the effects of local anesthetics.

11 ed to the increased interest in their use as local anesthetics.

12 nnel that is also inhibited by extracellular local anesthetics.

13 bing the physicochemical properties of novel local anesthetics.

14 loped to directly measure log k'(w) of eight local anesthetics.

15 king phenomenon reminiscent of the action of local anesthetics.

16 ne, that potentiates the effect of delivered local anesthetics.

17 ally inaccessible from extracellular charged local anesthetics.

18 the major cause of the inhibition of FAAT by local anesthetics.

19 BTX binding is inhibited allosterically by local anesthetics.

20 ed with various substances, especially other local anesthetics.

21 the additivity of the effect of general and local anesthetics.

22 bitors are used clinically as analgesics and local anesthetics.

23 ardiotoxicity caused by low and high-potency local anesthetics.

24 monitor needle placement and application of local anesthetics.

25 reduces the sensitivity of receptors to the local anesthetic [2-(triethylamino)-N-(2,6-dimethylpheny

26 Our results support a reinterpretation of local anesthetic action whereby lidocaine functions as a

27 affect fast-inactivation, slow-inactivation, local anesthetic action, and batrachotoxin (BTX) action.

28 are the key determinants of isoform-specific local anesthetic action.

29 ex, indicating that they did not result from local anesthetic actions of cocaine.

30 amine, a calcium channel blocker, has potent local anesthetic activity in vivo and in vitro.

31 tions with a reduction in the total doses of local anesthetic administered.

32 The results show that the investigated local anesthetics affect thermal thresholds to a differe

33 gineered mutation at an interaction site for local anesthetic agents (F1760A) partially attenuated th

34 citable cells, and are molecular targets for local anesthetic agents and intracellular free Ca(2+) ([

35 thod for measuring the hydrophobicity of the local anesthetic agents in the unionized form.

36 ly dependent on a known interaction site for local anesthetic agents.

37 that general anesthetics, barbiturates, and local anesthetics all display the same effect on melting

38 Local anesthetic amount, surgical field size, and the op

39 ures have been solved, exhibit modulation by local anesthetic and anti-epileptic agents, allowing mol

40 Lidocaine is a widely used local anesthetic and antiarrhythmic drug that is believe

41 We used lidocaine, a local anesthetic and antiarrhythmic drug, to probe the r

42 A standardized amount of local anesthetic and similar extent and duration of surg

43 Fluoroscopically guided injections of local anesthetic and steroid in the foot and ankle can i

44 ients, fluoroscopically guided injections of local anesthetic and steroid into the foot and ankle wer

45 small eyelid incision (8-13 mm) include less local anesthetic and tissue distortion, less ecchymosis

46 ed by needle sticks (Ns) for the delivery of local anesthetic and/or scaling and root planing (SRP) i

47 ree mutations had strong effects on block by local anesthetics and anticonvulsants.

48 tivity than the site occupied by traditional local anesthetics and anticonvulsants.

49 e lacosamide receptor overlaps receptors for local anesthetics and batrachotoxin.

50 A class of ligands, including galanthamine, local anesthetics and certain toxins, interact with nACh

51 ients randomized to receive a TAP block with local anesthetics and dexamethasone, PILA with dexametha

52 escribes the anti-inflammatory properties of local anesthetics and discusses the benefits seen when u

53 esuscitation from intravascular injection of local anesthetics and institutional procedures to positi

54 considered much less cardiotoxic than other local anesthetics and is used commonly as infusions for

55 n reverse cardiac pharmacotoxicity caused by local anesthetics and other lipophilic drugs.

56 r other small molecule inhibitors, including local anesthetics and TTX.

57 ients reported that bad taste, receiving the local anesthetic, and excessive fluid in the mouth were

58 positively charged small molecule used as a local anesthetic, and planar supported lipid bilayers (S

59 ng preoperative oral sedation (diazepam) and local anesthetic, and the second using local anesthetic

60 ystemic toxicity, local tissue toxicity from local anesthetics, and inflammation.

61 Local anesthetic antiarrhythmic drugs block Na+ channels

62 Local anesthetic antiarrhythmic drugs block voltage-gate

63 use-dependent Na channel inhibitors used as local anesthetic, antiarrhythmic, and anticonvulsant dru

64 -gated sodium channels are inhibited by many local anesthetics, antiarrhythmics, and antiepileptic dr

65 ffects of analgesic, sedative, beta-blocker, local anesthetic, antiemetic, and obstetric medications.

66 Local anesthetics are a group of drugs defined by their

67 teresting and promising areas where systemic local anesthetics are being implemented.

68 Local anesthetics are commonly administered to prevent t

69 Local anesthetics are drugs which have many potentially

70 Local anesthetics are known to inhibit neuronal fast ant

71 Local anesthetics are used in a wide range of clinical s

72 ely, it is the correct peri-neural spread of local anesthetic around a nerve that provides safe, effe

73 The use of EMLA (eutectic mixture of local anesthetics; Astra USA, Westborough, MA) cream (li

74 orrelate linearly with the solubility of the local anesthetic bases in medium chain triglycerides and

75 rmacodynamic response of cutaneously applied local anesthetic bases, this study was conducted to char

76 Channel block by the neutral local anesthetic benzocaine is unaffected by the distrib

77 Xenopus laevis oocytes, whereas the neutral local anesthetic, benzocaine, does not, suggesting that

78 Administration of a long-acting local anesthetic between the mesh and the peritoneum sig

79 titutions of the amino acids at the putative local anesthetic binding site (i.e., F1760, N1765, Y1767

80 The local anesthetic binding site in I1G1(M) is indistinguis

81 ing site on hNav1.5 differs from that of the local anesthetic binding site.

82 u1-Y401C/F1579A), which altered the putative local anesthetic binding site.

83 ion mutations in amino acids at the putative local anesthetic binding sites.

84 WT SoCal5 and SoCal5 with the local anesthetics binding site mutated (F1760A) could be

85 isoindoline carboxamides interacted with the local anesthetics binding site.

86 lasting increase in phosphorylation, and (3) local anesthetic block of the injected paw reversibly bl

87 of the mutant hNav1.5 channels compared with local anesthetic block.

88 ilter region as a structural determinant for local anesthetic block.

89 Local anesthetics block neurons, but are also potent ant

90 Local anesthetic blocks under image intensifier or CT gu

91 arge when peripheral inputs are disrupted by local anesthetic blocks with lidocaine (LID).

92 e inhibited by Zn2+ (IC50 = 175 microM), the local anesthetic bupivacaine (IC50 = 68 microM), and the

93 iently reduced the free concentration of the local anesthetic bupivacaine in 0.9% NaCl.

94 ellular application of the membrane-permeant local anesthetic bupivacaine selectively inhibited G pro

95 ls remained highly sensitive to block by the local anesthetic bupivacaine, unlike several other BTX-r

96 ated by electrospinning, with or without the local anesthetic bupivacaine.

97 After mesh placement, a long-acting local anesthetic (bupivacaine hydrochloride, 0.50%) or p

98 we examined whether a single injection of a local anesthetic (bupivacaine) into the cingulum bundle

99 Coincubation with local anesthetics but not tetrodotoxin attenuated compou

100 creases the [Ca(2+)](i) in the brain and its local anesthetic, but neither its catecholaminergic nor

101 block of hNav1.5 channels similar to that of local anesthetics, but the location of the prenylamine b

102 in contrast to the mostly positively charged local anesthetics, but their open/inactivated-state bloc

103 vidence remains mixed, but it is likely that local anesthetic cardiotoxicity primarily arises from a

104 use and best treatment of LAST (particularly local anesthetic cardiotoxicity) remain unclear.

105 Local anesthetics cause muscle necrosis, followed by reg

106 ed Na+ channels are the molecular targets of local anesthetics, class I antiarrhythmic drugs, and som

107 t determinant of the block of Na+ channel by local anesthetic-class drugs.

108 Local anesthetics, commonly used for treating cardiac ar

109 onselective cation channels are inhibited by local anesthetic compounds through an undefined mechanis

110 n = 8) or lidocaine (2%, n = 4), an internal local anesthetic control, or intravenous phenylephrine (

111 onal shake-flask method was obtained for the local anesthetics, demonstrating the reliability of the

112 l access pathway for the membrane-impermeant local anesthetic derivative QX-222 into the internal ves

113 local anesthesia has long been a key goal in local anesthetic development.

114 resent study tests this prediction using the local anesthetic dibucaine as a probe.

115 We conclude that the charged form of local anesthetics directly and reversibly inhibits kines

116 Local anesthetics do not penetrate readily through human

117 Ultrasound guidance may aid in reduction in local anesthetic dose, anatomical evaluation and avoidan

118 rated the deactivation of NsVBa, whereas the local anesthetic drug lidocaine was shown to antagonize

119 Use of enantiomeric local anesthetic drugs permits a safer and wider range o

120 s define cardiac-specific external paths for local anesthetic drugs.

121 e channel's inner pore overlap with those of local anesthetic drugs.

122 rall discomfort of patients and the need for local anesthetic during caries removal and subsequent re

123 antagonist into the ventricular system or a local anesthetic effect caused by infusion of the antago

124 aine is complicated, however, by an apparent local anesthetic effect of the drug.

125 ypomotility following cocaine seemed to be a local anesthetic effect, because it was mimicked by 50-2

126 Local anesthetics effectively suppress pain sensation, b

127 perties, and of lidocaine, which has similar local anesthetic effects as cocaine but is devoid of cat

128 Time- and voltage-dependent local anesthetic effects on sodium (Na) currents are gen

129 ium channels and has potent and long-lasting local anesthetic effects when tested in two pain assays

130 ckade of afferent input from the injury with local anesthetic elicits conditioned place preference, a

131 We have developed a local anesthetic-eluting suture system which would combi

132 Lidocaine is one of the most common local anesthetics employed for adulteration of illicit c

133 Patients undergoing local anesthetic endovenous thermal ablation were random

134 nation mutations and studies of block by the local anesthetic etidocaine favored the conclusion that

135 ion I409A in IS6 reduced the affinity of the local anesthetic etidocaine for the inactivated state by

136 7c89, 4030w92, and 619c89 as well as for the local anesthetic etidocaine.

137 the affinity of inactivated channels for the local anesthetic etidocaine.

138 ater number of patients (p < 0.05) requested local anesthetic for the tooth subjected to the control

139 detomidine enhanced the efficacy of released local anesthetics, greatly increasing the number of trig

140 logic anesthetic, many ester-and amide-based local anesthetics have been developed for a variety of s

141 Local anesthetics have many beneficial properties, and p

142 Given that site 2 neurotoxins and local anesthetics have nonidentical but overlapping bind

143 Local anesthetics have similar chemical structure but di

144 In the modified in vitro motility assay, local anesthetics immediately and reversibly stopped the

145 Bupivacaine is the indicated local anesthetic in caudal, epidural, and spinal anesthe

146 od for measuring the hydrophobicity of eight local anesthetics in current clinical use.

147 Dosing studies of local anesthetics in peripheral nerve blockade suggest t

148 The choice of local anesthetics in regional anesthesia depends on desi

149 The trend toward smaller doses of local anesthetics in ultrasound-guided regional anesthes

150 ion has emerged as an effective treatment of local anesthetic-induced cardiac arrest, but its therape

151 lipid emulsion as an effective treatment of local anesthetic-induced cardiac arrest.

152 The results suggest that local anesthetic-induced convulsive seizures are mediate

153 n and application, and proper preparation of local anesthetic infusate solutions are all considered e

154 gies for the relationship between continuous local anesthetic infusion volume and concentration as we

155 ral strategies such as continuous ambulatory local anesthetic infusions and adjuvants that may potent

156 We propose that membrane-permeant local anesthetics inhibit GIRK channels by antagonizing

157 These results fine tune our understanding of local anesthetic inhibition of voltage-gated sodium chan

158 Local anesthetic injection at the surgical site, though

159 When local anesthetic injection immediately preceded the doxo

160 in into the eyelid of rabbits 2 days after a local anesthetic injury, perhaps exploiting the toxic ef

161 We also determine whether prenylamine and local anesthetics interact with a common binding site on

162 The amine in local anesthetics interacts with the charged selectivity

163 investigate the efficacy of intraperitoneal local anesthetic (IPLA) on pain after acute laparoscopic

164 istent evidence that epidural analgesia with local anesthetics is associated with faster resolution o

165 Eutectic mixture of local anesthetics is currently the most frequently presc

166 Knowledge of the pharmacology of local anesthetics is essential for their safe use and se

167 Acute toxicity to cocaine and other local anesthetics is manifested in central nervous syste

168 Thus, the thermodynamic behavior of local anesthetics is very similar to that of general ane

169 obenzoic acid that finds an application as a local anesthetic, is found to adopt in its protonated fo

170 involving the use of opioid and non-opioid (local anesthetics, ketamine, acetaminophen, and non-ster

171 tested whether mibefradil interacts with the local anesthetic (LA) binding site, which includes resid

172 ) of the S5-S6 linkers in channel gating and local anesthetic (LA) block using site-directed cysteine

173 dues of I-S6 and II-S6 in channel gating and local anesthetic (LA) block was investigated using the c

174 -gated sodium (Na+) channels are targets for local anesthetic (LA) drugs that bind in the inner pore

175 h-frequency discharges of excitable cells by local anesthetics (LA) is largely determined by drug-ind

176 Local anesthetics (LAs) are noncompetitive antagonists o

177 channels in their open conformation, whereas local anesthetics (LAs) block Na(+) conductance.

178 these channels to open persistently, whereas local anesthetics (LAs) block Na(+) conductance.

179 Local anesthetics (LAs) block voltage-gated Na+ channels

180 Most local anesthetics (LAs) elicit use-dependent inhibition

181 The effects of local anesthetics (LAs) on G protein-mediated responses

182 ed Na(+) channels are the primary targets of local anesthetics (LAs).

183 -gated Na+ channels are a primary target for local anesthetics (LAs).

184 ed trials comparing epidural analgesia (with local anesthetics, lasting for >/= 24 hours postoperativ

185 In Experiment 2, the local anesthetic lidocaine (2%) was infused (0.5 microl)

186 caudal arcuate nucleus by microinjecting the local anesthetic lidocaine (2%; 0.1 or 0.3 microl) bilat

187 To test this, the local anesthetic lidocaine (2%; 0.5 microl) was microinj

188 e not mimicked by repeated injections of the local anesthetic lidocaine and were not observed in neur

189 The local anesthetic lidocaine appears to be able to access

190 Although the local anesthetic lidocaine modulates inflammatory proces

191 mcinolone, and methylprednisolone) and three local anesthetics (lidocaine, ropivacaine, and bupivacai

192 Microinjections of local anesthetics, lidocaine (100 microg) and procaine (

193 A) in a cream, and (iii) the analysis of the local anesthetics, lidocaine and prilocaine, in a gel an

194 er-reviewed literature regarding the role of local anesthetics, NSAIDs, gabapentinoids, and acetamino

195 We investigated the direct effect of local anesthetics on kinesin, using both in vitro motili

196 e effect of tetracaine aerosol inhalation, a local anesthetic, on lung volume decrements, rapid shall

197 n the spectrum of pharmacodynamic actions of local anesthetics, on comparison of pharmacodynamic and

198 ) and local anesthetic, and the second using local anesthetic only.

199 onset time.The addition of clonidine to the local anesthetic opioid mixtures seems to produce analge

200 responses to cytokines in addition to their local anesthetic or antiarrhythmic properties.

201 requested additional epidural bolus doses of local anesthetic (P=0.01).

202 study was conducted to characterize various local anesthetics pharmacodynamically by measuring therm

203 ther ultrasound-guided foam sclerotherapy or local anesthetic phlebectomy.

204 phosphate and preperitoneal instillation of local anesthetic (PILA) with dexamethasone vs control on

205 proved suitable for characterization of the local anesthetics, possibly because cold receptors are l

206 ) and were not mimicked by injections of the local anesthetic procaine (800 mm).

207 ffects of medial septal microinfusion of the local anesthetic, procaine (MS Pro), on hippocampal neur

208 saxitoxin (STX), a compound with ultrapotent local anesthetic properties but little or no cytotoxicit

209 Because it has been reported that local anesthetic properties may influence the reinforcin

210 amine uptake inhibitors, we investigated the local anesthetic properties of cocaethylene as well as i

211 aine (except for serotonin increases) but no local anesthetic properties, and of lidocaine, which has

212 ed tetrodotoxin (TTX), which has ultrapotent local anesthetic properties.

213 oxic effects of antidepressants when used as local anesthetics proved this to be the case.

214 n be also blocked by the membrane-impermeant local anesthetic QX via external paths not present in sk

215 A local anesthetic QX-314 injected at the end of Phase 2 b

216 veals sensitivity to inhibition by a charged local anesthetic, QX-314, applied extracellularly.

217 dium action potentials were blocked with the local anesthetic QX314.

218 Membrane-impermeant quaternary amine local anesthetics QX314 and QX222 can access their bindi

219 nt of hydrophobicity and has been applied to local anesthetics recently.

220 of open Na(+) channels is via the conserved local anesthetic receptor albeit with a relatively slow

221 A F1579K mutation at the local anesthetic receptor of inactivation-deficient Nav1

222 s containing lysine substitutions within the local anesthetic receptor region at residues F1760 or N1

223 nonidentical molecular determinants with the local anesthetic receptor site in transmembrane segment

224 I1760, F1764, and Y1771, which form part of local anesthetic receptor site in transmembrane segment

225 These results suggest that the local anesthetic receptor site is formed primarily by re

226 pared with wild-type by the mutations at the local anesthetic receptor site.

227 Thus, lubeluzole likely binds to the local anesthetic receptor through its phenoxy-propranol-

228 -inactivated state by binding at or near the local anesthetic receptor within the sodium channel pore

229 identical, or allosterically coupled, to the local anesthetic receptor.

230 endence, suggesting that A-core binds to the local anesthetic receptor.

231 1771A) channels, which reduce block by other local anesthetics, reduced high-affinity block of inacti

232 graphy allows for reduction of the volume of local anesthetic required to accomplish a nerve block, r

233 reduction in the amount or concentration of local anesthetic required to produce perioperative analg

234 gional neural blockade in combination with a local anesthetic results in increased duration of sensor

235 However, "chase" with free local anesthetic site inhibitors increased the rate of d

236 n VGSCs, both of which can be bound by known local anesthetic site inhibitors.

237 y have similar properties with regard to the local anesthetics solubility as the stratum corneum lipi

238 Local anesthetic solutions aerosolized onto skin-harvest

239 Local anesthetic solutions frequently contain vasoconstr

240 e are now able to use very low concentration local anesthetic solutions with a reduction in the total

241 Unlike previous local anesthetics studied, the strongest effect was obse

242 rent use for measuring the hydrophobicity of local anesthetics suffer from a number of limitations an

243 d eliminates the inhibition by extracellular local anesthetics, suggesting that the pore-loop complex

244 t for neonates, and guide us to safer use of local anesthetics suitable for neonates with their pharm

245 ith increases in use of regional anesthesia, local anesthetic systemic toxicity (LAST) has been a top

246 unt for the apparent enhanced sensitivity to local anesthetic systemic toxicity during pregnancy.

247 Strategies to reduce the risk of local anesthetic systemic toxicity should be employed wh

248 th apparent success early in the spectrum of local anesthetic systemic toxicity to preempt cardiac ar

249 can result in high plasma concentrations and local anesthetic systemic toxicity.

250 rmed the efficacy of lipid resuscitation for local anesthetic systemic toxicity.

251 Antiarrhythmics, anticonvulsants, and local anesthetics target voltage-gated sodium channels,

252 In some experiments, the local anesthetic tetracaine (10 microg) was then microin

253 Interestingly, the potency of the local anesthetic tetracaine for the inhibition of alpha3

254 In the single-molecule motility assay, the local anesthetic tetracaine inhibited the motility of in

255 amily of voltage-gated ion channels, and the local anesthetic tetracaine is known to block CNG channe

256 Co-infusion of the local anesthetic tetracaine with duodenal lipids abolish

257 Interactions of the local anesthetic tetracaine with unilamellar vesicles ma

258 ng mating can be prevented by injection of a local anesthetic (tetracaine) in the cloacal region prio

259 (azithromycin), antifungal (tolnaftate), and local anesthetic (tetracaine), were examined.

260 c sodium (Na) currents are more sensitive to local anesthetics than brain or skeletal muscle Na curre

261 ifiers contain an intrapore-binding site for local anesthetic that is normally inaccessible from extr

262 The amount of the local anesthetic that was injected was then recorded, as

263 stem toxicity are unwanted side-effects from local anesthetics that cannot be attributed to the inhib

264 Injectable local anesthetics that would last for many days could ha

265 lthough antidepressants indeed act as potent local anesthetics, their use in the clinical setting can

266 anesthetics as well as modifying injectable local anesthetic to decrease the pain of local infiltrat

267 pecific issues of nerve damage, treatment of local anesthetic toxicity with lipid solutions and preve

268 n neurologic assessment and the potential of local anesthetic toxicity.

269 Local anesthetic use in gynecologic laparoscopy appears

270 te or placebo) was injected per cartridge of local anesthetic used.

271 ural volume extension enhances the spread of local anesthetics using a combined spinal-epidural techn

272 ants (122) received one or two cartridges of local anesthetic/vasoconstrictor prior to dental treatme

273 More information is becoming available on local anesthetic volume and concentration relationships

274 inal anesthesia; considerations in selecting local anesthetic volume, concentration, and mass in peri

275 A local anesthetic was applied to the third finger of the

276 8-fold, whereas that of bupivacaine, a known local anesthetic, was reduced by as much as 68-fold comp

277 be a fundamental physicochemical property of local anesthetics, was in the past obtained by octanol/b

278 y phase HPLC column, the log k'(w) values of local anesthetics were determined by measuring the capac

279 has been conducted with the use of systemic local anesthetics when considering their cost effectiven

280 lurane effect was attenuated by lidocaine, a local anesthetic with anti-inflammatory property.

281 ed by procaine (PRO 5 mg/kg), a short-acting local anesthetic with negligible effect on the DA transp

282 t antidepressants exhibit many properties of local anesthetics with an extended duration of action.

283 The introduction of long acting local anesthetics with better safety profile as well as