ライフサイエンスコーパス: localisation

1 ermine the configurations' sensitivity field localisation.

2 ified, or the effects of S-acylation on IRAP localisation.

3 -YFP fusion in tobacco confirmed a tonoplast localisation.

4 near its C-terminus that are needed for this localisation.

5 ation that all control GalNAc-T sub-cellular localisation.

6 e C-terminal mutations have little effect on localisation.

7 are dependent on one another for centrosomal localisation.

8 ion owing to their sub-optimal intracellular localisation.

9 n in an hfnA(-) background rescues pstO cell localisation.

10 e inverted region are important for Xist RNA localisation.

11 tem exhibits sustained oscillations in NF-kB localisation.

12 t embryos, and is sufficient for centrosomal localisation.

13 ogenous aPKC and aPKC-CAAX show some nuclear localisation.

14 romatic sites that are coincident with DNMT1 localisation.

15 sm by which FlhF establishes flagellum polar localisation.

16 c oxide synthase activated, and its cellular localisation.

17 might have key roles in protein function or localisation.

18 wn to alter PIN1 and/or PIN2 plasma membrane localisation.

19 he 2-cell stage there was no evidence of PKA localisation.

20 oughout the cytoplasm and shows no punctuate localisation.

21 in moiety restores normal asymmetric Miranda localisation.

22 s with both kinesin-2 and kinesin-1 for this localisation.

23 il region of MKS-5 (Rpgrip1L/Rpgrip1) for TZ localisation.

24 l resource for data on mitochondrial protein localisation.

25 tightly regulated, including at the level of localisation.

26 l agenda that requires precise intracellular localisations.

27 f the inter-individual variability in source localisations.

28 c islands, despite their remote geographical localisations.

29 logical function of myocyte, to analyze NOS1 localisation, activity, dimerisation, and its relationsh

30 the standard of reference for the presence, localisation and activity of disease against which the d

31 ation of methods for determining subcellular localisation and assignment of enzymes.

32 its function in mammalian cells, subcellular localisation and binding partners.

33 help clarify how LIS1 promotes the plus-end localisation and cargo transport functions of dynein in

34 f the cell biology of the bacterium, viz its localisation and co-ordination with the bacterial cytosk

35 linical neurology (ie, history, examination, localisation and differential diagnosis) remain key.

36 f iNOS activation on the expression, nuclear localisation and function of beta-catenin in endothelial

37 e expression, dimer/monomer status, cellular localisation and function of Marchantia polymorpha and P

38 e definition of apicobasal polarity, but the localisation and function of Par3 in mesenchymal cells a

39 ies in rodents have described the anatomical localisation and function of the nicotinic acetylcholine

40 nteractions of TlpD and their impact on TlpD localisation and function.

41 P-290 and other MKS module components for TZ localisation and functions together with the NPHP module

42 More-reliable serum markers, better tumour localisation and identification of small lesions, and hi

43 y by scientists to study protein expression, localisation and interactions.

44 gests that this novel Staufen-dependent mRNA localisation and local translation pathway may play a ro

45 lato genospecies and characterised by tissue localisation and low spirochaetaemia.

46 We undertook this study to investigate the localisation and magnitude of the presumed tau Positron

47 us biosensors for detection, identification, localisation and manipulation of a wide spectrum of biol

48 ological consequences is the ultrastructural localisation and morphological form of amyloid species w

49 We scored the presence, localisation and pattern of imaging characteristics of i

50 Chromosomal localisation and PCR analysis, coupled to inspection of

51 Dystonia Coalition, included description of localisation and phenomenology of AM collected by system

52 ermal development, Claudin-1 plasma membrane localisation and Rab3Gap1 cell surface expression were c

53 nce of actin-binding residues for proper MAL localisation and regulation in vivo.

54 ain; removal of this domain disrupts Miranda localisation and replacement of this domain with a ubiqu

55 xclude a major role for cytoplasmic flows in localisation and reveal an organisation of the MT cytosk

56 Cep152 can occur independently of centrosome localisation and that the two proteins are dependent on

57 ects of these variants on normal subcellular localisation and the ability to desensitise receptor sig

58 However, their exact localisation and the cellular signalling pathway(s) they

59 In this study, we investigated the localisation and the mechanism(s) underlying the non-gen

60 In this study, we investigated the localisation and the mechanism(s) underlying the physiol

61 Together, our results establish Nmnat2 localisation and turnover as a valuable target for modul

62 Here, we characterise the subcellular localisations and expression patterns of these insertion

63 tion on the expression patterns, subcellular localisations and in vivo interaction partners of the tr

64 Here we review the discovery, localisation, and functional characterisation toolkit av

65 polarity field, highlighted by PIN1 protein localisation, and is modulated by dorsoventral gene acti

66 vered significant differences in subcellular localisation, and nuclear-cytoplasmic shuttling in respo

67 Methods for permanent localisation, dynamic localisation, and spatial control of functional material

68 ha activity, which requires GSK3beta nuclear localisation, as phosphorylation of Drosha at S(300) and

69 ese data suggest that ABCB19 stabilises PIN1 localisation at the plasma membrane in discrete cellular

70 We have systematically analysed subcellular localisations at cellularisation (stage 5) and recorded

71 at can increase the signal to noise ratio of localisation based microscopy.

72 ethods, in particular, can be susceptible to localisation bias and spurious sources under these condi

73 Any localisation bias caused by the presence of correlated s

74 perceptual biases, and (ii) whether auditory localisation biases can be reduced following training wi

75 Localisation biases decreased (improved) following train

76 sensory uncertainty, we found that auditory localisation biases increased when auditory localisation

77 isation Intensity Coefficients (CICs) and Co-localisation Binary Coefficients (CBCs), which uses rich

78 tive cameras are required to further improve localisation certainty.

79 disorder, where we directly observe quantum localisation.Cold atom quantum simulation has had challe

80 In situ localisation confirmed that GS1 transcripts were present

81 ix-month-olds, like adults, showed a tactile localisation deficit with their feet crossed, indicating

82 tumor specific characteristics (Lauren type, localisation), degree of mucosal abnormalities (intestin

83 umption, thus spatio-temporal changes in PKA localisation during development may determine the oocyte

84 these data show a dynamic regulation of PKA localisation during oocyte and early embryo development.

85 Methods for permanent localisation, dynamic localisation, and spatial control

86 a manner that correlates with changes in its localisation, dynamics and supercoiling activity.

87 evolution of wavepackets and show that self-localisation effects may be observed due to the curvatur

88 Here we tested (i) whether systematic localisation errors could reflect reliance on prior know

89 s also proven to be robust in recognising co-localisations even when images are polluted with a range

90 er integrates different types of subcellular localisation evidence with protein information from publ

91 Co-localisation experiments with fluorescence labelled dext

92 on specific endoplasmic reticulum subdomain localisation for key endogenous enzymes, and this organi

93 Fluorescence microscopy revealed localisations for TcEpsinR, TcCLC and TcCHC at the poste

94 hosphorylation of FOXOs, leading to their re-localisation from cytoplasm (inactive) to nucleus (activ

95 al domain of Pk(Sple) contains an additional localisation function, which confers a qualitatively dif

96 ation is hampered by the absence of adequate localisation, functional characterisation, and receptor

97 h functional analysis by subcellular protein localisation, gene expression analysis, in situ hybridis

98 ide array of applications, including protein localisation, gene interaction studies and high-throughp

99 genetic interaction, interdependent protein localisation (hierarchy), and proteomic studies.

100 ogical studies which measure fluorescence co-localisation in 3D.

101 ike those in wild type, PIN1 plasma membrane localisation in abcb19 roots was more easily perturbed b

102 in their antioxidative properties, and their localisation in emulsions has been shown to be affected

103 Efficient cellular uptake and localisation in endo/lysosomal vesicles was found using

104 ing enzyme of glycolysis displayed a nuclear localisation in hESCs and silencing PKM2 did not alter g

105 cellular distribution and protein-protein co-localisation in human skeletal muscle in the basal state

106 ights the complexity and significance of APC localisation in neurons.

107 07 lines, we assessed protein expression and localisation in ovaries, embryos, pupae or adults by sta

108 is the first method for predicting effector localisation in plants and is a valuable tool for priori

109 aPKC adopts a polarised localisation in PrE cells only after they reach the blas

110 The dynamics of Baz, Par-6 and Par-1 localisation in the oocyte indicate that the axis is not

111 ystematic analysis of protein expression and localisation in various cellular and developmental conte

112 a quantitative analysis of Dvl intracellular localisation in Xenopus chordamesoderm cells.

113 In this study, we have developed Co-localisation Intensity Coefficients (CICs) and Co-locali

114 Co-localisation is a widely used measurement in immunohisto

115 However the measurement of co-localisation is challenging due to the complex nature of

116 Kv subunit localisation is important in defining their functional r

117 We propose that TlpD localisation is instructed by metabolic activity and pro

118 with no peripheral exposure and nanoparticle localisation is observed within the brain parenchyma.

119 The importance of IL-1alpha nuclear localisation is poorly understood.

120 e ubiquitylation machinery, their asymmetric localisation is reduced and this leads to disruption of

121 , which functions with Staufen in oskar mRNA localisation, is also required for coracle mRNA localisa

122 systematic errors (biases) in their auditory localisation judgments.

123 The current state-of-art co-localisation measurements of 3-dimensional (3D) image st

124 The proposed CBCs and CICs produce robust co-localisation measurements which are easy to interpret, r

125 f representing problems involving individual localisation, memory and emerging properties, which are

126 ques such as interferometric photo-activated localisation microscopy (iPALM).

127 etion (g-STED) microscopy and photoactivated localisation microscopy (PALM).

128 Single-molecule localisation microscopy (SMLM) allows the localisation o

129 letion (STED) microscopy and Single Molecule Localisation Microscopy (SMLM) enable an increase in ima

130 Single molecule localisation microscopy (SMLM) has become an essential p

131 single molecule level using single molecule localisation microscopy (SMLM).

132 rate the application of this novel method to localisation microscopy and show both an increase in the

133 We present an imaging system for localisation microscopy based on non-destructive readout

134 The fitting precision in localisation microscopy is highly dependent on the signa

135 opy, structured illumination microscopy, and localisation microscopy, which have all produced stunnin

136 We show that a dominant-negative nuclear localisation mutant of Sox3 can cause ectopic expression

137 y we aim to establish whether changes in PKA localisation occur during oocyte and early embryo develo

138 dy was therefore designed to investigate the localisation of 5-HT(1A) and 5-HT(1B) receptors in CeA p

139 lts provide the first evidence for a spatial localisation of [H(+)]i regulation in ventricular myocyt

140 es of the anticancer properties and cellular localisation of a range of ruthenium complexes in eukary

141 sms that regulate PIN1 in apical tissues, as localisation of ABCB19 on the plasma membrane was not in

142 ed PKC activity drastically dysregulates the localisation of ADAM17.

143 a chromatin-associated protein required for localisation of Aly and Comr, but not Topi, to chromatin

144 C C-terminus, contributing to the peripheral localisation of APC in fibroblasts.

145 This is necessary for localisation of apical junctional proteins to the region

146 ative to equivalent-current dipole models in localisation of auditory evoked responses.

147 ion of the stage 9 oocyte and the subsequent localisation of bicoid and oskar mRNAs to opposite poles

148 ed virus yield to <1%, resulting in aberrant localisation of capsids.

149 were performed to further analyse the exact localisation of CD147 and MMP-2 positivity.

150 ll polarisation, reflected by expression and localisation of cell polarity molecules such as Par3 and

151 t or solid-state) environment on the partial localisation of charge.

152 Directed transport and subcellular localisation of Chc is strongly perturbed in BicD mutant

153 l images providing identification as well as localisation of chemical compounds in non-homogenous sam

154 estored barrier function and plasma membrane localisation of Claudin-1.

155 ion of Coracle protein without affecting the localisation of cora mRNA, suggesting that Staufen simil

156 junction (NMJ), where it is required for the localisation of coracle mRNA and protein.

157 The asymmetric localisation of core planar polarity proteins at apicola

158 a significantly higher frequency of nuclear localisation of Cten (P=0.002).

159 em that is required to control the level and localisation of Dachs.

160 homo- and heterophilically, and to study the localisation of DeltaC and DeltaD in the zebrafish nervo

161 SM we see an unexpected pattern in which the localisation of DeltaD varies according to the level of

162 Immunohistochemistry revealed co-localisation of eGFP in intrinsic cholinergic neurons (c

163 etic source imaging can be used to infer the localisation of epileptic foci and assist in the design

164 ing protein FlhF is required for the correct localisation of flagella in several bacterial species.

165 The intrinsic localisation of FlhF to the old cell pole membrane sugge

166 le localisation microscopy (SMLM) allows the localisation of fluorophores with a precision of 10-30 n

167 ar location of this process, we examined the localisation of FtsH metalloproteases, some of which are

168 rmal furrow formation and controls the tight localisation of furrow canal proteins and the formation

169 Very little co-localisation of GM atrophy and lesions was seen, and thi

170 The ECD can also regulate the subcellular localisation of Hippo pathway components, and possibly o

171 tiple combinations of interlinked levels and localisation of influx and efflux carriers.

172 he modified cysteines on the plasma membrane localisation of IRAP in HEK293T cells, suggesting that S

173 Transcription, protein expression and localisation of KCa3.1 was analysed by reverse transcrip

174 Co-localisation of Kdo-N3 labelling with the cellulose-bind

175 ts mechanistically via regulation of ciliary localisation of key components of its transduction machi

176 disparities (ITDs) are the primary cues for localisation of low-frequency sound stimuli.

177 tion, precise characterisation, and accurate localisation of malignant disease could be improved.

178 The cellular localisation of microRNAs within the oesophageal mucosa

179 ure miRs without altering levels or cellular localisation of miR biogenesis proteins.

180 n of Miranda are required for the asymmetric localisation of Miranda and its cargo proteins to the NB

181 on of TSC2 from Rheb and increased in the co-localisation of mTOR and Rheb post exercise in both FED

182 activation may contribute to the genesis and localisation of MYC-Immunoglobulin translocation breakpo

183 ntraction through changes in the subcellular localisation of myosin.

184 distribution, cytoplasmic flow patterns and localisation of oskar and naive bicoid mRNAs.

185 aufen plays a well-characterised role in the localisation of oskar mRNA to the oocyte posterior, wher

186 The localisation of oskar mRNA to the posterior of the Droso

187 Structural relaxation explains the localisation of Paneth cells to the crypt bottom in the

188 ite in Par-1 results in the uniform cortical localisation of Par-1 and the loss of cortical microtubu

189 Furthermore, we show that polar localisation of PIN1 generates an auxin flux circuit tha

190 Here we show that apical localisation of Pk(Pk) and Pk(Sple) isoforms are mutuall

191 Tip bubbles cause localisation of plectonemes within thermodynamically wea

192 ance drop at 528 nm gives evidence of the co-localisation of polyphenols and DPPH. in micelles.

193 Aberrant subcellular localisation of PRH is associated with breast cancer and

194 Localisation of Protein Kinase A (PKA) by A-Kinase Ancho

195 Sub-cellular localisation of proteins is an essential post-translatio

196 The ability to determine spatial localisation of proteins within the cell is likely to yi

197 We further suggest that the co-localisation of PrP(d) with exocytic granules of the hor

198 explicitly the topologically induced spatial localisation of quantum states in our systems.

199 We did not observe co-localisation of RABEP2 and Rab5 in cells, while ectopic

200 response to DNA-damaging agents, the nuclear localisation of RAD51 and BRCA2 and efficient homologous

201 ischemia/reperfusion-induced changes in the localisation of retinal Thy-1 and ChAT immunoreactivitie

202 Immunofluorescent localisation of RyR protein indicated bright, clustered

203 results in the disruption of expression and localisation of sarcomeric proteins, gross myofibril dis

204 ion of CIB1 by itself is sufficient to drive localisation of SK1 to the plasma membrane and enhance t

205 We have investigated the expression and localisation of SMADs2 and 3 in the fetal ovary between

206 E and USS for the correct identification and localisation of small bowel CD.

207 ISH) methodology in order to investigate the localisation of specific gene domains within an individu

208 o facilitate agonist-induced plasma membrane localisation of sphingosine kinase 1 (SK1), a location w

209 tyrosine phosphorylation and ectopic nuclear localisation of STATc.

210 he tail bud, the chordoneural hinge, but the localisation of such progenitors at earlier stages is so

211 that govern the cellular uptake and cellular localisation of such systems are determined they are fin

212 on of APC/C activity disrupts the asymmetric localisation of the adapter protein Miranda and its asso

213 to the mitochondria, as determined by the co-localisation of the affinity-purified antibodies against

214 entifying possible mechanisms leading to the localisation of the AIS's master organiser protein, anky

215 The cellular uptake and localisation of the amphiphilic bioconjugate was examine

216 mall-angle X-ray scattering data, allows the localisation of the B domain of the Psf1 subunit in the

217 riant is associated with predominant nuclear localisation of the CDKN2A transcript suggesting the fun

218 inases (MAPKK) in live cells and dictate the localisation of the complexes.

219 rmation about the expression and subcellular localisation of the corresponding proteins.

220 The mixed Near Eastern-Middle Eastern localisation of the Druze, shown using both modern and a

221 this, we assessed the effect of FlhF on the localisation of the earliest flagellar structural compon

222 psy type, underlying pathology, and accurate localisation of the epileptogenic brain region by variou

223 rin cytoskeleton is required to regulate the localisation of the Hippo pathway effector YAP in respon

224 The localisation of the mechanotransducer channels to the lo

225 Finally, we categorised the localisation of the membranous/cortical proteins during

226 ing, which we attribute in part, to improper localisation of the nuclear envelope protein TPR.

227 the oocyte, leading to the anterior/lateral localisation of the Par-6/aPKC complex and the posterior

228 wn of Sdmg1 in Sertoli cell lines causes mis-localisation of the secretory SNARE Stx2 and defects in

229 ce sustained oscillations in the subcellular localisation of the transcription factor nuclear factor

230 to the parental Ad5 vector, with reduced co-localisation of the viral beta-galactosidase transgene w

231 To investigate the localisation of these components of the RhoA pathway in

232 a membrane, although it is not clear how the localisation of these kinases is controlled.

233 lysosomal degradation and increasing the co-localisation of these neurotrophin receptors with retrom

234 g skeletal muscle fibres; however, the exact localisation of these receptors and how they signal to t

235 ore (the sarcoplasmic reticulum), and the co-localisation of these two structures to form dyads withi

236 These included the localisation of Thy-1 and choline acetyltransferase, the

237 We show that TZ localisation of TMEM-138 (Tmem138) and CDKL-1 (Cdkl1/Cdk

238 chi/vis, are required to maintain the normal localisation of Tomb.

239 vo quantification of tissue constituents and localisation of tracts potentially affected in alcohol d

240 The correct localisation of transcription factors is vitally importa

241 TEER), and strongly polarised (apical:basal) localisation of transporters and receptors.

242 Our results show the localisation of variants to genes implicated in adsorpti

243 yes of all rats were either analysed for the localisation of various antigens or extracts prepared fo

244 gnalling is a key determinant of the nuclear localisation of YAP/TAZ in basal layer cells and in skin

245 Although the subcellular localisations of ABCB19 and PIN1 in the reciprocal mutan

246 ata on permanent damage are rare and typical localisations of injuries were yet to be defined.

247 n on the expression patterns and subcellular localisations of many proteins in parallel, we have perf

248 osynthesis, possibly through the subcellular localisation or activity of lipid kinases.

249 er TMEM-138 or CDKL-1 exhibit interdependent localisation or genetic interactions with core MKS or NP

250 rtile patients), along with total levels and localisation patterns of PLCzeta within the sperm head.

251 The automatic landmark localisation performance was within the inter-observer v

252 Expression, nuclear localisation, post-translational modifications and funct

253 h which takes full account of the individual localisation precisions in all three dimensions.

254 ls of influx carriers with the same nonpolar localisation, requires simultaneous modulation of efflux

255 FOXO phosphorylation and predominant nuclear localisation, resembling the pattern in normal stem cell

256 Mutations that do prevent localisation result in only a slight reduction in the ca

257 eta, IL-1alpha carries an N-terminal nuclear localisation sequence (NLS) and is trafficked to the nuc

258 lular domain of Celsr is fused to a membrane localisation signal (Lyn), inhibits Fz-Dsh complex forma

259 contains an unusually long bipartite nuclear localisation signal (NLS), comprising two basic elements

260 onstitutively active aPKC fused to a nuclear localisation signal has the same phenotypic effect as aP

261 Deletion of the nuclear localisation signal led to low CHK1 activation and low c

262 s nuclear transport, preventing NLS (nuclear localisation signal)-cargo release from RanGTP-importin

263 RNA localisation signals stimulate the processive movements,

264 r a role of ISTID sequences in tuning Nmnat2 localisation, stability and protective capacity in vivo.

265 Localisation studies suggest that DivIB only transiently

266 Through biochemical and localisation studies, we placed Nod1 in a complex with t

267 alisation, is also required for coracle mRNA localisation, suggesting that similar mechanisms target

268 man volunteers performed an auditory spatial localisation task whilst transitioning in and out of sle

269 achieved using insufficiently precise source localisation techniques, therefore casting doubt on repo

270 , in part by adopting asymmetric subcellular localisations that are likely to serve as cues for cell

271 of the cytoplasmic lines (67) show discrete localisations that provide clues on the function of the

272 166-residue B-region was required for polar localisation, though they were essential for FlhF functi

273 Depletion of NAC from polysomes and re-localisation to protein aggregates is observed during ag

274 his was accompanied by a change of Claudin-1 localisation to the cell surface and interaction between

275 ities of Bub1 and Mps1 are required for Sgo2 localisation to the centromere region.

276 Mps1 kinase activities are required for Sgo2 localisation to the centromere region.

277 glycosomal matrix enzymes, indicative of mis-localisation to the cytosol.

278 Importantly, their localisation to the polysome fraction is independent of

279 We observed a significant change in TlpD localisation towards the cell body in cheAY2-, catalase-

280 localisation biases increased when auditory localisation uncertainty increased.

281 alysed for their structural conservation and localisation using crystallographic data.

282 s were used successfully for storage protein localisation via electron microscopy.

283 Active contacts localisation was calculated and compared with clinical o

284 Mis-localisation was confirmed by digitonin fractionation ex

285 gets remained largely unchanged, although AR localisation was genotype- and tissue-dependent.

286 the MVN (2.5+/-1.1 per 50 microm(2)) and co-localisation was not observed.

287 Co-localisation was observed between RNS-modified tyrosine

288 Subcellular localisation was observed by immunofluorescence microsco

289 unction of rs2421947 genotype, and dynamin-3 localisation was perturbed in murine LRRK2 Gly2019Ser co

290 ious studies showing nuclear and cytoplasmic localisation, we observed synaptic enrichment of HDAC11.

291 Event-related beamformer localisations were also compared with more traditional s

292 t of nsP3 on stress granule responses and co-localisation with GTPase Activating Protein (SH3 domain)

293 Localisation with retinotopic mapping is difficult and t

294 ulf1 expression in all vertebrates is its co-localisation with that of Sonic hedgehog in the floor pl

295 pecific remorin proteins and differential co-localisation with the cytoskeleton.

296 Presynaptic Kv3.3 co-localisation with the GABAergic marker GAD67 was also no

297 essfully applied to interrogate biomolecular localisation within delicate cellular membranes.

298 inflammation and evidence suggests their sub-localisation within the airway is altered in asthma.

299 t the effect of corticosteroids on mast cell localisation within the bronchi.

300 y was affected by carotenoid species and its localisation within the matrix.