ライフサイエンスコーパス: localization

1 lating translation (but not RNA stability or localization).

2 for auditory spatial awareness (e.g., sound localization).

3 peptide that is sufficient to confer nuclear localization.

4 ed decorin-evoked TFEB induction and nuclear localization.

5 light-controlled change in COP1 subcellular localization.

6 mbrane interactions, and protein subcellular localization.

7 alpha-helices to be critical for membranous localization.

8 e proximity of mackinawite to selective Mott localization.

9 that is independent of altered expression or localization.

10 hydrolysis or GTP/GDP exchange modified this localization.

11 mutant in the cytoplasm, as well as nuclear localization.

12 ome shell protein, RuBisCO, and CcmM isoform localization.

13 body (MNTB) plays an important role in sound localization.

14 ith changes in auxin activity maxima and PIN localization.

15 omology domain and interrupts AKT's membrane localization.

16 Grb2 binding affinity is altered by membrane localization.

17 ent genetic information that can be used for localization.

18 FTY720; we then studied HSC mobilization and localization.

19 iate receptor protein expression and nuclear localization.

20 enin while CHIR99021 increased it in nuclear localization.

21 ive for quantitative measurements and lesion localization.

22 ultures as determined by the nuclear Smad2/3 localization.

23 ar processes, and showed diverse subcellular localizations.

24 no evidence for peroxisomal or mitochondrial localizations.

25 To determine the localization accuracy and its predictive performance, th

26 ime picking that will ultimately improve the localization accuracy.

27 itant toxic host responses, we evaluated the localization, activity, and toxicity of BoNT/C1 ad in vi

28 here was little change in CaN expression and localization after injury, SCI induced upregulation of t

29 show that modifying phosphoRS (a phosphosite localization algorithm) to include phosphate neutral los

30 d at the tip and base of flagella, and their localization also changes during flagellar assembly and

31 This differential localization also correlates with their associations wit

32 The current study examined mGluR2/3 localization and actions in the primate dlPFC layer III

33 Localization and adherence of the biofilm to the flea fo

34 itro splicing activity and inducing aberrant localization and aggregation in cells.

35 Localization and agreement analysis of (18)F-PSMA-1007 P

36 relies on regulation of MCL-1 mitochondrial localization and BFL-1 transcription by the viral EBNA3A

37 to the equatorial membrane affects anillin's localization and causes cytokinesis phenotypes.

38 -associated estrogen receptors; however, the localization and distribution of such receptors within t

39 y and consequently reduces NF-kappaB nuclear localization and downregulates NF-kappaB targets.

40 single functional complex, (b) TCR membrane localization and dynamics at the plasma membrane and in

41 iew of 100 women who underwent breast lesion localization and excision by using the Savi Scout surgic

42 ctivity resulting from endogenous changes in localization and expression.

43 multiple steps in mRNA metabolism and their localization and function are frequently controlled by m

44 of proteins with carbohydrates shapes their localization and function.

45 nd cellular machinery regulating Gli ciliary localization and identifies Kapbeta2 as a critical regul

46 hese RASVs, the relationship between antigen localization and immunogenicity in infected C57BL/6 mice

47 We characterized the localization and interaction properties of the p24 and E

48 genotoxic agents by modulating YB-1 nuclear localization and interaction with the splicing factor U2

49 Dylation-deficient HBx showed less chromatin localization and less DDB1 binding.

50 en identified based on their distinct tissue localization and morphology, but their developmental ori

51 Nuclear localization and nucleosome remodeling and histone deace

52 (AAs 23-40) that mediates the CASZ1b nuclear localization and NuRD interaction.

53 We examined the cellular localization and potential interactions of IGFBP-1, CSNK

54 confirmed between automated and manual fluid localization and quantification, yielding an average Pea

55 at our model is suitable for monitoring drug localization and regulation of histone PTMs after drug t

56 PH-domain mutants alter subcellular localization and result in decreased interactions with p

57 ces a poly-lysine tag, which might alter the localization and solubility of the associated protein.

58 affect heat-induced oligomerization, nuclear localization and specific DNA binding but inhibited the

59 Because the subcellular localization and substrate specificity of the catalytic

60 Both the defective localization and the reduced levels of Ena1 contribute t

61 ER that is required for regulation of Opi1p localization and thus phospholipid metabolism in yeast.

62 n-receptor interactions determines bacterial localization and thus the outcome of these interactions.

63 Localization and time-lapse imaging analysis reveals tha

64 y regulated at the levels of mRNA stability, localization and translation.

65 ing of UL20 and its subsequent effects on gK localization and virus replication.

66 rdered materials, is caused by Anderson-Mott localization and which is not desirable for conventional

67 to examine how PTEN's stability, subcellular localization, and catalytic activity affect neuronal gro

68 analyses of domain associations, subcellular localization, and co-complex formation.

69 s modification influences protein stability, localization, and function.

70 2 which regulates its stability, subcellular localization, and functions.

71 nous cysteine, cellular metabolism, cellular localization, and Hg(II) coordination in aerobically res

72 s are essential in, e.g., RNA stabilization, localization, and protein interaction, and their conserv

73 hat mtATP5alpha (AA42-72) showed an aberrant localization, and resulted in a decreased ATP production

74 ycle by promoting TDG function, TET1 nuclear localization, and TET/TDG association.

75 ACLY phosphorylation and nuclear localization are necessary for its role in promoting BRC

76 CaMKII locus, but only viability and CaMKII localization are rescued by genomic fosmids lacking the

77 minimal domains required for efficient Ede1 localization at CME sites are the third EH domain, the p

78 ucture, together with previously observed M2 localization at phase boundaries, suggests that choleste

79 domains within GFP-FIP2(S227E) rescued Eps15 localization at the lateral membrane and reestablished s

80 ockdown (KD) impairs beta-Arrestin1 membrane localization, beta-Arrestin1-ARHGAP21 interactions, Cdc4

81 Given the disparity of localization between Rab11A and vRNA segments in the abs

82 rexpressed C3G shows predominant cytoplasmic localization, but endogenous C3G is a component of nucle

83 that contributed multiplicatively to nuclear localization, but the conserved DNA binding residues wer

84 rent proportions of nucleoid and cytoplasmic localization by altering their length and/or translation

85 L290P/V mutations enhance ERK3's cytoplasmic localization by increasing the interaction with the nucl

86 ace electrons are exceptionally resistant to localization by non-magnetic disorder, and have been ado

87 Third, delta suppresses alpha6 synaptic localization by preventing assembly with GARLHs/NL2.

88 ions of the cytoplasm contributes to protein localization by providing local control over translation

89 Altman 95% confidence intervals (CIs) for VP localization by SVM and experts for AC stress images (bi

90 lated tumor suppressor and its intracellular localization can be modulated by ultraviolet light, sugg

91 Strikingly, this asymmetric localization cannot be explained by the distribution of

92 First, localization capabilities were demonstrated by reconstru

93 input timing adjustment in a brainstem sound localization circuit.

94 into contractile stress fibers revealed its localization complementary to actinin-1.

95 ic Hamiltonian to the system under many-body localization conditions, and observe a subharmonic tempo

96 and the establishment of PIN1 polar membrane localization consistent with auxin export, both precedin

97 on and regression models with expression and localization data from 218 ChR chimeras chosen from a 11

98 temporal expression profiles, and 10 protein-localization, degradation and solubility tags.

99 tion to oscillating, MinC exhibits a midcell localization dependent on MinD and the DivIVA-like prote

100 RNAi cell lines shows that its mitochondrial localization depends on pATOM36 but does not require Sam

101 suggest that, after ANCA-induced neutrophil localization, deposited MPO within glomeruli is recogniz

102 r, more information about the spatiotemporal localization, deposition, and function of their componen

103 This localization did not depend on the N-terminal signal pep

104 Moreover, ACOT1 exhibited partial nuclear localization during fasting and cAMP/cAMP-dependent prot

105 netochore attachment, but not its centrosome localization, during mitosis.

106 other proteins these same CTPs have reduced localization efficiencies or fail completely.

107 ved sequence coverage and accurate glycosite localization, enabling the first large-scale discovery o

108 t-independent manner and required lipid raft localization for CSC maintenance and cisplatin resistanc

109 promising strategy for directing subcellular localization for therapeutic and fundamental application

110 Analysis of subnuclear localization, gene expression, and chromatin association

111 es, direct evidence for the precise synaptic localization has been difficult to achieve due to the la

112 However, a general understanding of RNA localization has been hindered by a lack of simple, high

113 y signaling in terms of sub-cellular protein localization; however, Fat2/Lar signaling mediates short

114 nuclear localization signal and that nuclear localization impairs the ability of ICAP1 to suppress in

115 restore normal lipid accumulation and GLUT4 localization in adipocytes are present in 1.3% of Europe

116 ate neutral losses can significantly improve localization in AI-ETD spectra.

117 ping patterns of gene expression and protein localization in developing Arabidopsis plants and Nicoti

118 de the first direct report on tRNA diffusion localization in live bacteria.

119 retinoschisin treatment altered Na/K-ATPase localization in photoreceptors of Rs1h(-/Y) retinae.

120 can facilitate near-infrared imaging of mRNA localization in vivo and in ex-vivo tissue sections, whi

121 potential for tracking miRNA expression and localization in vivo.

122 rnal effectors may influence the observed co-localization independently from the local interaction of

123 orylation significantly disrupts its nuclear localization, interaction with VDR, intra-nuclear traffi

124 acts with peptidoglycan and thus assists its localization into the outer membrane.

125 by integrating exchangeable single-molecule localization (IRIS) approach to SMLM, in the context of

126 Because MT localization is a hallmark of most IQD family members, w

127 This dynamic localization is driven by MinD-catalyzed ATP hydrolysis,

128 Protein subcellular localization is fundamental to the establishment of the

129 Broadband light trapping and field localization is highly desired in enhanced light-matter

130 actility protrusions and, accordingly, their localization is promoted by increasing stiffness of the

131 These results suggest that plasma membrane localization is required for Ser5 antiviral activity, an

132 olet measurements suggest that small polaron localization is responsible for the ultrafast trapping o

133 iquitously expressed human Arf6 GTPase, PSD3 localization is restricted to the brain, particularly th

134 Localization is routinely limited to a peptide resolutio

135 e molecular level to regulate YAP1's nuclear localization is still puzzling.

136 ut how centrosomal proteins regulate GABARAP localization is unknown.

137 our findings imply that direct subarcsecond localizations may be the only way to provide reliable as

138 ribe an approach to cryogenic photoactivated localization microscopy (cPALM) that permits the use of

139 this can be used to perform single-molecule localization microscopy (SMLM) on cells expressing mCher

140 In this study we have used single-molecule localization microscopy (SMLM) to investigate integrin b

141 FPs) are powerful tools for super-resolution localization microscopy and protein tagging.

142 f LacI in live bacteria using photoactivated localization microscopy combined with single-particle tr

143 etical foundation for applying superresolved localization microscopy to the problem of molecular coun

144 holds particularly true for super-resolution localization microscopy where high demands are placed es

145 Using photoactivated localization microscopy, we reveal that the contact area

146 r molecule, which is a crucial parameter for localization microscopy.

147 namics of Dendra2, a well-known PAFP used in localization microscopy.

148 the cytoplasm and nucleus due to its nuclear localization (NLS) and export sequences (NES).

149 depletion of Repo-Man alters the peripheral localization of a subset of these regions and alleviates

150 reover, stable expression of PDHK4 increased localization of activated KRAS at the plasma membrane an

151 rastructural analysis revealed submembranous localization of Ank-G at nodes of Ranvier and AIS.

152 Subcellular localization of antigen, HLA molecules, and tryptase was

153 Specifically, PFOS caused mis-localization of Arp3 (actin-related protein 3, a branche

154 f pinna cross-sections revealed preferential localization of As on the pinna surface in the proximity

155 Immunodetection and in vivo localization of AtCPT7 fluorescent protein fusions showe

156 ytical TEM allowed assessing the homogeneous localization of bdc-NH2 in these mixed-linker MOFs.

157 CRM also enabled the localization of beta-carotene in an emulsion.

158 for the first time demonstrate this extreme localization of BISER by direct observation of nano-scal

159 leptomycin B resulted in predominant nuclear localization of C3G.

160 diol targeted the cell membrane to alter the localization of cholesterol-binding proteins, and preven

161 Together, our results show that cellular localization of Clusterin leads to divergent effects on

162 sites in LCL GM12878 revealed substantial co-localization of EBNA3s with RUNX3-a protein induced by E

163 in vitro Inhibition of calpain increases the localization of endogenous adhesion signaling to growth

164 Ultrastructural localization of endogenous ligands support these functio

165 a wide-gap core material (CdS) promoting the localization of excitons in the shell domain, as was con

166 Examination of subcellular localization of FOXO protein via CRISPR-assisted, single

167 t into FMRP involvement in the intracellular localization of FUS and pathology of FUS-related amyotro

168 jor SG effector protein G3BP1 and subsequent localization of G3BP1 and other SG-associated proteins a

169 nt chain libraries enable single-molecule co-localization of genotypes with phenotypes, are well suit

170 in cocaine treated DCs revealed increased co-localization of HIV-1 with endosomal or multi vesicular

171 acids substitution I2771R which affects the localization of hVps13A in skeletal muscles.

172 Expression and sub-cellular localization of IFT43 in the retina and transiently tran

173 traditional optical microscopy, enabling the localization of individual molecules even in densely lab

174 sorting was investigated by assessing the co-localization of internalized GPRC6A with selected Rab pr

175 PM localization of Kit(mut) is not required for its signali

176 Moreover, we observed co-localization of LFABP and apoB, independent of the OA tr

177 Heat inactivation of HIV-1 blocks nuclear localization of LysRS, but treatment with a reverse tran

178 ) structure, which coordinates the polarized localization of MCAM, actin, and myosin IIB in a Wnt5a-i

179 omains in the cell membrane, facilitates the localization of Mcp5 and that of cytoplasmic dynein on t

180 on the concentration, dynamics, and spatial localization of molecules in cells.

181 experimental indication of the preferential localization of more highly charged cations to the inner

182 We conclude that nuclear localization of MS is a unique feature of respiratory ye

183 ine triphosphatases (GTPases) to promote the localization of mTORC1 to the lysosomal surface, its sit

184 proper protein trafficking and cell surface localization of multiple biosynthetic mutants.

185 0N, which is also required for the nucleolar localization of NADs and Ki-67 during interphase.

186 is injected in the ipsilateral upper arm for localization of nonbreast lymphatics.

187 tients diagnosed with DCIS, making a precise localization of nonpalpable DCIS lesions even more impor

188 ngs by dermoscopy correlated with follicular localization of pagetoid cells by RCM (kappa = 0.499, P

189 We demonstrate that forced apical localization of Par3, which is normally restricted to ti

190 quence was altered, resulting in cytoplasmic localization of PELP1 (PELP1-cyto).

191 the fatty acyl chain-dependent differential localization of phospholipids and triacylglycerols was o

192 trophoresis (SDS-PAGE) analysis revealed the localization of phosvitin in the plasma fraction, which

193 Moreover, the nuclear localization of PINN-1 is altered in dapk-1 mutants.

194 of plasticity in PV+ cells by regulating the localization of potassium channels and AMPA receptors, r

195 capitulated their effects on the subcellular localization of ProP.

196 We determined the expression and localization of protein phosphatase 1 regulatory inhibit

197 Polar cellular localization of proteins is often associated with their

198 Tumor cell invasion involves targeted localization of proteins required for interactions with

199 f disease they produce and especially by the localization of PrP(Sc) deposits within the brain and th

200 Localization of PRX17 was examined by transient expressi

201 The resulting localization of reactive regions, determined by hot-carr

202 me, response to treatment, and incidence and localization of relapse and transformation.

203 ions, changed the subcellular expression and localization of RNAs within the neurons, showing a spati

204 we show that the expression and subcellular localization of Shh effectors and ciliary proteins are s

205 diated depletion of UBF diminishes nucleolar localization of SmgGDS and promotes proteasome-mediated

206 enomatous polyposis coli (APC) regulates the localization of some mRNAs at cellular protrusions but t

207 side CpG islands (CGIs) and could facilitate localization of some transcription factors within regula

208 sphosphate (PI[4,5]P2) levels, important for localization of STIM1 and E-Syts at ER-PM junctions, wer

209 Nuclear localization of TFPI-2 contributed to inhibition of MMP-

210 together sufficient for the robust cortical localization of the ActBD during cytokinesis.

211 mislocalize APC-dependent RNAs suggests that localization of the APC-dependent RNA subgroup is functi

212 Technetium is injected subareolarly for localization of the breast SLN and isosulfan blue dye (5

213 Conversely, hypophosphorylated Amot shifts localization of the complex to the nucleus, where it fac

214 An analysis of the subcellular localization of the DHARs in Arabidopsis lines stably tr

215 Cellular localization of the MybA::Gfp fusion and immunoprecipita

216 (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME2, which

217 ex and dependent on antigenic properties and localization of the stimulus.

218 Based on previous localization of the taiep mutation to rat chromosome 9,

219 e paralleled by modifications in the nuclear localization of the transcriptional regulator YAP, thus

220 d cIAP2 and observe differential subcellular localization of the two proteins in OSCC.

221 a wing primordium typically show subcellular localization of the unconventional myosin Dachs on the d

222 abeling in slowly dividing cells allowed for localization of these cells to the corneal limbus and th

223 an important role in controlling the precise localization of these receptors at specific region of th

224 phosphorylation of Amot at Serine 176 shifts localization of this complex to the plasma membrane, whe

225 Finally, an impaired nuclear localization of TRADD triggers cell death through the pe

226 we found that DMF treatment reduced nuclear localization of transcriptional coactivator with PDZ bin

227 to this question, we investigated the axonal localization of translational regulators and associated

228 metry-based imaging indicated a differential localization of triterpenoids to the periderm and sesqui

229 TATOC PET/CT is an effective modality in the localization of unknown primary in patients with metasta

230 The expression pattern and localization of Vimentin confirmed the mesenchymal origi

231 Spindle pole localization of WDR62 and mitotic progression are defect

232 -Myc), reduced proliferation (Ki67), nuclear localization of XPO1 cargos (p53, PTEN), and increased a

233 articular, ARF knockdown reduced non-nuclear localization of YAP which led to an increase in F-actin.

234 eus that may further lead to the non-nuclear localization of YAP.

235 d to a decrease in the cell area and nuclear localization of YAP/TAZ, and subsequent stiffening (from

236 28 kPa) increased the cell area and nuclear localization of YAP/TAZ.

237 The localization of ZNF804A protein was examined in neurons

238 lytic activity or protein levels but not its localization or binding with substrate.

239 mutations but not when grouped according to localization or type of mutation.

240 However, the localization pattern and genetic requirements for the SM

241 bind nascent mRNAs in the nucleoid, and (ii) localization patterns and distribution volumes of sRNAs

242 ptide degrading enzyme in the matrix.Protein localization plays an important role in the regulation o

243 overy highlights the role that intracellular localization plays in specialized metabolism, and sets t

244 sicle fusion events with approximately 27 nm localization precision at single hippocampal synapses un

245 nfluences both integrin activation and KRIT1 localization, presumably impacting nuclear functions of

246 in as a regulator of plant metal transporter localization, providing evidence that PH domain proteins

247 Fancd2 mitochondrial localization requires Atad3.

248 X (BRX) display shootward and rootward polar localization, respectively, in developing root protophlo

249 Coupling the co-localization results to iron K-edge X-ray absorption spe

250 ues from a phosphorylation-sensitive nuclear localization sequence located in the PLD.

251 LP1-wt, or mutant PELP1 in which the nuclear localization sequence was altered, resulting in cytoplas

252 x virus 1 (HSV-1) mutant lacking the nuclear localization signal (NLS) on the ICP0 gene (0DeltaNLS) i

253 phate (RanGTP) gradient that imports nuclear localization signal (NLS)-specific cargoes (NLS-cargoes)

254 of both a peptide-encoded N-terminal nuclear localization signal and C-terminal nuclear export signal

255 how that ICAP1 contains a functional nuclear localization signal and that nuclear localization impair

256 sequences do not correspond to known nuclear localization signal motifs, they represent a new motif f

257 rallels effects of the attachment of nuclear localization signal to Sis1, indicating that Cur1 acts o

258 n, which could be reversed after the nuclear localization signal was deleted.

259 ll length, containing the N-terminal nuclear localization signal.

260 ant pathogen Phytophthora sojae uses nuclear localization signals (NLSs) for translocation of protein

261 ng enzyme 1 (BACE1) trafficking and synaptic localization significantly influence its beta secretase

262 Here we use co-localization single-molecule spectroscopy (CoSMoS) to fo

263 ter gene expression by regulating transcript localization, stability and/or translation, while change

264 protein structure and performed subcellular localization studies.

265 ed as an accurate and cost-effective initial localization study for patients with primary hyperparath

266 Subcellular localization study indicated that it is an integral plas

267 ed changes in nuclear morphology and protein localization that are consistent with disruption of the

268 merging data imply that intraprostatic tumor localization, therapy stratification, and treatment moni

269 s exist to predict plant protein subcellular localization, they perform poorly for effectors.

270 ulation of BACE1 trafficking and presynaptic localization through Snapin-mediated dynein-driven retro

271 ans VAPB homolog VPR-1 promote mitochondrial localization to actin-rich I-bands in body wall muscle.

272 oximately 12.5 nm), we demonstrated specific localization to breast cancer bone metastases in mice.

273 rotein conformation and transcription factor localization to chromosome reorganization and membrane d

274 eraction after DNA damage and promotes PALB2 localization to DNA damage sites.

275 )-anchored membrane protein whose reversible localization to ER-plasma membrane (PM) contacts is gove

276 ng subunit 1 (MYPT1), and we show that MYPT1 localization to kinetochores depends on Cyclin A/Cdk1 ac

277 Protein N-myristoylation enables localization to membranes and helps maintain protein con

278 roxide, is necessary and sufficient for Vms1 localization to mitochondria, through binding the MTD in

279 1 and Pet1 (Tac1-Pet1 neurons), mapping soma localization to the caudal medulla primarily and axonal

280 ivery of GJA1-20k to the heart protects Cx43 localization to the intercalated discs against acute isc

281 ns similar to other teleosts, which included localization to the lateral tuberal nucleus (NLT), the p

282 Reticulon-1 subcellular localization to the periphery after exposure to CSF-1 fo

283 TbPLK localization to the tip of the new FAZ is also blocked.

284 tion of a Gaussian mixture that accounts for localization uncertainty and background.

285 Mutations lacking nuclear localization uncover a novel mechanism whereby lipid pho

286 The cellular uptake and localization was assessed by confocal microscopy.

287 By analyzing chromosome and replisome localization, we demonstrated that chromosome positionin

288 erformance, the individual and combined test localizations were compared to the presumed EZ and to th

289 ever, a major hindrance is STING's cytosolic localization which requires intracellular delivery of it

290 display drastically reduced plasma membrane localization, which effectively prevents TF from partici

291 One instance of this is sound localization, which improves with increasing bandwidth.

292 otential and play a crucial role in Anderson localization, which is the absence of diffusion due to d

293 Their partial co-localization with canonical endosomal markers thus refle

294 istribution within the nucleus, decreased co-localization with endogenous Matrin 3 and increased co-l

295 on with endogenous Matrin 3 and increased co-localization with specific TREX components.

296 rkers such as CD81 and VPS4 and decreased co-localization with the phagolysomal marker LAMP1; this si

297 Plains exemplify such intraplate earthquake localization, with both natural and induced seismicity g

298 unolocalization analysis reveals that Notch1 localization within a tubulovesicular compartment is alt

299 Given their co-localization within the DCT2, we hypothesized that NCC a

300 ncy, their beating angle, and their distinct localization within the mouse brain-lateral ventricle.