ライフサイエンスコーパス: localized

1 terference appears even when the particle is localized.

2 te and has a component that is not spatially localized.

3 protein (BTA121) is predicted to be surface localized.

4 ly enlarged and the left kidney could not be localized.

5 e data from [Formula: see text] DO mice, and localized 2.2 million CO events to intervals with a medi

6 a linkage backcross involving these strains localized a Chr 10 QTL contributing to the difference.

7 We localized a subpopulation of excitatory vasopressin neur

8 c, integrin-targeting (90)Y-DOTA-RGD and the localized activation of Cy7 azide.

9 The localized activation of Toll a few cell diameters from w

10 Immunohistochemistry localized ACVR2A and ACVR2B to osteoblasts and osteocyte

11 of the Solanaceae family-specific, trichome-localized acylsugar biosynthetic pathway using a combina

12 Once localized, additional properties such as fast neutron en

13 ein-calcium (AGP-Ca(2+) ) capacitor with tip-localized AGPs as the source of tip-focussed cytosolic C

14 genes among patients with systemic (ALS) and localized (ALL) amyloidosis and to assess for associatio

15 the epileptogenic zone (EZ) can be correctly localized and characterized.

16 Kindlin-2 co-localized and co-immunoprecipitated with vascular endoth

17 systems, such as YbAl3, interactions between localized and delocalized electrons can lead to fluctuat

18 enerates a time-varying field that is highly localized and heterogeneous at the molecular scale, and

19 The insights range from revealing localized and heterogeneous deformations of the membrane

20 interplay between hot electrons generated by localized and propagating plasmons, and demonstrate wave

21 irectionality between the hot electrons from localized and propagating plasmons.

22 f delivering hyperthermia to tumors was more localized and uniform across the tumor mass when compare

23 ivities are found to be concentrated in very localized areas, whereas a large fraction of the globe i

24 forbidden gap, which are related to defects localized around selected edges and grain boundaries.

25 flow plastically via particle rearrangements localized around structural defects.

26 The CAPN14 gene is localized at chromosome 2p23.1-p21 and is most homologou

27 tion that is determined by gating mechanisms localized at the base of the cilium.

28 Additionally, c-di-GMP was found to be localized at the outer boundary of mature colonies in co

29 s thaliana FLA4 we show that this protein is localized at the plasma membrane as well as in endosomes

30 ence studies showed that alpha1D protein was localized at the plasma membrane, in cytosol and cell nu

31 are caused by thrombotic arterial occlusion localized at the site of high-risk atherosclerotic plaqu

32 cteriochlorins are thus excellent models for localized bacteriochlorin chromophore deformations that

33 rough a nucleolar localization signal (NoLS) localized between residues 33 and 51 of the protein.

34 largely RhoA-dependent, the process by which localized biochemical signals are translated into cell-l

35 entrated shear stresses, and (3) repetitive, localized biting.

36 ound contrast agent microbubbles (MB) causes localized blood-brain barrier (BBB) disruption that is c

37 Solitary perturbations (SPs) localized both poloidally and radially are detected with

38 Interestingly, in a model of localized breast cancer, metaphyseal HA nanocrystals wer

39 dge states are shown to coexist with a quasi-localized bulk.

40 y-wave insulator 1T-TaS2 decomposes into two localized but nonconducting states at the center or edge

41 ated hyperacetylated megadomains, distinctly localized but otherwise analogous to those found in BRD4

42 mited number of release sites through highly localized Ca(2+) elevations and support short-term facil

43 ived clonal insulin 1 (INS1) cells for which localized Ca2+ influx triggers exocytosis with high prob

44 nlarged ribbons had larger global and ribbon-localized calcium currents.

45 Thus, we propose MCTP as a novel, ER-localized calcium sensor and a source of calcium-depende

46 constitutively-active (ca) forms of nuclear-localized CaMKIV and measured the induction of all three

47 eals differential kinetics and amplitudes of localized cAMP signals.

48 S1 status improves patient stratification in localized ccRCC, which supports further integration of l

49 While the localized changes suggest compositional or physical hete

50 From December 2014 to June 2016, numerous localized changes were observed, which we attribute to c

51 Exposure to 5 localized civil conflict fatalities (mean +/- SD: 1.41 +

52 Here, localized CL-induced fluorescence was detected in the tu

53 tified branch of the UPR initiated by the ER-localized co-chaperone from Arabidopsis thaliana, AtBAG7

54 onditions, endogenous FVIIa engages its cell-localized cofactor tissue factor (TF), which stimulates

55 bacterial migration in response to multiple localized contaminant sources within porous media.

56 e biogene tradition, such indicators include localized crystal structural blocks in real space or ban

57 Leishmania (Viannia) braziliensis can cause localized cutaneous leishmaniasis (LCL), which heals spo

58 y that likely reflect specialized tuning for localized cytoskeletal determinants, whereas dynein acti

59 ties of a material along an edge or around a localized defect.

60 n the epidermis of psoriatic skin leading to localized deficiency of cortisol.

61 The nanopillars create localized deformations in the material resulting in the

62 rect priming by resident macrophages and the localized delivery of innate signals to antigen-experien

63 Mf3 and Mf4 localized differently in SI; Mf3 formed a dense network

64 tion was more pronounced among patients with localized disease at diagnosis (n = 517; adjusted HR, 0.

65 -19.1 y) underwent PET imaging; 25 (74%) had localized disease.

66 Simulations revealed that highly localized dispersal and small total population size, but

67 burst durations are caused by dendritically localized Dmca1D channels, which activate upon cholinerg

68 rt on binding of trans-acting factors to cis-localized DNA sequence motifs.

69 lator compound, IWP-051, and MS analysis, we localized drug binding to the beta1 heme domain of sGC p

70 The response to this perturbation is localized due to distinct physico-biogeochemical environ

71 s loudness, we assessed resting-state source-localized EEG before and after one to three months of VN

72 resonances, hence optimizing the associated localized electric field intensity.

73 ed sample and a microelectrode probe for the localized electrochemical analysis of the surface.

74 monolayer/dielectric interfaces, leading to localized electronic states that serve as a basis for el

75 NA expression levels for 198 mitochondrially localized energy production components, including Krebs

76 eurons in predatory dragonflies that exhibit localized enhanced sensitivity for targets displaced to

77 ifs that can be O-glycosylated by several ER-localized enzymes, including protein O-glucosyltransfera

78 r state and lower lying charge-separated and localized excitonic states are dominated by asymmetric a

79 s mediated by beta-arrestin 1 from receptors localized exclusively at Rab4/5 compartments.

80 etwork contains 1,147 reviewed proteins (559 localized exclusively in plastids, 68 in at least one ad

81 GDF15 activates GFRAL-expressing neurons localized exclusively in the area postrema and nucleus t

82 Kidney FATP2 localized exclusively to proximal tubule epithelial cell

83 This study provides a link between localized experiments and regional-scale modeling to hig

84 Localized extracellular matrix (ECM) remodeling is thoug

85 To directly test the localized feedback model, we developed a synthetic biolo

86 models suggest that polarity can arise from localized feedbacks on Fat-Ds complexes at the cell boun

87 In this instance, localized Fgf signaling performs dual roles, as it regul

88 main walls in magnetic tracks produce strong localized fields and can be used to capture, transport,

89 Such actin assembly can generate significant localized forces that have not been characterized in the

90 Arabidopsis thaliana and Brassica nigra that localized FR enrichment at the lamina tip induces upward

91 rovide a promising new delivery platform for localized gene therapy in the brain.

92 Knowledge of localized gene-expression and corresponding bacterial be

93 onsent, 341 (85.9%) had centrally confirmed, localized GISTs with mutation analysis for KIT and PDGFR

94 how this influences their ability to control localized GTPase activity in the context of migration an

95 was developed for patients with inoperable, localized HCC who were eligible for both RFA and SBRT to

96 um niobate crystals were grown in 3D through localized heating by femtosecond laser irradiation deep

97 Histopathology suggested localized hepatobiliary tuberculosis with features of se

98 We focused on validating endosome/Golgi-localized hits specific for STx2 and found that depletio

99 te HIV testing program designed to encourage localized HIV testing programs focused on self-identifie

100 ustained site of nutrient acquisition induce localized host endoreduplication.

101 physically adsorbed pentene in ZSM-5 and the localized hydrogen-bonded pi-complex at Bronsted acid si

102 ing five of stem/progenitor cell markers are localized in basal layer of entire murine corneal epithe

103 We found that NUMB is asymmetrically localized in CE cells, suggesting that it might be invol

104 be synthesized in the roots, with HSS being localized in cells of the root endodermis.

105 affolding protein p130Cas is a Src substrate localized in focal adhesions (FAs) and functions in inte

106 ne system that is ubiquitously expressed and localized in mitochondria.

107 the most abundant TRIM family member and is localized in nuclei of ECs.

108 Strain Lupac 08 was localized in plant tissues, confirming its capacity to e

109 ation schemes and RNA-Seq, we find that RNAs localized in protrusions of migrating fibroblasts can be

110 Both cytosolic targets and targets localized in subcellular compartments were investigated.

111 ions and Western blots confirmed MzASMT9 was localized in the chloroplasts.

112 extracellular environment through receptors localized in the ciliary membrane, but mechanisms direct

113 t METTL12 methylates CS on Lys-395, which is localized in the CS active site.

114 ion, we demonstrate that Nbeal2 is primarily localized in the cytoplasm and Dock7 on the membrane of

115 OsHAC4-eGFP was localized in the cytoplasm and the nucleus.

116 under the control of their native promoters, localized in the cytoplasm of pollen grains, pollen tube

117 ity but unlike full-length SENP7L, SENP7S is localized in the cytosol.

118 ryotic cells contain a labile copper(I) pool localized in the matrix where also the mitochondrial iro

119 In this study, we found that NSs is mainly localized in the nucleus of infected cells and specifica

120 of the 4,4'-bipyridine radical anion species localized in the plasmonic hot spots of individual gold

121 d by considering only those protein pairs co-localized in the same cellular compartment and involved

122 Forty percent of the lesions are localized in the tongue and 30% in the floor of the oral

123 ANCE STATEMENT: The mu-opioid receptor (MOR) localized in the ventral tegmental area (VTA) plays a ke

124 was expressed in the IVC wall, where it was localized in the vicinity of the abluminal side of the e

125 In this sense, Pru p 3 protein was also localized in trichomes covering the fruit epidermis.

126 n skin, kidney, lung, and lymph node samples localized in typical PDNS lesions, including necrotizing

127 metamaterial optical properties and causes a localized increase in emissivity.

128 of the right amygdala and left thalamus, and localized increases and decreases in subregions of the c

129 anchored protein known as viral mitochondria-localized inhibitor of apoptosis (vMIA) traffics from th

130 Conclusion SBRT for initial treatment of localized, inoperable HCC is not cost-effective.

131 ctures studied in this work, the presence of localized interfacial optical modes mediate thermal cond

132 a type-I energy level alignment and strongly localized interfacial states.

133 Target and reflector were localized intraoperatively by one of two breast surgeons

134 the stalled fork, which primarily consist of localized losses and duplications of DNA sequences.

135 Localized lysosome exocytosis fuels generation of large,

136 nction mutations in SLC30A10, a cell-surface-localized manganese efflux transporter, cause a heritabl

137 ous mastocytosis, systemic mastocytosis, and localized mast cell tumors.

138 We find that localized mechanical forces are sufficient to induce the

139 Here, we study the propagation of localized mechanical pulses in aqueous monolayers of mic

140 ads via an atomic force microscope induced a localized mechanical response from the VSMCs that oppose

141 Importantly, localized microinjection of PMN-MPs into wounded colonic

142 nal influxes of O2 and NO3(-) may cause only localized mobilization of U without leading to export of

143 he pedestal ingrained with quasi-stable edge-localized mode (QSM) which commonly appears during the i

144 ynamical phase diagram, such as self-trapped localized motion, 2-D diffusive exploration, and super-d

145 al misfolded aggregates of the mitochondrial-localized mutant ornithine transcarbamylase (DeltaOTC).

146 A-ATP dimers equilibrate to HDRs shown to be localized near cell poles of dividing chromosomes, thus

147 e revealed that most of these mutations were localized near or at conserved residues essential for di

148 in the proximity of veins, with the majority localized near the midrib.

149 ry of therapeutic agents targeted to inhibit localized neointimal hyperplasia.

150 nstrate that UNC-45A is a novel growth cone--localized, NMII-associated component of the multiprotein

151 est unoccupied molecular orbital of Ru3Rh is localized on a bridging ligand, it is Rh-centered in Ru3

152 ic of aliphatic organic matter and is mainly localized on a broad region of 1000 square kilometers c

153 temperatures holes in deep ground states are localized on N atoms axially bonded to Mg acceptors.

154 y, the exciton chirality model with excitons localized on the arene scaffold, here generalized to Cn

155 ndothelial growth factor receptor 2 (VEGFR2) localized on the surface of endothelial cells (ECs) is a

156 the migratory neural crest cells and pigment localized only to PNA-free areas.

157 es in vaccination worldwide that have caused localized outbreaks, measles virus (MeV) has regained im

158 c. 3.0 billion yr ago (Ga) onwards, creating localized 'oxygen oases' under a reducing atmosphere, wh

159 m wave passing through both slits, we have a localized particle with nonlocal interactions with the o

160 Complete image datasets, clinically localized PCa, availability of Gleason score, data avail

161 ranscript, and primary islet ChIP-sequencing localized PDX1 to the Atf5 promoter, implicating Atf5 as

162 yses we show that AI-ETD can identify 24,503 localized phosphopeptide spectral matches enriched from

163 lectrons are typically generated from either localized plasmons in metal nanoparticles or propagating

164 n with specific sequences of amino acids and localized post-translational modifications, are identifi

165 Versican localized preferentially to the vicinity of tumor vascul

166 olutionary conserved multifunctional protein localized primarily in the mitochondrial matrix and has

167 ho were age </= 75 years when diagnosed with localized prostate cancer between October 1994 and Octob

168 Purpose Men with localized prostate cancer often are treated with externa

169 uary 2002, we randomly assigned 731 men with localized prostate cancer to radical prostatectomy or ob

170 dverse effects of contemporary approaches to localized prostate cancer treatment could inform shared

171 In this cohort of men with localized prostate cancer, each treatment strategy was a

172 In this cohort of men with localized prostate cancer, radical prostatectomy was ass

173 nearly 20 years of follow-up among men with localized prostate cancer, surgery was not associated wi

174 osed in 2011-2012 with clinical stage cT1-2, localized prostate cancer, with prostate-specific antige

175 decision regret among long-term survivors of localized prostate cancer.

176 s have been developed that perform spatially localized protein extraction and digestion prior to down

177 omoting its dephosphorylation by kinetochore-localized protein phosphatase 1, which allows Cdc20 to a

178 IFITM3) is a cellular endosome- and lysosome-localized protein that restricts numerous virus infectio

179 insights into the quality control of plastid-localized proteins and establish a hitherto unidentified

180 ler biological features for robust spatially localized proteomic analyses.

181 We here asked how fast and how far localized pulses of mechanical stress dynamically propag

182 es in the analysis of brain imaging data, we localized purely experience-based fear processing and me

183 r nature of the peripheral signals and brain-localized receptors that activate these circuits remains

184 d whole eisosomes and, after photobleaching, localized recruitment of new Pil1p molecules with approx

185 e wherein partial amputation culminates in a localized regeneration instead of global hypertrophy and

186 Ultralow-velocity zones are localized regions of extreme material properties detecte

187 ith NMR-detected structural perturbations in localized regions of KRAS important for recognition of t

188 ort the existence of clearly defined dynamic localized regions of substantially increased stress that

189 from the eutectic composition exists in some localized regions resulting in a mushy zone with a thick

190 Localized resonances in ultrathin metal nano-strip optic

191 n, or phloem protein accumulation, causing a localized response and/or systemic effect on phloem tran

192 lity, and is regulated by the asymmetrically localized RhoGAP Deleted in liver cancer (DLC1) in the c

193 quality control specifically on mitochondria-localized ribosomes, ultimately preventing protein aggre

194 Among well-localized S-GlcNAcylation sites, several motifs with an

195 In contrast, during localized s.c. infection, IL-10 production plays a detri

196 The plasma membrane-localized SbSUT1 and SbSUT5 exhibited a strong selectivi

197 Suc transport by the tonoplast localized SbSUT4 could not be detected using yeast or X.

198 ough all three diseases have been modeled on localized scales, no previous study has used harmonic mo

199 = 10), as well as fibrotic skin lesions from localized scleroderma and uninvolved skin (n = 6).

200 s experiencing similar flux, suggesting that localized sediment conditions are important to controlli

201 Understanding the trend of localized severe weather under the changing climate is o

202 chanisms and functional significance of this localized signaling are unknown.

203 nflorescence branching is regulated by novel localized signaling centers.

204 heterogeneous structures in glasses-such as localized soft spots-and understanding structure-dynamic

205 Thus, we have localized spatially in the cell different complexes form

206 Piezo2 immunoreactivity localized specifically within EC cells of human and mous

207 ngling bonds at their surface can act as the localized spins of magnetic ions.

208 pping of photoexcited charge carriers in the localized states in sp(3) domains.

209 Here we show that localized states of a disordered optical fibre are singl

210 Localized states trap waves propagating in a disordered

211 This leads to localized strains that can be larger than the remotely a

212 o efficiently reconstruct stress fields with localized structure from simulated and experimental subs

213 , both Fe-rich and Ga-rich GFO NCs exhibit a localized surface plasmon resonance in the near-infrared

214 tory indicator (THI) taking advantage of the localized surface plasmon resonance of gold nanoparticle

215 mtosecond pulses through gold nanorods whose localized surface plasmon resonance overlaps with the ex

216 colored perovskite solar cells that exploit localized surface plasmon resonances in ultrathin subwav

217 rid sensor that integrates transmission-mode localized surface plasmonic resonance (LSPR) into a quar

218 otentially able to function on both a highly localized, synapse-specific level and on a larger, spati

219 t adolescence and, by establishing precisely localized synapses, calibrates cognitive function.

220 duced after UV-C irradiation, whereas a more localized synthesis of stilbenes in stomata guard cells

221 ed by introduction of cortical division site localized TANGLED1-YFP.

222 Unexpectedly, immunofluorescence microscopy localized TbRFT1 to both the endoplasmic reticulum and t

223 By generating localized telomere-specific DNA damage in a real-time fa

224 ar wave systems, manifesting themselves as a localized temporal structure that exhibits oscillatory b

225 s at synapses), we show that Pc detected and localized temporary changes of diffusive behavior both i

226 Here we show that ER-localized THBS1 is cytoprotective to rat, mouse, and hum

227 gene expression in muscle tissue by qPCR and localized this expression in mechanosensilla via in situ

228 ScxGFP(+) cells were localized throughout the healing callus after fracture.

229 In adult mice, lung-localized, tissue-resident memory T cells (TRMs) mediate

230 e DMRs revealed differential DNA methylation localized to a 600 bp region in the promoter of the Ifit

231 ow that the microtubule depolymerase Kif2 is localized to a cortical subdomain of the ER that is invo

232 unknown whether this preparatory activity is localized to ALM or widely distributed within motor cort

233 a, whereas NFIB expression was predominantly localized to astrocytes and neurons.

234 We find that Psd1 is localized to both mitochondria and the ER.

235 and PCO2Tac1-Pet1 axonal boutons were found localized to brainstem areas implicated in respiratory m

236 not previously implicated in ciliary biology localized to cilia and further investigated ENKUR, a TRP

237 backbone and sugar modifications can become localized to cytoplasmic ribonucleoprotein granules such

238 Various isoforms localized to different regions of the pollen tube plasma

239 reticulon 1A (RTN1A), an ER-shaping protein localized to EMCs as an EMC promoter.

240 ociated protein (Plvap) that is specifically localized to endothelial caveolae in vivo and compared i

241 KCC2 is highly localized to excitatory synapses where it regulates spin

242 te that representation of facial identity is localized to face patches, but activity in these patches

243 drial DNA lesions (8-oxoguanine) exclusively localized to glomerular endothelial cells after 3 weeks

244 show by proteomic analysis that P450 27C1 is localized to human skin, with two proteins of different

245 of 5f electrons in actinide materials, from localized to itinerant and in between, together with the

246 A fraction of Stx3 is localized to late endosomes/lysosomes, although how it t

247 oteins that were not previously annotated as localized to mitochondria.

248 RabA2 localized to mobile vesicles around the IT, but mutation

249 s (GWASs) have identified sequence variants, localized to non-coding genomic regions, associated with

250 is expressed with true late kinetics and is localized to nucleolin-containing nuclear domains.

251 Observed focal uptake in the prostate was localized to PSMA-expressing malignant tissue on histopa

252 ntricular injection to ATXN2-Q127 mice, ASO7 localized to Purkinje cells, reduced cerebellar ATXN2 ex

253 s association with deprotected telomeres and localized to sites of DNA damage in S phase.

254 Endogenous ZNF804A protein localized to somatodendritic compartments and colocalize

255 Additionally, a fraction of these proteins localized to structures surrounding mitochondria.

256 The conserved ARF-like small GTPase ARL-8 is localized to SVPs and directly activates UNC-104/KIF1A,

257 as found for couples, but not for strangers, localized to temporal-parietal structures and expressed

258 s, hundreds of maternal RNAs are selectively localized to the animal or vegetal pole, including deter

259 Furthermore, Amd1-GFP localized to the ascus membrane and Amd1 orthologs are o

260 show that the Legionella export apparatus is localized to the bacterial poles, as is consistent with

261 into the duplex, with conformational changes localized to the bulge site, thereby having minimal impa

262 Furthermore, SLC30A10 and SLC39A14 localized to the canalicular and basolateral domains of

263 s, including vascular tissues, and PRX17 was localized to the cell wall.

264 n every subtype and all implicated genes are localized to the chromosomal cytoband 1p36.3.

265 Those cells localized to the cortex and efficiently emigrated in a m

266 er investigation revealed that MIWI2 protein localized to the cytoplasm of a discrete population of m

267 nthamiana leaf cells, whereas N. munroi CA1a localized to the cytosol.

268 is, in part, controlled via gating residues localized to the ends of the heptameric barrel-like CP s

269 les the regional heritabilities were further localized to the gene and subregion levels.

270 tor cells that overexpressed MFSD2A not only localized to the inflamed mucosa but also restored the a

271 ide is conserved between human and mouse, is localized to the late endosome/lysosome and interacts wi

272 preferred carbon sources, Msn2 is constantly localized to the nucleus in wild-type cells.

273 fp or MybA::3xHa protein showed that MybA is localized to the nucleus.

274 remodeling and are transiently and partially localized to the nucleus.

275 Topo-II localized to the perimeter of mitotic chromosomes, exclu

276 esidues mutated, TF is much less efficiently localized to the plasma membrane, and it is not incorpor

277 When expressed in yeast, human Eps15 localized to the plasma membrane, where it recruited lat

278 d alterations of lipid profiles specifically localized to the retinal pigment epithelium (RPE) in Abc

279 lretinin immunoreactivity, which could be co-localized to the same cells.

280 Engrafted cells could be localized to the stroma surrounding acini and ducts.

281 the amount of ACT, and >/=90% of this ACT is localized to the supernatant, unlike growth without FBS,

282 the size of the nanocubes, and that they are localized to the surfaces of the nanocube.

283 hCD39 transgene expression was localized to the vascular endothelium at baseline and di

284 ty (suppressed posterior alpha power, source-localized to the visual cortex-cuneus and precuneus) and

285 KK174), we mapped a binding pocket in mVDAC1 localized to Thr(83) and Glu(73), respectively.

286 mputational analyses indicate that astrocyte-localized translation is both sequence-dependent and enr

287 , here we confirmed that the plasma membrane-localized transporter (renamed CDR6/ROA1 for consistency

288 organoids in vitro, we observed ectopically localized Tuj1(+) cells in RB-KO teratomas grown in vivo

289 light on how the jigsaw shape can arise from localized variations in wall stiffness between adjacent

290 d largely through endoplasmic reticulum (ER)-localized vIL-6, which can induce signal transduction vi

291 he authors describe a method that allows the localized visualization of oxidized intermediates of PTP

292 B, which is involved in DNA methylation, was localized with 5-methylcytosine in the prophase nucleus

293 ents with alcoholic liver injury, and was co-localized with alphaSMA-expressing activated HSC.

294 taining immunohistochemistry showed CXCL9 co-localized with CD68(+) dermal macrophages.

295 Most epithelially generated ROS co-localized with polarized mitochondria.

296 ovalent intermolecular interactions that are localized within and adjacent to the C-terminal regions

297 These nanoparticles were localized within macrophage autophagosomes, leading to a

298 also utilize Agap2 as an example of GAP/GEFs localized within multiple neuronal compartments and dete

299 ts in obsessive compulsive disorder patients localized within the anterior and ventral subthalamic nu

300 n is sustained by epidermal progenitor cells localized within the basal layer of the skin epithelium.