ライフサイエンスコーパス: locally

1 educes the effective tunneling barrier width locally.

2 heir global structure can look quite similar locally.

3 ) for reconfiguring the extracellular matrix locally.

4 many tissue macrophages, they self-maintain locally.

5 related to independently process information locally.

6 ulcus, which may impact pellicle composition locally.

7 near-zero shear that allow matrix mutants to locally accumulate.

8 This suggests a triggering function of locally accumulating Pip for systemic resistance inducti

9 side effects, we evaluated the effects of a locally acting ROCK inhibitor (AMA0825) on intestinal fi

10 Herein we report the discovery of LX2761, a locally acting SGLT1 inhibitor that is highly potent in

11 Here we demonstrate that, in addition to locally acting signals, tissue-wide mechanical forces ca

12 A locally actionable mutation (i.e., available targeted tr

13 This mechanism enables VWF to be locally activated by hydrodynamic force in hemorrhage an

14 ing the capacity to disperse to new sites or locally adapt.

15 tion in a collection of 3,012 georeferenced, locally adapted landraces from a broad geographical rang

16 on the basis of neutral genetic markers and locally adapted populations, are associated with differe

17 it with the existence of potentially new and locally adapted species never described before at the mo

18 ions can be readily introduced into elite or locally adapted tomato varieties in less than a year wit

19 S. bungeana seeds were collected from eight locally-adapted populations in 2015 and 2016.

20 automatically delineated on PET with a fuzzy locally adaptive bayesian algorithm.

21 Locally, adhesion molecules are distributed at the tips

22 MA immunization significantly expanded upon locally administered antigenic challenge and showed a pr

23 treatment, according to their perception as locally advanced (cT3) or early-stage tumors (stage II).

24 Patients and Methods Patients with locally advanced (cT3-4 or cN+) rectal cancer who were t

25 categorized as localized (stages I and II), locally advanced (stages III and IVB), or metastatic (st

26 For patients with locally advanced (T3, T4) disease, organ-preservation su

27 n combined with gemcitabine in patients with locally advanced and metastatic pancreatic cancer.

28 izumab in cisplatin-ineligible patients with locally advanced and unresectable or metastatic urotheli

29 erall survival (OS) benefit in patients with locally advanced and/or positive regional lymph node dis

30 The LABC (locally advanced breast cancer) group included 17 patien

31 The study comprised 52 patients with locally advanced carcinoma, treated first with combined

32 ckade may be a viable therapeutic option for locally advanced cSCC and provides rationale for further

33 A single patient with locally advanced cSCC who declined surgery and radiother

34 In 1 patient with locally advanced cSCC who was treated with pembrolizumab

35 d cell death 1 receptor (PD-1) inhibitors in locally advanced cSCC.

36 es are available in patients with inoperable locally advanced cutaneous squamous cell carcinoma (cSCC

37 with metastases and 11 patients [6.0%] with locally advanced disease) at the National Institutes of

38 esophagectomy is indicated for patients with locally advanced disease.

39 r patients is increasing beyond the scope of locally advanced disease.

40 eived neoadjuvant chemotherapy for localized/locally advanced disease; 51 received chemotherapy for u

41 se, we reviewed 97 consecutive patients with locally advanced EC and a pretreatment (18)F-FDG PET/CT

42 step in predicting tumor response to nCRT in locally advanced EC.

43 f sarcopenia in the multimodal management of locally advanced esophageal cancer (LAEC), and to assess

44 ence treatment and outcomes of patients with locally advanced esophageal cancer.

45 adiotherapy (CRT) for patients with resected locally advanced head and neck cancer (LAHNC) with negat

46 nce every 3 weeks is the standard of care in locally advanced head and neck squamous cell cancer (LAH

47 apy, a standard of care for the treatment of locally advanced head and neck squamous cell cancers.

48 of response to radiotherapy and cetuximab in locally advanced head and neck squamous cell carcinoma (

49 Women who have large or locally advanced invasive breast cancer (tumor size T3/T

50 Twenty-four women with a new diagnosis of locally advanced invasive ductal breast cancer (n = 18)

51 oxic effects in the definitive management of locally advanced non-small cell lung cancer (NSCLC), but

52 therapy (IMRT) is increasingly used to treat locally advanced non-small-cell lung cancer (NSCLC), IMR

53 nt FDG-PET to improve local tumor control of locally advanced non-small-cell lung cancer (NSCLC).

54 study compares 3D-CRT and IMRT outcomes for locally advanced NSCLC in a large prospective clinical t

55 diac events exceeded 10% among patients with locally advanced NSCLC treated with definitive radiation

56 0617, which supports routine use of IMRT for locally advanced NSCLC.

57 upplemented surgery as standard treatment of locally advanced oesophageal cancer.

58 uvant concurrent chemoradiotherapy (CRT) for locally advanced or incompletely resected non-small-cell

59 rs or older with HER2-positive unresectable, locally advanced or metastatic breast cancer previously

60 mal growth factor (HER2)-negative inoperable locally advanced or metastatic breast cancer whose disea

61 ed hormone-receptor-positive, HER2-negative, locally advanced or metastatic breast cancer, who had re

62 t patients (aged >/=18 years) diagnosed with locally advanced or metastatic carcinoma of the pancreas

63 Patients and Methods Eligible patients had locally advanced or metastatic ccRCC that had progressed

64 adults (aged >/=18 years) with unresectable locally advanced or metastatic gastric or gastro-oesopha

65 thods Patients with histologically confirmed locally advanced or metastatic PRCC were enrolled and re

66 It recruits men with high-risk, locally advanced or metastatic prostate cancer who were

67 Among men with locally advanced or metastatic prostate cancer, ADT plus

68 For many years, first-line treatment for locally advanced or metastatic soft-tissue sarcoma has b

69 ents when selecting first-line treatment for locally advanced or metastatic soft-tissue sarcoma.

70 years or older with measurable, inoperable, locally advanced or metastatic triple-negative breast ca

71 recruited previously untreated patients with locally advanced or metastatic urothelial cancer who wer

72 PD-1 antibody pembrolizumab in patients with locally advanced or metastatic urothelial cancer.

73 th histologically or cytologically confirmed locally advanced or metastatic urothelial carcinoma that

74 For most sarcomas, locally advanced or unresectable disease is still treate

75 2015, 25 patients with histologically proved locally advanced pancreatic cancer 5 cm or smaller (13 w

76 neous irreversible electroporation (IRE) for locally advanced pancreatic cancer and (b) evaluate the

77 Conclusion Percutaneous IRE for locally advanced pancreatic cancer is generally well tol

78 In the PRT setting of locally advanced RC, SRCC patients had significantly wor

79 py followed by total mesorectal excision for locally advanced rectal cancer, patients who experience

80 ted with a survival benefit in patients with locally advanced rectal cancer.

81 are needed to improve chemoradiotherapy for locally advanced rectal cancer.

82 nce of metastatic or surgically unresectable locally advanced sarcoma, had received up to three previ

83 ssible impact of neoadjuvant pretreatment in locally advanced tumors should be considered with cautio

84 r with metastatic or surgically unresectable locally advanced urothelial carcinoma, measurable diseas

85 itive advanced gastric cancer (unresectable, locally advanced, or metastatic gastric cancer, includin

86 ith single-drug doxorubicin in patients with locally advanced, unresectable, or metastatic soft-tissu

87 nhancing the hormone-dependent cAMP response locally, affects mitochondria dynamics and protects from

88 low growing and do not metastasize; however, locally aggressive desmoid tumors can cause severe morbi

89 Ependymoma is a locally aggressive tumor with metastatic potential that

90 Epithelioid hemangioma is a locally aggressive vascular neoplasm, found in bones and

91 ransformations involving nematic stripes and locally aligned focal conic domains.

92 the nanoscale, but specific ions are able to locally alter molecular organization and mobility, and s

93 d enhances engagement of integrin receptors, locally amplifying ECM input to internal signaling casca

94 ter antibiotic therapy, contributes to IL-33 locally and associated with Gr + bacteria colonization i

95 for the initiation of immune responses both locally and at distant sites.

96 llations alter functional connectivity, both locally and between distant brain areas, and these long-

97 ssive cortical activity that propagates both locally and distally.

98 the encoding and integration of information, locally and globally within a neuron.

99 tically during neutrophil shape change (both locally and globally) and can be triggered by elevating

100 transformations occur in Li4/3Ti5/3O4, both locally and globally, giving rise to a multi-stage kinet

101 h symbiosis), we show that GmCLV1A functions locally and has no apparent function in nodulation or ro

102 term implications of these developments both locally and internationally.

103 however, seizures persist and propagate both locally and into homotopic distal regions, and eventuall

104 r treating melasma that is administered both locally and orally and inhibits excessive melanin via me

105 r microenvironment triggers Treg instability locally and restores anti-tumor immunity.

106 We locally and reversibly cooled brain areas in songbirds d

107 tributes to antiviral immune protection both locally and systemically via stimulation of CD8 cellular

108 set the immunological tone of tissues, both locally and systemically, requires tonic sensing of micr

109 crophages recruited into muscle proliferated locally and were skewed toward a cyto-destructive phenot

110 es, including the pituitary, suggesting that locally- and AT-produced adipokines might comprise a reg

111 ration modality and its distribution varying locally as a function of nanoscale film morphology, ion

112 ive tolerability of diclofenac HPbetaCD used locally as a submucosal injection prior to third molar s

113 ed recurrent or metastatic colorectal cancer locally assessed as dMMR/MSI-H from 31 sites (academic c

114 Locally assessed progression-free survival was 2.7 month

115 find that nonaggregated pathogenic Htt acts locally at synaptic terminals to disrupt endosomal compa

116 relationships, both of which are represented locally at the earliest stages of cortical visual proces

117 proposed that horizontal cells can also act locally at the level of individual cone photoreceptors.

118 l, and regulation of physiological functions locally, at the barrier level, and systemically.

119 and exploit their tissue-niche by utilising locally available fuels to implement specific metabolic

120 ongside a weakening monsoon circulation, the locally available moisture and the frequency of moisture

121 ermined concentrations of arsenic species in locally available seaweeds, and assessed urinary arsenic

122 Knowledge of the amount of drug that is locally available to bind intracellular targets provides

123 mechanism that approximates how fMRI voxels locally average distinct neuronal tunings.

124 model suggest that NuMA-mediated crosslinks locally bear load, providing mechanical isolation and re

125 That is, initiation sites have the locally "best" initiator (INR) sequence and/or shape.

126 t survival when substrates are available not locally but rather at a distance.

127 le of cold rolled aluminum, further deformed locally by a hardness indentation.

128 pecific recognition of the DRE is determined locally by the DNA-binding residues, which discriminates

129 parable to the weekend-weekday effect, which locally changes ozone production rates by 40%.

130 Results were similar adjusting for locally circulating ribotypes.

131 Native SLII adopts a locally compact structure wherein stacking interactions

132 snHi-C, suggesting a mechanism where cohesin locally compacts chromatin by active loop extrusion, who

133 is due to the combination of two different, locally confined effects, namely the release of thermal

134 We find that load redistribution is locally confined in all directions: along the first 3-4

135 erion, we required ten or more patients with locally confirmed FLT3 mutations (FLT3(mut+)) to be enro

136 oamine-receptor activity causes pericytes to locally constrict capillaries, which reduces blood flow

137 granule cells (GCs) and project back to GCs locally, contralaterally, and along the longitudinal axi

138 To locally control the buckling direction, masks with holes

139 LW can be utilized to create structures with locally controllable residual stresses that enable progr

140 sic photon interferometry to demonstrate the locally-correlated quantum advantage.

141 , we analyse the genomes of 155 weedy and 76 locally cultivated rice accessions from four representat

142 H-BLAST employs a locally decoupled seed-extension algorithm for better pe

143 ies within the TenoRes collaboration who had locally defined viral failure on first-line therapy with

144 pth reduction at sites treated with SRP plus locally delivered MF in patients with CP in both initial

145 s with data on comparison between adjunctive locally delivered statin use to mechanical scaling and r

146 However, effect of locally delivered statins on periodontal treatment has n

147 to enrich the body's own endogenous Tregs by locally delivering a specific combination of Treg induci

148 els for food-borne exposure typically assume locally derived diets or use concentrations directly mea

149 ntion, Abangane ("friends" in isiZulu), is a locally derived, curriculum-based support group focused

150 IR works by using the tip of an AFM probe to locally detect thermal expansion in a sample resulting f

151 each fjord contains a unique population with locally determined dynamics.

152 UEa , estimated from satellite imagery, with locally determined soil CUEh for 100 globally distribute

153 orming defined GMP clusters, which, in turn, locally differentiate into granulocytes.

154 inputs of two different transmitter classes locally direct dendrite growth in a competitive manner.

155 hymal cell condensation at hair follicles is locally directed by an epidermal prepattern.

156 Therefore, synaptic input locally directs dendrite growth, but intra-neuronal dend

157 ), and 'sink' regions (areas where isotherms locally disappear).

158 so-scale turbulence through the evolution of locally disordered patches (active puffs) from an ordere

159 n model; we find that the primordial clay is locally disrupted by impacts and buried by impact-ejecte

160 We used virally mediated RNA interference to locally downregulate SERT expression and compared the re

161 Locally, each velocity jump corresponds to a fracture ap

162 34% of the released drug was locally effective and the rest permeated through the ski

163 in the cone-degeneration retinas, suggesting locally elevated TR signaling.

164 nsidering the nascent technology as a way to locally eliminate the mammalian pests that threaten its

165 Random eruption of locally endemic populations was tested using artificiall

166 be strengthened through the establishment of locally endorsed guidelines and ensured availability of

167 rock3 alleles revealed how plants respond to locally enhanced cytokinin signaling.

168 half-cells as well as in situ collection of locally evolved O2 by photosystem 2 using a positioned s

169 Committee review, download each data set and locally examine them for potentially relevant informatio

170 try that is intermediate between that of the locally excited and CT states, approximately reflecting

171 y half of the configurations sampled, on the locally excited state.

172 free BODIPY-anthracene dyads (BADs) generate locally excited triplet states by way of photoinduced el

173 ept that when the single-focus progenitor is locally excursive, the daughter foci undergo directed se

174 heoretical advantages for undergoing surgery locally exist.

175 that horizontal cells can process cone input locally, extending the classical view of horizontal cell

176 ments could prevent species losses and allow locally extinct species to recolonize former habitats.

177 tivated formation of nitrenes from azides to locally fix a fluorescent probe in tissue by the formati

178 Systematic errors were observed locally for key functional groups and carbon types, and

179 Locally, for the blocking-residue Tyr31 and the water mo

180 nucleus and competes LGN from E-cadherin to locally form the LGN/NuMA complex.

181 In-situ weathered bedrock, saprolite, is locally found in Scandinavia, where it is commonly thoug

182 within the complex coacervate phase, tau is locally freely tumbling and capable of diffusing through

183 kably, dynactin can bias motility initiation locally from microtubule plus ends by autonomous plus-en

184 chromaffin cells and norepinephrine released locally from sympathetic nerve terminals are significant

185 First, locally generated DA release signals are organized over

186 hat autocrine and/or paracrine signaling via locally generated SPMs in the vasculature may represent

187 d for polyamine determination in some of the locally grown fruit and vegetables and the results were

188 fast collapse of nanocells, which produces a locally hardened region and significantly increases the

189 er juxtaposition ensures KCNQ2/3 exposure to locally high myo-inositol-derived PIP2 concentrations.

190 s hypothesized that isohydry is related to a locally higher sensitivity of stomata to the drought-hor

191 hout the range of a species and yet still be locally highly variable, and why some events seem readil

192 scopy (CARS) microspectroscopy allowed us to locally identify acylglycerols as the main constituents

193 and for the first time ever, we are able to locally identify the oxidation state of iron compounds e

194 an advancing upper plate-motion setting can locally impede rollback and maintain flat slabs until sl

195 ion were achieved in mid-aged mice that were locally implanted with healthy hypothalamic stem/progeni

196 ides strong evidence that the brain operates locally in a CAS regime, allowing it to have an unlimite

197 Inhibition of miR-142-3p, locally in EAE brain and in a MS chimeric ex vivo model,

198 nd activated C1 were significantly increased locally in NP tissue.

199 otide phosphate (NADPH) oxidases produce ROS locally in response to various stimuli, and thereby regu

200 e2 ectodomain can suppress Angpt1 signalling locally in the cells in which the receptor is lost, our

201 hese turbulent-turbulent spots are generated locally in the fully turbulent environment, and they are

202 L10 might influence the cellular composition locally in the islet graft, thereby playing a role in th

203 dings support the view that inhibition of TR locally in the retina is a therapeutic strategy for reti

204 from cholinergic interneurons (ChIs) acting locally in the striatum.

205 Locally, in the United States, the proportions of influe

206 trategies to reduce pathogen virulence or to locally increase iron levels to activate a toxic oxidati

207 r cerebrospinal fluid efflux and can lead to locally increased pressures in the subarachnoid space wi

208 Modulation of the complement system by locally increasing CRP expression using targeted gene th

209 eate silencing in a small region within FLC, locally increasing H3K27me3 levels.

210 owards the subdomain of cortical ER, whereas locally increasing microtubule depolymerization causes e

211 in different saline solutions, that ions can locally induce ordering of the lipid molecules within th

212 activates an integrated stress response that locally induces muscle atrophy, but via secretion of FGF

213 une response in systemic, healthy tissues of locally infected plants.

214 aspects to these tumors are that they can be locally infiltrative and/or impinge on critical organs,

215 et out to assess whether their functions are locally influenced by the signals present at the onset o

216 rage DSB landscape but also demonstrate that locally inhibitory effects of an artificial hotspot inse

217 all the required software and databases are locally installed on the system, significantly reducing

218 ts of voxels with opposite selectivities are locally intermingled and each set can support orientatio

219 Its shape deforms the membrane locally into a dome.

220 P 36216, intracerebroventricularly (ICV), or locally into the dorsal hippocampus, ventral hippocampus

221 reproducing diploid organisms to study how a locally introduced gene drive allele spreads to replace

222 paminergic and GABAergic AOB interneurons or locally introducing DA or GABA receptor antagonists alte

223 invasive glioblastomas, 14 of 61 (23%) were locally invasive, and five of 61 (8%) were minimally inv

224 Mice were locally irradiated with a synchrotron X-ray broad beam a

225 Locally, it alters the nucleosomal response, and acts as

226 pagation front elevates Ca(2+) inside the SR locally, leading to luminal RyR sensitization and loweri

227 gion of the conventional outflow pathway and locally liberates a controlled dose of NO is reported.

228 tigate roles for homeostatic plasticity both locally (local inhibition adjusting to balance excitator

229 subjectively not noticed and was related to locally lower values of slow-wave energy during precedin

230 MDSCs may therefore play a role in locally maintaining immune balance during vaccine-induce

231 motaxis, the infotaxis algorithm showed that locally maximizing the expected information gain leads t

232 rturbations in mono- and bi-layer WSe2 which locally modify the band-gap, leading to efficient funnel

233 s to protect and deliver active mediators to locally modulate cellular function during inflammation.

234 e attachment from 5,403 respondents residing locally, nationally, and internationally, we identified

235 (or molecules) in which the image can be non-locally observed by coincidence recording of entangled p

236 uclear molecular system occurs predominantly locally on a heavy atom (provided that the absorption cr

237 cessing, spatially separated parties operate locally on their respective subsystems, but coordinate t

238 ve to elevate surface temperatures, at least locally, on Hesperian Mars.

239 ophage interactions with other cells, either locally or at distances, are imperative in both normal a

240 plex disease cycle and its ability to spread locally or over long distances without a vector.

241 ate bioavailability of BMPs, either produced locally or reaching the pituitary via blood circulation.

242 ified that are released from tissues and act locally or systemically to promote insulin sensitivity a

243 ativistically stable, the plasma wave can be locally overloaded without compromising the witness bunc

244 can transport RNAs to sites near synapses to locally produce proteins.

245 activation provides an alternative source of locally produced catecholamines during the thermogenic p

246 ILC2s lack a TCR and respond instead to locally produced cytokines such as IL-33.

247 carbon fiber/polymer hybrid materials having locally programmable complex electrical, thermal and mec

248 Here, we isolate a unique population of locally projecting neurons in the central nucleus of the

249 Interestingly, locally proliferating macrophages were not classically a

250 ncy-dependence: survival was highest for the locally rare ecotype, rather than natives.

251 ossible rectal wall invasion consistent with locally recurrent and metastatic urothelial cancer.

252 t episcleral plaque brachytherapy (EPBT) for locally recurrent posterior uveal melanoma (PUM).

253 trastuzumab and docetaxel for patients with locally recurrent, unresectable, or metastatic HER2-posi

254 atterning and evidence that a temporally and locally regulated interaction between Fgf and Wnt signal

255 genes on 299 samples from 170 patients with locally relapsed or metastatic breast cancer.

256 quires responsive OXT neurons of the PVN and locally released OXT.

257 The ease with which water may be locally removed from around the target protein crucially

258 These scaffolds locally retained growth factors, displayed degradation r

259 arily shaped structures of released film and locally specified thickness for each region.

260 ing dependent species, and second, we sample locally stable parameter sets to reflect realistic biolo

261 are confined within the dextran droplets and locally stain the tissue below with a contrast similar t

262 ncreased OSM levels in patients with CRS was locally stimulated and produced.

263 meta-analysis of existing data sets, whether locally stored or available from public repositories.

264 A method to locally strain-engineer antimonide-based membranes is th

265 o release TGF-beta1, Rapamycin, and IL-2, to locally sustain a microenvironment that promotes Treg di

266 the discovery of multiple proteins that are locally synthesized for functional roles such as axon gu

267 the present study shows that neuroestradiol, locally synthesized in the hypothalamus, is a part of es

268 a unique optogenetic approach to induce and locally target a rotor in atrial monolayers.

269 9) per patient, the panel was less expensive locally than performing more than two or three single ge

270 ignorant of the genetic networks controlling locally the most important decision during branch develo

271 ase (MELD) scores >/=35 before being offered locally to candidates with MELD scores <35.

272 and LXB4 are small lipid mediators that act locally to dampen inflammation, but they have not been l

273 istinct phenotypes, indicating that Htt acts locally to disrupt synaptic growth.

274 zed in the spinal cord and brainstem and act locally to influence pain processing.

275 Our findings suggest that UBE3A may act locally to regulate individual synapses while also media

276 is (AR) that delivers standardized allergens locally to the nasal mucosa allowing clinical symptoms a

277 Thus, small molecules applied locally to the skin can be used to modulate touch and ma

278 Data were collected by locally trained health-care workers according to patient

279 rates as a type I excitable medium but it is locally transformed into a type II medium by optogenetic

280 Locally translated CaMKII has a privileged role in regul

281 ach to define candidate transcripts that are locally translated in astrocyte processes.

282 y hundreds of neurite-localized proteins and locally translated mRNAs.

283 ple regions for many months before the first locally transmitted cases were confirmed, highlighting t

284 rapeutic effects of human CD34(+) stem cells locally transplanted in patients with myocardial and cri

285 w vesicle immobilization and fusion are then locally triggered is unclear.

286 generate CAR T-cells that are only effective locally (tumor tissue), potentially also increasing the

287 Away from the dislocation, the magnets are locally unfrustrated, but frustration of the lattice per

288 If these emissions deposit locally, UNG extraction activity could contribute to cri

289 We reveal locally unidirectional striped domains as small as 5 nm

290 We further showed that blunt dsRNA is locally unwound and threaded through the helicase domain

291 is and meiosis, microtubule (MT) assembly is locally upregulated by the chromatin-dependent Ran-GTP p

292 Such locally varied thalamocortical projections may be useful

293 ted molecules called photoantimicrobials act locally via the in-situ production of highly reactive ox

294 On Mars, locally warm surface temperatures ( 293 K) occur, leadin

295 Locally weighted scatterplot smoothing curves were used

296 W systems (SUFEWS), which can meet FEW needs locally while reducing the overall environmental impact

297 ully classifies networks even when estimated locally with a few neurons at a time.

298 sforming growth factor beta-high environment locally within target tissue that results in scleroderma

299 not of central memory CD8(+) T cells (TCM), locally within TG, and improved protection against recur

300 or very low-energy ions, it has been defined locally within thin slabs.