ライフサイエンスコーパス: locus

1 d shorter than the DNA contour length in the locus.

2 without affecting SMAD4 binding to the Rorc locus.

3 reciprocal genomic variation at the 22q11.2 locus.

4 P]) or an NSs-eGFP fusion protein in the NSs locus.

5 iation was knocked into its respective mouse locus.

6 egion with a high degree of LD near the AHSG locus.

7 enetic risk factors can converge on the same locus.

8 from the loss of heterozygosity at the TP53 locus.

9 with humanized exons 10-12 of the mouse Dpp4 locus.

10 t the developmentally controlled beta-globin locus.

11 NAs from the ribosomal protein L13a (Rpl13a) locus.

12 ms of synaptic plasticity with a presynaptic locus.

13 es, with an average value of 6.8 alleles per locus.

14 the North Carolina macular dystrophy (MCDR1) locus.

15 ) to discrete regulatory elements in the Wt1 locus.

16 agnitude of allelic heterogeneity within the locus.

17 overwhelming effect of the established TCF4 locus.

18 igated the transcriptional regulation of the locus.

19 uses SC that is physically unlinked to the S-locus.

20 leles associated with complex traits in each locus.

21 holesterol-related differentially methylated locus.

22 lications have been described at the 22q11.2 locus.

23 lved association of SMCR8 with the ULK1 gene locus.

24 tations and epitope tagging at an endogenous locus.

25 e transgene inserted at the targeted genomic locus.

26 rotein gene, W1-COE, within the W1 multigene locus.

27 mice expressing these proteins from the Pax5 locus.

28 rted type 1 diabetes and autoimmune disorder locus.

29 d 1 independent variant at an established BP locus.

30 nts who were homozygous for at least one HLA locus.

31 mitotic recombination were restricted to one locus.

32 c expression and disease association at this locus.

33 fied the most likely functional SNPs at each locus.

34 opsis is the causal gene underlying the l-D1 locus.

35 istance was associated with CN-LOH at the TK locus.

36 Locus 1p36.12 is significantly associated (P=2.2 x 10(-8

37 st association with serum MMP-8 was found in locus 1q31.3, containing the gene for complement factor

38 iation studies (GWASs) implicate the PHACTR1 locus (6p24) in risk for five vascular diseases, includi

39 n of ZCCHC14 and DNA methylation suggest the locus acts through changes to regulatory elements.

40 Three variants in locus ADAM12 achieved genome-wide significance, although

41 te Polycomb factors, which spread across the locus after cold to enlarge the domain that contains H3K

42 in gene (fHbp), and the capsule biosynthetic locus, all of which are loci previously suggested to be

43 r locus that modulates the effects of target-locus alleles.

44 ts that recruit PcG complexes to a repressed locus also encode transcriptional enhancers that functio

45 The locus also has a pleiotropic effect on grain width (1.5%

46 We have used targeted locus amplification (TLA) to efficiently map the transge

47 ation tests can be more powerful than single-locus analyses because they aggregate the variant inform

48 ing model, and expression quantitative trait locus analyses.

49 Here we performed quantitative trait locus analysis, utilizing RNA-seq data from human skin a

50 association between variation at the SLC4A7 locus and blood pressure.

51 porting the statistical fine-mapping at this locus and demonstrating that RBPMS is a regulator of ery

52 of deletions or duplications at the 22q11.2 locus and estimate the incidence rate ratios (IRRs) and

53 th hTau inserted into the endogenous fly tau locus and expressed under the control of the endogenous

54 causing phospho-SMAD3 to bind to the miR-140 locus and inhibit miR-140 transcription.

55 sulted in hypermethylation of the Foxp3 gene locus and inhibited Foxp3 transcription, which is essent

56 tes the recombination propensity at the Tcrb locus and provide new mechanistic insight into the histo

57 nd comparing large sets of SNPs in a genomic locus and rapidly identifying consensus SNPs with the hi

58 romosomal translocation frequency to the Igh locus and to several AID off-target sites.

59 odality by activating a pre-existing genomic locus, and extend piRNA defense roles to include the per

60 ived genomic position of the Leavenworthia S locus, and in place of the more typical Lal2 and SCRL se

61 arate, reduced methylation of the Foxp3 gene locus, and increased Foxp3 expression.

62 basis that is specific for each chromosomal locus, and it can be inferred from detailed functional a

63 mere establishment at an ectopic chromosomal locus, and maintain centromere function indefinitely.

64 Common genetic variants at the ARL15 locus are associated with plasma adiponectin, insulin an

65 The CRISPR and the cas locus are often located next to each other in the genome

66 By linking to medical records, we discover a locus associated with both elevated genetic relatedness

67 ear PATJ (INADL) and HCRTR2) and replicate a locus associated with sleep duration (at PAX8).

68 A differentially methylated locus associated with triglycerides and high-density lip

69 structs were active and disrupted the target locus at high frequencies.

70 alysis detected a previously unreported risk locus at TNFSF15 (rs6478108; P = 1.50 x 10-8, OR = 1.10)

71 ng the chromatin architecture at the histone locus body.

72 Recently the polysaccharide locus bpsABCD has been demonstrated to serve a critical

73 nding and EZH2-mediated repression at the GR locus, but is restored in advanced prostate cancers upon

74 Moreover, the Rroid locus, but not the lncRNA itself, controlled the identit

75 ess of cell-cell transfer required the UL128 locus, but not the RL13 gene, and was significantly less

76 osmid containing the entire wild-type CaMKII locus, but only viability and CaMKII localization are re

77 genes predicted to interact with the 7p14.3 locus by Hi-C chromosome conformation capture data.

78 Here, we characterized the "D" locus by quantitative trait loci (QTL) mapping and ident

79 ed the effects on transcription of FLOWERING LOCUS C (FLC) and PERPETUAL FLOWERING 1 (PEP1), two orth

80 TANS (CO) and positively modulates FLOWERING LOCUS C (FLC).

81 gnal in the immunoglobulin heavy chain (IGH) locus centring on a haplotype of nonsynonymous variants

82 inactive form of the 5-HT2C receptor in the locus ceruleus is associated with decreased 5-HT2A-depen

83 y the anterior SNpc (-49%; P < .001) and the locus coeruleus (-37%; P < .05).

84 The locus coeruleus (LC) projects throughout the brain and s

85 The brainstem locus coeruleus (LC) supplies norepinephrine to the fore

86 of the stress response is activation of the locus coeruleus (LC)-norepinephrine system.

87 dium-sized Bar neurons located medial to the locus coeruleus (LC).

88 omic components of the limbic forebrain, the locus coeruleus and cerebellar Purkinje cells, or for CR

89 ggests that aberrant tau accumulation in the locus coeruleus and noradrenergic dysfunction may be a c

90 oss of hippocampal norepinephrine levels and locus coeruleus fibres in the medial entorhinal cortex a

91 tively regulate noradrenergic neurons in the locus coeruleus, a brain center implicated in attention,

92 luded: cuneiform/subcuneiform, dorsal raphe, locus coeruleus, median raphe, parabrachial complex, pon

93 aracterize CO2/H+-sensitive neurons from the locus coeruleus.

94 ry processing through its connections to the locus coeruleus.

95 l arousal state, including the noradrenergic locus coeruleus.

96 in which the human low-affinity IgG receptor locus, comprising both activating (hFcgammaRIIA, hFcgamm

97 We report that the FGF13 locus, comprising FGF13 and miR-504, is transcriptionall

98 acking an extracellular polysaccharide (EPS) locus consistently failed to transmit.

99 the risk for schizophrenia, with the 22q11.2 locus consistently implicated.

100 -specific single-copy endogenous chromosomal locus containing a DNA double-strand break (DSB).

101 e have addressed this question in the casein locus containing five mammary and two non-mammary genes

102 Altered functions for the IBD risk locus containing rs7554511, which encompasses the C1orf1

103 analysis in MF5L6 identified a chromosome 3 locus containing the tissue factor gene (F3).

104 The nict-1 locus contains a Piwi-interacting small RNA (piRNA) clus

105 ng the fetal globin genes from the enhancer (locus control region [LCR]).

106 TAOK2 is one of the genes in the 16p11.2 locus, copy number variations of which are associated wi

107 has been inserted into the equivalent murine locus, corresponding to a locus swap.

108 The stic1 locus corresponds to the gene ALBINO4 (ALB4), which enco

109 In summary, the piRNA-rich nict-1 locus could define a novel mechanism underlying phoretic

110 ers and alternative splicing at the foraging locus creates diversity and flexibility in the regulatio

111 hybrid voltage sensor (hVOS) probe within a locus designed for efficient Cre recombinase-dependent e

112 al. demonstrate that the hepcidin-chromatin locus displays HDAC3-mediated reversible epigenetic modi

113 a particular variant encoded at another NLR locus, DM1.

114 , with increased transcription of the entire locus driving Flt1 upregulation in both EO-PE and LO-PE.

115 We assessed expression quantitative trait locus effects in human lung specimens and blood, as well

116 short foreign DNA fragments into the CRISPR locus, enabling adaptation to new viruses.

117 The Cngb1 locus-encoded beta-subunit of rod cGMP-gated cation chan

118 The human APOBEC3 locus encodes seven proteins, of which A3D, A3F, A3G, an

119 The cov-3 locus encodes the O. tipulae ortholog of C. elegans mig-

120 The knirps (kni) locus encodes transcription factors required for inducti

121 An SGG-specific locus encoding a bacteriocin ("gallocin") is shown to ki

122 We performed expression quantitative trait locus (eQTL) analyses by using abdominal subcutaneous ad

123 Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue sample

124 OCRs, including rs1198588, at a leading risk locus flanking MIR137.

125 77R mutation, establishing RT as the genetic locus for aptamer-mediated HIV-1 inhibition.

126 eep-layer projection neurons, as a potential locus for autism pathology.

127 rection for multiple testing, with one novel locus for BUA at FAM167A (8p23.1) (P = 1.4 x 10-6).

128 er mouse with Salsa6f targeted to the Rosa26 locus for Cre-dependent expression in specific cell type

129 n-A, has been identified as a susceptibility locus for diabetes and metabolic syndrome.

130 lyze the genomic region surrounding the Eya1 locus for enhancer activity.

131 We surveyed the Gdf5 locus for regulatory regions in transgenic mice and fine

132 The lysosomal membrane is the locus for sensing cellular nutrient levels, which are tr

133 dies have identified a signal at the SLC22A1 locus for serum acylcarnitines, intermediate metabolites

134 APOC3/APOA5 constitutes a major locus for serum triglycerides in Amerindians, especially

135 nly' cells, be utilized to protect a genomic locus from transposon integration, and enrich for Cas9-m

136 An miR482/2118 targeted locus gave rise to four main transcript isoforms through

137 Ox40 ligand (Ox40L) locus genetic variants are associated with the risk for

138 protein content (PC) using single- and multi-locus genome-wide association studies.

139 train, with multiple mutations at the mating locus, had defects in sexual mating ability but appeared

140 e-wide associations for asthma, although one locus has been implicated in joint susceptibility to ast

141 how the Drosophila erecta even-skipped (eve) locus has evolved by testing its activity in the diverge

142 ses >70 genes at the clustered protocadherin locus (hereafter referred to as cPcdh).

143 Locus heterogeneity characterizes a variety of skeletal

144 ng other congenital disorders featuring high locus heterogeneity.

145 nal pipeline and apply it to SNPs at 1p22, a locus identified in several GWAS for non-syndromic cleft

146 en mutation rate and population density at 1 locus in 1 species of bacterium.

147 ents across the three replicates (except one locus in a wolf sample).

148 e characterized the proteins encoded by this locus in Bacteroides thetaiotaomicron, a member of the h

149 association studies have implicated the ANK3 locus in bipolar disorder, a major human psychotic illne

150 A known significant locus in chromosome 8p was excluded before estimating FD

151 to the role of germline variation in the IGH locus in disease susceptibility.

152 CSR creates a virtually unique IgH locus in every B cell clone by intrachromosomal recombin

153 cally increases CpG methylation at the HOXA5 locus in human embryonic kidney (HEK293T) cells.

154 We used it to interrogate the 2-Mb POU5F1 locus in human embryonic stem cells, and identified 45 c

155 irect homologs exist at the syntenic genomic locus in metatherian (marsupial) or prototherian (monotr

156 romatin accessible regions within the Zbtb16 locus in mouse, we identify a critical enhancer controll

157 ucted a functional study of variants at this locus in primary cultures of vascular smooth muscle and

158 nges in chromatin modifications at the OsBZ8 locus in salt-tolerant Nonabokra and salt-sensitive IR64

159 hannel subfamily M member 8 (TRPM8(EGFPf/+)) locus in the 3 branches.

160 pothalamus (LH) is also a key reward-control locus in the brain.

161 Here, Lee et al. identify a genetic locus in the nematode Caenorhabditis elegans that underl

162 us, despite the absence of the human Vlambda locus in these humanized mice, the dominance of Vlambda

163 ary reporter molecules from the murine Hmox1 locus, including firefly luciferase, to allow long-term,

164 ed by natural variation at the drl2 enhancer locus, including reduced expression of the drl2-Mo17 all

165 The interferon (IFN) lambda 3/4 (IFNL3/4) locus, influencing innate immunity regulation, has been

166 ing confidence in the causality of a disease locus is a complex task that often requires supporting d

167 ed in most AML patient samples, and the GLI3 locus is abnormally methylated.

168 segments leads us to propose that the ERBB2 locus is amplified through the mechanism that repeatedly

169 In conclusion, LHPP locus is associated to AD-RSB interaction; and with brai

170 Here we show that the Xist locus is coated with a broad H3K27me3 domain that is est

171 The miR-302 locus is found broadly among vertebrates, whereas the mi

172 The 5q14.3 locus is known to associate with variation in retinal va

173 e T2D risk associated with variation at this locus is mediated through reduction in STARD10 expressio

174 The locus is recognised for its ability to modulate efflux p

175 The Ms2 locus is remarkable in several ways that have implicatio

176 state of haploinsufficiency for the Il4 gene locus is specifically relevant for IL-4-dependent IgE re

177 The MCDR3 locus is thus refined to a shared region of 39 kb that c

178 ong vertebrates, whereas the miR-290/miR-371 locus is unique to eutheria, suggesting a role in placen

179 For one locus (KCNQ1), we were able to provide further evidence

180 onymous variant in an established heart rate locus (KIAA1755).

181 ctive, H3K9me3 accumulates at the HIF-1alpha locus, leading to a decrease in HIF-1alpha mRNA and a re

182 der the transcriptional control of the Cspg4 locus led to ventricular arrhythmias, atrial fibrillatio

183 hus provide an in-depth analysis of the 7p21 locus linked by GWASs to frontotemporal lobar degenerati

184 tr each contain a polymorphic microsatellite locus located in their 5' regulatory region (the regulat

185 Quantitative trait locus mapping of a Pla-1 X Col-0 F2 population was used

186 determined by genes at the MAT (mating-type) locus; mating occurs between MATa and MATalpha cells.

187 The newly discovered locus may enhance understanding of the pathophysiology o

188 ophila shows that mutation of a single miRNA locus (miR-iab4/iab8) affects the capacity of the larva

189 ed mutations in a previously uncharacterized locus, mmpT5 Preliminary analysis suggested similarities

190 the selected markers were placed into multi-locus model, these effects were estimated by empirical B

191 morphism is an expression quantitative trait locus modulating CHRNA4 expression levels.

192 at function in different lineages where that locus must be expressed.

193 ously undiscovered basophil count-associated locus near the master hematopoietic transcription factor

194 ys and linkage mapping to identify a genetic locus (nict-1) that mediates the phoretic interaction wi

195 to the T-cell receptor alpha constant (TRAC) locus not only results in uniform CAR expression in huma

196 This results in a decrease in locus number per monoploid genome, forming part of the d

197 xploited to study relationships between rDNA locus number, distribution, the occurrence of linked (L-

198 Samples of molecular sequence data of a locus obtained from random individuals in a population a

199 l pyramidal neurons and their targets, a key locus of action of many drugs, and highly vulnerable to

200 Therefore, we named this PAI as Locus of Adhesion and Autoaggregation (LAA).

201 The hippocampus is the main locus of episodic memory formation and the neurons there

202 Moreover, the major capsid protein locus of pacmanvirus appears to be different from those

203 ception and have implications for the neural locus of the cone-specific circuitry supporting color vi

204 7, which is an expression quantitative trait locus of the human serine racemase (SRR) gene, was assoc

205 To examine the neural locus of this effect, we then combined the adaptation pa

206 s mapped to the site of a quantitative trait locus on Ca5 that explained 59% of flowering time variat

207 thors identified one genome-wide significant locus on chromosome 12 (rs4622308) in a region harboring

208 these DMCs, 52% were located in one 15.5-Mb locus on chromosome 13, which encompassed the Bhmt gene

209 els; this BALB/cJ trait had been mapped to a locus on chromosome 15.

210 imaging demonstrating its enrichment at this locus on chromosome 16.

211 Focal deletions of the RanBP6 locus on chromosome 9p were found in a subset of gliobla

212 BCG (Bacillus Calmette-Guerin), and a second locus on chromosome region 3q affecting IFN-gamma produc

213 ious linkage analyses, we identified a major locus on chromosome region 8q controlling IFN-gamma prod

214 Loss of imprinting (LOI) at the IGF2/H19 locus on the maternal chromosome is associated with the

215 IFN-kappa (chIFN-kappa) near the type I IFN locus on the sex-determining Z chromosome.

216 h could not be detected by a traditional one-locus/one-transcript analysis approach.

217 of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, includin

218 it is still not clear how mutations at this locus produce this array of phenotypes.

219 We identified 120 locus-protein associations in genome-wide analyses and 4

220 ilitated the mapping of a dominant monogenic locus, Prs, conferring Papaya ring-spot virus (PRSV) res

221 sistance Phytophthora sojae-susceptible gene locus, PSS1 In this study, we identified six candidate P

222 date and fine-map a major quantitative trait locus (QTL) on wheat chromosome 5A associated with grain

223 o-localised with a single quantitative trait locus (QTL) that harbours the FGR gene responsible for t

224 ated as a cis-methylation quantitative trait locus (QTL) variant associated with higher DNMT3B methyl

225 even loci for erythrocyte traits including a locus (RBPMS/GTF2E2) associated with mean corpuscular he

226 sing populations on average harbour 5 to 9 S-locus receptor kinase (SRK) alleles, but only two, S1 an

227 Unsupervised clustering and single-cell TCR locus reconstruction identified three cell populations,

228 We found one genome-wide significant locus related to the broad depression phenotype (rs98258

229 s to and suppresses expression from the HRAS locus; repression of HRAS is sufficient to promote the t

230 complex trait of interest in each discovered locus, researchers must assess the magnitude of allelic

231 We also narrowed the genetic locus responsible for citrus polyembryony, a form of apo

232 IRF4 is a key locus responsible for skin color, with a vitamin D recep

233 ositioned the her2 mutation to the At5g63620 locus, resulting in a phenylalanine instead of serine on

234 Two SNPs at the CFH locus, rs10922109 and rs570618, were associated with the

235 ied a single mutation in SLC30A9 within this locus, segregating as expected within the kindred and no

236 Patterns of natural Tgr locus sequence polymorphisms predict partner-specific pa

237 Multi locus sequence typing (MLST) suggests presence of geneti

238 Only marker rs6874700 at the ISL1 locus showed association (p = 2.22 x 10(-08)).

239 within the previously reported CELF1 AD risk locus, showed association with delayed AD onset and lowe

240 Application to alpha-globin locus shows that these constraints ( approximately 20%)

241 Of the nine genes at this locus, SNAP29, AIFM3, and CRKL appear to be critical to

242 om amplification mechanisms, or if a genomic locus-specific amplification mechanism plays a role.

243 ts (CAPTURE) approach to unbiasedly identify locus-specific chromatin-regulating protein complexes an

244 espite the extensive utility of these tools, locus-specific delivery of synthetic molecules remains l

245 We report locus-specific disintegration of megabase-scale chromoso

246 omplex is a potent accelerator of global and locus-specific DNA demethylation in somatic and pluripot

247 Taken together, our data suggest that locus-specific epigenetic divergence between the parenta

248 Efforts to manipulate locus-specific histone acetylation to assess their causa

249 Locus-specific markers indicated that c.254-649T > G CLR

250 While both technologies can assay locus-specific organization, how to integrate views from

251 tforms make them impractical for quantifying locus-specific RE methylation.

252 that is replication-independent, rapid, and locus-specific.

253 tyltransferase genes in the serotype 35C cps locus suggested that it could be incomplete, as the repo

254 related to the bi-functional galE of the cnl locus suggesting common ancestry.

255 ng to the nuclear periphery of a transcribed locus suppressed R loops in mlp1 cells.

256 equivalent murine locus, corresponding to a locus swap.

257 tion of gamete frequencies in dominant three-locus system in an F2 population and BAT is a computatio

258 ns by decreasing the expression of FLOWERING LOCUS T This phenotype is genetically dependent on CO.

259 clude by showing that CONSTANS and FLOWERING LOCUS T, components of the photoperiod pathway that regu

260 istant (35S::TOE1(R) ) and mutant (flowering locus T-10 (ft-10)) lines were used for functional analy

261 aecalis, which only possess an orphan CRISPR locus, termed CRISPR2, lacking cas genes.

262 e first study to report association with the locus TGIF1.

263 sm and recombination evolve between a target locus that codes for a seasonally selected trait and a p

264 Rhg4 is a major genetic locus that contributes to soybean cyst nematode (SCN) re

265 CHRNA7 is the only gene in this locus that has been deleted entirely in cases involving

266 lly selected trait and a plasticity modifier locus that modulates the effects of target-locus alleles

267 HC-linked Ir gene in a T cell receptor (TCR) locus that was required for CD8(+) T cell responses to t

268 almost exclusively recombined only one Tcrb locus (that predicted a functional receptor sequence), w

269 ting to disrupt the endogenous human MRP RNA locus, thereby attaining what has eluded RNAi and RNase

270 s, we localize the causal variant(s) at this locus to a 5 kb region that overlaps a stretch-enhancer

271 significant association signal in the 1q42.2 locus ( TSNAX-DISC1 noncoding RNA, lead single-nucleotid

272 ear genome, connects Auts2 to the Caln1 gene locus under baseline conditions.

273 Additionally, this locus underlies a trade-off between offspring production

274 aining UQCR, TCF3 and MBD3 genes was a novel locus underlying lean mass variation.

275 unctional binding site in the murine Dnajc22 locus using ChIP-qPCR and luciferase assays and verified

276 vessels, and that editing of genomic VEGFR2 locus using rAAV1-mediated CRISPR/Cas9 abrogates angioge

277 chain reaction (PCR) ribotyping and multiple-locus variable-number tandem-repeat analysis (MLVA) of s

278 = 4.2 x 10(-8), beta = 1.03 s.d.), four IGH locus variants influencing class switching, and ten new

279 enome, but the presence of each feature at a locus varies between cells.

280 Deletion of this locus via CRISPR-Cas9 leads to deregulation of the genes

281 a 1.75-Mb genomic region spanning the Gli-2 locus was analyzed in the diploid grass, Aegilops tausch

282 Methylation at the PON1 locus was associated with PON1 expression in an independ

283 55-kb transgene encompassing the human renin locus was crossed onto the mouse Ren1d-null background,

284 ts, only the variant rs12785878 in the DHCR7 locus was significantly associated with an SVR.

285 n the heterozygous state from its endogenous locus, we here report that mutant Pik3ca induces centros

286 At the 1q24 locus, we hypothesized that the transcription factor PRR

287 ed pfhrp2-deleted samples with intact pfhrp3 locus were positive by HRP2-based RDT.

288 ith glycerol, strains carrying the pocR gene locus were potent reuterin producers, with L. reuteri 17

289 locate to the centromeric region of the KIR locus, whereas their human counterparts also populate th

290 ce of copy number variation (CNV) at the K3L locus, which in multiple copies strongly reduced PKR act

291 ted similarities between mmpT5 and the mmpR5 locus, which is associated with low-level BDQ resistance

292 e aryl hydrocarbon-receptor repressor (AHRR) locus, which is observed in blood and squamous epithelia

293 oduced by the i(i) and i(k) alleles of the I locus, which restrict pigment to the hilum or saddle reg

294 l region 2 (DGCR2) is located in the 22q11.2 locus, whose deletion is a major risk factor for SZ.

295 evealed that clone SA possesses a unique CPS locus with a mosaic structure, which has been stably mai

296 Associations of the locus with expression of ZCCHC14 and DNA methylation sug

297 tion of the rs3750846 SNP at the ARMS2/HTRA1 locus with subretinal/sub-retinal pigment epithelial (RP

298 ions of common genetic variants at the CXCR4 locus with the risk for coronary heart disease, along wi

299 bolic gene malic enzyme 2 (ME2) in the SMAD4 locus would create cancer-specific metabolic vulnerabili

300 lity to form mature biofilms and the bpsABCD locus would serve a key role in this process.