ライフサイエンスコーパス: locus ceruleus

1 ear group of the thalamus, raphe nuclei, and locus ceruleus.

2 h wake-active neuronal nuclei, including the locus ceruleus.

3 study tagged MOR receptors in neurons of the locus ceruleus.

4 Lewy bodies in the brainstem, mainly in the locus ceruleus.

5 mygdala but decreased dopamine in septum and locus ceruleus.

6 ral NE levels were depleted by lesion of the locus ceruleus.

7 dorsal pontine tegmentum just ventral to the locus ceruleus.

8 t not the major noradrenergic areas [A5, A6 (locus ceruleus), A7], as a significant source of TH-posi

9 o enforced wakefulness in both noradrenergic locus ceruleus and dopaminergic ventral periaqueductal g

10 BOLD signal increases were also observed at locus ceruleus and in anteromedial pons.

11 rodorsal tegmental nuclei, dorsal raphe, and locus ceruleus and subceruleus.

12 Rat brain locus ceruleus and thalamus NET mRNA levels were also on

13 pression in the downstream arousal-promoting locus ceruleus and tuberomammilary nucleus but not after

14 ed neuronal loss in the substantia nigra and locus ceruleus and widespread Lewy bodies, many of them

15 iaqueductal gray, lateral pontine tegmentum, locus ceruleus, and dorsal raphe.

16 were made into the VTA or a nonreward area, locus ceruleus, and morphine or placebo pellets were imp

17 motoneurons, cerebellar granule neurons, the locus ceruleus, and raphe nuclei and in various nuclei o

18 led c-fos mRNA expression in the cerebellum, locus ceruleus, and red nucleus.

19 e (DA) neurons, noradrenergic neurons of the locus ceruleus, and retinal ganglion cells.

20 eptum and noradrenergic innervation from the locus ceruleus are required for hippocampal-dependent le

21 effect when stimulating raphe magnus and/or locus ceruleus, but became critical when alpha1 NE and 5

22 ber density in nucleus basalis of Meynert or locus ceruleus compared to controls.

23 (5-HT) and dopamine (DA) derived from feline locus ceruleus complex (LC) and amygdala.

24 microl/min infusion rate) from amygdala and locus ceruleus complex (LC) during four, 6-8-h polygraph

25 obtained from left amygdala and ipsilateral locus ceruleus complex (LC) under 3 experimental conditi

26 preparatory inhibition of DBS, including the locus ceruleus complex and parabrachial nuclei, may inte

27 uleus or from neuroblastoma (SK-N-BE()C) and locus ceruleus-derived (CATH.a) cell lines.

28 amine and cell loss in the substantia nigra, locus ceruleus, dorsal motor nucleus of the X cranial ne

29 illary tangles, and aminergic neurons in the locus ceruleus, dorsal raphe nucleus, substantia nigra,

30 lthough loss of noradrenergic neurons in the locus ceruleus has been consistently demonstrated postmo

31 4.99; Lewy bodies in substantia nigra and/or locus ceruleus in ACT: RR for TBI with LOC >1 hour, 3.30

32 n-pigmented noradrenergic cell bodies in the locus ceruleus in Parkinson's Disease and to the degener

33 In turn, the ZI projects to the locus ceruleus, indicating that the ZI is part of a circ

34 inactive form of the 5-HT2C receptor in the locus ceruleus is associated with decreased 5-HT2A-depen

35 al forebrain, perifornical hypothalamus, and locus ceruleus (LC) across the sleep-wake cycle using mi

36 cAMP response element-binding protein in the locus ceruleus (LC) and certain other brain areas.

37 The locus ceruleus (LC) can exhibit tonic or phasic activity

38 To assess the consequences of locus ceruleus (LC) degeneration and subsequent noradren

39 NE neurons in the locus ceruleus (LC) die in Alzheimer's disease (AD).

40 The noradrenergic brain nucleus locus ceruleus (LC) has appeared to be an exception to t

41 sts and antagonists into the vicinity of the locus ceruleus (LC) have contrasting effects on evoked a

42 ous work also suggests an involvement of the locus ceruleus (LC) in behavioral and neuroendocrine res

43 ating the importance of the amygdala and the locus ceruleus (LC) in responding to stress, aversive me

44 input from regions such as the noradrenergic locus ceruleus (LC) in the brainstem.

45 cause a potent inhibition of neurons in the locus ceruleus (LC) in vivo in brain slices and isolated

46 The noradrenergic nucleus locus ceruleus (LC) is associated classically with arous

47 In mammals, the pontine nucleus locus ceruleus (LC) is the sole source of norepinephrine

48 phe system and decreases norepinephrine (NE) locus ceruleus (LC) neural activity, suggesting a robust

49 Locus ceruleus (LC) neuronal activity is correlated with

50 We examined desensitization in mature rat locus ceruleus (LC) neurons and confirmed that morphine

51 ent study, homologous MOR desensitization in locus ceruleus (LC) neurons and MOR internalization in H

52 Endogenous opioids target noradrenergic locus ceruleus (LC) neurons and potently inhibit LC acti

53 State-dependent activity of locus ceruleus (LC) neurons has long suggested a role fo

54 CE STATEMENT Electrophysiological studies of locus ceruleus (LC) neurons have long suggested a role f

55 pling synchronizes the spontaneous firing of locus ceruleus (LC) neurons in the neonatal rat brain, w

56 indicated that electrotonic coupling between locus ceruleus (LC) neurons is involved in synchronizing

57 Here we report that noradrenergic locus ceruleus (LC) neurons of mice with a conditional d

58 el currents in mouse brain slices containing locus ceruleus (LC) neurons to determine the effects of

59 ticotropin-releasing hormone (CRH) activates locus ceruleus (LC) neurons, thereby increasing norepine

60 millary nucleus (TMN), and the noradrenergic locus ceruleus (LC) neurons, three neuronal populations

61 sine hydroxylase (TH) protein and TH mRNA in locus ceruleus (LC) neurons.

62 d administration causes hyperpolarization of locus ceruleus (LC) neurons.

63 Locus ceruleus (LC) noradrenergic neurons are critical i

64 disease (AD), there is a significant loss of locus ceruleus (LC) noradrenergic neurons.

65 Neurons in the brainstem nucleus locus ceruleus (LC) often exhibit phasic activation in t

66 r, either a decrease in TH expression in the locus ceruleus (LC) or a blockade of the norepinephrine

67 This rapid learning requires reward-evoked locus ceruleus (LC) release of copious amounts of norepi

68 The noradrenergic locus ceruleus (LC) system has been implicated in severa

69 by different brain regions, for example, the locus ceruleus (LC), a noradrenergic nucleus, is implica

70 y bulb norepinephrine (NE), release from the locus ceruleus (LC), and amygdala suppression by low cor

71 ating the actions of chronic morphine in the locus ceruleus (LC), but direct evidence to support such

72 The norepinephrine nucleus, locus ceruleus (LC), is activated by diverse stimuli and

73 d neurochemical properties of neurons in the locus ceruleus (LC), the major source of noradrenergic i

74 Here, we report that NA release from locus ceruleus (LC), when coupled to odor presentation,

75 Chronic morphine selectively sensitized locus ceruleus (LC)-norepinephrine (NE) neurons to corti

76 Substantial evidence indicates that the locus ceruleus (LC)-norepinephrine (NE) projection syste

77 has been attributed to CRF regulation of the locus ceruleus (LC)-norepinephrine arousal system.

78 entrolateral periaqueductal gray (vlPAG) and locus ceruleus (LC).

79 somato-sensory and association cortices, and locus ceruleus (LC).

80 cleus (LDT), dorsal raphe nucleus (DRN), and locus ceruleus (LC).

81 Using embryonic chick locus ceruleus (LoC) as a model, we quantified and compa

82 of wake neurons, including the orexinergic, locus ceruleus, mesopontine cholinergic, and dopaminergi

83 Despite the loss of locus ceruleus neurons in Alzheimer's disease, the aging

84 measured using voltage-clamp recordings from locus ceruleus neurons in brain slices from naive or mor

85 lar and whole-cell recordings were made from locus ceruleus neurons in rat brain slices to characteri

86 e onset and recovery from desensitization in locus ceruleus neurons recorded in brain slices taken fr

87 rafficking was observed in both amygdala and locus ceruleus neurons that naturally coexpress these re

88 s MORs simultaneously in primary cultures of locus ceruleus neurons using fluorescently tagged peptid

89 Locus ceruleus neurons were identified by their neuromel

90 ization of mu-opioid receptors in mature rat locus ceruleus neurons when protein kinase C is also act

91 cell imaging of Flag-tagged MOPRs from mouse locus ceruleus neurons, to examine the role of protein k

92 n the recovery from acute desensitization in locus ceruleus neurons.

93 regions arise primarily from A1, A2, A5, and locus ceruleus neurons.

94 oid receptor-evoked potassium current in rat locus ceruleus neurons.

95 ne hydroxlyase-immunoreactive neurons in the locus ceruleus nor tryptophan hydroxlyase-immunoreactive

96 ulla, raphe pallidus, and magnus, the A5 and locus ceruleus noradrenergic cell groups.

97 trated neuron-specific GK mRNA expression in locus ceruleus norepinephrine and in hypothalamic neurop

98 results support the adaptive gain theory of locus ceruleus-norepinephrine (LC-NE) function and the p

99 inergic neuromodulatory systems, such as the locus ceruleus-norepinephrine system, which send diffuse

100 age-dependent bilateral degeneration at the locus ceruleus nucleus and display mild motor behavior d

101 ion and Lewy bodies can also be found in the locus ceruleus, nucleus basalis, hypothalamus, cerebral

102 , periaqueductal gray, parabrachial nucleus, locus ceruleus, nucleus of the solitary tract, spinal tr

103 ral gray; raphe nuclei; parabrachial nuclei; locus ceruleus, nucleus of the solitary tract; area post

104 The locus ceruleus of this and other avian atlases was noted

105 m, nucleus basalis of Meynert, thalamus, and locus ceruleus) of affected subjects were analyzed postm

106 lly from patterns exhibited by extracts from locus ceruleus or from neuroblastoma (SK-N-BE()C) and lo

107 ia nigra), intercollicular n., central gray, locus ceruleus, parabrachial n., ventrolateral medulla,

108 sing the release of noradrenaline in the rat locus ceruleus prolonged the duration of alpha2-receptor

109 ts overlap in a variety of tissues including locus ceruleus, retina, hippocampus, dorsal root ganglia

110 For MOPr in neurons in brainstem locus ceruleus slices, the peptide agonists [d-Ala(2),N-

111 s to S/N in vivo We show, in male rats, that locus ceruleus stimulation and pharmacological infusions

112 tional connectivity between the RTPJ and the locus ceruleus, suggesting noradrenergic processes under

113 diffusion was nearly fivefold greater in the locus ceruleus than dopamine in the midbrain.

114 tal gray (PAG), rostral ventral medulla, and locus ceruleus that have substantial roles in descending

115 ia nigra pars compacta dopamine neurons, the locus ceruleus, the cerebellar dentate nucleus, Purkinje

116 es whole-cell recordings from neurons in the locus ceruleus to measure the potassium current induced

117 rain areas (central nucleus of the amygdala, locus ceruleus, ventrolateral septal nucleus, paraventri

118 ne neurons in IPD, and ND1 expression in the locus ceruleus was also unchanged.

119 e dorsal motor nucleus of the vagus, and the locus ceruleus were not affected by exposure to VPA, eve

120 rebral cortex; those in the hypothalamus and locus ceruleus were often of bizarre shapes.

121 ontrast, NET proteins levels in thalamus and locus ceruleus were strongly affected by regional iron d

122 ns in the substantia nigra pars compacta and locus ceruleus, without Lewy body pathology.