ライフサイエンスコーパス: locus coeruleus

1 l arousal state, including the noradrenergic locus coeruleus.

2 ei, and noradrenergic input from the nucleus locus coeruleus.

3 phrine transporter (NET) availability in the locus coeruleus.

4 s prepro-galanin messenger RNA levels in the locus coeruleus.

5 od brain barrier, the inferior olive and the locus coeruleus.

6 area X following injections of CTB into the locus coeruleus.

7 t loss of norepinephrine (NE) neurons in the locus coeruleus.

8 e nucleus, Edinger-Westphal nucleus, and the locus coeruleus.

9 dorsoventral and rostrocaudal extent of the locus coeruleus.

10 medulla, nucleus of the solitary tract, and locus coeruleus.

11 riaqueductal gray, the dorsal raphe, and the locus coeruleus.

12 ased the number of Fos-li neurons within the locus coeruleus.

13 noradrenergic influences originating in the locus coeruleus.

14 aracterize CO2/H+-sensitive neurons from the locus coeruleus.

15 ry nucleus, ventral periaqueductal gray, and locus coeruleus.

16 t not into the ventral tegmental area or the locus coeruleus.

17 ry processing through its connections to the locus coeruleus.

18 ilateral nucleus in the brainstem called the locus coeruleus.

19 disease due to the early degeneration of the locus coeruleus.

20 o be triggered by sympathetic stress via the locus coeruleus; [3] sodium salicylate induces an acute

21 y the anterior SNpc (-49%; P < .001) and the locus coeruleus (-37%; P < .05).

22 tively regulate noradrenergic neurons in the locus coeruleus, a brain center implicated in attention,

23 in this issue of Neuron shows that the human locus coeruleus, a brain stem nucleus containing cell bo

24 ation revealed age-dependent degeneration of locus coeruleus, a major player in contextual learning,

25 VLM (RVLM) catecholaminergic neurons contact locus coeruleus, A1, and A2 noradrenergic neurons, and u

26 positive norepinephrine neurons was found in locus coeruleus/A5/A7 noradrenaline cell groups, whereas

27 the number of catecholaminergic cells in the locus coeruleus (A6) and the ventral tegmental area (A10

28 amic neurons were measured before and during locus coeruleus activation in waking animals.

29 ttermates, which was rescued by chemogenetic locus coeruleus activation via designer receptors exclus

30 Locus coeruleus activation was eliminated by intracerebr

31 ry auditory cortex (A1), pairing sounds with locus coeruleus activation.

32 directionally influence pain perception, and locus coeruleus activity mirrors the interaction between

33 he prominent state-modulating actions of the locus coeruleus, additional studies examined: 1) lateral

34 eleased within primary sensory circuits from locus coeruleus afferent fibers can produce a spectrum o

35 duced in the superior vestibular nucleus and locus coeruleus after estradiol replacement; estradiol t

36 ns of the substantia nigra pars compacta and locus coeruleus, among other regions.

37 radrenergic part homologous to the mammalian locus coeruleus and a rostral region corresponding to th

38 There was extensive loss of NA cells in the locus coeruleus and A5 and A7 cell groups.

39 Locus coeruleus and A5 inhibition was not seen unless pr

40 nduced loss of norepinephrine neurons in the locus coeruleus and adjoining A5 and A7 noradrenaline ce

41 man tissues confirmed high expression in the locus coeruleus and adrenal gland, but also in sympathet

42 n 2 rs1108580, but only small differences in locus coeruleus and adrenals.

43 w a loss of catecholaminergic neurons in the locus coeruleus and an accompanying loss of norepinephri

44 omic components of the limbic forebrain, the locus coeruleus and cerebellar Purkinje cells, or for CR

45 ified alpha-syn aggregates in neurons of the locus coeruleus and cingulate cortex.

46 xpression was decreased by phenelzine in the locus coeruleus and decreased by imipramine in the dorsa

47 pression of tyrosine hydroxylase mRNA in the locus coeruleus and decreased pituitary adrenocorticotro

48 Mild neuronal loss was identified in the locus coeruleus and dorsal motor nucleus of the vagus, b

49 ificantly greater BOLD responses in the left locus coeruleus and hypothalamus after placebo compared

50 on of tyrosine hydroxylase is delayed in the locus coeruleus and is markedly deficient in the medulla

51 However, the locus coeruleus and medial vestibular nucleus, which con

52 ggests that aberrant tau accumulation in the locus coeruleus and noradrenergic dysfunction may be a c

53 al area and hindbrain structures such as the locus coeruleus and parabrachial nucleus.

54 the right side compared to left side in the locus coeruleus and parabrachial, superior vestibular, a

55 We made whole-cell recordings from rat locus coeruleus and primary auditory cortex (A1), pairin

56 In contrast to the strong innervation of locus coeruleus and raphe in mammal, the MCH and hypocre

57 uctures and neurochemical modulation via the locus coeruleus and raphe nuclei.

58 ns shell, and moderately to medial amygdala, locus coeruleus and solitary tract, consistent with the

59 ed projections from the noradrenergic nuclei locus coeruleus and subcoeruleus, and injections of biot

60 ted the asymmetry of c-Fos expression in the locus coeruleus and supragenualis nucleus, created an as

61 ignificantly reduced NET availability in the locus coeruleus and that greater NET availability in thi

62 mRNA levels, especially in the noradrenergic locus coeruleus and the dorsal raphe nucleus, in paralle

63 m the HSD2 neurons to the forebrain--the pre-locus coeruleus and the innermost region of the external

64 l brainstem contained a dense innervation of locus coeruleus and the nucleus subcoeruleus.

65 binding potential of NET availability in the locus coeruleus and the severity of PTSD symptoms assess

66 ic antidepressant treatment on brainstem GR, locus coeruleus and ventral tegmental area (VTA) tyrosin

67 he brain that are involved in sleep arousal (locus coeruleus) and preference/aversion (nucleus accumb

68 e pontine noradrenergic cell groups, A5, A6 (locus coeruleus), and A7, provide the only noradrenergic

69 ising a region of interest that includes the locus coeruleus), and cerebellum.

70 ucleus accumbens shell, inferior colliculus, locus coeruleus, and flocculus compared to morphine-depe

71 fied NPS fibers originating in the brainstem locus coeruleus, and projecting to the PVN.

72 ortical structures, including basal ganglia, locus coeruleus, and raphe nuclei (phase II), followed b

73 t in Barrington's nucleus, the dorsal raphe, locus coeruleus, and retrorubral nucleus.

74 y little to the catecholamine neurons in the locus coeruleus, and selectively targets the viscerosens

75 sine hydroxylase (TH) mRNA expression in the locus coeruleus, and stimulated sympathoadrenal catechol

76 laterodorsal tegmentum, superior colliculus, locus coeruleus, and the nucleus of the solitary tract.

77 e external lateral parabrachial nucleus, the locus coeruleus, and the nucleus of the solitary tract.

78 ne nuclei, the dorsal tegmental nucleus, the locus coeruleus, and the reticular formation.

79 Westphal nucleus, the hippocampus, amygdala, locus coeruleus, and the ventral tegmental area.

80 n the substantia nigra pars compacta (SNpc), locus coeruleus, and ventral tegmental area in Parkinson

81 volumes of the anterior and posterior SNpc, locus coeruleus, and ventral tegmental area were determi

82 entral striatum, and nucleus accumbens), the locus coeruleus, and white matter, and deactivation of m

83 l system and of noradrenergic neurons in the locus coeruleus are important pathological features of P

84 ct ipsilaterally, whereas projections to the locus coeruleus are more bilateral (65%).

85 PPG(+) neurons in the RTN and locus coeruleus are selectively activated (Fos) followin

86 rainstem in only three distinct regions: the locus coeruleus area, the principal sensory trigeminal n

87 tyrosine hydroxylase gene expression in the locus coeruleus as a measure of central norepinephrine f

88 the noradrenergic fibres originating in the locus coeruleus as an additional source of neurotransmit

89 RVLM catecholaminergic neurons activate the locus coeruleus as well as A1 and A2 noradrenergic neuro

90 lopment was significantly compromised in the locus coeruleus as well.

91 reviously identified as sending axons to the locus coeruleus, as well as from newly identified presyn

92 sustained, high-frequency stimulation of the locus coeruleus at frequencies of 5 Hz and above caused

93 mus (13-fold and 80-fold, respectively), the locus coeruleus-Barrington's nucleus complex (2-fold), a

94 underlying mechanisms and the development of locus coeruleus-based therapies.

95 review is to emphasize the complexity of the locus coeruleus beyond its primary definition as a norep

96 lar potency to morphine-mediated currents in locus coeruleus brain slice preparations.

97 gions including the hypothalamus, raphe, and locus coeruleus, commercial antibodies to LGI1 bound to

98 erations in LCGU, but LCGU was higher in the locus coeruleus compared to quinpirole alone (P<0.05), w

99 Neural activity in the noradrenergic locus coeruleus correlates with periods of wakefulness a

100 immunized mice showed neuronal damage in the locus coeruleus detected by a reduction of average cell

101 DA neurons and noradrenergic neurons in the locus coeruleus display distinct group-specific signatur

102 equire Math1, whereas the inferior olive and locus coeruleus do not.

103 These include the locus coeruleus, dorsal and pedunculopontine tegmental n

104 addition, neurodegeneration occurred in the locus coeruleus, dorsal motor nucleus of the vagus, and

105 ed for histological and behavioural signs of locus coeruleus dysfunction reminiscent of mild cognitiv

106 Approximately 80-85% of locus coeruleus efferents to these regions project ipsil

107 ional studies examined: 1) lateralization of locus coeruleus efferents to these regions; 2) the topog

108 nk between pretangle tau accrual and altered locus coeruleus fibre morphology.

109 oss of hippocampal norepinephrine levels and locus coeruleus fibres in the medial entorhinal cortex a

110 equency-dependent, causal relationship among locus coeruleus firing, cortical activity, sleep-to-wake

111 ds to raise noradrenaline levels or increase locus coeruleus function may be of benefit in treating m

112 ivation increased galanin mRNA levels in the locus coeruleus, further underlining the connection betw

113 to sudden sounds in PTSD is associated with locus coeruleus hyperresponsiveness.

114 ns of the substantia nigra pars compacta and locus coeruleus in all four DYT1 dystonia cases, but not

115 yte activation in the ventral portion of the locus coeruleus in immunized mice.

116 compacta and noradrenergic neurons from the locus coeruleus in monkeys performing a task manipulatin

117 lated with decreased TH transcription in the locus coeruleus, indicating a decreased central sympathe

118 ors; increased AT(2) receptor binding in the locus coeruleus, inferior olive, and adrenal cortex; and

119 tau accrual in the locus coeruleus, loss of locus coeruleus innervation and deficits locus coeruleus

120 stochastic behavioral modes is controlled by locus coeruleus input into ACC.

121 y modulating norepinephrine release from the locus coeruleus into the olfactory bulb.

122 a (SNpc) and of noradrenergic neurons in the locus coeruleus is accompanied with increases in apoptos

123 Here we report that neuronal firing in the locus coeruleus is especially sensitive to environmental

124 These results suggest that the locus coeruleus is finely tuned to regulate organismal a

125 Our results demonstrate that locus coeruleus is highly plastic, leading to substantia

126 x, challenging the long-held belief that the locus coeruleus is the sole source of norepinephrine pro

127 om primary somatosensory cortex and from the locus coeruleus (LC) (the neuromodulatory nucleus releas

128 sing factor (CRF)-mediated increase in tonic locus coeruleus (LC) activity and consequent release of

129 rostimulation, Joshi et al. (2016) show that locus coeruleus (LC) activity closely matches moment-to-

130 ine noradrenergic cell groups, including the locus coeruleus (LC) and A5.

131 medulla (VLM), and to a lower extent, in the locus coeruleus (LC) and Barrington nucleus.

132 scribed group of neurons located between the locus coeruleus (LC) and Barrington's nucleus.

133 defined cluster of cells located between the locus coeruleus (LC) and Barrington's nucleus.

134 essenger RNA (mRNA) for galanin (GAL) in the locus coeruleus (LC) and brain-derived neurotrophic fact

135 The locus coeruleus (LC) and dorsal raphe (DR) are monoamine

136 hology of the main noradrenergic nuclei, the locus coeruleus (LC) and LC-associated behaviors includi

137 t from the pontine micturition center (PMC), locus coeruleus (LC) and medial prefrontal cortex (mPFC)

138 nt in noradrenergic circuits associated with locus coeruleus (LC) and prefrontal cortex, where emotio

139 ar glutamate transporters (VGLUT 1-3) in the locus coeruleus (LC) and the dorsal raphe nucleus (DRN)

140 TNF bioactivity in total homogenates of the locus coeruleus (LC) and the hippocampus as assessed by

141 tegmental area (VTA), substantia nigra (SN), locus coeruleus (LC) and the nucleus of solitary tract (

142 gitudinal fasciculus (MLF) as well as in the locus coeruleus (LC) and the periventricular gray substa

143 Mice with locus coeruleus (LC) area injection of lentivirus encodi

144 Recordings from acute slices of rat locus coeruleus (LC) demonstrated that photorelease of L

145 and downstream noradrenergic neurons in the locus coeruleus (LC) during nonrapid eye movement (NREM)

146 um, and these patterns paralleled changes in locus coeruleus (LC) fiber innervation, respectively.

147 The noradrenergic locus coeruleus (LC) has been implicated in the promotio

148 ificant loss of noradrenergic neurons in the locus coeruleus (LC) in addition to the loss of dopamine

149 pharmacological inactivation of amygdala and locus coeruleus (LC) in mice.

150 f the cytokine interleukin-1 (IL-1) into the locus coeruleus (LC) increased the electrophysiological

151 The locus coeruleus (LC) is a dense cluster of neurons that

152 The locus coeruleus (LC) is a major noradrenergic brain nucl

153 ave indicated that the noradrenergic nucleus locus coeruleus (LC) is one site at which DYN may contri

154 The brainstem nucleus locus coeruleus (LC) is the primary source of norepineph

155 The brainstem nucleus locus coeruleus (LC) is the sole source of norepinephrin

156 The noradrenergic brain nucleus locus coeruleus (LC) modulates arousal and may have effe

157 le-cell voltage-clamp recordings from KF and locus coeruleus (LC) neurons contained in acute rat brai

158 Loss of noradrenergic locus coeruleus (LC) neurons is a prominent feature of a

159 Activation of noradrenergic locus coeruleus (LC) neurons promotes wakefulness and be

160 In rat locus coeruleus (LC) neurons, tolerance to morphine was

161 by riluzole in the regulation of activity of locus coeruleus (LC) neurons, which provide the major in

162 ectal distension (CRD)-induced activation of locus coeruleus (LC) neurons.

163 endomorphin-2, and morphine in rat and mouse locus coeruleus (LC) neurons.

164 Activity of locus coeruleus (LC) noradrenergic neurons was determine

165 ry deficits coupled with degeneration of the locus coeruleus (LC) norepinephrine (NE) neurons.

166 pression in the dorsal raphe (DR) and in the locus coeruleus (LC) of mice lacking orexin receptors in

167 The nucleus locus coeruleus (LC) plays an important role in analgesi

168 The locus coeruleus (LC) projects throughout the brain and s

169 The rat dorsal raphe nucleus (DR) and the locus coeruleus (LC) receive cholinergic input and expre

170 The noradrenergic locus coeruleus (LC) regulates arousal, memory, sympathe

171 Here, we developed an ex vivo locus coeruleus (LC) slice culture system and successful

172 The brainstem locus coeruleus (LC) supplies norepinephrine to the fore

173 hms and impairment of the noradrenergic (NA)-locus coeruleus (LC) system.

174 ntations increases local NE release from the locus coeruleus (LC) to generate "NE hotspots." At these

175 pha(1)-Adrenoceptors are concentrated in the locus coeruleus (LC) where they appear to regulate vario

176 innervated by NE-containing fibers from the locus coeruleus (LC), a pathway known to modulate state-

177 orphinergic projections terminate within the locus coeruleus (LC), a primary source of norepinephrine

178 e hydroxylase (TH), in the brainstem nucleus locus coeruleus (LC), a region that is the sole source o

179 at originate from pontine neurons in the A5, locus coeruleus (LC), and A7 cell groups.

180 ves dense noradrenergic (NE) inputs from the locus coeruleus (LC), and the LC-NE system is heavily im

181 nucleus and the norepinephrine (NE) nucleus, locus coeruleus (LC), are integral to a circuit that lin

182 -containing neurons in the brainstem nucleus locus coeruleus (LC), but there is little direct evidenc

183 the raphe nuclei, Edinger-Westphal nucleus, locus coeruleus (LC), lateral parabrachial nucleus, vent

184 ucleus (SON), paraventricular nucleus (PVN), locus coeruleus (LC), rostral raphe pallidus (rRPa), nuc

185 The locus coeruleus (LC), the main source of brain noradrena

186 ave global effects on behavior is within the locus coeruleus (LC), the major brain norepinephrine (NE

187 of action was a priority and focused on the locus coeruleus (LC), the major noradrenergic control ce

188 Degeneration of the locus coeruleus (LC), the major noradrenergic nucleus in

189 ted whether noradrenergic neurons within the locus coeruleus (LC), the major source of forebrain nore

190 visceral states and it provides input to the locus coeruleus (LC), the major source of norepinephrine

191 smitter in the brain norepinephrine nucleus, locus coeruleus (LC), to activate this system during str

192 Applying MAPseq to the locus coeruleus (LC), we find that individual LC neurons

193 els of norepinephrine (NE) released from the locus coeruleus (LC), we interpret these results as sugg

194 ing factor (CRF) to modulate activity of the locus coeruleus (LC)-norepinephrine (NE) system.

195 The locus coeruleus (LC)-norepinephrine system is a target o

196 of the stress response is activation of the locus coeruleus (LC)-norepinephrine system.

197 evel-dependent (BOLD) responses in the human locus coeruleus (LC).

198 dium-sized Bar neurons located medial to the locus coeruleus (LC).

199 ave global effects on behavior is within the locus coeruleus (LC).

200 individual CO2/H+-sensitive neurons from the locus coeruleus (LC).

201 nucleus (Sp5), dorsal raphe nucleus (DR) and locus coeruleus (LC).

202 specific noradrenergic proteins in the human locus coeruleus (LC).

203 os labeling in these areas as well as in the locus coeruleus (LC).

204 neuronal degeneration in such nuclei as the locus coeruleus (LC).

205 ntia nigra (SN), nucleus accumbens (NA), and locus coeruleus (LC).

206 (NE) is produced primarily by neurons in the locus coeruleus (LC).

207 sal raphe nucleus (DRN) and up to 6 h in the locus coeruleus (LC).

208 homogeneous cell population in the brainstem locus coeruleus (LC).

209 s the rostral ventromedial medulla (RVM) and locus coeruleus (LC).

210 al hippocampus originate from neurons of the locus coeruleus (LC).

211 5HT), and singly labeled Fos(+) cells in the locus coeruleus (LC).

212 tonomic dysfunction involving the brain stem locus coeruleus (LC).

213 as an astrocytic signalling molecule in the locus coeruleus (LC).

214 includes early pretangle tau accrual in the locus coeruleus, loss of locus coeruleus innervation and

215 ress-related brain regions (for example, the locus coeruleus, medial amygdala and paraventricular nuc

216 single or double retrograde tracing from the locus coeruleus, medial preoptic area, medial septal are

217 These regions include the locus coeruleus, medial septal area, medial preoptic are

218 luded: cuneiform/subcuneiform, dorsal raphe, locus coeruleus, median raphe, parabrachial complex, pon

219 hat unclear, although cortical inputs to the locus coeruleus mediating arousal are likely involved.

220 pinal projections observed suggests that the locus coeruleus might have the greatest effect on somato

221 observations indicate coordinated actions of locus coeruleus neurons across these basal forebrain reg

222 he degree of collateralization of individual locus coeruleus neurons across these regions.

223 We examined how locus coeruleus neurons are modified by experience and t

224 These results suggest that loss of locus coeruleus neurons contributes to motor dysfunction

225 Although initially unresponsive, locus coeruleus neurons developed and maintained auditor

226 human catecholaminergic substantia nigra and locus coeruleus neurons express MHC-I, and that this mol

227 Cultured mouse locus coeruleus neurons expressing hyperphosphorylation-

228 Additionally, a large proportion of locus coeruleus neurons project simultaneously to these

229 When tagged D2 receptors were expressed in locus coeruleus neurons, a desensitizing protocol induce

230 els are a consequence of stress or damage to locus coeruleus neurons.

231 l organization of basal forebrain-projecting locus coeruleus neurons; and 3) the degree of collateral

232 For example, locus coeruleus noradrenaline (also known as norepinephr

233 , the raphe region (5-HT) and, possibly, the locus coeruleus (noradrenaline).

234 Increased tonic activity of locus coeruleus noradrenergic (LC-NE) neurons induces an

235 The locus coeruleus noradrenergic (LC-NE) system is one of t

236 The locus coeruleus-noradrenergic system exerts an activatin

237 The locus coeruleus-noradrenergic system exerts an activatin

238 involved in the stress response, as are the locus coeruleus norepinephrine (LC-NE) and dorsal raphe

239 ameter, which are thought to track levels of locus coeruleus norepinephrine activity and neural gain,

240 eous Type Serial Token (ST(2)) model and the Locus Coeruleus-Norepinephrine (LC-NE) model.

241 ponses to stress, in part, by activating the locus coeruleus-norepinephrine (LC-NE) projection system

242 suggests that CRF-mediated activation of the locus coeruleus-norepinephrine (LC-NE) system contribute

243 Historically, the locus coeruleus-norepinephrine (LC-NE) system has been i

244 The locus coeruleus-norepinephrine (LC-NE) system is a major

245 Because the locus coeruleus-norepinephrine (LC-NE) system is a major

246 posit a key modulatory role for the pontine locus coeruleus-norepinephrine (LC-NE) system.

247 ive responses to stress are regulated by the locus coeruleus-norepinephrine (LC-NE) system.

248 ng innovative technologies highlight how the locus coeruleus-norepinephrine system can now be targete

249 nd humans suggests that sensitization of the locus coeruleus-norepinephrine system may underlie behav

250 that a substantial window of opportunity for locus coeruleus/ norepinephrine-based therapeutics exist

251 of locus coeruleus innervation and deficits locus coeruleus/norepinephrine modulated behaviours, doe

252 ts to the ventral attention network from the locus coeruleus/norepinephrine system.

253 tional key neural system into the model, the locus coeruleus/norepinephrine system.

254 loss in the substantia nigra, raphe nuclei, locus coeruleus, nucleus basalis of Meynert and dorsal m

255 gmental area); and later on in the anterior (locus coeruleus/nucleus subcoeruleus) and posterior (vag

256 Analysis of the locus coeruleus of multiple sclerosis and control brains

257 minergic neurons in the substantia nigra and locus coeruleus of the brainstem, resulting in early-ons

258 the frontal and temporal cortex, and in the locus coeruleus, of drug users aged > 30 years (all P =

259 us and general visceral nuclei, but not with locus coeruleus or raphe nuclei support the view that th

260 several key criteria for a suitable model of locus coeruleus pathology and dysfunction early in Alzhe

261 dified by experience and the consequences of locus coeruleus plasticity for cortical representations

262 Locus coeruleus plasticity induced changes in A1 respons

263 rvate numerous brain sites including the pre-locus coeruleus (pre-LC) and PB external lateral-inner (

264 eus of the stria terminalis (BSTvl), the pre-locus coeruleus (pre-LC), and the inner division of the

265 hyperphosphorylated tau was detected in the locus coeruleus prior to accrual in the medial entorhina

266 Photolysis in slices of rat locus coeruleus produced a rapid inhibition of the ionic

267 Results indicate that the locus coeruleus provides the majority of noradrenergic i

268 modulatory systems such as the noradrenergic locus coeruleus, providing information about internal st

269 n the caudate putamen (R=0.436, p=0.033) and locus coeruleus (R=0.86; p<0.001).

270 ected) and midbrain with pons, including the locus coeruleus (R2=0.18; P<.01 corrected), which corrob

271 ST), optic tectum, various tegmental nuclei, locus coeruleus, raphe nuclei, reticular nuclei, and the

272 rior raphe nuclei, parabrachial nucleus, pre-locus coeruleus region, NTS, and A1 noradrenergic neuron

273 postrema, A2, A5, ventrolateral medulla and locus coeruleus regions are sources of catecholaminergic

274 receptor levels in hippocampus, amygdala and locus coeruleus regions of the brain.

275 reactive neurons of the hypothalamus and the locus coeruleus, respectively.

276 e nucleus tractus solitarius, but not in the locus coeruleus, restored CPP for morphine.

277 raphe nuclei, lateral parabrachial nucleus, locus coeruleus, spinal trigeminal tract, rostral ventro

278 rior colliculi, the parabrachial nuclei, the locus coeruleus, subcoeruleus and periolivary areas, and

279 However, direct evidence linking locus coeruleus system hyperactivity to PTSD hyperrespon

280 D participants exhibited larger responses in locus coeruleus (t = 2.60, region of interest familywise

281 Phenelzine increased locus coeruleus TH and imipramine increased dorsal raphe

282 Thus, locus coeruleus TH(+) neurons can mediate post-encoding

283 o the hippocampus, optogenetic activation of locus coeruleus TH(+) neurons mimics the novelty effect,

284 pecially sensitive to environmental novelty, locus coeruleus TH(+) neurons project more profusely tha

285 Surprisingly, two effects of locus coeruleus TH(+) photoactivation are sensitive to h

286 ning neurons in the nucleus raphe magnus and locus coeruleus that project to the spinal cord.

287 ntral gray matter (periaqueductal gray), the locus coeruleus, the ventromedial nucleus of hypothalamu

288 In neurons of the periphery and locus coeruleus, this up-regulation is associated with a

289 stream of the amygdala via the noradrenergic locus coeruleus to enable threat (fear) learning, specif

290 nucleus, raphe nuclei, periaqueductal gray, locus coeruleus, trigeminal nucleus, reticular formation

291 inputs from the dorsal raphe, median raphe, locus coeruleus, ventral tegmentum and nucleus basalis o

292 In the PTSD group, NET availability in the locus coeruleus was independently positively associated

293 tex or hippocampus, and tau pathology in the locus coeruleus was negatively correlated with noradrene

294 r source of noradrenaline are neurons in the locus coeruleus, we hypothesized that alterations in nor

295 ntrast, hypocretin neurons projecting to the locus coeruleus were located primarily within the dorsal

296 tivation from the ventral tegmental area and locus coeruleus were used to identify hypocretin (Hcrt)

297 Also the A6 region (locus coeruleus), which contains CA neurones sensitive t

298 minergic neurons of the substantia nigra and locus coeruleus, which are implicated in neurodegenerati

299 .001) with increased Mn concentration in the locus coeruleus, while decreased Fe was associated with

300 al pons, the PVH projects heavily to the pre-locus coeruleus, yet very little to the catecholamine ne