ライフサイエンスコーパス: locus control region

1 and thymic T cell compartments using the CD2 locus control region.

2 hypersensitivity sites in the T(H)2 cytokine locus control region.

3 tion of cytokine-encoding genes by the T(H)2 locus control region.

4 rsensitive site two (HS2) of the beta-globin locus control region.

5 riched both at betamajor and at the upstream locus control region.

6 the HS2 and HS3 elements of the beta-globin locus control region.

7 linked to hypersensitive site 3 (HS3) of the locus control region.

8 competing for the enhancing activity of the locus control region.

9 bin gene together with large segments of its locus control region.

10 HS2, HS3, and HS4) of the human beta-globin locus control region.

11 9me3 across the beta-globin gene cluster and locus control region.

12 is an inherent component of the beta-globin locus control region.

13 7) is expressed under the control of the CD2 locus control region.

14 he AP-1-like cis-elements in the beta-globin locus control region.

15 oduction through its modification of the Th2 locus control region.

16 NP directly associating with the beta-globin locus control region.

17 med by molecular analyses of the beta-globin locus control region.

18 tween the replication origin (Rep-P) and the locus control region.

19 luding enhancers, promoters, insulators, and locus control regions.

20 es, which resembled enhancers in beta-globin locus control regions.

21 ancers, promoters, insulators, silencers and locus control regions.

22 oters, enhancers, silencers, insulators, and locus control regions.

23 ncluding promoters, enhancers, silencers and locus control regions.

24 cluding promoters, enhancers, insulators and locus-control regions.

25 all therian mammals so far examined, with a locus control region 1.54 kb upstream.

26 of the (A)gamma-globin gene inserted between locus control region 5' DNase I-hypersensitive site 1 an

27 variegate, which consisted of a beta-globin locus control region 5' HS-2 linked in tandem to a tagge

28 eta-globin locus is regulated in part by the locus control region, a region upstream of the genes con

29 ranscription factor NF-E2 in the beta-globin locus control region activate high-level beta-globin gen

30 rking together, the Ikzf1 enhancers provided locus control region activity, allowing reporter express

31 in which stochastic pairing occurs between a locus control region and either the red or the green pig

32 n and KLF2 binding to HS2 of the beta-globin locus control region and enhanced -globin mRNA productio

33 sh spatial proximity between the beta-globin locus control region and gene and for transcription acti

34 LTR in the direction of the downstream beta locus control region and globin genes in ovary and eryth

35 es of HS2 and HS3 from the human beta-globin locus control region and of the TATA, CACCC, and stage s

36 eam of the HS5 site in the human beta-globin locus control region and possesses unique enhancer activ

37 ge intrachromosomal interactions between the locus control region and promoters of the T(H)2 cytokine

38 ort, we describe a targeted deletion of this locus control region and show that this mutation acts at

39 situated between the 5' growth hormone (GH) locus control region and the 3' GH gene cluster.

40 l type-specific loop between the beta-globin locus control region and the downstream beta major promo

41 trate physical interactions between the beta locus control region and the downstream structural gamma

42 transiently transfected templates, both the locus control region and the EKLF-binding site are impor

43 ther demonstrated in mice transgenic for the locus control region and the entire beta-globin gene loc

44 action in K562 cells between the beta-globin Locus Control Region and the gamma-beta-globin intergeni

45 tivity site 2 (HS2) of the human beta-globin locus control region and the globin gene promoters as a

46 rsensitivity site 2 of the human beta-globin locus control region and the globin gene promoters as a

47 lymerase II, and cofactor recruitment to the locus control region and to the adult beta-globin gene.

48 II (pol II) recruitment to subregions of the locus control region and to the beta-globin promoters.

49 elements - particularly enhancers, but also locus control regions and insulators - have been defined

50 y activities including enhancers, promoters, locus control regions and insulators as well as novel el

51 promoter regulation by distant enhancers or locus control regions and may underlie phenomena such as

52 e protein complexes that bind at beta-globin locus control region, and purified and characterized the

53 ere required for BRG1 recruitment to the Th2 locus control region, and STAT6 associated with BRG1 in

54 Locus control regions are cis gene regulatory elements c

55 h1-globin genes, and also to the beta-globin locus control region, as demonstrated by ChIP assays wit

56 This Alu element is one component of the locus control region associated with the K18 gene.

57 " boundary area of the erythroid beta-globin locus control region (beta-LCR) and the intron of the em

58 cus where the ERV-9 LTR is juxtaposed to the locus control region (beta-LCR) far upstream of the glob

59 h tBHQ, but it did not increase KLF2 mRNA or locus control region binding above levels seen with norm

60 ing a deletion of the endogenous beta-globin locus control region, but no change in expression of the

61 E to the study of the human beta-globin gene Locus Control Region by integrating at the same genetic

62 One part of the locus control region, called hypersensitive site 2 (HS2)

63 that only when GATA-1 attracts pol II to the locus control region can pol II access the promoter in a

64 tiation complex (chromosome 1q21.3), the Th2 locus control region (chromosome 5q31.1), and the major

65 ative order of the genes with respect to the locus control region contributes to the temporal regulat

66 matin insulator from the chicken beta-globin locus control region could protect a retrovirus vector f

67 n promoter and elements from the beta-globin locus control region demonstrated a higher probability o

68 eles harboring deletions of promoters or the locus control region demonstrates that these sequences a

69 tioning as barriers, silencers, enhancers or locus control regions, depending on their positions rela

70 essary for the formation and function of the locus control region DNase I hypersensitive site (HS) co

71 orescent erythroid cells using a beta-globin locus control region driving the enhanced cyan fluoresce

72 nished association of RNA polymerase II with locus control region element HS2 and with the beta-globi

73 KLF1 with the beta-globin gene, but not with locus control region element HS2, and led to reduced tra

74 The approximately 6-kb locus control region element lying between them contains

75 ere the major roles played by 2 lesser-known locus control region elements, termed HS1 and HS4.

76 In embryonic erythropoiesis the locus control region enhancer is able to interact with t

77 beta-globin genes are activated by a distant locus control region/enhancer.

78 endogenous beta-globin gene promoter and the locus control region enhancers.

79 functional relevant polymorphism in the TH 2 locus control region, equivalent to RHS7 in mice, affect

80 eam of the HS5 site in the human beta-globin locus control region exhibits prominent enhancer activit

81 SNPs tagging a locus control region for IL4 and IL13 were associated wi

82 In mice, this region harbors a locus control region for nearby TH 2 cytokines, which is

83 We have previously characterized a locus control region for the GH1 gene consisting of four

84 3'E(Cgamma1), constitutes a T cell-specific locus control region for the TCR-gamma locus.

85 ersensitive site HS2, HS3, or HS234 (a large locus control region fragment containing HS2, HS3, and H

86 ng the HS2 enhancer of the human beta-globin locus control region from activating a downstream epsilo

87 enes in a manner consistent with a potential locus control region function.

88 tive site 5 (5'HS5) of the human beta-globin locus control region functions as a chromatin insulator

89 uman erythroleukemia cell line (K562) with a locus control region gamma/Luc-beta/Cat reporter and an

90 hypersensitive site (HS)3 of the beta-globin locus control region, GATA-1-induced histone acetylation

91 ntified 5' hypersensitive sites in the mouse locus control region had no effect on initiation from wi

92 nsitive site 3 (HS3) of the beta-like globin locus control region has been implicated as an important

93 ific human growth hormone (hGH) gene and its locus control region (hGH LCR).

94 n templates containing the human beta-globin locus control region HS2 enhancer and a target globin ge

95 one modification mediated by the beta-globin locus control region HS2 enhancer at nucleosome-level re

96 e epsilon-globin promoter by the beta-globin locus control region HS2 enhancer is correlated with an

97 tion elements (MAREs) within the beta-globin locus control region HS2 enhancer, to which the erythroi

98 The human beta-globin locus control region hypersensitive site 2 plays differe

99 betah1-, epsilon- and gamma-globin genes and locus control region in KLF1(-/-) embryos, correlating w

100 P, similar to Brg1, to the mouse beta-globin locus control region in MEL cells.

101 me close to a known tissue-specific enhancer/locus control region in the apoAI-CIII gene cluster, and

102 ersensitive site (HS) 2 from the beta-globin locus control region is a potent enhancer of globin gene

103 The T helper type 2 (T(H)2) locus control region is important in the regulation of t

104 This locus control region is known to drive T-cell-specific T

105 Recent studies have shown how this locus-control region is turned on and off.

106 the adult beta-globin gene in wild-type (WT)/locus control region knockout (DeltaLCR) heterozygous mi

107 e rep78 gene under the control of the globin locus control region (LCR) (Ad.LCR-rep78) conferred Rep7

108 required for the activity of the beta-globin locus control region (LCR) 5'HS3.

109 hat all potentially active genes compete for locus control region (LCR) activity.

110 ng-range interaction between the beta-globin locus control region (LCR) and active globin genes, and

111 -1 was sufficient to direct formation of the locus control region (LCR) and an erythroid pattern of g

112 In erythroid cells, the locus control region (LCR) and beta-globin promoter form

113 These cis-acting sequences included a locus control region (LCR) and conferred developmentally

114 on of the IgH locus functions as an enhancer-locus control region (LCR) and directs a similar pattern

115 a copy of HS5 placed between the beta-globin locus control region (LCR) and downstream genes on a tra

116 at the ancestral primate cluster contained a locus control region (LCR) and five paralogously related

117 ng-range interaction between the beta-globin locus control region (LCR) and gene in adult mouse eryth

118 tail to study the effect of the beta-globin locus control region (LCR) and promoter elements on the

119 physical interaction between the beta-globin locus control region (LCR) and the beta-major globin pro

120 a beta(m)-globin gene was placed between the locus control region (LCR) and the epsilon-globin gene,

121 d increases the recruitment of GATA-1 to the locus control region (LCR) and the proximal promoter and

122 er to the hypersensitive site 2 (HS2) in the locus control region (LCR) and to the epsilon-globin pro

123 The beta-globin locus control region (LCR) and transcriptionally active

124 ing factor Nipped-B-like (Nipbl) bind to the locus control region (LCR) at the CTCF insulator and dis

125 CB3 cells lack the beta-globin locus control region (LCR) binding protein p45/NF-E2.

126 ormone gene (hGH-N) is regulated by a distal locus control region (LCR) composed of five deoxyribonuc

127 s the presence of a previously characterized locus control region (LCR) composed of multiple chromati

128 cluster is regulated, at least in part, by a locus control region (LCR) composed of several developme

129 Activation of the cluster is dependent on a locus control region (LCR) comprising pituitary- specifi

130 The human beta-globin locus control region (LCR) confers high-level, tissue-sp

131 The human beta-globin locus control region (LCR) consists of five erythroid-li

132 In erythroid cells, the locus control region (LCR) contacts beta-type globin gen

133 The recently described T(H)2 locus control region (LCR) coordinately regulates the T(

134 The locus control region (LCR) did not have any enhancer act

135 communication by using the human beta-globin locus control region (LCR) DNase I-hypersensitive site 2

136 same time increased the binding of Pol II at locus control region (LCR) element HS2, suggesting that

137 e 11 and their expression is controlled by a locus control region (LCR) embedded within this locus.

138 a-globin locus, Pol II binds the beta-globin locus control region (LCR) far upstream of the beta-glob

139 ll as activity consistent with function as a locus control region (LCR) for the flanking Th2 cytokine

140 We previously identified a locus control region (LCR) for the hGH gene composed of

141 The human beta-globin locus control region (LCR) harbors both strong chromatin

142 The function of the beta-globin locus control region (LCR) has been studied both in cell

143 onated erythroid cells derived from WT/Delta locus control region (LCR) heterozygous mice reveals no

144 t a tandem Maf recognition element (MARE) in locus control region (LCR) hypersensitive site 2 (HS2) r

145 hypersensitive site (HS) of the beta-globin locus control region (LCR) in humans (5' HS 5) and chick

146 DNase I hypersensitive site 3 (5'HS3) of the locus control region (LCR) in the context of a human bet

147 contiguous with the previously described TH2 locus control region (LCR) in the mouse.

148 of regulatory elements from the beta-globin locus control region (LCR) in the transgene construct.

149 , and demonstrated that transcription of the locus control region (LCR) initiates within an ERV9 endo

150 The beta-globin locus control region (LCR) is a cis regulatory element t

151 A locus control region (LCR) is a cis-acting gene-regulato

152 The essence of this hypothesis is that the locus control region (LCR) is a genetic entity highly ac

153 The beta-globin locus control region (LCR) is a large DNA element that i

154 The beta-globin locus control region (LCR) is a powerful regulatory elem

155 The beta-globin locus control region (LCR) is able to enhance the expres

156 ve sites (HSs) that comprise the beta-globin locus control region (LCR) is highly conserved among mam

157 The beta-globin locus control region (LCR) is necessary for high-level b

158 The distal locus control region (LCR) is required for high-level ex

159 The beta-globin locus control region (LCR) is the founding member of a n

160 ent on its linkage to a previously described locus control region (LCR) located -15 to -32 kilobases

161 a, are close together and are regulated by a locus control region (LCR) located at the 5' end of the

162 Earlier work demonstrated that a locus control region (LCR) located upstream of these gen

163 two male donors showed that the L/M enhancer locus control region (LCR) loops with either the L or M

164 nsitive sites (HSs) of the human beta-globin locus control region (LCR) may function as part of an LC

165 The locus control region (LCR) of mammalian beta-globin gene

166 al enhancer element, HS2 of the prototypical locus control region (LCR) of the beta-globin gene clust

167 ress C3 transferase under the control of the locus control region (LCR) of the CD2 gene; this regulat

168 The locus control region (LCR) of the human CD2 gene (hCD2)

169 The locus control region (LCR) of the human red and green vi

170 To study the influence of a locus control region (LCR) on the expression of a highly

171 hypersensitive sites 2 to 5 (5'HS2-5) of the locus control region (LCR) plus an additional 27-kb upst

172 led to the model that the human beta-globin locus control region (LCR) regulates the transcription,

173 The HS2 enhancer in the beta-globin locus control region (LCR) regulates transcription of th

174 The locus control region (LCR) regulates transcription of th

175 gene, a region previously shown to contain a locus control region (LCR) regulating Th2-specific expre

176 se TCRalpha/TCRdelta/Dad1 gene locus bears a locus control region (LCR) that drives high-level, posit

177 alpha-chain gene locus contains a cis-acting locus control region (LCR) that has been shown to direct

178 used a transgenic mouse assay to identify a locus control region (LCR) that supports integration sit

179 t adenovirus vector carrying the beta-globin locus control region (LCR) to drive green fluorescent pr

180 persensitive site 4 (HS4) of the beta-globin locus control region (LCR) to overall LCR function we de

181 d is required for looping of the beta-globin locus control region (LCR) to the active beta-globin pro

182 n promoter and elements from the beta-globin locus control region (LCR) totaling 1.7 kb could correct

183 Previous studies identified a locus control region (LCR) upstream of the human alpha1-

184 , deletion of a previously identified serpin locus control region (LCR) upstream of the proximal subc

185 f the previously described mouse beta-globin locus control region (LCR) using fetal liver cells.

186 sing this common standard, we found that the locus control region (LCR) was acetylated to the same le

187 The murine beta-globin locus control region (LCR) was deleted from its native c

188 The locus control region (LCR) was thought to be necessary a

189 sensitive site 2 [HS2]) from the beta-globin locus control region (LCR) were essential to maximal SCF

190 ized chromatin structure that juxtaposes the locus control region (LCR) with downstream globin genes.

191 pression is dependent on the presence of the locus control region (LCR), a powerful regulatory elemen

192 human beta-globin genes are regulated by the locus control region (LCR), an element composed of multi

193 to transcription level or distance from the locus control region (LCR), and that the large increases

194 of the human beta-globin locus requires the locus control region (LCR), composed of a series of nucl

195 of the beta-globin genes is regulated by the locus control region (LCR), composed of multiple DNase I

196 nhancer of the beta-globin locus, called the locus control region (LCR), dynamically interacts with t

197 BCL11A binds the upstream locus control region (LCR), epsilon-globin, and the inte

198 s located within the beta-globin domain: the locus control region (LCR), globin enhancer elements (3'

199 1 preferentially occupied GATA motifs at the locus control region (LCR), in which chromatin accessibi

200 sequence for the beta-globin gene locus, the locus control region (LCR), is composed of multiple hype

201 The mouse beta-globin gene locus control region (LCR), located upstream of the beta

202 ed complexes at the promoters and the distal locus control region (LCR), revealed molecular intermedi

203 A conserved regulatory element, the locus control region (LCR), was revealed by analyzing DN

204 t mediate long-range transactivation by this locus control region (LCR), we assessed the influence of

205 globin genes is conferred by the beta-globin locus control region (LCR), which consists of four eryth

206 The human beta-globin locus control region (LCR), which consists of four eryth

207 eta-globin genes is regulated by the distant locus control region (LCR), which is brought into direct

208 hormone (hGH) locus is regulated by a distal locus control region (LCR), which is required in cis for

209 complex, and MeCP1, which are members of the locus control region (LCR)-associated remodeling complex

210 The hGH gene is activated by a 5'-remote locus control region (LCR).

211 pendent silencer activity of the beta-globin locus control region (LCR).

212 , and a far upstream regulatory element, the locus control region (LCR).

213 a significant effort has been focused at the locus control region (LCR).

214 histones at the active globin genes and the locus control region (LCR).

215 ong these promoters for interaction with the locus control region (LCR).

216 GH) gene cluster is regulated by a remote 5' locus control region (LCR).

217 e pituitary is dependent on a multicomponent locus control region (LCR).

218 regulated by a distal regulatory region, the locus control region (LCR).

219 with a targeted deletion of the beta-globin locus control region (LCR).

220 aseI hypersensitive sites (HSs) known as the locus control region (LCR).

221 n genes for interaction with the beta-globin locus control region (LCR).

222 ndem array flanked on the upstream side by a locus control region (LCR).

223 hroid cells is regulated by the far-upstream locus control region (LCR).

224 nsitive site (HS) 5 of the human beta-globin locus control region (LCR).

225 additional elements located upstream in the Locus Control Region (LCR).

226 element located 5' to the genes known as the locus control region (LCR).

227 ong-range transactivation by the beta-globin locus control region (LCR).

228 sitive site 2 (HS2) of the human beta-globin locus control region (LCR).

229 ay through embryogenesis by a multicomponent locus control region (LCR).

230 ta-globin gene locus requires the associated locus control region (LCR).

231 transgenic mice requires the presence of the locus control region (LCR).

232 b upstream of the epsilon gene, known as the locus control region (LCR).

233 placenta by distinct components of a remote locus control region (LCR).

234 lements, including promoter, enhancer, and a locus control region (LCR).

235 A-1/SCL/LMO2 bind in vivo to the beta-globin locus control region (LCR).

236 ize demethylation events of the Th2 cytokine locus control region (LCR).

237 d Pol II transcription factories require the locus control region (LCR).

238 globin gene family members with the powerful locus control region (LCR).

239 es the enhancement by a distant element, the locus control region (LCR).

240 e in pituitary somatotropes is mediated by a locus control region (LCR).

241 C), mediator and cohesin to establishment of locus control region (LCR)/beta-globin proximity.

242 bin gene under the control of a reduced-size locus-control region (LCR).

243 ng the fetal globin genes from the enhancer (locus control region [LCR]).

244 Locus control regions (LCRs) are capable of activating t

245 Locus control regions (LCRs) are cis-acting DNA segments

246 Locus control regions (LCRs) are cis-acting gene regulat

247 Locus control regions (LCRs) are cis-acting regulatory e

248 Locus control regions (LCRs) are defined by their abilit

249 Locus control regions (LCRs) are defined by their abilit

250 Locus control regions (LCRs) are gene regulatory element

251 Locus control regions (LCRs) are operationally defined b

252 Locus control regions (LCRs) are regulatory DNA sequence

253 Locus control regions (LCRs) are thought to provide a do

254 Locus control regions (LCRs) comprise sets of DNA elemen

255 Locus control regions (LCRs) confer transgene expression

256 However, insertion of the locus control regions (LCRs) derived from the beta-globi

257 It is well established that locus control regions (LCRs) generally overcome position

258 Locus control regions (LCRs) refer to cis-acting element

259 ffold/matrix attachment regions (S/MARs) and locus control regions (LCRs) that are involved in the si

260 Enhancers and locus control regions (LCRs) that are remote from the ge

261 Locus control regions (LCRs), which are cis-acting eleme

262 III and V) and placental (HSIII, IV, and V) locus control regions (LCRs).

263 er green fluorescent protein transgene gives locus control region-like activity.

264 Ralpha recombination in collaboration with a locus control region-like element located downstream of

265 r, indicating that the gamma2a gene includes locus control region-like elements.

266 ty sites appear to be critical components of locus control region-mediated Kit gene activation in mas

267 silon-promoter truncations linked to a micro-locus control region (microLCR).

268 eK4 at hypersensitive site 2 of the upstream locus control region, neither factor was required to est

269 in the murine locus, neither the beta-globin locus control region nor the gene promoters were require

270 ls to germinal center B cells, centered on a locus control region of Bcl6.

271 , but not B cells and fibroblasts, the T(H)2 locus control region participates in this configuration.

272 n-globin gene locus, the HS2 enhancer in the Locus Control Region regulates transcription of the embr

273 The HS2 enhancer in the beta-globin locus control region regulates transcription of the glob

274 hypersensitivity site (RHS)6 and RHS7 of the locus control region relative to AP-1 sites surrounding

275 anscriptional control, such as enhancers and locus-control regions, represent major sites of extragen

276 nes betamajor and betaminor and the upstream locus control region reside in hyperacetylated chromatin

277 expressing Stat6VT under control of the CD2 locus control region, restricting expression to lymphoid

278 We have used a beta-globin gene/beta-locus control region retroviral vector containing severa

279 e (A(gamma)*) and sites 2, 3, and 4 from the locus control region (rHS432A(gamma)*), but lacking a dr

280 ancers are often tissue-specific and overlap locus control regions, suggesting that they are importan

281 cluded a 2.5-kb composite of the beta-globin locus control region (termed a muLCR), a combination of

282 nd is not coordinately regulated by the same locus control region that directs the expression of othe

283 ant Stat6 (Stat6VT) under control of the CD2 locus control region that is transcriptionally active in

284 ulin intragenic mu enhancer region acts as a locus control region that mediates transcriptional activ

285 h constructs containing HS3 and HS2 from the locus control region, the gamma-globin gene with promote

286 In the absence of a well defined locus control region, the nuclear matrix is considered t

287 ing provides a remarkable example of a small locus control region--the Recombination Enhancer--that c

288 sociated factor is recruited by FKLF2 to the locus control region to acetylate histones 3 and 4 at th

289 ls; it extends from the region just past the locus control region to before beta-major and encompasse

290 This is the largest deletion at the mouse locus control region to show no apparent phenotype, and

291 ion of the HS2 enhancer from the beta-globin locus control region to the Ank/(A)gamma-globin transgen

292 ing in Drosophila, and the addition of LCRs (locus control regions) to transgenes overcomes position

293 her alone or together, did not function as a locus control region upon chromosomal integration.

294 eletion of a GC-specific, highly interactive locus control region upstream of Bcl6 abrogated GC forma

295 on spanning up to 6 kilobase pairs 5' to the locus control region using reporter gene constructs with

296 same unit linked to a composite beta-globin locus control region was expressed at high levels in tra

297 D2 promoter, the EGFP transgene, and the CD2 locus control region was injected into B6CBA/F1 pronucle

298 latory element of the beta-globin locus, the locus control region, was preserved, the genes of the be

299 ive STAT6 (STAT6VT) under control of the CD2 locus control region, which directs expression to the T-

300 human Th2 cytokine locus in particular in a locus control region within the DNA repair gene RAD50, c