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1 plied for distinguishing hydrogen-bonded and lone (17)O sites on the surface of silica gel; the one-d
2 Markovnikov directing effect is relieved and lone abstraction is observed, affording the 5-hydroxy-is
4 and 2008, and those with a family history of lone AF (AF without preceding cardiovascular/endocrine d
5 udies conducted using 1,335 individuals with lone AF (cases) and 12,844 unaffected individuals (refer
6 ere identified in all subjects with familial lone AF (n = 33) as well as apparently unaffected family
7 5A coding region in 375 subjects with either lone AF (n=118) or AF associated with heart disease (n=2
9 association in two independent cohorts with lone AF (overall combined odds ratio = 1.52, 95% CI 1.40
10 ntified an association on chromosome 1q21 to lone AF (rs13376333, adjusted odds ratio = 1.56; P = 6.3
11 s, and anatomic remodeling) in patients with lone AF and are strong predictors of recurrent arrhythmi
13 Guidelines provide a vague definition of lone AF but do not provide direction about how much or w
21 the intervening years is that definitions of lone AF in the literature are inconsistent so that studi
23 experience with the CMP in the treatment of lone AF over 2 decades and compares the original cut-and
26 Risk In Communities Study, Cleveland Clinic Lone AF Study, Cardiovascular Health Study, and Rotterda
30 TS3-associated variants in the patients with lone AF was much higher than expected, compared with the
34 ical variables (including age, hypertension, lone AF) failed to significantly predict response to AAD
35 es mellitus, or obstructive sleep apnea (ie, lone AF) undergoing ablation and 25 matched control subj
38 Tc intervals was stronger for the outcome of lone AF, as evidenced by a hazard ratio of 2.32 (95% con
39 In a cohort of patients with early-onset lone AF, we identified a high prevalence of SCN5A mutati
40 ne AF is associated with substantial risk of lone AF, with the strongest risks associated with young
55 (2)DS(2)-VASc score reliably identified the "lone" AF patients who were at "truly low risk" for throm
58 growth modes are achieved which result in a lone Ag structure emanating from a single (100) Au facet
59 ne-rich superfamily, but the position of the lone alpha helix differs due to interactions with the un
60 cated rare variants in 25 different genes in lone and familial atrial fibrillation (AF) using linkage
61 d whether an individual's risk of developing lone atrial fibrillation (AF) before age 60 years is ass
64 n=34), persistent (n=37), or permanent (n=5) lone atrial fibrillation at initial diagnosis met inclus
65 perimental study investigating patients with lone atrial fibrillation identified six novel mutations
67 Overall survival of the 76 patients with lone atrial fibrillation was 92% and 68% at 15 and 30 ye
69 helpers produced more direct offspring than lone breeders, some while still subordinate but most aft
72 perons) and CO(2) fixation (cbbLS), a third, lone copy of amoC (amoC(3)), and two representative hous
74 ited in SSA) by chemical modification of the lone cysteine residue (Cys(10)) through mixed disulfide
79 agment corresponding to cleavage between the lone double bond and the carboxyl group and defining the
81 n to be significantly more emissive than the lone dye, with a concentration-independent emission and
82 explained by assuming the association of the lone electron pair at sulfur to the Co-alkyne complexes.
83 r is of the conventional type, involving the lone electron pair of an oxygen donor, the latter is per
84 ics and OP identification confirmed that the lone electron pair of the amine-N is the predominant sit
85 s along the short axis and bonds through the lone electron pair of the nitrogen atom instead, and bot
86 different types of hyperconjugation between lone electron pairs of nitrogen atoms and sigma*C-N orbi
88 d in small airway epithelium of smokers with lone emphysema and normal spirometry (n = 13, p < 0.01)
89 M >/= 5.5 have not been identified, with the lone exception of an M = 6.9 quake remotely triggered by
93 tion in atrial fibrillation, with studies in lone forms of the arrhythmia suggesting a traditional mo
97 ion of methylation in the heart, enriched in lone intergenic CpGs and depleted from CpG islands aroun
98 strate methyl contact shifts that places the lone iron pi-spin in the d(xz) orbital, rather than the
99 nd between males in long-term pair-bonds and lone males in areas including the nucleus accumbens, ven
103 DAGK) and undecaprenol kinase (UDPK) are the lone members of a family of multispan membrane enzymes t
108 --> sigma* orbital delocalization between a lone pair (n) of a (thio)amide donor and the antibonding
109 ong HB, involves charge transfer between the lone pair (n) of Y, and the sigma* orbital of E-X as emp
110 low-lying dark state, involving the nitrogen lone pair (nNpi*), does significantly participate in the
114 d the electron-rich character of the carbene lone pair and also enhanced the CO(2) binding energy to
116 bilizing interaction between a nitrogen atom lone pair and an aromatic sulfur system (nN --> sigma*S-
121 onic effects (repulsion between the nitrogen lone pair and polarized C-Pd bond at C2-/C6-positions an
122 icated weak interaction between the nitrogen lone pair and proximal radical center in angular 5,6-die
123 cceptor substituents delocalize the nitrogen lone pair and stabilize the reactant state of 2-azetines
124 is depends on the dihedral angle between the lone pair and the C-H, a further consequence is a prefer
125 favorable overlap between the diffuse ligand lone pair and the primarily 7s/6d acceptor orbitals on U
127 ning pH-responsive species, namely, an amine lone pair as the electron donor and a cationic ring of m
131 ly, resulting from the delocalization of the lone pair at the nucleophilic center, a sigma CC bond, a
132 of the bonding was attributed to the reduced lone pair bond weakening effect, LPBWE, upon substitutio
133 bond with one water molecule at the nitrogen lone pair but only weakly N-H donating hydrogen bonds.
134 ereochemical activity due to the Sn(2+) s(2) lone pair causes a crystallographically hidden, locally
135 plexes, increasing the energy of the N(beta) lone pair decreases the ligand-to-metal CT (LMCT) energy
136 educing anomeric power by diminishing either lone pair donor ability (solvent) or antibonding accepto
137 en atoms in these cases are valence electron lone pair donors, and the sigma*Xe-O orbitals are lone p
138 confirmation of unusual features including a lone pair effect on (3)J(PH), the negative coupling cons
139 ontrary to common wisdom, fluorine is a good lone pair electron donor toward geminal sigma bonds.
140 meanwhile, it is enhanced by the strength of lone pair electrons coordination with the heme iron.
146 teract with the gold nanofingers through the lone pair electrons of pyridyl nitrogens, not through de
149 l, and the excitation primarily derives from lone pair electrons on the oxygen atom of water molecule
151 tween the radical alpha-C-H and the nitrogen lone pair followed by hydrogen abstraction within the co
152 the coordination geometry selected to favor lone pair formation on Pb(2+) ions and electrostatically
153 hown by quantum mechanical calculations, its lone pair having an energy significantly lower than that
154 and manifold originating from the hybridized lone pair in nitrogen orbitals of the Phthalocyanine rin
155 addition, we analyze the role of a carbanion lone pair in the rearrangement step, concluding that it
158 ron-donor amine moiety converts the nitrogen lone pair into a sigma bond and the HOMO into a lower-ly
164 iated with a dominant donation from a p-type lone pair localized on one of two iodine atoms, the sigm
166 MO is a Ge-C bonding combination between the lone pair of electrons on the germanium atom and the C-N
168 redominantly by the presence of the Sn 5s(2) lone pair of electrons rather than the steric or electro
169 , which show that pyridinic defects retain a lone pair of electrons that are capable of binding CO2.
171 d involve two ammonia molecules in which the lone pair of one NH(3) becomes associated with the empty
173 ive interaction of the trityl group with the lone pair of the enamine nitrogen is supported by the fi
174 n involves coordination of the SmI(2) to the lone pair of the nitrile nitrogen followed by an inner s
175 e of the reagent for substrates in which the lone pair of the nitrogen is electron releasing and thus
176 i))-sigma*CC interactions between the p-type lone pair of the terminal oxygen and adjacent unfilled C
177 -donation is better represented by an oxygen lone pair on flat sites, whereas it is delocalized on bo
179 state of the drug shows a highly delocalized lone pair on the amine nitrogen of the melphalan, which
180 ansfer (ET) via nucleophilic attack by its N lone pair on the C of CO(2), and finally (c) proton tran
181 tead: the nucleophilic attack of the carbene lone pair on the imino nitrogen (pathway "a") or on the
182 calcium ions electrostatically stabilize the lone pair on the nitrogen atom that forms during the iso
183 calculations revealed that the stereoactive lone pair on the Pb(2+) cation is critical to producing
185 ndent interaction between sulfur or selenium lone pair orbitals and sigma-orbitals, especially Si-Si
186 c potential minimum, observed at the carbene lone pair region of NHC (V(min1)) as well as at the carb
188 ic potential minimum (V(min)) at the carbene lone pair suggested that annelation of heterocycle to a
190 d relatively weak pi donation from the amide lone pair to platinum and supports a 14-electron assignm
193 es bind to the metal substrate through the O-lone pair while making H-bonds with neighboring molecule
194 rise from electron repulsion of the nitrogen lone pair with electron density from the butadiene moiet
195 y increasing orbital overlap of the nitrogen lone pair with the incipient oxyallyl cation, is coupled
196 he sigma-hole on bromobenzene (BrPh) and the lone pair(s) of Pz significantly lowers the energies of
197 teraction between K(+), the tryptamine NH(2) lone pair, and the indole ring in K(+)(Tryp) favors the
198 e radical prefers to align with the nitrogen lone pair, and this interaction leads to an A(1,3)-strai
199 anism involves Cu(II) binding to the amide N lone pair, decoupling it from >N-C horizontal lineO reso
202 ation energy (E(aroma)), strength of carbene lone pair, proton affinity, and CuCl binding energy.
203 environment attributable to its stereoactive lone pair, which was qualitatively described by pseudopo
206 by the competition between ferroelectric Bi lone pair-driven A site displacement, chemical order of
207 nt pyrazine and quinoxaline units involves a lone pair-heteroarene interaction which is much stronger
208 witterionic transition states facilitated by lone pair-LUMO interactions between the migrating R grou
209 this selectivity reversal is the result of a lone pair-pi interaction between the substrate ligated b
210 PYCH dihedral angle theta (Y = O, N, C) and lone pair-PYC dihedral angle omega shows similar theta,o
217 t-enhanced reactivity of nucleophiles with a lone-pair adjacent to the attacking center-was recently
218 condary orbital effect role for the nitrogen lone-pair and hence the process is likely neither purely
220 demonstrates the large non-Karplus effect of lone-pair conformation on vicinal phosphorus-hydrogen co
221 cophore for nAChRs and suggest that nitrogen lone-pair directionality and steric factors may be impor
224 he shift to be associated with the loss of a lone-pair donor interaction from the distal histidine th
225 ctric phase transition ascribed to the 6s(2) lone-pair effects of Bi(3+) at around 135 K, and a long-
226 ransfer transition involving donation of the lone-pair electron density on both Sb(III) and Sn(II) to
227 However, for substituents that stabilize by lone-pair electron donation, such as N or O centers, the
228 .82-0.85) and the NBO energy of the nitrogen lone-pair electrons of amines (N = 59, R(2) values of 0.
230 ressure-induced delocalization of non-bonded lone-pair electrons to sp(3)d(2) hybridization in two-di
233 become competitive with the commonly favored lone-pair interaction whenever the carbonyl group carrie
234 e of distinctly coexisting weak covalent and lone-pair interactions, give rise to cooperative structu
236 volving an antibonding, b(1), combination of lone-pair MOs, occur in forming all (CO)(2n) molecules f
237 al disconnections-one involving the nitrogen lone-pair orbital and the other the carbonyl carbon of t
239 an antibonding, b(1g) combination of carbon lone-pair orbitals in four CO molecules and the b(2g) an
240 and a natural population analysis of natural lone-pair orbitals on the donor atoms support the mechan
241 f the oxyallyl LUMO with the carbonyl pi and lone-pair orbitals, making this reaction "hemipseudoperi
245 F --> Te chelate motif supported by a strong lone-pair(F) --> sigma*(Te-C) donor-acceptor interaction
246 he alpha-C-H sigma* orbital and a heteroatom lone-pair, increasing the C-H BDE and destabilizing the
249 e opposed by the Pauli repulsion between the lone pairs (n) of O(i-1) and the bonding orbital (pi) of
250 z trajectory, involves delocalization of the lone pairs (n) of the oxygen (O(i-1)) of a peptide bond
251 z trajectory, involves delocalization of the lone pairs (n) of the oxygen (O(i-1)) of a peptide bond
253 mides, and esters, and particularly when the lone pairs are engaged in orthogonal hydrogen bonding (h
254 spectrum despite the fact that the nitrogen lone pairs are held in a perpendicular geometry that wou
258 nerates the favored diastereomer, the oxygen lone pairs from the substituent are closer to the cation
259 ased on the simple orbital mixing model, the lone pairs in a pair of neutral directly connected heter
261 = -0.83) and reinforces the notion that the lone pairs in these phenols are not readily available fo
262 part, stabilized by delocalization of the N lone pairs into the vacant p-orbital at carbon (or a hea
263 gma orbital by two, adjacent, sp(2) nitrogen lone pairs of electrons and stabilization of the carbene
266 ich include n-pi* interactions involving the lone pairs of electrons on water oxygen atoms and the an
268 a weak electrostatic interaction between the lone pairs of the nitrogen atoms and the positively char
272 fect at present is hyperconjugation from the lone pairs on the ring heteroatom to the antibonding orb
273 is of DFT calculations, to the twisting of N lone pairs out of conjugation with the carbonyl pi orbit
275 on produces electron-rich heterocycles (four lone pairs) and features homoatomic sigma-bond heterolys
276 o the aromatic pi-system via the chalcogen p lone pairs, and greater overlaps among these components
278 nto the chemical-bonding network, as well as lone pairs, of the prototypical PCM, Ge2 Sb2 Te5 (GST).
287 ergistic effect of two types of stereoactive lone-pairs on Sb(III) and Sn(II) is critical for the cha
288 NT binding ability in liquid compared to the lone PEGM surface and 3-fold higher TNT binding compared
289 tating the localization of the remaining two lone pi-electrons on each of the end atoms, therefore in
291 obilities in transistors made with Te as the lone semiconductor or from Te-organic multilayer semicon
296 in APH-1 serves as a scaffold, anchoring the lone transmembrane helix from nicastrin and supporting t
297 er the interaction of QCN with TbHK1, as the lone Trp residue (Trp-177) was quenched under all condit
298 TWA and MA when compared with patients with lone TWA (median, 37 [interquartile range, 26-61] versus
299 uilding design and access, communication and lone working, provision of equipment and consumables, an
300 In contrast, our results show that Dpo4, the lone Y-family DNA polymerase in S. solfataricus, can fai
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