ライフサイエンスコーパス: loneliness

1 , 3-12, with higher score indicating greater loneliness).

2 ly sensitive to subjective social isolation (loneliness).

3 across a variety of diseases exacerbated by loneliness.

4 ocial isolation and mortality is mediated by loneliness.

5 the association between the pSTS volume and loneliness.

6 m the first genome-wide association study of loneliness.

7 an important role in shaping an individual's loneliness.

8 e well-being and of subjective well-being on loneliness.

9 both have an effect on an individual's final loneliness.

10 Robots provide benefits such as relieving loneliness and enabling communication.

11 We estimated the chip heritability of loneliness and examined coheritability between lonelines

12 Those without kin report higher rates of loneliness and experience elevated risks of chronic illn

13 ies deficient in participants who experience loneliness and in many psychopathologies.

14 rpinnings and disease mechanisms involved in loneliness and may enhance early detection and intervent

15 The coheritability between loneliness and neuroticism may reflect the role of negat

16 neliness and examined coheritability between loneliness and several personality and psychiatric trait

17 Developing interventions for loneliness and subjective well-being could have substant

18 back of fairly substantial magnitude between loneliness and subjective well-being.

19 cted sustained psychological wellbeing, less loneliness, and a lower incidence of new chronic disease

20 bute to the development of social isolation, loneliness, and consequent cognitive decline and depress

21 There was no significant change in loneliness, and mean degree of loneliness during the stu

22 to life evaluation, but health, care giving, loneliness, and smoking are relatively stronger predicto

23 Both social isolation and loneliness are associated with increased mortality, but

24 easurement and environmental determinants of loneliness are well understood, but its genetic basis is

25 rrying about family or friends overseas, and loneliness as post-migration stressors.

26 We conclude that loneliness, as defined in this study, is a modestly heri

27 Main Outcomes and Measures: Loneliness, as determined by the 3-item UCLA Loneliness

28 Loneliness-associated genes derived primarily from plasm

29 s studies have estimated the heritability of loneliness between 37 and 55% using twins and family-bas

30 n about the neural processes associated with loneliness (but see [12-14]).

31 en was significantly associated with greater loneliness: compared with individuals in the amyloid-neg

32 1.48 for the top quintile of isolation), but loneliness did not (hazard ratio 0.92, 95% confidence in

33 ant change in loneliness, and mean degree of loneliness during the study was robustly associated with

34 areas of chronic dysphoria (e.g., anger and loneliness/emptiness) and interpersonal symptoms reflect

35 Loneliness has been shown to longitudinally predict subj

36 ubstrate for the negative affective state of loneliness has remained elusive.

37 Although both isolation and loneliness impair quality of life and well-being, effort

38 al amyloid burden is associated with greater loneliness in cognitively normal older adults.

39 (PiB-PET), was examined in association with loneliness in linear regression models adjusting for age

40 disease (AD) genes (that was correlated with loneliness in this sample, although gene expression anal

41 Loneliness is a complex biological trait that has been a

42 itively normal older adults, suggesting that loneliness is a neuropsychiatric symptom relevant to pre

43 Loneliness is a perceived state of social and emotional

44 Loneliness is a risk factor for depression and other ill

45 the emotion of loneliness, susceptibility to loneliness is a stable trait that varies across individu

46 Loneliness is associated with an increased risk of late-

47 Loneliness is associated with impaired mental and physic

48 Loneliness is increasingly prevalent in modern societies

49 Loneliness is the distressing feeling associated with th

50 h indicates that perceived social isolation (loneliness) is a risk factor for morbidity and mortality

51 risk associated with perceived isolation, or loneliness, is not well understood.

52 role for DRN dopamine neurons in mediating a loneliness-like state.

53 h amyloid burden (amyloid-positive group) to loneliness (lonely group) using logistic regression, con

54 leus accumbens from donors (N=26) with known loneliness measures.

55 hypothesized that individual differences in loneliness might be reflected in the structure of the br

56 We hypothesized that loneliness might occur in association with elevated cort

57 g, less depression, low social isolation and loneliness, more close relationships, better self-rated

58 entified strong genetic correlations between loneliness, neuroticism, and a scale of 'depressive symp

59 re resettlement related stressors, including loneliness (odds ratio 1.17, 95% CI 1.05-1.28 for PTSD a

60 magnitude and persistence of the effects of loneliness on subjective well-being and of subjective we

61 ty, and empathy independently contributed to loneliness, only basic social perception skills mediated

62 is discussed because stress, lack of sleep, loneliness, or lack of exercise each impair EFs.

63 and spiritual well-being (P < .05) and more loneliness (P < .05) than both survivors and controls.

64 her their effects are independent or whether loneliness represents the emotional pathway through whic

65 Prior-day feelings of loneliness, sadness, threat, and lack of control were as

66 Loneliness, as determined by the 3-item UCLA Loneliness Scale (possible range, 3-12, with higher scor

67 was 1.230 (0.209), and the mean (SD) UCLA-3 loneliness score was 5.3 (1.8).

68 ) are far less important than mental health (loneliness), sensory function (hearing), mobility, and b

69 nships can transiently induce the emotion of loneliness, susceptibility to loneliness is a stable tra

70 ore strongly to the subjective experience of loneliness than to objective social network size.

71 -reported isolation (a three-item scale) and loneliness (two questions).

72 of social defeat (U=109, z=-2.09, P=.04) and loneliness (U=87.5, z=-2.72, P=<.001) than did healthy c

73 d hazard ratio for mortality risk related to loneliness was 1.38 (95% CI 1.30-1.47), which reduced to

74 A standard questionnaire measure of loneliness was administered also.

75 Loneliness was assessed with a 5-item scale at baseline

76 Loneliness was associated with 1710 differentially expre

77 finding predicted, we further confirmed that loneliness was associated with difficulty in processing

78 Loneliness was associated with lower level of cognition

79 isolation with mortality was unchanged when loneliness was included in the model.

80 However, the effect of loneliness was not independent of demographic characteri

81 , the association of high amyloid burden and loneliness was stronger in APOEepsilon4 carriers than in

82 in whom autopsy of the brain was performed, loneliness was unrelated to summary measures of AD patho

83 ple experiencing perceived social isolation (loneliness), we conducted integrative analyses of leukoc

84 Both social isolation and loneliness were associated with increased mortality.

85 r results indicate that, if interventions on loneliness were made 1 and 2 years prior to assessing fi

86 CHRNA4, IL-1A, CRHR1, MTHFR, DRD2, APOE) and loneliness were replicated (p>0.05), despite our much la

87 on to the potential expansion of older adult loneliness, which is increasingly considered a threat to

88 Relevance: We report a novel association of loneliness with cortical amyloid burden in cognitively n

89 ich the associations of social isolation and loneliness with mortality were attributable to differenc

90 The associations of social isolation and loneliness with premature mortality are well known, but

91 ndardized effect = -0.13) to assessing final loneliness would both have an effect on an individual's