ライフサイエンスコーパス: long

1 like cohesin for which the search process is long ( 1 min vs. 33 min).

2 arthquake recurrence intervals are generally long (10s to 100s of thousands of years) relative to con

3 fy the effect on bleeding and ischaemia of a long (12-24 months) or short (3-6 months) treatment in r

4 in response to systemic administration of a long-acting analog of the gut-hormone glucagon-like pept

5 ssessment, three intramuscular injections of long-acting cabotegravir 800 mg or saline placebo at 12

6 results of the first phase 3 trial assessing long-acting intramuscular pasireotide in patients with C

7 are modestly augmented by the addition of a long-acting ss-agonist.

8 connexin 40), are persistently downregulated long after a transient Notch pulse.

9 Afterglow optical agents, which emit light long after cessation of excitation, hold promise for ult

10 n the treatment of angina pectoris began not long after its original synthesis in 1847.

11 Tuberculosis (TB) treatment is long and complex, typically involving a combination of d

12 ester transfer protein) inhibitors has had a long and difficult course with 3 compounds failing in ph

13 e thoracic vertebrae before giving rise to a long and extensive cauda equina.

14 Long and short doublets were the dominant songs in South

15 dominant songs in Southern California, while long and short triplets were dominant in the Gulf of Cal

16 This signals a new chapter in the long and unusual story of GO, which was the first antibo

17 ugh liquids or crawl on surfaces by rotating long appendages called flagella.

18 genomes showed that numerous strains possess long arrays of orphan immunity genes encoded in the 3' r

19 ar, and the children were followed up for as long as 10.7 years (median, 5.5 years).

20 ransmission and will sustain transmission as long as they do not attain high vaccination coverage.

21 1R or TLQ mutations have serum half-lives as long as wild-type human IgG1.

22 Our microsecond-long atomistic simulations elucidate key structural diff

23 uccessfully isolated, paving the way for the long-awaited (6,12)-c MOF with alb topology.

24 nalyze molecule displacements only along the long axis of the cell, where molecules experience the le

25 sults in a high degree of twisting along the long axis.

26 rystal lithium iron phosphate microrods with long-axis along the [010] direction.

27 Season-long bee abundance and richness were not detectably diff

28 The amyloid precursor protein (APP) has long been appreciated for its role in Alzheimer's diseas

29 tance of cell death in brain development has long been appreciated, but many basic questions remain,

30 and pH-dependent reduction potential, N2 has long been considered a candidate for the elusive "energy

31 otic plasma membrane organization theory has long been controversial, in part due to a dearth of suit

32 ween genetic variation and drug response has long been explored to facilitate the optimization and pe

33 The adenosine A2A receptor (A2AR) has long been implicated in cardiovascular disorders.

34 Dysregulated catecholamine signaling has long been implicated in drug abuse.

35 spartyl proteinases of Candida albicans have long been implicated in virulence at the mucosal surface

36 The bacterial flagellar filament has long been studied to understand how a polymer composed o

37 Renal cell carcinoma has long been understood to have a component of immune media

38 Long bone length in dogs is a unique example of multiple

39 expression in joints versus growing ends of long bones.

40 hat TmELO1 and TmELO2 function to synthesize long chain and very long chain fatty acids.

41 2 function to synthesize long chain and very long chain fatty acids.

42 MenA inhibiting, long chain-based compounds were designed, synthesized an

43 activity, this enzyme can use cellobiose and long-chain cellodextrins with a degree of polymerization

44 Proportions of n-3 PUFAs (very long-chain n-3 [VLC n-3; sum of eicosapentaenoic acid, d

45 most abundant protein in the blood and has a long circulation half-life (19 days).

46 apable of achieving a high energy density, a long cycle life and an excellent power density, has the

47 overpotential ( approximately 0.025 V) for a long cycle life.

48 ains such as 'Ug99' (5,6) pose a threat from long-distance dispersal out of East Africa to the large

49 the ribosome-binding kl-TSS that provides a long-distance interaction with the 5' end is unique.

50 Improved understanding of the mechanism of long-distance iron signaling will allow improved strateg

51 tudy reports a novel technique that analyses long-distance subionospheric very low frequency radiowav

52 le and its ability to spread locally or over long distances without a vector.

53 for capturing fluorescent signal patterns of long DNA molecules (in the range of 0.1-1 Mbp).

54 In low-frequency AC fields, long DNA molecules form macro-ion clusters.

55 The portability and long DNA sequences of RTnS offer great potential for fie

56 development of KOP-r selectivity, extremely long duration of action) that limit translation to human

57 ntly more spontaneous termination of initial long-duration VF was observed (66.67%; P=0.01).

58 cations within the lung, and are preceded by long-duration waves of airway smooth muscle contraction.

59 atment of asymptomatic bacteriuria (ASB) and long durations of therapy for symptomatic urinary tract

60 This trial was not large enough or of long enough duration to draw conclusions about safety.

61 Electrophysiologists have long experienced the trade-offs between anatomically-acc

62 e domestication for directional selection of long fibers.

63 The beta-sheet self-assembles to form long fibrils with the hydrophobic edge and histidine res

64 Alongside the FN pillars, long filopodia protrude from the basal surfaces of somit

65 CHD and ASCVD prognostic indicators during a long follow-up period.

66 Ecosystems with long histories of habitat disturbance, however, could be

67 campal activity remained uncertain despite a long history of investigation.

68 entification and characterization of a novel long intergenic non-coding RNA with MyoD-regulated and s

69 Our deletion-based approach identified two long intergenic non-coding(linc)RNAs, lincRNA-Cox2 and l

70 In contrast, Tcf1 long isoforms were required for differentiation of T fol

71 Physiologists have long known that CO2 directly affects acid-base and ion r

72 rly timed replication origins connecting the long-known effect of genomic context on replication timi

73 a2 channels are a novel target to facilitate long-lasting extinction of alcohol-seeking behavior.SIGN

74 al key kinases can predict the occurrence of long-lasting forms of LTP for multiple experimental prot

75 Given the long latency period of pancreatic cancer, exploring the

76 tion between primary SLCs and less frequent, long-latency startle responses (LLCs).

77 appear to independently sustain appreciable long-lived charge generation.

78 change, potentially aiding the adaptation of long-lived corals.

79 ii) d(5) complex, and emission occurs from a long-lived doublet ligand-to-metal charge-transfer ((2)L

80 ly showed that humanized mice immunized with long-lived induced-dendritic cells loaded with the pp65

81 for NK cells to adapt and differentiate into long-lived memory cells has added further complexity to

82 Here, we demonstrate that integration of long-lived Mn(2+) upconversion emission and relatively s

83 As a result of the presence of the long-lived PCs, it also generated prolonged virus-neutra

84 Radiolabeling with long-lived positron emission tomography (PET) radionucli

85 that accompanied the extremely energetic and long-lived prompt gamma-ray emission from GRB 160625B.

86 ngth, as a loss of Abl2 leads to excessively long myofibers in the diaphragm, intercostal and levator

87 Notably, ZNF750 promoted the expression of a long non-coding RNA (TINCR), which mediated both cancer-

88 transcriptional profiling, we found that the long non-coding RNA MIR100HG and two embedded microRNAs,

89 To date, a large number of long non-coding RNAs (lncRNAs) have been recently discov

90 s such as small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs), undergo trans-splicing a

91 ribed ultraconserved regions (T-UCRs) encode long non-coding RNAs implicated in human carcinogenesis.

92 ymorphism (SNP) located in the intron of the long noncoding RNA (lncRNA) LINC00305 by searching the G

93 study was designed to determine the role of long noncoding RNA (lncRNA), metastasis-associated lung

94 Many long noncoding RNAs (lncRNAs) are unstable and rapidly d

95 Increasing evidences have demonstrated that long noncoding RNAs (lncRNAs) play important roles in ma

96 Typically, sRNAs, originating from long noncoding RNAs, guide Argonaute-containing effector

97 added dimensions of modulation by miRNAs and long-noncoding RNA (lncRNA).

98 Star-PAP impacting lowly expressed mRNAs and long-noncoding RNAs to the greatest extent.

99 of clinical practice and with a sufficiently long observation period outside the clinical trial scena

100 Inner membrane-anchored long OPA1 (L-OPA1) undergoes proteolytic cleavage result

101 The mechanical response time of a 100 nm long origami lever to an applied voltage step is less th

102 these results, we propose a revised model of long-patch BER and a new key regulation point for pathwa

103 r the most part, derived from the relatively long persistence of sea ice in the autumn.

104 cs using PET radionuclides with a relatively long physical half-life, such as (89)Zr.

105 Long-QT syndrome is a potentially fatal condition for wh

106 tion expected for a spin solid, a state with long range order.

107 s ultimately responsible for the appropriate long-range AMPAR-mediated recruitment of neurogliaform c

108 temporal ventriloquism - however, unlike the long-range apparent motion paradigm, this was unaffected

109 However, in contrast to the Arctic, long-range atmospheric transport is deemed less importan

110 CDK9 activity is also associated with long-range chromatin interactions, suggesting that enhan

111 forms the synaptic mechanism responsible for long-range coherent activity in the retina.

112 nectivity analyses suggest reorganization in long-range connections from early visual areas to the fa

113 d as a state characterized by a breakdown of long-range correlations.

114 wever, little is known about whether and how long-range cross-frequency coupling across distant brain

115 c chromatin-regulating protein complexes and long-range DNA interactions.

116 We demonstrate that long-range electrostatic fields emanating from the oxide

117 The antiferromagnetic long-range order manifests through the divergence of the

118 The long-range order over hundreds of microns of these cryst

119 where tiling units arrange with local but no long-range order, remains challenging.

120 of field along the magnetic easy-axis melts long-range order, revealing a bistable, strongly correla

121 ectin domain, thus modulating the GalNAc-Ts' long-range preferences.

122 for how MRX-Sae2 creates entry sites for the long-range resection machinery.

123 r Exo1, retaining the exonuclease on DNA for long-range resection.

124 correct it with the aligned contig regions (long read support based validation approach).

125 then constructs a contig graph and, for each long read, references the other long reads' alignments t

126 improved the original approach by developing long-read ChIA-PET, in which the length of the paired-en

127 Recent advances in long-read DNA sequencing technologies, specifically Nano

128 Long-read sequencing can overcome the weaknesses of shor

129 iae and Piromyces finnis were assembled with long-read, single-molecule technology.

130 nd, for each long read, references the other long reads' alignments to find the most accurate alignme

131 ired a model that shows how pairings between long repeated sequences could be efficiently rejected ev

132 py number variation of paralogous genes, and long repetitive sequences.

133 omplete RNA cargo, including both small- and long-RNAs, in a single library preparation step.

134 Data on the burden of disease have long served as a cornerstone to health policymaking, pla

135 vel, UBP684 produced a dramatic reduction in long shut times and a robust increase in mean open time.

136 scriptional repression of 15-PGDH elucidates long sought-after molecular mechanisms that govern PG ac

137 Thus, vasohibin/SVBP complexes represent long-sought TCP enzymes.

138 Long-sought transporters involved in mitochondrial calci

139 s that are missing in chicken, including the long-sought-after nephrin and tumor necrosis factor gene

140 eracting magnetic fine particle systems is a long standing and difficult inverse problem.

141 dented and exciting opportunities to address long standing questions in biomedical research.

142 mit Texas hold'em, the leading benchmark and long-standing challenge problem in imperfect-information

143 First, a long-standing debate about the significance of aggressio

144 debris volume, revealing the origins of the long-standing hypothesized correlation between the wear

145 There are long-standing interests in the potential benefits of vit

146 Modular redefinition: A long-standing paradigm in modular polyketide synthase en

147 A long-standing question in evolutionary developmental bio

148 hicle-related emissions on health has been a long-standing question in human health sciences; however

149 organic donor-acceptor interfaces has been a long-standing question in the organic photovoltaics comm

150 nder biologically relevant conditions-answer long-standing questions in membrane biology and illustra

151 hium/sodium metals, and hence eliminates the long-standing safety issue.

152 The 6 week long stimulation had no residual adverse effects on the

153 ycosylated surface fibers, but features 30 A-long surface protrusions that are formed by loops of the

154 that tool-assisted foraging on shellfish by long-tailed macaques (Macaca fascicularis) in Khao Sam R

155 Long term evaluation of the electrode was found to be st

156 The remarkable analytical parameters and long term stability of both the sensors could be envisio

157 chemical properties, in-vivo performance and long term stability under electrical stimulation of a ne

158 e printed black phosphorus is stable against long-term (> 30 days) oxidation.

159 -scale biosand filters (BSFs) and assess the long-term (9 month) efficacy for particulate and Escheri

160 ts short in vivo half-life is an obstacle to long-term administration.

161 enology than above-average temperatures, the long-term advance in phenology was reduced.

162 ory deaths in 2010 that were attributable to long-term annual O3 exposure based on the updated relati

163 nent surfaces may have an edge in creating a long-term antibacterial environment.

164 We are unable to comment on long-term antibody sensitisation effects.

165 blood of aviremic HIV-1-infected patients on long-term antiretroviral therapy, and their frequency in

166 Long-term aspirin use was not associated with cancer-spe

167 In patients with long-term aspirin use, the changes of molecular events i

168 , this is the first study to investigate the long-term association of antioxidant supplement use and

169 in a neuronal mRNA pool during an olfactory long-term associative memory (LTAM) in Caenorhabditis el

170 ntral nervous system (CNS) inflammation with long-term behavioral and cognitive alterations.

171 this requires additional information on the long-term benefits (e.g., life-years gained and mortalit

172 In long-term bioluminescence recordings, GABAA receptor blo

173 n how net and gross carbon fluxes affect the long-term carbon isotope mass balance, and may lead to r

174 eta-blockers, dual antiplatelet therapy, and long-term cardiovascular events.

175 59 Dutch nursing home wards for long-term care.

176 change to the CS-US time interval results in long-term changes in cortico-striatal synaptic efficacy

177 lonized water reservoirs may be required for long-term clearance.

178 We evaluated long-term clinical features, longitudinal immunoreconsti

179 resence of obesity have potential short- and long-term clinical implications.

180 Further study is needed to assess safety and long-term clinical outcome.

181 ently restructured to ensure that short- and long-term clinical outcomes continue to improve.

182 Further research is needed on procedural and long-term clinical outcomes.

183 extensive neural damage, often resulting in long-term cognitive impairments.

184 carcinoma is an exceptional and poorly known long-term complication after pancreaticoduodenectomy.

185 weeks (WCWs) have been used to assess asthma long-term control but have never been validated for AD.

186 al antibody responses, involved in providing long-term cross-protection against H3N2 influenza virus

187 Our data demonstrates that extensive long-term culture-induced MSC aging impaired their osteo

188 The primary outcome was a composite of long-term CV events or death, which was assessed via nat

189 tative genetic framework to individual-based long-term data for a wild rodent population and show tha

190 ver time at half (50%) of the locations with long-term data, the vast majority of which (74%) were in

191 cings, such as tectonics, sea-level fall and long-term decline in greenhouse gas concentrations durin

192 d, elevated CO2 and temperature will lead to long-term declines in the amount of carbon stored in agr

193 ement (PROM) tools is recommended to capture long-term degree of health outcomes.

194 learn with very little data, and (c) bridge long-term dependencies between actions and rewards.

195 role for this pathway in activity-dependent long-term depression (LTD) at hippocampal Schaffer colla

196 mpal neurons abolishes NMDA-induced chemical long-term depression.

197 than 800,000 people annually, while creating long-term disability in millions more.

198 Former smokers with long-term e-cigarette-only or NRT-only use may obtain ro

199 aphic cycle of trees, efforts to predict the long-term effects of a changing climate on tropical fore

200 to ecological processes that demonstrate the long-term effects of soil contamination.

201 bsence of clear evidence in support of their long-term efficacy is leading many patients who could be

202 ldlife, livestock and humans world-wide, but long-term empirical datasets describing this condition a

203 erein primary human healthy liver cells form long-term expanding organoids that retain liver tissue f

204 Also, long-term follow-up of patients with TTP is crucial to i

205 Conclusion With an 83% 8-year OS rate, long-term follow-up of the FOLL05 trial confirms the fav

206 remained significantly increased, even after long-term follow-up of up to 20 years.

207 emic safety signals were observed during the long-term follow-up period.

208 y of wind power, suggesting that advances in long-term forecasting could be exploited to markedly imp

209 tential to improve the therapeutic ratio and long-term function for these patients.

210 on regulates HSC fate and how it affects the long-term functionality of HSCs and the blood system as

211 emissions from waste treatment plants, (iv) long-term gaseous and liquid emissions from landfills, (

212 teract with genetic risk to produce negative long-term health consequences such as neurodegenerative

213 ldren is associated with poor short-term and long-term health outcomes; however, the frequency of AKI

214 tus (SES) can have negative consequences for long-term health.

215 ously established Drosophila heart model for long-term hypoxia exposure, we found that hypoxia caused

216 ffer from low potency, inability to generate long-term immune memory and decreased activities against

217 t common congenital infection that can cause long-term impairment (LTI).

218 ck of non-specific sensor fouling may enable long-term in situ sensor array operation in low resource

219 Long-term increased lithium exposure in drinking water m

220 onsidered to be an inevitable consequence of long-term inflammation in patients who did not respond t

221 ects of TRPV1-mediated hypothermia by DHC on long-term ischemic stroke injury and functional outcome.

222 We evaluated the responses of AM fungi in a long-term leaf litter addition and removal experiment in

223 (+) T cells) from donor mice with HF induced long-term left ventricular dysfunction, fibrosis, and hy

224 nducible expression of OCT4 (iOCT4) supports long-term LIF-independent self-renewal of ES cells cultu

225 ating prescription opioid dependence, and is long-term maintenance of opioid agonist treatment associ

226 Vector-induced short- and long-term Mef2c upregulation in mouse prefrontal project

227 ced memory reactivation during sleep renders long-term memories of negative experiences more negative

228 mission of food preference (STFP), mice form long-term memory of food odors presented by a social par

229 hought to be a critical mechanism supporting long-term memory stabilization.

230 schema congruence has a strong influence on long-term memory.

231 ring remains important for the prevention of long-term microvascular complications in adults with typ

232 erals it does not provide a simple proxy for long-term monitoring of biodegradation of hydrocarbons i

233 ensory-predominant with pain and can lead to long-term morbidity in survivors.

234 The long-term mortality among patients with undiagnosed diab

235 We found an increased long-term mortality in individuals with wet AMD treated

236 Long-term mortality in the propensity score-matched popu

237 chronic dialysis, hospital readmission, and long-term mortality.

238 Our model allowed the long-term multisite recording from pure axonal branches

239 lpine areas, it is crucial to identify their long-term natural trends, ecological thresholds, and res

240 Childhood CSE is associated with substantial long-term neurological morbidity, but primarily in those

241 Prevalence of long-term opioid therapy among patients with polyneuropa

242 ients with polyneuropathy who were receiving long-term opioids had multiple functional status markers

243 aim of the present study was to analyze very long-term outcome after MV repair and replacement for de

244 We assess long-term outcome and prognosis factors for vascular com

245 s and quantifies PR and CR as surrogates for long-term outcome in MGN.

246 hese noncardiac complications may affect the long-term outcome in these patients and what modifiable

247 nical value of this marker as a predictor of long-term outcome merit further evaluation.

248 sed or treated at our institution to analyze long-term outcome, response to treatment, and incidence

249 The results suggest that good long-term outcomes can be achieved using aflibercept for

250 ffolds have the potential to further improve long-term outcomes, they have not yet achieved results e

251 vide complementary prognostic information on long-term outcomes.

252 of previous COPD admissions, previous use of long-term oxygen, age, and BMI.

253 We examined the long-term population dynamics of the invasive common was

254 odic memory, and synaptic changes induced by long-term potentiation (LTP) are thought to underlie mem

255 ors (betaARs) enhances both the induction of long-term potentiation (LTP) in hippocampal CA1 pyramida

256 hannels completely suppressed development of long-term potentiation (LTP) in the CA1-subiculum, but n

257 showed reduced initiation and maintenance of long-term potentiation of glutamatergic synapses.

258 sh oil might have prophylactic potential for long-term prevention of asthma in offspring.

259 earch on vaccine approaches that can provide long-term protection against dengue virus infection is n

260 received sacubitril/valsartan had a greater long-term reduction in HbA1c than those receiving enalap

261 matic changes, in which sky-islands acted as long-term refuges and cradles of genetic diversity.

262 capacity, biocompatibility, scalability, and long-term reliability.

263 ing studies have investigated short- but not long-term risk.

264 his study will provide more insight into the long-term safety and efficacy of bariatric embolization.

265 Long-term SSRI treatment may delay progression from MCI

266 effects on regeneration dynamics play out in long-term stand dynamics.

267 All of the reagents are stable during long-term storage and can be prepared in advance.

268 Additional studies of long-term surgeon trainer proficiency, community-specifi

269 n of transcriptional mechanisms that support long-term survival and differentiation of repair cells w

270 ansplantation may offer their best chance at long-term survival.

271 abnormalities that are associated with poor long-term survival.

272 tying and bile reflux are common concerns in long-term survivors after Whipple surgery.

273 l therapies were enumerated and described in long-term survivors.

274 raised interest in accessing the quality of long-term survivorship.

275 amine receptor (D1R) expression, and ensures long-term synaptic plasticity.

276 ation of photosynthetic rates constrains the long-term temperature dependence of GPP, and highlights

277 (grade 0, 1, or 2) demonstrated a favorable long-term treatment response in 87% of patients (complet

278 Continuation of omalizumab after long-term treatment results in continued benefit, as evi

279 it is unclear if this net decline reflects a long-term trend.

280 Long-term trends in excess risk of death and cardiovascu

281 o functional status markers were improved by long-term use of opioids.

282 rs in the environment and landfills can be a long-term, (potentially) substantial source of PFOS.

283 ocus, including firefly luciferase, to allow long-term, non-invasive imaging of Hmox1 expression, and

284 anges of transient species expanded over the long-term, slowly increasing their regional retention an

285 reproductive endocrine system that persisted long-term.

286 r, the transcriptional activity of the viral long terminal repeat (LTR) from Vpr-deficient proviruses

287 rough recombination with specific classes of long terminal repeat (LTR) retrotransposons and organize

288 promoter phenotypically resembles endogenous long terminal repeat (LTR) sequences, pointing to a sele

289 Despite long theoretical and experimental exploration, the natur

290 toxic to the environment and organisms for a long time and is hard to excrete from the body.

291 variant electrode area), to "convergent" at long time where its response now tends toward that of a

292 at low temperature has been predicted for a long time, it has not been directly observed on polycrys

293 ablished short travel/low-volume (ST/LV) and long travel/high-volume (LT/HV) cohorts.

294 for less funding, this may reverse a decades-long trend of more money going to older PIs.

295 tively small size, SN-NPM possessed superior long tumor retention time (>5days) and much higher accum

296 alphaPEG, short-type cells; 293T/L-alphaPEG, long-type cells; 293T/SL-alphaPEG, hybrid-type cells) to

297 in the 5'-UTR also changes the inclusion of long upstream ORFs (uORFs).

298 Designing complexes with sufficiently long values of T2 requires an understanding of precisely

299 Three proteins found in human cones, i.e. long-wavelength (L)-, middle-wavelength (M)-, and short-

300 n causes drainage directions to diverge from long-wavelength topography, as observed on Earth.